「hie」の検索結果

Assigns isolate identity at the right resolution for the question -- ANI/Mash species triage, 7-locus MLST historical comparability, cgMLST/wgMLST outbreak resolution (chewBBACA, BIGSdb, Ridom SeqSphere, EnteroBase HierCC), in-silico serotyping (SISTR/SeqSero2 Salmonella, SerotypeFinder E. coli, Kaptive Klebsiella, SeroBA pneumococcus, spa+SCCmec S. aureus), and lineage callers (TB-Profiler/Mykrobe barcode for MTBC, Pangolin + Nextclade for SARS-CoV-2, PopPUNK GPSC for S. pneumoniae). Use when typing bacterial isolates for surveillance or outbreak investigation, choosing between cgMLST allele distance and core-SNP distance for cluster definition, harmonising calls across schemas/database versions, assigning MTBC lineage with the Napier 90-SNP barcode, calling Salmonella serovar via SISTR with monophasic Typhimurium awareness, running Pangolin UShER mode with pangolin-data version pinning, or selecting a typing resolution to match the surveillance question.

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Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

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Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.

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Runs JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens; Allen et al 2019 Genome Research) which models per-sgRNA log-fold-change as the product of a treatment-dependent gene-essentiality term and a treatment-independent guide-efficacy term. Covers the Bayesian decomposition math, the hierarchical efficacy prior shared across screens performed with the same library, when JACKS outperforms MAGeCK (multi-screen joint analysis, libraries with broad efficacy variance) and when it does not (single screen, novel libraries with no prior efficacy), library-reuse efficacy transfer, downstream essentiality interpretation, and the 2.5x sample-size reduction enabled by efficacy-aware testing. Use when running multiple screens with the same library, when guide-level noise is suspected to dominate per-gene signal, when reusing published essentiality reference screens for efficacy priors, or when comparing screens performed across cell lines that share library but differ biologically.

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Infer orthologous genes and gene families across species using OrthoFinder3 (HOG-based phylogenetic orthology), SonicParanoid2, Broccoli, ProteinOrtho, OMA / FastOMA hierarchical orthologous groups, eggNOG-mapper, JustOrthologs, and TOGA whole-genome-alignment orthology. Use when building single-copy ortholog sets for phylogenomics, classifying co-orthologs and in/out-paralogs after gene duplication, propagating functional annotation via orthology with awareness of the ortholog conjecture, distinguishing speciation from duplication via gene-tree species-tree reconciliation, computing Quest-for-Orthologs benchmark performance, or running synteny-aware ortholog detection in WGD-affected lineages.

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Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

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Integrate Game Center features using GameKit. Use when authenticating GKLocalPlayer, checking player restrictions, submitting leaderboard scores, reporting achievements, implementing real-time or turn-based matchmaking, handling GKMatch data, showing the Game Center dashboard or access point, adding challenges and friend invitations, saving game data, or verifying player identity on a server.

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Use when planning or restructuring what pages a site has and how they connect: hierarchy, navigation, URL patterns, breadcrumbs, and internal linking. Not for XML sitemaps, which are in seo-audit.

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Implement SOC 2 Trust Services Criteria. Configure security, availability, and processing integrity controls. Use when achieving SOC 2 certification.

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Star Seller achievement guide — response time, shipping tracking, 5-star ratings, maintaining status

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Use when users need visual direction, interface hierarchy, layout decisions, design specifications, or prototypes before implementing a Web or mini program UI.

日本語の概要は準備中です。原文の説明を表示しています。

Debug a specific session by inspecting its full event chain (PreToolUse, PostToolUse, Stop, SubagentStop, Compaction, APIError, TurnDuration, Notification events), agent hierarchy (recursive parent/child tree with subagent_type and depth), token usage with compaction baselines, workflow intelligence data (orchestration DAG, error propagation by depth), and session metadata (thinking_blocks, turn_count, total_turn_duration_ms).

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Generate a comprehensive session report with per-model token usage (input, output, cache_read, cache_write including compaction baselines), cost breakdown via the pricing engine, tool invocations, agent hierarchy, compaction events, API errors, turn durations, and thinking block counts. Use when reviewing a specific session or summarizing activity over a date range.

