「ida」の検索結果

Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Download raw sequencing reads from NCBI SRA using sra-tools (prefetch, fasterq-dump, vdb-validate) or the ENA mirror. Use when pulling FASTQ for SRR/ERR/DRR accessions, deciding between SRA-direct, ENA mirror, or AWS/GCP cloud mirror (STRIDES), handling --include-technical for 10x and other single-cell records, validating with MD5/vdb-validate, navigating SRR/SRX/SRS/SRP/PRJNA hierarchy, or finding accessions via pysradb. Encodes SRA cloud-egress economics, the fasterq-dump uncompressed-scratch trap, and the --max-size default that silently truncates large prefetches.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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[60] VALIDATE. Ensure new (staged and unstaged) changes are covered by tests at >70% and the full test suite is green. Use when asked to validate coverage for recent changes, add tests for modified code, or verify nothing else broke.

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Verify a released archon binary works end-to-end via a specific install path. Use when: cutting a new release, reproducing a user bug report on the released version, or validating that a hotfix binary actually works after a re-tag. Triggers: "test the release", "test 0.3.1 via brew", "verify the curl install", "smoke test the binary", "did the release binary work", "run /test-release", "verify the release". NOT for: testing dev work (use bun link directly), testing unreleased changes (build locally via scripts/build-binaries.sh first), or running the full validate suite (bun run validate is separate).

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Decision validation and thinking frameworks for startup founders. Use when you need to pressure-test a decision, validate your next steps, think through strategic options, or sanity-check your approach. Triggers on phrases like "should I", "help me think through", "is this the right move", "validate my thinking", "what am I missing". Covers fundraising, customer development, runway management, prioritization, and crypto/web3 founder challenges.

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Performs comprehensive preflight validation of Bicep deployments to Azure, including template syntax validation, what-if analysis, and permission checks. Use this skill before any deployment to Azure to preview changes, identify potential issues, and ensure the deployment will succeed. Activate when users mention deploying to Azure, validating Bicep files, checking deployment permissions, previewing infrastructure changes, running what-if, or preparing for azd provision.

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Proactive monitoring of Aave V3 borrow positions with liquidation alerts. Queries user collateral, debt, and health factor across chains (Ethereum, Polygon, Arbitrum, etc.). Sends urgent alerts to Telegram/Discord/Slack when health factor drops below configurable thresholds (critical at 1.05, warning at 1.2). Use when you need continuous monitoring of Aave positions, want alerts before liquidation risk occurs, or need periodic summaries of your borrowing health.

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Rigorous visual validation expert specializing in UI testing, design system compliance, and accessibility verification. Masters screenshot analysis, visual regression testing, and component validation. Use PROACTIVELY to verify UI modifications have achieved their intended goals through comprehensive visual analysis.

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You are a configuration management expert specializing in validating, testing, and ensuring the correctness of application configurations. Create comprehensive validation schemas, implement configuration testing strategies, and ensure configurations are secure, consistent, and error-free across all environments.

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Validates MCP server connectivity and health. Checks stdio and http MCP servers for availability, reports connection status, and provides fallback guidance. Triggers on: mcp health, check mcp, validate mcp, mcp status, mcp connectivity.

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Specialized skill for handling complex object comparison and deep validation. Use when you need to compare deep objects, exclude specific properties, handle circular references, or validate DTOs/Entities. Covers BeEquivalentTo, Excluding, Including, custom comparison rules, etc. Keywords: object comparison, deep comparison, BeEquivalentTo, DTO comparison, Entity validation, excluding properties, circular reference, Excluding, Including, ExcludingNestedObjects, RespectingRuntimeTypes, WithStrictOrdering, ignore timestamp, exclude timestamp

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Complete guide for ASP.NET Core Web API integration testing. Use when performing integration testing on Web API endpoints or validating ProblemDetails error format. Covers WebApplicationFactory, IExceptionHandler, Testcontainers multi-container orchestration, Flurl URL construction, and AwesomeAssertions HTTP validation. Keywords: webapi integration testing, WebApplicationFactory, asp.net core integration test, webapi integration test, IExceptionHandler, ProblemDetails, ValidationProblemDetails, AwesomeAssertions, Flurl, Respawn, Be201Created, Be400BadRequest, multi-container testing, Collection Fixture, global exception handling

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Performs runtime mobile security exploration of iOS applications using Objection, a Frida-powered toolkit that enables security testers to interact with app internals without jailbreaking. Use when assessing iOS app security posture, bypassing client-side protections, dumping keychain items, inspecting filesystem storage, and evaluating runtime behavior. Activates for requests involving iOS security testing, Objection runtime analysis, Frida-based iOS assessment, or mobile runtime exploration.

