4,571 件 ・ 関連度順
概要と使いどころ
Use when you need to understand the Academy of Management Review (AMR) developmental, multi-round review and interpret a decision letter focused on theoretical novelty and logical soundness. Explains the process and decision types; it does NOT draft the response document (that is amr-rebuttal).
日本語の概要は準備中です。原文の説明を表示しています。
Use when you need to understand or set expectations for the Academy of Management Journal (AMJ) editorial and peer-review process — desk review, the developmental multi-round R&R culture, and reading a decision letter. Explains the process and how to read decisions; it does not draft the response letter (amj-rebuttal).
日本語の概要は準備中です。原文の説明を表示しています。
Research a company's ideal customer profiles and build detailed synthetic buyer personas. Identifies 4-6 distinct buyer segments through web research, then creates rich, realistic personas with demographics, motivations, skepticism profiles, decision criteria, and language patterns. Use when you need to understand who your buyers are at a deep level — their motivations, objections, and how they evaluate solutions.
日本語の概要は準備中です。原文の説明を表示しています。
Use this skill when the user asks to summarize, or asks why Simulink Coverage objectives are missing, unsatisfied, or uncovered on a coverage result they already have — why specific decision, condition, MCDC, relational-boundary, or saturation/overflow outcomes weren't exercised, whether uncovered logic is dead code, or how to close the gap (a test, a coverage filter, or a design change). It reads an existing cvdata, .cvt file, sim-with-coverage output, or Simulink Test result; it never runs cvsim to collect coverage.
日本語の概要は準備中です。原文の説明を表示しています。
Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
日本語の概要は準備中です。原文の説明を表示しています。
Balances Hi-C contact matrices (ICE via cooler.balance_cooler, KR/SCALE/VC context), computes distance-decay expected with cooltools (expected_cis per-diagonal P(s), expected_trans scalar), builds observed/expected (O/E) matrices, and diagnoses polymer state from the P(s) log-derivative. Covers the within-matrix-vs-cross-sample distinction (balancing is NOT a normalizer), the equal-visibility assumption that CNV/aneuploidy violates (use raw counts for copy-number), cis-only balancing, mad_max/blacklist masking before balancing, multiplicative cooler weights vs divisive juicer weights, and the resolution-vs-depth budget. Use when balancing a .cool/.mcool, computing expected or P(s), making O/E matrices for compartments/loops, deciding ICE vs KR vs SCALE, choosing a resolution for a given depth, or troubleshooting NaN/all-NaN balanced matrices; route cross-sample comparison to hic-differential.
日本語の概要は準備中です。原文の説明を表示しています。
Turns Hi-C/Micro-C FASTQ into a deduplicated, filtered .pairs file with pairtools and decides whether the library worked. Covers the bwa mem -SP5M / bwa-mem2 / chromap --preset hic alignment idiom (mates mapped as independent single-end reads), pairtools parse vs parse2 and the walks-policy choice (5unique pairwise vs all for Pore-C/Micro-C concatemers), pair-type classification (keep UU and rescued UC), dedup (PCR vs optical/by-tile), select by pair_type/MAPQ/distance, restriction-fragment handling (restrict, Arima dual-enzyme, Micro-C/DNase fragment-free), and allele-specific phasing (pairtools phase to two coolers). The library-QC decision uses % long-range cis as the one-number quality metric, trans as the noise floor, orientation balance as fragment-map-free dangling-end/self-circle QC, and % duplicates as a complexity proxy. Use when processing Hi-C/Micro-C/Omni-C reads into pairs, judging library quality, handling multi-enzyme or restriction-agnostic protocols, or generating allele-specific contacts.
日本語の概要は準備中です。原文の説明を表示しています。
Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
日本語の概要は準備中です。原文の説明を表示しています。
Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.
日本語の概要は準備中です。原文の説明を表示しています。
Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.
日本語の概要は準備中です。原文の説明を表示しています。
Simulate Bluetooth system-level networks using the Bluetooth Toolbox. Use this skill for any Bluetooth topology: BLE ACL (Asynchronous Connection-Less) data connections, CIS (Connected Isochronous Stream) and LE Audio for stereo speakers or hearing aids, BLE GAP (Generic Access Profile) connection establishment with advertising and scanning, Classic BR/EDR piconets with ACL data and SCO (Synchronous Connection-Oriented) voice links, and BLE+BR/EDR coexistence with adaptive frequency hopping. Covers bluetoothLENode, bluetoothNode, bluetoothLEConnectionConfig, bluetoothLECISConfig, bluetoothLEGAPConfig, bluetoothConnectionConfig, configureConnection, kpi (), updateChannelList, and all Bluetooth statistics.
日本語の概要は準備中です。原文の説明を表示しています。
Audit and remediate CIS benchmark violations. Use automated tools to assess compliance and implement hardening recommendations. Use when meeting compliance requirements or implementing security baselines.
