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Queries the UniBind database for experimentally validated transcription factor (TF) binding sites. Use when retrieving direct TF-DNA interaction datasets, downloading binding site coordinates (BED/FASTA) for local analysis, or listing available datasets by species, cell line, or TF name. Don't use to query specific intervals, locations, genes, motif models or expression data.

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Constructs deep-links and URLs for the AlphaGenome Atlas website. Supports generating single-variant exploration links (1-based chr:pos:ref>alt), genomic locus views (1-based closed chr:start-end), candidate summary tables, and AlphaGenome reference vs. alternate predictions. Use whenever visualizing, exploring, charting, or linking genetic variants and genomic loci on the AlphaGenome Atlas, or when asked to inspect, view, or link predictions for a genomic variant.

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Visualize, analyze, and render protein and molecular structures using PyMOL. Use when the user wants to create images of protein structures, perform structural alignments or superposition, measure distances or contacts, highlight binding sites or active site residues, color by B-factor/pLDDT, or analyze protein-ligand interactions. Do not use for docking, molecular dynamics, or sequence-only analysis.

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Packages generated wiki Markdown into a VitePress static site with dark theme, dark-mode Mermaid diagrams with click-to-zoom, and production build output. Use when the user wants to create a browsable website from generated wiki pages.

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Plan, deploy, operate, and troubleshoot Azure Local (formerly Azure Stack HCI): sizing and prerequisites, Arc registration, lifecycle updates, workloads (Azure Local VMs, AKS on Azure Local, images, disks, logical networks), SDN and network security, and failure triage — starting read-only and confirming before risky changes. WHEN: Azure Local, Azure Stack HCI, Arc resource bridge, custom location, Azure Local VM, Arc VM, AKS on Azure Local, AKS hybrid, SDN, Lifecycle Manager, Azure Local update, disconnected site.

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Predict CRISPR off-target sites using Cas-OFFinder and CFD scoring algorithms. Identify potential unintended cleavage sites genome-wide and assess guide specificity. Use when evaluating guide RNA specificity or selecting guides with minimal off-target risk.

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Use when the user asks to "track our share of voice", "what share of the conversation do we own vs competitors", or "trend our SOV this quarter"; computes SOV% = brand mentions ÷ (brand + competitor panel mentions) per platform per period on a LOCKED competitor panel — a panel switch invalidates the trend (restart the series and log the break; the ECHO O3 rule) — plus a sentiment-weighted SOV variant (sentiment labeled Estimated unless human-coded) and a Wikipedia-pageviews attention-share alternative; built from keyless listening connectors, gdelt.py news echo, and user exports — public counts only, closed platforms are never scraped. Not for backlink or offsite SEO signals — use offsite-signal-analyzer. 声量份额/竞品声量对比/提及份额/注意力份额

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Use when the user asks to "build programmatic SEO pages", "generate pages at scale", "rank on a high-authority third-party site", "borrow domain authority", "build a vs / alternative page", "do local SEO", "optimize a Google Business Profile", or "fix NAP" — one page-build router with four modes: programmatic (template × dataset systems), parasite (barnacle publishing on Medium/Reddit/LinkedIn/GitHub), comparison (vs / alternative pages in four formats), and local (GBP + NAP + citations + location pages), each with its own thin/duplicate, honesty, or reputation-abuse guardrail. Not for finding what to target — use keyword-research or content-gap-analysis; not for drafting one standalone article — use content-writer; not for scoring a page for publish — use content-quality-auditor. 程序化SEO/批量页面/寄生SEO/借势权重/对比页/vs页/替代页/本地SEO/谷歌商家档案/NAP一致性

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Use when the user asks to "plan my paid account structure", "pick Search vs PMax", "lay out ad groups / asset groups", or "audit paid-vs-organic cannibalization"; designs campaign-type selection, ad-group/asset-group layout, targeting + match types, negative/exclusion hygiene, and a paid↔organic overlap audit, and scores the ROAS A (Audience) dimension + structure. Not for computing the final RQS — use ad-account-auditor; not for budget split — use budget-optimizer; not for organic site architecture — use site-structure-optimizer. 付费广告账户结构/广告系列规划/否定关键词

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Run an evidence-led web quality audit covering performance, accessibility, SEO, best practices, and agentic browsing. Use when asked to "audit my site", "review web quality", "run lighthouse audit", "check page quality", or "optimize my website".

