「nct」の検索結果

Expert en infrastructure Azure (AKS, Functions, Cosmos DB, AD, ARM templates, cost optimization)

日本語の概要は準備中です。原文の説明を表示しています。

Expert en construction d'outils pour agents IA (function calling, tool schemas, MCP, validation, error handling)

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Use this skill when writing unit tests, mocking dependencies, testing pure functions, or measuring coverage with Vitest. Trigger words: ユニットテスト, 単体テスト, Vitest, モック, テストを書く, カバレッジ, describe, it, expect, vi.mock.

Use this skill when implementing form submissions, data mutations, or any 'use server' function in Next.js 16. Trigger words: フォーム送信, mutation, 更新処理, 保存, Server Action, use server, useActionState, revalidatePath, データ更新.

Guide for when to use and when not to use return validators in Convex functions. Use this skill whenever the user is writing Convex queries, mutations, or actions and needs guidance on return value validation. Also trigger when the user asks about Convex type safety, runtime validation, AI-generated Convex code, Convex AI rules, Convex security best practices, or when they're debugging return type issues in Convex functions. Trigger this skill when users mention "validators", "returns", "return type", or "exact types" in the context of Convex development. Also trigger when writing or reviewing Convex AI rules or prompts that instruct LLMs how to write Convex code.

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Activate for any ticket that touches a Supabase RPC, edge function, or TypeScript client function in src/lib/. Ensures both caller and callee are verified before state:ready-for-qa.

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Firebase gives you a complete backend in minutes - auth, database, storage, functions, hosting. But the ease of setup hides real complexity. Security rules are your last line of defense, and they're often wrong. Firestore queries are limited, and you learn this after you've designed your data model. This skill covers Firebase Authentication, Firestore, Realtime Database, Cloud Functions, Cloud Storage, and Firebase Hosting. Key insight: Firebase is optimized for read-heavy, denormalized data. I

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Focused Signals scout for PostHog projects moving data through pipelines. Watches the three delivery surfaces — CDP destinations and transformations (hog functions), batch exports, and hog flows (workflows/messaging) — for contradictions between configured state and actual delivery: functions the watcher quietly degraded or disabled, failure rates stepping above a pipeline's own baseline, batch export runs failing or stalling (a growing data gap), and active flows failing for the people they trigger on. Emits findings only when they clear the confidence bar; otherwise writes durable memory and closes out empty. Self-contained peer in the signals-scout-* fleet — no dependencies on other skills.

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Training patterns for autoregressive neural PDE solvers (FNO, DeepONet, CNO). Covers rollout training, noise injection for stability, multi-component loss functions (H1, frequency-sensitive, boundary-aware), per-channel normalization for coupled multi-variable systems, and the PDEBench nRMSE metric. Use when training any neural operator that predicts time-dependent PDE solutions.

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Designs and analyzes stable-isotope-resolved metabolomics (SIRM / isotope tracing / fluxomics) experiments that measure metabolic ACTIVITY via 13C/15N/2H tracers, distinct from steady-state pool profiling. Covers tracer choice, isotopologue vs isotopomer, mass-isotopomer distributions (MID), fractional enrichment, the mandatory natural-abundance + tracer-purity correction (IsoCor, AccuCor), and the metabolic/isotopic steady-state vs non-stationary (INST-MFA) distinction. Use when feeding a labeled tracer and interpreting labeling patterns, correcting raw isotopologue intensities, computing or plotting an MID, or deciding tracing vs abundance profiling. For absolute pool concentration and MRM mechanics see metabolomics/targeted-analysis; for constraint-based genome-scale flux (FBA, not empirical tracing) see systems-biology/flux-balance-analysis; for feature detection see metabolomics/xcms-preprocessing; for pathway enrichment that ignores the pool-vs-flux caveat see metabolomics/pathway-mapping.

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Windows アプリ開発 (WinUI 3 / XAML) の UI 基盤リファレンス。 レイアウトパネル Grid, StackPanel, Canvas, RelativePanel, SplitView, ScrollViewer、 XAML マークアップ x:Bind, x:Name, x:Class, StaticResource, ThemeResource、 添付プロパティ, 依存関係プロパティ、 スタイル・テーマ Style, ControlTemplate, DataTemplate, VisualStateManager, ResourceDictionary, Acrylic, Mica, SystemBackdrop、 データバインディング Binding, INotifyPropertyChanged, ObservableCollection, IValueConverter, DataContext, MVVM、 アニメーション Storyboard, DoubleAnimation, EasingFunction, ThemeTransition, ConnectedAnimation, ImplicitAnimation。

