「copy」の検索結果

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

日本語の概要は準備中です。原文の説明を表示しています。

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

日本語の概要は準備中です。原文の説明を表示しています。

Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Admin debug system wiring for the floating AdminIndicator's live debug data and Copy Full Context. Use when adding debug visibility to a route or feature, wiring useDebugContext or the debug panel, capturing console errors, or enabling the copy-context workflow for a page.

日本語の概要は準備中です。原文の説明を表示しています。

Rules for every string rendered inside the app, plus the sweep that removes in-app prose. Use when writing or changing a label, hint, description, tooltip, empty state or KPI tile in a .tsx file, or when running Pattern Patrol P14 or asked to find or fix long UI text.

日本語の概要は準備中です。原文の説明を表示しています。

Improve unclear UX copy, error messages, microcopy, labels, and instructions to make interfaces easier to understand. Use when the user mentions confusing text, unclear labels, bad error messages, hard-to-follow instructions, or wanting better UX writing.

日本語の概要は準備中です。原文の説明を表示しています。

Rust のコードを書く・直す・レビューするときに使う。所有権、借用、Clone/Copy derive、文字列型 (`String`, `&str`, `Cow`, `'static str`) の選び方を、安易な複製や過剰な lifetime 固定に寄せず、実際のデータ所有者と呼び出し境界に合わせて判断するためのスキル。

セールスレターを書き始める前に、素材（読者・約束・抵抗・証拠・価格や保証などの確定事項）を一問ずつ執拗に聞き出すスキル。「セールスレターについて質問攻めして」「レターを書く前にヒアリングして」「素材を聞き出して」「grillして」、または具体性の乏しいブリーフのままセールスレター執筆を依頼されたときに使う。コピーライティングの「構想メモ」を、書く前に埋めるための対話手順。このスキル自体はレター本文を書かない。

Write copy following Sentry brand guidelines. Use when writing UI text, error messages, empty states, onboarding flows, 404 pages, documentation, marketing copy, or any user-facing content. Covers both Plain Speech (default) and Sentry Voice tones.

日本語の概要は準備中です。原文の説明を表示しています。

Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, algorithmic art, flow fields, or particle systems. Create original algorithmic art rather than copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

World-class autonomous sales and revenue skill system. Use ANY time the user asks to sell, pitch, prospect, close, negotiate, launch, monetize, build funnels, write outreach, craft proposals, develop pricing, design offers, write sales copy, create email sequences, plan campaigns, position products, handle objections, create playbooks, build pipeline, forecast revenue, develop GTM strategy, optimize conversions, write ad copy, create sales decks, score leads, nurture prospects, upsell, cross-sell, retain customers, write case studies, price products, structure enterprise deals, create battle cards, script discovery calls, build affiliate programs, plan product launches, create webinar funnels, design pricing pages, A/B test offers, analyze unit economics, calculate LTV/CAC, or ANY other sales, revenue, monetization, go-to-market, or commercial growth task. If it involves selling, revenue, deals, pipeline, or commercial strategy — USE THIS SKILL. Trigger aggressively.

日本語の概要は準備中です。原文の説明を表示しています。

Creates and refines Founder Story and brand narrative content for DTC/independent stores selling founder-driven products (e.g. handcrafted leather, artisan sauces, small-batch goods). Use whenever the user mentions founder story, brand story, about page, origin story, artisan brand, handcrafted brand, "who we are" copy, brand voice, mission/vision for a product brand, landing page hero narrative, PDP brand block, or wants to differentiate through authenticity and founder-led storytelling—even if they do not say "founder story" explicitly. Output structured narrative frameworks, placement guidance, and ready-to-use copy aligned with DTC best practices.

日本語の概要は準備中です。原文の説明を表示しています。

When the user wants to create sales collateral, pitch decks, one-pagers, objection handling docs, or demo scripts. Also use when the user mentions 'sales deck,' 'pitch deck,' 'one-pager,' 'leave-behind,' 'objection handling,' 'deal-specific ROI analysis,' 'demo script,' 'talk track,' 'sales playbook,' 'proposal template,' 'buyer persona card,' 'help my sales team,' 'sales materials,' or 'what should I give my sales reps.' Use this for any document or asset that helps a sales team close deals. For competitor comparison pages and battle cards, see competitor-alternatives. For marketing website copy, see copywriting. For cold outreach emails, see cold-email.

日本語の概要は準備中です。原文の説明を表示しています。

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, algorithmic art, flow fields, or particle systems. Create original algorithmic art rather than copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Create beautiful visual art in .png and .pdf documents using design philosophy. You should use this skill when the user asks to create a poster, piece of art, design, or other static piece. Create original visual designs, never copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

Creating algorithmic art using p5.js with seeded randomness and interactive parameter exploration. Use this when users request creating art using code, generative art, algorithmic art, flow fields, or particle systems. Create original algorithmic art rather than copying existing artists' work to avoid copyright violations.

日本語の概要は準備中です。原文の説明を表示しています。

OpenClawの脆弱性報告を、公開済みのバージョンと信頼範囲の根拠で確認し、終了・継続・影響の絞り込みを判断して、管理者向けの返信案をまとめます。

• OpenClawの脆弱性報告を判断したいとき
• 公開版に不具合が残るか確認したいとき
• 既存の勧告との重複を調べたいとき

Rustのコード作成・レビュー・改修で、所有権やエラー処理、型設計、並行処理を見直し、安全性・性能・保守性を意識した実装へ整えるスキル。

• Rustの所有権と借用のレビュー
• 異常時に停止するエラー処理の改修
• Rustアプリの型とモジュール設計

公開前の文章やコードを二つの独立したエージェントが同じ基準で審査し、両方の合格まで修正と再審査を繰り返し、上限を超えたら人へ判断を引き継ぐスキル。

• 公開前に文章の事実関係を確認したいとき
• 顧客向け文章とブランドルールの照合
• 本番配布前に独立した審査を加えたいとき

実際のメールボックスで受信メールの仕分け、返信の下書き、送信確認を進めるスキル。履歴と送信済みの記録を確かめ、使用アカウントや対応状況を明確にします。

• 受信箱の仕分けとアーカイブ候補整理
• 履歴を踏まえた返信を下書きしたいとき
• メールを送信して記録を確認したいとき

Create strategic HTML presentations with Chart.js, design tokens, responsive layouts, copywriting formulas, and contextual slide strategies.

日本語の概要は準備中です。原文の説明を表示しています。