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概要と使いどころ
Use when choosing or evaluating a startup revenue model, pricing/value metric, packaging/tier design, or calculating unit economics (LTV, CAC, payback, gross margin, NRR), including usage-based/credit/AI pricing and variable compute/COGS constraints.
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Use when evaluating business model viability, analyzing profitability per customer/product/transaction, validating startup metrics (CAC, LTV, payback period), making pricing decisions, assessing scalability, comparing business models, or when user mentions unit economics, CAC/LTV ratio, contribution margin, customer profitability, break-even analysis, or needs to determine if a business can be profitable at scale.
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Use this skill when a user wants to create, run, or analyze evaluation suites for Microsoft 365 Copilot declarative agents with the public @microsoft/m365-copilot-eval CLI. Trigger on intents such as "evaluate my agent", "test my agent", "run my evals", "create eval prompts", "add multi-turn tests", "tune evaluator thresholds", "why is my agent failing", or "set up eval environment variables".
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Azure Queue Storage SDK for Python. Use for reliable message queuing, task distribution, and asynchronous processing. Triggers: "queue storage", "QueueServiceClient", "QueueClient", "message queue", "dequeue".
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Azure Service Bus SDK for .NET. Enterprise messaging with queues, topics, subscriptions, and sessions. Use for reliable message delivery, pub/sub patterns, dead letter handling, and background processing. Triggers: "Service Bus", "ServiceBusClient", "ServiceBusSender", "ServiceBusReceiver", "ServiceBusProcessor", "message queue", "pub/sub .NET", "dead letter queue".
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Supervised and unsupervised multi-omics integration with mixOmics. Includes sPLS for pairwise integration and DIABLO for multi-block discriminant analysis. Use when performing supervised multi-omics integration or identifying features that discriminate between groups.
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Remove batch effects from RNA-seq data using ComBat, ComBat-Seq, limma removeBatchEffect, and SVA for unknown batch variables. Use when correcting batch effects in expression data.
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Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression. Reliably detects mutations at VAF above 0.5 percent using consensus-based approaches. Use when identifying tumor mutations from plasma DNA or tracking specific variants.
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JACKS (Joint Analysis of CRISPR/Cas9 Knockout Screens) for modeling sgRNA efficacy and gene essentiality. Use when analyzing multiple CRISPR screens simultaneously or when accounting for variable sgRNA efficiency across experiments.
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Decompose genetic effects into direct and indirect paths through mediating variables using the mediation R package. Tests whether gene expression, methylation, or other molecular phenotypes mediate the effect of genetic variants on disease. Use when testing whether a molecular phenotype mediates the genotype-to-phenotype relationship.
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Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Apply Michael T. Nygard-inspired production reliability rules when designing failure handling, timeouts, retries, circuit breakers, observability, or deployment behavior.
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Apply Steve McConnell-inspired construction rules when implementing routines, variables, classes, control flow, defensive code, or tests.
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Apply Martin Kleppmann-inspired data-system rules when designing reliability, scalability, consistency, replication, transactions, streams, or schema evolution.
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Generate falsifiable trade strategy hypotheses from market data, trade logs, and journal snippets. Use when you have a structured input bundle and want ranked hypothesis cards with experiment designs, kill criteria, and optional strategy.yaml export compatible with edge-finder-candidate/v1.