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Validates environment variables in CI, prevents secret leaks, enforces masking, and provides fail-fast validation with clear documentation. Use for "secrets management", "env var validation", "credential security", or "secret masking".

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Design, validate, and plan a startup from scratch. Covers market research, competitive analysis, business model, brand identity, product definition, financial projections, and validation experiments. Trigger when the user has a startup idea to explore, wants to validate a business concept, needs a business plan or lean canvas, asks for market sizing or competitive landscape, wants brand positioning or go-to-market strategy, or says anything like "I have an idea for..." or "is this idea worth pursuing". Also handles resuming from a previous checkpoint.

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Identifies and fixes XSS, SQL injection, and command injection vulnerabilities with validation schemas, sanitization libraries, and safe coding patterns. Use for "input validation", "XSS prevention", "SQL injection", or "sanitization".

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Hunt Session Management vulnerabilities — session fixation (no regeneration on login), insufficient invalidation on logout / password-change / email-change, predictable or low-entropy session IDs, JWT-as-session with no exp/revocation, refresh-token rotation/reuse-detection gaps, OAuth/SSO session linkage, device-bound-session (DBSC) downgrade, and cookie attribute issues (Secure/HttpOnly/SameSite/__Host-). Validate with TWO real sessions (attacker A + victim B), body-diff every 200, and OOB confirmation for theft chains. Medium to Critical (fixation→admin hijack, no-invalidation→persistent ATO).

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Bug bounty report writing for H1/Bugcrowd/Intigriti/Immunefi — report templates, human tone guidelines, impact-first writing, CVSS 3.1 scoring, title formula, impact statement formula, severity decision guide, downgrade counters, pre-submit checklist. Validation gates and the submittability/always-rejected decision are owned by triage-validation; this skill owns the written report itself (templates, tone, formulas). Use after validating a finding and before submitting. Never use 'could potentially' — prove it or don't report.

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Comprehensive methodology for auditing and exploiting TLS/SSL implementations and misconfigurations across network services and mobile applications. Covers protocol downgrade attacks including POODLE (CVE-2014-3566) against SSLv3 CBC padding, DROWN (CVE-2016-0800) cross-protocol attack leveraging SSLv2 export ciphers to decrypt TLS sessions, and FREAK (CVE-2015-0204) forcing RSA export-grade key exchange. Addresses BEAST (CVE-2011-3389) exploiting CBC IV predictability in TLS 1.0, CRIME (CVE-2012-4929) and BREACH targeting TLS-level and HTTP-level compression oracles respectively, and Heartbleed (CVE-2014-0160) for OpenSSL memory disclosure. Covers certificate validation bypass techniques for applications with improper hostname verification or chain validation, certificate pinning bypass using Frida and Objection for mobile application interception, HSTS bypass via NTP manipulation and subdomain exploitation, TLS 1.3 0-RTT replay attacks against non-idempotent endpoints, mutual TLS (mTLS) authentication a...

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Find and validate email addresses using Snov.io via Chrome DevTools MCP. Takes LinkedIn profile URLs and returns verified emails. Replaces ZeroBounce.

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Large-scale data migrations with validation, rollback, and zero-downtime strategies. Activate on: data migration, database migration, zero-downtime migration, dual-write, backfill, cutover, data validation, schema migration. NOT for: schema evolution in streams (use schema-evolution-manager), API versioning (use api-versioning-backward-compatibility).

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Validates typed DAG dependency declarations, returns Kahn linear extensions or generations and residual cycle witnesses, and identifies changed consumers for revalidation. NOT for constructing graphs, scheduling resource capacity, granting effects, or executing nodes.

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Architect data fetching with TanStack Query v5, SWR, optimistic updates, prefetching, and cache invalidation strategies. Activate on: React Query, SWR, optimistic updates, cache invalidation, prefetching, stale-while-revalidate, infinite queries. NOT for: REST API design (use api-architect), database queries (use database skills), GraphQL schema (use graphql-expert).

日本語の概要は準備中です。原文の説明を表示しています。