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概要と使いどころ
Analyze competitors with strengths, weaknesses, and differentiation opportunities. Identifies direct competitors and maps the competitive landscape. Use when doing competitive research, preparing a competitive brief, or finding differentiation opportunities.
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Think and work like an expert Galactic Astronomer. Use when a task calls for Galactic Astronomer judgment. Reasons from distance ladders, dust extinction, and survey selection functions through Gaia DR3 cross-matches, isochrone and Bayesian SFH fitting (PARSEC/MIST, Starfish), and orbit integration in named potentials (McMillan17, MWPotential2015) via galpy, Agama, and Gala, while treating parallax-S/N and RUWE failures, unresolved binaries and fiber collisions, dust-or-crowding overdensities, and spiral-arm-mimicking-streams as first-class failure modes.
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Competitive positioning, strategic group mapping, differentiation analysis, competitive advantage assessment, market positioning map, value chain positioning, brand positioning, cost leadership vs differentiation, niche strategy analysis, disruptive positioning
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Identify differentially bound regions across CLIP-seq conditions (knockdown vs control, treatment vs vehicle, disease vs healthy) using DEWSeq (sliding-window DESeq2), Flipper (Skipper-downstream), ASpeak, edgeR, or limma-voom. Use when computing condition-level changes in RBP binding intensity, choosing peak-level vs window-level vs crosslink-level testing, designing replicate experiments, or distinguishing biological binding shifts from technical confounders.
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Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Differential abundance testing for microbiome data using compositionally-aware methods like ALDEx2, ANCOM-BC2, and MaAsLin2. Use when identifying taxa that differ between experimental groups while accounting for the compositional nature of microbiome data.
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Visualize differential expression results using DESeq2/edgeR built-in functions. Covers plotMA, plotDispEsts, plotCounts, plotBCV, sample distance heatmaps, and p-value histograms. Use when visualizing differential expression results.
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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.
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Differential abundance and state analysis for cytometry data. Compare cell populations between conditions using statistical methods. Use when testing for significant changes in cell frequencies or marker expression between groups.
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Identify differentially accessible chromatin regions across conditions using DiffBind, csaw, DESeq2, or edgeR. Use when comparing ATAC-seq accessibility between treatment groups, choosing between consensus-peak vs sliding-window approaches, picking the correct normalization (full library vs reads-in-peaks), correcting batch with SVA/RUVseq, or interpreting log2FC and FDR thresholds in a chromatin context.
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Per-CpG differential methylation testing from bisulfite sequencing count data or beta-value matrices. Covers beta and M-value computation, coverage filtering, statistical tests (Welch t-test, Mann-Whitney, limma, DSS beta-binomial), multiple testing correction, and effect size calculation. Use when comparing methylation at individual CpG sites between experimental groups from WGBS, RRBS, or targeted bisulfite sequencing.
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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.
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Perform differential expression analysis of miRNAs between conditions using DESeq2 or edgeR with small RNA-specific considerations. Use when identifying miRNAs that change between treatment groups, disease states, or developmental stages.
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End-to-end ATAC-seq workflow from FASTQ files to differential accessibility and TF footprinting. Covers alignment, peak calling with MACS3, QC metrics, and optional TOBIAS footprinting. Use when running end-to-end ATAC-seq analysis from FASTQ to differential accessibility.
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Statistical testing for differentially abundant proteins between conditions. Covers preprocessing (log2 transformation, normalization), limma and DEqMS workflows with empirical Bayes moderation, fold change shrinkage for accurate effect size estimation, and Python alternatives. Use when identifying proteins with significant abundance changes between experimental groups.
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Workflow for spatial transcriptomics preprocessing, domain detection, deconvolution, neighborhood analysis, and publication-ready maps.
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Bulk transcriptomics differential expression with count-aware modeling, design validation, contrast handling, thresholded exports, and publication-ready DE figures.
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World-class level design expertise - spatial storytelling, player flow, blockout methodology, and the invisible hand that guides players without them knowingUse when "level design, blockout, graybox, whitebox, player flow, level layout, combat arena, exploration space, map design, multiplayer map, pacing, weenie, landmark, gating, metroidvania, open world design, linear level, environmental storytelling, teaching through design, playtesting, heatmap, metrics, sightlines, level-design, game-development, spatial-design, blockout, graybox, player-flow, pacing, environmental-storytelling, combat-design, multiplayer-maps, open-world, linear-design, metroidvania" mentioned.
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Expert in CrewAI - the leading role-based multi-agent framework used by 60% of Fortune 500 companies. Covers agent design with roles and goals, task definition, crew orchestration, process types (sequential, hierarchical, parallel), memory systems, and flows for complex workflows. Essential for building collaborative AI agent teams. Use when "crewai, multi-agent team, agent roles, crew of agents, role-based agents, collaborative agents, crewai, multi-agent, agents, orchestration, roles, collaborative-ai" mentioned.
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World-class brand positioning expertise combining David Ogilvy's direct response wisdom, Emily Heyward's obsessive brand strategy (Red Antler), and Al Ries/Jack Trout's positioning classics. This skill answers: "What space do we own in the customer's mind, and why does it matter?" Brand isn't what you say about yourself - it's what others say when you're not in the room. Positioning isn't about creativity - it's about claiming territory in an overcrowded mind. Use when "brand positioning, positioning statement, brand strategy, category design, competitive positioning, how should we position, brand differentiation, value proposition, what makes us different, brand platform, brand values, brand personality, brand promise, brand manifesto, tagline, unique selling proposition, usp, category creation, own a word, mind share, brand, positioning, strategy, differentiation, category, competitive, values, identity" mentioned.
