「endpoints」の検索結果

Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Maps between gene identifier systems (Ensembl, Entrez, HGNC symbol, UniProt, RefSeq, MANE) using AnnotationDbi, biomaRt, mygene, pyensembl, and Ensembl REST. Encodes Ensembl version stripping with GENCODE _PAR_Y preservation, the Ziemann 2016 Excel autocorrect debacle and Bruford 2020 HGNC renames (SEPT*->SEPTIN*, MARCH*->MARCHF*, MARC*->MTARC*, DEC1->DELEC1), OCT4/POU5F1 alias resolution, biomaRt archive endpoints for release pinning, the `filters` (plural) gotcha, MANE Select for clinical reporting, cross-species orthology via Ensembl Compara / OMA / OrthoDB, and tx2gene construction for tximport. Use when converting gene IDs across systems, handling renamed symbols, building tx2gene, pinning to a specific Ensembl release for reproducibility, or mapping cross-species orthologs.

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Query the Ensembl REST API for gene/transcript/protein lookup, sequence retrieval, comparative genomics (Compara), variant effect prediction (VEP), regulatory features, and cross-species ortholog/paralog calls. Use when pulling Ensembl-native data (Ensembl Gene IDs, version-pinned releases, archive endpoints for reproducibility), gene/transcript/exon structure with stable IDs, or VEP for variant annotation. Encodes the 15 req/sec rate limit, archive (e110.rest.ensembl.org) for reproducibility, Ensembl divisions (vertebrates / plants / fungi / metazoa / bacteria), and the symbol-vs-ID stability problem.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Comprehensive backend development guide for Langfuse's Next.js 14/tRPC/Express/TypeScript monorepo. Use when creating tRPC routers, public API endpoints, BullMQ queue processors, services, or working with tRPC procedures, Next.js API routes, Prisma database access, ClickHouse analytics queries, Redis queues, OpenTelemetry instrumentation, Zod v4 validation, env.mjs configuration, tenant isolation patterns, or async patterns. Covers layered architecture (tRPC procedures → services, queue processors → services), dual database system (PostgreSQL + ClickHouse), projectId filtering for multi-tenant isolation, traceException error handling, observability patterns, and testing strategies (Jest for web, vitest for worker).

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Predicts ADMET properties using ADMETlab 3.0 (119 platform features, including 77 prediction models with modeled-endpoint uncertainty), ADMET-AI, DeepChem MolNet, and chemprop D-MPNN with explicit handling of OECD QSAR principles, applicability domain assessment, calibration, hERG/CYP/AMES endpoints, and PAINS / Lipinski / Ro5 / Veber / BBB druglikeness filters. Use when filtering compounds for drug-likeness, prioritizing leads by predicted safety, or building an in-house ADMET QSAR model.

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Use when the user asks to generate API tests, create integration test suites, test REST endpoints, or build contract tests.

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Builds production-ready REST API endpoints with validation, error handling, authentication, and documentation. Follows best practices for security and scalability.

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Comprehensive REST API design review with automated linting, breaking-change detection, and design scorecards. Catches inconsistent conventions, missing versioning, and design smells before APIs ship. Use when reviewing a PR that adds or changes API endpoints, auditing an existing API for v2 migration, or establishing API standards for a team.

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Generate comprehensive, developer-friendly API documentation from code, including endpoints, parameters, examples, and best practices

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Guides Quarkus development across REST APIs, CDI dependency injection, Hibernate ORM, Panache, configuration, OpenAPI, templates, messaging, security, observability, packaging, and tooling. Use when building Quarkus applications, adding endpoints or clients, configuring datasources or OIDC, debugging build or runtime issues, or choosing extensions.

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REST/GraphQL API testing with automated validation — test endpoints, validate responses, check status codes, and ensure API contracts

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Guides stable API and interface design. Use when designing APIs, module boundaries, or any public interface. Use when creating REST or GraphQL endpoints, defining type contracts between modules, or establishing boundaries between frontend and backend.

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Error handling patterns for API endpoints. Use when implementing error handling, writing middleware, or reviewing how errors are caught and formatted in API code.

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REST API design conventions for this codebase. Use when writing or reviewing API endpoints, route definitions, response formatting, or client code that calls the API.

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API design conventions for this codebase. Use whenever writing or reviewing API endpoints, route handlers, or HTTP clients.

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Design and review intuitive, scalable, maintainable HTTP APIs. Use this skill whenever the user wants to design a new REST API, review an existing API or spec, write OpenAPI 3.x definitions, or work with HTTP semantics (GET/POST/PUT/PATCH/DELETE), status codes, idempotency (Idempotency-Key), error envelopes (RFC 7807 problem+json), pagination, filtering, versioning, or API auth (API keys, OAuth2 client credentials, rate limits). Also trigger for "API design", "RESTful", "endpoints", "OpenAPI", "Swagger", "ReDoc", "contract testing", or GraphQL and gRPC design questions.

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Systematically find and fix performance problems in applications, frontend and backend, by measuring first. Use this skill whenever the user reports slow endpoints, high latency, poor throughput, memory leaks, large bundles, or slow page loads; wants to profile with cProfile, py-spy, Chrome DevTools, Node --cpu-prof, or perf; run load tests with locust or k6; set performance budgets or SLOs; optimize database queries (EXPLAIN, indexes, N+1); add caching (Redis); improve frontend performance (code splitting, lazy loading, image optimization, memoization, virtualization); or tune the network (CDNs, gzip/br, HTTP/2/3). Also trigger for p50/p95/p99 latency, throughput, error rate, connection pooling, async vs threads, GIL, and memory leak investigations.

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Use when adding auth, webhooks, uploads, queues, secrets, tenant boundaries, or public endpoints — produces trust boundaries + abuse cases mapped to files, BEFORE implementation.

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Use when designing APIs, planning endpoints, REST conventions, versioning, or deprecation — even when the user just says 'expose this as an endpoint' without naming API design.

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Use this skill when adding authentication, handling user input, working with secrets, creating API endpoints, or implementing payment/sensitive features. Provides comprehensive security checklist and patterns.

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