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Write a resume / CV or cover letter tailored to a specific role. Handles regional format differences (AU/NZ, US, UK), ATS-friendly formatting, achievement-focused bullets, and cover letter structure. Use whenever the user mentions a job application, resume, CV, cover letter, career document, applying for a role, or needs help framing their experience for a specific job.

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Review a web app or page for visual design quality — layout, typography, spacing, colour, hierarchy, consistency, interaction patterns, and responsive behaviour. Not a UX audit (that checks usability) — this checks whether it looks professional and polished. Produces a design findings report with screenshots. Triggers: 'design review', 'does this look good', 'review the design', 'check the layout', 'is this polished', 'visual review', 'design audit', 'make it look better', 'it looks off'.

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Write compelling award submissions, grant applications, and competition entries. Maps achievements to selection criteria using evidence-based narratives. Use whenever the user is applying for a business award (Telstra, chamber of commerce, industry awards), a grant, a competition, or any submission demonstrating merit against defined criteria.

日本語の概要は準備中です。原文の説明を表示しています。

The Power BI report design canon covering design identity, visual hierarchy and the 3-30-300 rule, layout/spacing/alignment, color discipline, chart selection, KPI and card design, tables and matrices, accessibility, and the closing design gate. The shared reference home for report design judgment, routed to by the create-pbi-report, pbir-cli, review-report, modifying-theme-json, and custom-visual skills. Load when committing a design identity or making a design, layout, color, chart-selection, or accessibility decision for a report.

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When the user wants to plan website structure, decide which pages to build, or prioritize pages for a new or existing site. Also use when the user mentions "website structure," "site structure," "which pages do I need," "page planning," "sitemap planning," "Must Have pages," "website architecture," or "site hierarchy." For a specific page template (e.g. homepage), use homepage-generator or landing-page-generator as appropriate. Not for organic SEO roadmap alone; use seo-strategy.

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When the user wants to write or optimize H1-H6, fix heading hierarchy, improve content structure, rewrite an H1, or align headings with page intent. This skill owns actual heading changes; page-metadata may only check and report metadata-to-heading alignment.

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Reviews the design of an existing Power Pages site - a live URL or a local project folder - and recommends what to change, without modifying anything. Captures up to eight key pages at desktop and mobile, scores them against the plugin's design rubric (first impression, hierarchy, narrative, copy, trust, brand, responsive and accessible design, motion, detail), and returns prioritized, concrete recommendations. Use when the user wants a design review, critique, or audit of a site, asks how to make an existing site look better, more polished, or more impressive, or asks why it looks generic or dated.

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Migrates a traditional Power Pages site from Bootstrap 3 to Bootstrap 5. Downloads the site, runs the pac pages bootstrap-migrate engine, reviews the change report, applies AI-assisted fixes for the residual hierarchy/CSS changes the engine only flags, uploads the migrated site (which auto-enables the Bootstrap 5 runtime flag), verifies the flag, and validates. Use when the user wants to upgrade an older Bootstrap-3 portal to Bootstrap 5. NOT for code sites (React/Vue/Angular/Astro) — those are never Bootstrap-3.

日本語の概要は準備中です。原文の説明を表示しています。

Apply production-grade design standards when building or reviewing pages, components, or UI. Use this skill whenever the user asks to build a page, design a component, lay out a section, review the UI, fix the layout, or check design quality. Triggers on build a page, create a component, design a section, hero, card, CTA, layout, review the UI, fix the design, design system, design tokens, spacing, typography scale, button standards, mobile design. Also triggers for any production design decision where contrast, accessibility, spacing, or visual hierarchy matters.

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Design measurement frameworks including event taxonomy, KPI hierarchy, dashboard architecture, attribution models, and analytics implementation strategy. Use this skill whenever the user wants to plan analytics, design dashboards, build event taxonomies, define KPIs, set up tracking, or audit existing measurement. Triggers on analytics strategy, measurement plan, event taxonomy, tracking plan, KPI framework, dashboard design, north star metric, attribution model, conversion tracking, GA4 setup, Mixpanel setup, analytics audit. Also triggers when the user has data but no clear way to use it, or wants to make decisions but doesn't know what to track.

日本語の概要は準備中です。原文の説明を表示しています。

Manage, format, and organize scientific citations and bibliographies

日本語の概要は準備中です。原文の説明を表示しています。