Vercel プラットフォームリファレンス。Vercel CLI、vercel.json / vercel.ts 設定、 Vercel Functions（Node.js / Edge / Fluid Compute / ISR / Middleware）、 Vercel Blob、Edge Config、Marketplace Storage（Neon / Upstash / Supabase）、 デプロイメント管理（Git 連携 / rollback / rolling release）、 環境変数、ドメイン、DNS、ログ、キャッシュ、CDN。

OpenAI API (developers.openai.com) の Responses API リファレンス。 text generation, embeddings, structured outputs, streaming, function calling, programmatic tool calling, conversation state, prompt caching, reasoning models, background mode, compaction, multi-agent。 webhooks, error codes, rate limits, Realtime API server controls。 公式 SDK (Python / JavaScript(JS) / .NET / Java / Go / Ruby), openai CLI。 Chat Completions / Assistants からの移行, deprecations。

Storybook (UI コンポーネントカタログ・テストツール) リファレンス。 story, CSF (Component Story Format)、args, argTypes, decorators、 play function、interaction tests、autodocs、 main.ts / preview.ts 設定、アドオン (a11y, controls, viewport, themes)。

Inngest イベント駆動 Durable Execution プラットフォームリファレンス。 サーバーレス環境での長時間ワークフロー、バックグラウンドジョブ、スケジュールタスク実装。 createFunction, step.run, step.sleep, step.sleepUntil, step.waitForEvent, step.waitForSignal, step.invoke, step.sendEvent, step.fetch, step.ai.infer, step.ai.wrap, inngest.send, serve, connect。 concurrency, throttle, debounce, rate-limit, batching, priority, idempotency, singleton フロー制御。 Realtime（channels, topics, publish, subscribe, useRealtime, subscription tokens）による進捗配信。 Agent Evals, scoring, group.experiment, MCP dev server などエージェント運用機能。 Next.js / Express / Hono / Cloudflare Workers / Vercel / Netlify / DigitalOcean / Render デプロイ対応。

Supabase (オープンソース Firebase 代替・BaaS) リファレンス。 PostgreSQL データベース、Auth (Email / OAuth / Magic Link / Phone / SSO)、Storage、 Edge Functions (Deno)、Realtime (subscriptions / presence / broadcast)、Vector embeddings、 supabase-js、supabase CLI、RLS (Row Level Security)、migrations。 PostgreSQL ベース。SQL Server / node-mssql は別スキル mssql。

OpenAI API (developers.openai.com) の Agents SDK (Python / TypeScript) リファレンス。 Agent, Runner, handoffs, guardrails, tracing、 built-in tools（web search, file search, computer use, code interpreter, image generation）、 function tools, vector stores, MCP (Model Context Protocol) connectors, background mode, multi-agent orchestration、 SandboxAgent（隔離実行環境）。

CadQuery (Python 製 3D CAD スクリプティングライブラリ) リファレンス。 Workplane API (lineTo / extrude / revolve / sweep / loft / fillet / chamfer / shell)、 Sketch API、Assemblies (Constraint solver, 9 種制約)、Free Function API、 Selectors、Class hierarchy (Shape / Vertex / Edge / Wire / Face / Shell / Solid)、 Import / Export (STEP / DXF / STL / glTF / SVG)、Visualization (VTK, Jupyter)、CQGI。

Analyzes base-editing screens for variant function. Covers library design (Sanson 2020 GRACE, Hanna 2021 BRCA1/2 SNV scanning, Cuella-Martin 2021), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end, wider for ABE8e), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.

日本語の概要は準備中です。原文の説明を表示しています。

Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

日本語の概要は準備中です。原文の説明を表示しています。

Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

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Analyzes differential transcript usage (DTU) and isoform switches with functional consequence prediction (NMD via 50nt rule, ORF disruption, protein domain loss/gain, signal peptide changes, IDR alterations, coding-potential shifts). Tools include IsoformSwitchAnalyzeR v2 (auto-selects satuRn for >5 reps else DEXSeq), the manual DRIMSeq -> DEXSeq/satuRn -> stageR DTU pipeline, and fishpond/swish for inferential-uncertainty-aware DTE. Distinguishes DTU from DGE and DTE; integrates external annotators (CPC2, Pfam, SignalP, IUPred2A or DeepTMHMM). Use when investigating how splicing differences alter protein function or trigger NMD-mediated degradation.

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Build and configure Laravel 10+ applications, including creating Eloquent models and relationships, implementing Sanctum authentication, configuring Horizon queues, designing RESTful APIs with API resources, and building reactive interfaces with Livewire. Use when creating Laravel models, setting up queue workers, implementing Sanctum auth flows, building Livewire components, optimising Eloquent queries, or writing Pest/PHPUnit tests for Laravel features.

日本語の概要は準備中です。原文の説明を表示しています。