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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Use when implementing, testing, or evaluating ANY Apple Intelligence, on-device AI, or speech-to-text feature. Covers Foundation Models, @Generable, LanguageModelSession, Tool protocol, eval suites, model-as-judge scoring, SpeechTranscriber, CoreML.

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Apply modern Swift language patterns and idioms for non-concurrency, non-SwiftUI code. Covers if/switch expressions (Swift 5.9+), typed throws (Swift 6+), result builders, property wrappers, opaque and existential types (some vs any), guard patterns, Never type, Regex builders (Swift 5.7+), basic Codable shaping (CodingKeys, custom decoding, nested containers), modern collection APIs (count(where:), contains(where:), replacing()), basic FormatStyle usage, and string interpolation patterns. Use when writing core Swift code involving generics, protocols, enums, closures, or modern language features; route deep Codable to swift-codable, detailed formatting/localization to swift-formatstyle, and API naming to swift-api-design-guidelines.

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Implement, review, or improve SwiftUI gesture handling. Use when adding tap, long press, drag, magnify, or rotate gestures, composing gestures with simultaneously/sequenced/exclusively, managing transient state with @GestureState, resolving parent/child gesture conflicts with highPriorityGesture or simultaneousGesture, building custom Gesture protocol conformances, or migrating from deprecated MagnificationGesture to MagnifyGesture or using the newer RotateGesture.

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Apply Swift API Design Guidelines to name, label, and document Swift APIs. Covers argument label rules (prepositional phrase rule, grammatical phrase rule, first-label omission), mutating/nonmutating pair naming (-ed/-ing participle pattern, form- prefix, sort/sorted, formUnion/union), side-effect naming (noun for pure, verb for mutating), documentation comment structure (summary by declaration kind, O(1) complexity rule), clarity at call site, role-based naming, protocol naming (-able/-ible/-ing), default arguments over method families, casing conventions, and terminology. Use when designing new Swift APIs, reviewing naming and argument labels, writing documentation comments, or refactoring for call site clarity.

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Automate Electron desktop apps (VS Code, Slack, Discord, Figma, Notion, Spotify, etc.) using agent-browser via Chrome DevTools Protocol. Use when the user needs to interact with an Electron app, automate a desktop app, connect to a running app, control a native app, or test an Electron application. Triggers include "automate Slack app", "control VS Code", "interact with Discord app", "test this Electron app", "connect to desktop app", or any task requiring automation of a native Electron application.

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Maintain, debug, and recover MTGA's Trae native custom-model route. Use when Trae native integration fails, Trae updates shift ai_agent.dll hook offsets, errors such as 4028/4054/429 appear, native rewriter or SseOpenPayload URL rewriting needs diagnosis, or Codex needs to avoid repeating prior renderer-JS/private-protocol dead ends.

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Establish MAVLink connections between MATLAB and PX4/ArduPilot autopilots. Use when connecting to a drone, flight controller, or autopilot via MAVLink protocol over UDP. Covers dialect setup, UDP transport, timer-based heartbeat, and client discovery. Use when: "connect to PX4", "MAVLink connection", "heartbeat", "ground control station", "GCS", "connect to ArduPilot", "drone communication", "mavlinkio", "SITL".

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Use when setting up vehicle network communication in MATLAB using Vehicle Network Toolbox. Covers CAN/CAN FD (fully implemented), with architecture for J1939, XCP, and future protocols. Handles hardware discovery, channel creation, bus configuration, message exchange, signal encoding/decoding, and analysis across all supported vendors. (Vector, Kvaser, PEAK-System, NI, SocketCAN, MathWorks Virtual).

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Generate Euro NCAP test scenarios and variants using the ADT Euro NCAP support package. Use when creating NCAP seed scenarios, generating variants, translating between drivingScenario and RoadRunner, plotting scenario descriptors, computing NCAP scores, or exporting reports. Triggers on: ncapScenario, euroAssessment, getScenario, getScenarioDescriptor, generateVariants, ScenarioDescriptor, ScenarioDescriptorPlot, ncapScore, ncapReport, exportReport, configureVUT, assessmentTable, Euro NCAP, CCRs, CCRm, CCRb, CCFtap, CCCscp, CPNA, CPFA, CBNA, variant generation.

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Secure Model Context Protocol (MCP) servers with transport encryption, tool authorization, input validation, and audit logging for safe AI agent integrations.

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Bug → spec protocol. When a bug is found or a test fails, trace the cause, decide whether a new §V invariant would catch recurrence, append to §B. This is the one non-obvious thing SDD does that plan-then-execute doesn't. Triggers on test failure, bug report, post-mortem, or explicit user ask.

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Author or revise a cloud-api-operations recipe (config/source/skills/cloud-api-operations/references/recipes/). Encodes why the long tail of control-plane capabilities is deliberately NOT wrapped as MCP/CLI tools, the API-first admission test for whether a capability deserves a recipe, the negative and positive lists, the fixed recipe structure, the writing rules distilled from writing-for-agents, the user-facing copy red lines, and the product regeneration/verification pipeline. Also routes contributors (and their agents) to the contribution flow and the pre-PR self-test protocol in references/contributing.md. Use when adding a recipe, judging whether a scenario belongs in the recipe set, updating the recipes index, re-checking existing recipes against the admission test, or onboarding someone who wants to submit one.

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Discover profitable business ideas from scratch. Analyzes market gaps, trending niches, user skills, and competitive landscapes with a competitive intelligence protocol including 4-filter benchmark stress test and Blue Ocean differentiation grid. Use when the user has no idea what to build, wants to explore opportunities, needs market research, competitive benchmarking, or says 'find me a business idea', 'what should I build', 'market research', 'find opportunities', or 'competitive analysis'.

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Build the actual product — from landing page to deployed MVP with payment integration, QA testing, and post-deploy canary monitoring. Handles code generation, deployment, database setup, authentication, Stripe/payment integration, systematic QA protocol, and production health scoring. Use when the user needs to build something, deploy a product, set up payments, create a landing page, or says 'build this', 'deploy', 'create MVP', 'set up payments', or 'ship it'.

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蒸馏协议：为个人数字资料生成人类可读条款与机器可读 manifest；戏称「牛马保护法」仅为传播梗，非法律意见。

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Trace bugs and manual fixes back to kits and prompts; fix at the source so the iteration loop can reproduce the fix autonomously. Six-step revision process plus the single-failure backpropagation protocol. Use when a manual hot-fix has been applied, when convergence stalls, or when the same class of bug keeps reappearing.

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Validation-first design for Cavekit — every kit requirement must be automatically verifiable. Six-gate validation pipeline, phase gates, merge protocol, completion signals, acceptance criteria patterns. Use when designing acceptance criteria, wiring CI gates, or debugging why an agent is producing output that nobody can verify.

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Builds iOS/macOS/watchOS/tvOS applications with Swift 5.9+, SwiftUI, async/await concurrency, actors, protocol-oriented programming, and Vapor.

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Integrates with Atlassian products to manage project tracking and documentation via MCP protocol, including Jira issue management, Confluence page editing, sprint and backlog management.

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Track DeFi protocol metrics including TVL, yields, and liquidations

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Build MCP (Model Context Protocol) servers with tool definitions, resource providers, prompt templates, and transports. Use when exposing APIs to AI agents, building tool servers, converting OpenAPI to MCP, or creating MCP integrations.

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Design multi-agent orchestration with workflow DAGs, routing, handoff protocols, and state management. Use when building pipelines of specialized agents, designing fan-out/fan-in patterns, or implementing fault-tolerant workflows.

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