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Creates and deploys Node.js HTTP web applications on AWS Lambda Web Functions. Guides users through building web apps and APIs with Express, Fastify, or Hono, packaging, deploying via the aws lambda-web CLI, and iterating. Triggers when user wants to deploy a website or web app to AWS as serverless, deploy a Node.js HTTP server to AWS, build a serverless website or API with Node.js, deploy Express/Hono/Fastify apps, set up multi-region HTTP endpoints, connect a Node.js web app to private VPC resources, or explicitly mentions Lambda Web Functions. Does NOT trigger for non-Node.js runtimes, event-driven patterns (SQS, Kinesis, S3 events), or container deployments.

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Configures AWS Transit Gateway: creating a hub and attaching VPCs, segmenting traffic with route tables, centralizing egress and inspection through a hub (appliances or a Gateway Load Balancer endpoint), forcing east-west traffic between VPCs through AWS Network Firewall, connecting on-premises networks over the transit-gateway side of a Site-to-Site VPN or Direct Connect attachment (including ECMP to aggregate bandwidth across multiple VPN tunnels), peering transit gateways across Regions, migrating from a VPC peering mesh, and routing IP multicast. Applicable when connecting many VPCs through one router, isolating environments, forcing VPC-to-VPC traffic through a central Network Firewall, reaching on-premises over the hub, linking Regions, or moving off a peering mesh. Not applicable for single-VPC routing, VPC peering between two VPCs (vpcpeering skill), Direct Connect gateway or virtual interface setup (directconnect skill), or Route 53 DNS work.

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Migrates vibe-coded web applications to AWS. Handles the full workflow from analysis through migration to deployment, producing deployable AWS Blocks infrastructure code. Supports full-stack apps built with vibe-coding platforms (Lovable, Bolt.new, Replit) and frontend web applications and websites: React, Vue, Angular, Next.js, Nuxt, Astro, SvelteKit, Gatsby, Vite, Svelte, Solid, Docusaurus, and others (static sites, SPAs, and SSR frameworks with static export). Triggers on: launch with AWS, launch on AWS, deploy to AWS, migrate to AWS, host my app on AWS, move my app to AWS, transfer my app to AWS. Activates when the user wants to migrate a vibe-coded app or frontend web app to AWS, even if they don't say 'migrate' explicitly.

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Routes AWS networking requests to the correct service skill for implementation. Covers Route 53 (DNS, health checks, routing policies, Resolver, DNS Firewall), CloudFront (caching, edge, OAC, mTLS, signed URLs), Transit Gateway (multi-VPC hub, segmentation, centralized egress), Direct Connect (hybrid link, DX Gateway, MACsec), Site-to-Site VPN (IPsec tunnels, static or BGP), WAF (web ACLs, AWS Managed Rules, rate-based rules, Bot and Fraud Control), and Shield Advanced (L3/L4 DDoS). Applicable when creating, configuring, troubleshooting, or designing across these services, choosing between them, or diagnosing connectivity or traffic-filtering issues. Not for VPC subnets and route tables, load balancers, VPC endpoints, PrivateLink, API Gateway, IAM policy logic, container or serverless networking, or IaC authoring.

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Analyze HTTP security headers of web domains to identify vulnerabilities and misconfigurations. Use when you need to audit website security headers, assess header compliance, or get security recommendations for web applications. Trigger with phrases like "analyze security headers", "check HTTP headers", "audit website security headers", or "evaluate CSP and HSTS configuration".

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Generate CHANGELOG.md entry from recent commits in conventional format. Also syncs the website changelog page. Use this skill whenever the user asks to: generate a changelog, document what changed between tags, or create a new CHANGELOG entry. If you see requests like "write the changelog for v0.17", "what changed since last release", this is the skill to use. Do NOT manually edit CHANGELOG.md without this skill — it ensures proper formatting, user-perspective writing, and website changelog sync. For full release workflows (Release PR review, tests, draft assets, publication, announcements), use /release instead.