日本語の概要は準備中です。原文の説明を表示しています。
Plan and execute user research including research planning, recruiting, interview design, qualitative synthesis, and translating findings into product decisions. Use this skill whenever the user wants to plan user research, design interviews, recruit participants, conduct discovery, run formative research, or synthesize qualitative findings. Triggers on user research, UX research, user interviews, discovery research, generative research, formative research, qualitative research, user insights, research synthesis, recruitment, interview guide, jobs to be done. Also triggers when product decisions are being made without user input and the user wants to fix that.
日本語の概要は準備中です。原文の説明を表示しています。
The Jobs-to-be-Done framework as applied product methodology. Job statements, struggling moments, hire and fire criteria, the difference between feature-thinking and job-thinking. Honest about where JTBD adds clarity (discovery, prioritization, positioning) and where it becomes performative ritual (job-statement workshops that do not drive decisions, persona-theater disguised as JTBD). Triggers on jobs-to-be-done, JTBD, job statements, struggling moments, hire criteria, fire criteria, switch triggers, functional emotional social jobs, outcome-driven innovation. Also triggers when a team is over-relying on feature-request lists or persona archetypes that do not drive product decisions, when a positioning conversation needs the framing JTBD provides, or when discovery is producing outputs that do not connect to product strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Running closed and open betas that produce real signal. Beta participant selection, structured feedback collection, beta-to-GA decision criteria, and the difference between soft-launch (no structure, no signal), kitchen-sink (everyone in, no actionable feedback), and structured beta (calibrated cohort, intentional feedback loops, clear graduation criteria). Triggers on beta program, alpha test, beta cohort, beta participant, beta feedback, beta to GA decision, design partner, early access program, closed beta, open beta, RC release. Also triggers when a feature is approaching launch and the team needs structured pre-GA validation, when prior betas produced noise rather than signal, or when the team has soft-launched before but wants more structured feedback this time.
日本語の概要は準備中です。原文の説明を表示しています。
Designing side-by-side comparison tools (plan-compare, product-compare, alternative-compare) that help users decide rather than just listing features. Axis selection, default-comparison logic, recommendation discipline. Honest about feature-list-dump (every feature in a row, no decision support), hidden-recommendation (biased comparison pretending to be neutral), and honest-comparison-with-guidance (genuine comparison plus opinionated recommendation) patterns. Triggers on comparison tool, plan compare, product compare, alternative compare, vs page, decision support tool. Also triggers when conversion through comparison stages is poor, when users are abandoning at the comparison step, or when a comparison tool is being scoped for the first time.
日本語の概要は準備中です。原文の説明を表示しています。
Plan, manage, and optimize a domain portfolio. Use this skill for DNS architecture decisions, redirect strategies, registrar choice, parking unused domains, multi-site setups, and domain consolidation or split planning. Triggers on DNS, domain, registrar, redirect, parking, subdomain, apex, www vs non-www, multi-site, portfolio, hreflang setup, domain migration. Also triggers when planning a new site that needs domain decisions made before launch.
日本語の概要は準備中です。原文の説明を表示しています。
Expert TSA cybersecurity compliance advisor for critical infrastructure owners and operators. Use this skill whenever a user asks about TSA Security Directives for pipelines, freight railroads, passenger rail, public transit, or bus operators; the TSA Cyber Risk Management Program (CRMP); Cybersecurity Implementation Plan (CIP); Cybersecurity Operational Implementation Plan (COIP); Cybersecurity Assessment Plan (CAP); incident reporting to CISA; designation of a Cybersecurity Coordinator; Critical Cyber Systems (CCS); OT/IT network segmentation; the TSA November 2024 NPRM; or any directive in the SD Pipeline-2021 series, SD 1580-21-01 (freight rail), or SD 1582-21-01 (public transit/passenger rail). Also trigger for questions like "are we covered by TSA directives?", "what does the TSA require for pipeline cybersecurity?", "how do I build a CIP?", "what must I report to CISA?", or any request involving transportation critical infrastructure cybersecurity compliance.
日本語の概要は準備中です。原文の説明を表示しています。
Fully automated review pipeline: CEO, Design, and Eng reviews with auto-decisions using 6 principles (completeness, boil lakes, pragmatic, DRY, explicit over clever, bias toward action). Only pauses for premise confirmation. Classifies decisions as Mechanical (silent) or Taste (surfaced at final gate).
日本語の概要は準備中です。原文の説明を表示しています。
Evidence-based clinical decision support and diagnostic reasoning
日本語の概要は準備中です。原文の説明を表示しています。
Architecture Decision Record documentation
日本語の概要は準備中です。原文の説明を表示しています。
Notion expert for product management workflows. Use for database design for PRDs/OKRs/Roadmaps/Decisions, property and view design, page architecture, Notion REST API, and sync with Jira, Linear, and GitHub.
日本語の概要は準備中です。原文の説明を表示しています。
Turn meeting notes into an accountable register — extract decisions, actions and open questions, flag ownerless items, track follow-through. Use when commitments get dropped or a recurring meeting decides nothing.
日本語の概要は準備中です。原文の説明を表示しています。