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Use when the user asks to "check our positioning against what we can actually ship", "trace which differentiators we can defend", or "reconcile the positioning canvas with the claims ledger"; reconciles the reused positioning canvas against the shippable stage and the claims ledger to produce a differentiation truth set — every differentiating claim verifiable or marked '[needs source]' — that TALE-T1 is judged against. Not for building the canvas — use positioning-mapper; not for adjudicating claims — use offer-claims-registry; not for authoring the message house — use message-system-architect. 定位真相/差异化校准/可交付现实/主张核对
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Use when the user asks to "map our positioning", "name our competitive alternatives", or "pick a beachhead segment for the launch"; produces a Dunford-style positioning canvas — named competitive alternatives (including spreadsheet and status quo), unique attributes (verifiable, or routed to the claims ledger), value themes (attribute→benefit→value chains), a target beachhead segment scored on serviceability / pain intensity / reachability, and a one-sentence onlyness statement — the sole upstream of the message house and the entity-signal source for the canonical entity profile. Not for the message house or per-channel launch copy — use message-house-builder; not for audience/persona profiling itself — use audience-mapper; not for SEO keyword positioning — use keyword-research. 定位画布/竞争替代品/独特价值/滩头细分
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Use when the user asks to "design our change narrative", "build the old-world-to-new-game story arc", or "frame the shift our category is undergoing"; produces a Raskin-style strategic narrative arc — old world → the undeniable shift → winners vs losers under the new rules → the promised land → proof the promised land is real — derived from the positioning truth set and the belief/objection map, feeding the TALE Architecture arc sub-item. Every proof beat is labeled Measured / User-provided / [needs source] and this skill never adjudicates a claim. Not for the message house hierarchy — use message-system-architect; not for the pitch deck narrative — use pitch-narrative-builder; not for claim substantiation — use offer-claims-registry. 变革叙事弧/旧世界/应许之地/战略叙事结构
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Use when the user asks to "build our pitch deck narrative", "write a fundraising story", or "structure the sales pitch narrative"; derives from the narrative canon a company pitch/deck narrative — problem → the undeniable shift → product-as-hero → proof → the ask — as a slide-beat outline (one narrative beat per slide, with the claim ID each proof beat rests on), for both a sales pitch and a fundraising deck. Every proof beat is labeled Measured / User-provided / '[needs source]' and unverified ones route to the claims candidates. Not for the launch-window battle cards and talk track — use sales-enablement-kit; not for the durable message hierarchy or the arc itself — use message-system-architect / strategic-narrative-designer; not for finished deck visual design — out of scope; not for claim adjudication — use offer-claims-registry. 路演叙事/融资故事/销售 pitch/幻灯节拍
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Provider-agnostic multi-LLM deliberation. Three phases — independent responses, cross-model anonymized ranking, chairman synthesis. Credentials come from explicit plugin configuration or pro-workflow-specific CLI variables. Persists transcript to a wiki page when --wiki <slug> is passed. Use when the user wants multiple AI perspectives, consensus-building, or the "LLM Council" approach for high-stakes reviews, plan critique, or contested learning rules.
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Builds resilient, long-running, multi-step applications with AWS Lambda durable functions with automatic state persistence, retry logic, and orchestration for long-running executions. Covers the critical replay model, step operations, wait/callback patterns, error handling with saga pattern, testing with LocalDurableTestRunner. Triggers on phrases like lambda durable functions, durable execution, workflow orchestration, state machines, retry/checkpoint patterns, long-running stateful Lambda functions, saga pattern, human-in-the-loop callbacks, reliable serverless applications, context.step, context.wait, context.invoke, context.runInChildContext, withDurableExecution, DurableContext, UnrecoverableInvocationError, durable-execution-sdk, qualified ARN invocation, and durable handler replay.
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Connects AI agents to remote Windows desktop applications on Amazon WorkSpaces Applications (AppStream 2.0) through the managed Agent Access MCP server, and guides reliable desktop automation. Covers connecting an agent to the MCP endpoint (SigV4, streaming URL, and Active Directory SAML/Domain Join), BLOCKING vs POLLING connect modes, the computer-use tools (screenshot, click, type, key, scroll), screenshot-budget and action-batching discipline, MCP tool forwarding (forwarded___ tools), session lifecycle and expire-on-delete, and troubleshooting connection errors. Use when building or debugging an agent that drives a remote Windows desktop or GUI application via WorkSpaces Applications / AppStream — including "dcv session not ready", "client_disconnected", 400 signing-region, POLLING/connection_status, SAML assertion, or forwarded tool questions. Not for Amazon WorkSpaces Personal/Core virtual desktops or general AppStream fleet administration unrelated to agent access.
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Authors and edits AWS Step Functions state machines: writes Amazon States Language (ASL) in JSONata, and chooses and structures state types (Task, Choice, Map, Parallel, Pass, Wait, Succeed, Fail). Covers ASL syntax, JSONata data transformation and variables, Retry/Catch error handling, service integrations (.sync, waitForTaskToken callbacks), Distributed Map for large-scale S3/CSV processing, saga/compensation patterns, Standard vs Express workflow choice, TestState API unit testing, and migrating state machines from JSONPath to JSONata. Use when the user is building, authoring, debugging, or migrating a Step Functions state machine or ASL definition, or orchestrating multi-step workflows with branching, retries, or human-approval callbacks, even if they don't say 'Step Functions.' Do NOT use for general Lambda function code, API Gateway, EventBridge wiring, or SAM/CDK application packaging.
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