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SEO best practices for the Grida project across Next.js pages, blog posts, and documentation. Covers Next.js metadata API, Open Graph / Twitter cards, sitemaps, image search optimization, structured data (JSON-LD), Docusaurus frontmatter, and content writing for search. Use when creating or editing public-facing pages under editor/app/(www), writing blog posts, authoring docs, or reviewing SEO-related metadata. Trigger phrases: "SEO", "metadata", "sitemap", "open graph", "og image", "meta tags", "search ranking", "structured data", "JSON-LD".

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CSRF testing playbook. Use when reviewing state-changing web flows, anti-CSRF defenses, SameSite behavior, JSON CSRF, login CSRF, and OAuth state handling.

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Create award-winning, immersive web experiences at the level of Awwwards-featured agencies. Use when the user mentions "Awwwards quality", "make my site stunning", "scroll animations", "parallax storytelling", "cinematic web design", "portfolio site", or "brand experience". Also trigger when elevating a standard landing page into a memorable digital experience. Covers dramatic typography, purposeful motion, scroll-based composition, and performance-optimized animation. For foundational UI, see refactoring-ui. For type selection, see web-typography.

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Guided journey from a working codebase grown slow and tangled to one measurably fast, cleanly bounded, and readable. Orchestrates eight skills phase by phase - working-with-legacy-code, clean-architecture, software-design-philosophy, refactoring-patterns, system-design, ddia-systems, release-it, pragmatic-programmer - every phase carries its method inline so it runs standalone, asking the user questions at every decision point and recording results in the project docs/ folder (PERFORMANCE.md, ARCHITECTURE.md, ARCHITECTURE-OPTIMIZATION-PLAN.md) so the journey resumes across sessions. Use when the user wants to make an app faster, untangle drifted boundaries, fix slow endpoints and queries, or says 'it works but it is slow and getting worse'. For an untested prototype, improve-code-quality; for an aged codebase you fear to touch, remove-technical-debt; for greenfield structure, design-code-architecture; for marketing-site page speed, improve-website. For one framework in isolation, invoke that skill directly.

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Guided journey from a raw app idea to a validated, cleanly architected first version that ships on a sustainable cadence. Orchestrates ten skills phase by phase - lean-startup, design-sprint, clean-architecture, domain-driven-design, clean-code, pragmatic-programmer, system-design, ios-hig-design, 37signals-way, software-design-philosophy - asking the user questions at every decision point and recording results in the project docs/ folder (PRODUCT.md, ARCHITECTURE.md, EXPERIMENTS.md, CREATE-APP-PLAN.md) so the journey resumes across sessions. Use when the user wants to build a new app, validate an idea before writing code, architect an MVP that will not need a rewrite, or says 'help me build my app the right way'. App already exists: use improve-app or grow-app. Business idea not yet validated: run create-business first. Marketing site only: use create-website. Architecture-only question: design-code-architecture. For one framework in isolation, invoke that skill directly.

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Guided journey from a shipped app that works but feels rough to a product that fits the job, flows without friction, reads clearly, and persuades honestly. Orchestrates nine skills phase by phase - jobs-to-be-done, ux-heuristics, design-everyday-things, refactoring-ui, microinteractions, made-to-stick, influence-psychology, high-perf-browser, steve-jobs-design-review - asking the user questions at every decision point and recording results in the project docs/ folder (CUSTOMER.md, DESIGN.md, POSITIONING.md, IMPROVE-APP-PLAN.md) so the journey resumes across sessions. Use when the user wants to fix a clunky product, cut UX friction, sharpen in-app copy, or says 'the app works but feels rough'. Not for code, tests, or hardening - use improve-code-quality (fresh prototype) or remove-technical-debt (aged); no app yet, create-app; needs growth loops, grow-app; marketing-site friction, improve-website; one leaking flow, conversion-optimization. For one framework in isolation, invoke that skill directly.

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Audits and improves organic search performance — technical health, site architecture, internal linking, structured data, and the content decisions that determine what can rank. Use this to run an SEO audit, diagnose why pages are not ranking or were deindexed, plan a site's URL and navigation structure, add structured data, or prioritize which SEO fixes are worth doing.

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Operate websites and Electron apps through CLI commands, reusing Chrome login sessions. Prefer over browser_task for supported sites (GitHub, Bilibili, Twitter/X, YouTube, etc.) — deterministic commands with structured JSON output.

日本語の概要は準備中です。原文の説明を表示しています。