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The art and science of narrative-driven brand communication. This skill transforms brand messages into compelling stories that connect emotionally, build memory, and drive action. In a world of infinite content, story is the only thing that cuts through. Great brands don't sell products—they tell stories. Apple tells the story of creative rebels. Nike tells the story of human potential. Patagonia tells the story of environmental stewardship. This skill teaches you to find, craft, and tell your brand's story across every touchpoint. AI amplifies storytelling capability—generating variations, adapting across channels, maintaining consistency—but the human insight that identifies the true story remains essential. This skill bridges narrative craft with AI execution. Use when "story, storytelling, narrative, brand story, origin story, hero journey, emotional connection, customer story, testimonial, case study, brand film, about us, storytelling, narrative, brand-story, emotional, hero-journey, content" mentioned.
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Antigravity UI & Motion Design Expert workflow skill. Use this skill when the user needs Core UI/UX engineering skill for building highly interactive, spatial, weightless, and glassmorphism-based web interfaces using GSAP and 3D CSS and the operator should preserve the upstream workflow, copied support files, and provenance before merging or handing off.
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红队渗透 / 攻防 — 受授权的红队作业者 + 渗透测试工程师 + 攻击型安全顾问的认知操作系统 (侦察 OSINT / 外网渗透 / 内网 AD 渗透 BloodHound + Kerberoasting + ADCS 利用 + 横向移动 / Web 应用渗透 OWASP WSTG / 移动 OWASP MASTG / 云渗透 AWS Azure GCP IAM 路径 + 容器逃逸 + K8s / C2 操作 Cobalt Strike Sliver Mythic Havoc + OPSEC / 初始访问 + AV EDR 绕过 (仅授权场景) / 无线 RF / 物理社工 / 报告与整改 / 框架 MITRE ATT&CK + D3FEND + PTES + OSSTMM + NIST 800-115 + Kill Chain / 法律伦理 CFAA + 网络安全法 + 刑法 285 286 + 数据安全法 + GDPR + 授权书 + 范围 + 交战规则 — 不含 黑产 / 未授权攻击 / 大规模 exploitation / 供应链投毒 / 未授权 DoS — 这是 重罪 + 行业封杀 + 律师吊销, 本 skill 严守 authorized-only 边界 — 也不含 蓝队 SOC + 恶意软件 即服务 / 僵尸网络 / 勒索软件作者 — 这是 cybercrime 不是 红队) (Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasion (phishing infrastructure, payload development, AV / EDR evasion, BYOVD, AMSI / ETW bypass — strictly for authorized engagements), (i) wireless / RF (WPA2/3, evil twin, Wi-Fi pivots), (j) physical / social engineering (badge cloning, pretexting, vishing — under engagement letter), (k) reporting & remediation (executive summary, technical findings, CVSS, MITRE ATT&CK mapping, retest), (l) frameworks & methodology (MITRE ATT&CK, MITRE D3FEND, PTES, OSSTMM, NIST SP 800-115, OWASP WSTG / MASTG, Cyber Kill Chain, Unified Kill Chain, Diamond Model), (m) law & ethics (CFAA US, Computer Misuse Act UK, 中国 刑法 285/286 + 网络安全法 + 数据安全法, GDPR for tested EU systems, engagement letter, scope, rules of engagement, safe harbor for bug bounty); NOT criminal hacking / 黑产 / unauthorized targeting / mass exploitation / supply-chain compromise / DoS against unconsented systems (这是 重罪 + 业内开除 + 律师执照吊销, 本 skill 严守 authorized-only 边界), NOT pure defensive blue team / SOC analyst tradecraft (是 平行学科, 仅做 边界标注 + ATT&CK 反推方向), NOT malware-as-a-service development / botnet ops / ransomware authoring (是 cybercrime 不是 红队), NOT 'ethical hacking' 在 'just curious 看看' 自我合理化的灰色操作 (违反 authorization 原则即不是 红队).) Master OS — automated mastery of Cybersecurity Red Team / Offensive Security Operations — the cognitive operating system of authorized red team operators, penetration testers, and offensive security consultants covering (a) reconnaissance & OSINT (passive + active discovery, asset surface mapping), (b) external network pentest (perimeter, exposed services, web), (c) internal network / Active Directory pentest (AD enumeration via BloodHound, Kerberos abuse — Kerberoasting / AS-REP-roasting / Unconstrained delegation / S4U2self, NTLM relay, ADCS abuse, GPO abuse, lateral movement, privilege escalation), (d) web application pentest (OWASP WSTG, authentication, authorization, SSRF, XXE, deserialization, SSTI, prototype pollution, GraphQL, JWT, API), (e) mobile pentest (OWASP MASTG, iOS / Android, instrumentation Frida / Objection, MASVS), (f) cloud pentest (AWS / Azure / GCP — IAM enumeration, privilege escalation paths, container escape, K8s RBAC, serverless), (g) C2 operations & post-exploitation (Cobalt Strike / Sliver / Mythic / Havoc, beacon ops, malleable profiles, OPSEC), (h) initial access & evasi
日本語の概要は準備中です。原文の説明を表示しています。