1,316 件 ・ 関連度順
概要と使いどころ
Calculate polygenic risk scores using PRSice-2, LDpred2, or PRS-CS from GWAS summary statistics. Use when predicting disease risk from genome-wide genetic variants.
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Visualize ChIP-seq data using deepTools, Gviz, and ChIPseeker. Create heatmaps, profile plots, and genome browser tracks. Visualize signal around peaks, TSS, or custom regions. Use when visualizing ChIP-seq signal and peaks.
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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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Query dbSNP for rsID lookups, variant annotations, and cross-references to other databases. Use when mapping between rsIDs and genomic coordinates or retrieving basic variant information.
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Read, write, and convert multiple sequence alignment files using Biopython Bio.AlignIO. Supports Clustal, PHYLIP, Stockholm, FASTA, Nexus, and other alignment formats for phylogenetics and conservation analysis. Use when reading, writing, or converting alignment file formats.
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Parse and analyze multiple sequence alignments using Biopython. Extract sequences, identify conserved regions, analyze gaps, work with annotations, and manipulate alignment data for downstream analysis. Use when parsing or manipulating multiple sequence alignments.
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Calculate alignment statistics including sequence identity, conservation scores, substitution matrices, and similarity metrics. Use when comparing alignment quality, measuring sequence divergence, and analyzing evolutionary patterns.
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Estimate causal effects between exposures and outcomes using genetic variants as instrumental variables with TwoSampleMR. Implements IVW, MR-Egger, weighted median, and MR-PRESSO methods for robust causal inference from GWAS summary statistics. Use when testing whether an exposure causally affects an outcome using genetic instruments.
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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for causal inference.
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Cloud laboratory platform for automated protein testing and validation. Use when designing proteins and needing experimental validation including binding assays, expression testing, thermostability measurements, enzyme activity assays, or protein sequence optimization. Also use for submitting experiments via API, tracking experiment status, downloading results, optimizing protein sequences for better expression using computational tools (NetSolP, SoluProt, SolubleMPNN, ESM), or managing protein design workflows with wet-lab validation.
日本語の概要は準備中です。原文の説明を表示しています。
Call accessible chromatin regions from ATAC-seq data using MACS3 with ATAC-specific parameters. Use when identifying open chromatin regions from aligned ATAC-seq BAM files, different from ChIP-seq peak calling.
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Quality control metrics for ATAC-seq data including fragment size distribution, TSS enrichment, FRiP, and library complexity. Use when assessing ATAC-seq library quality before or after peak calling to identify problematic samples.
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Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.
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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
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Find differentially accessible chromatin regions between conditions using DiffBind or DESeq2. Use when comparing chromatin accessibility between treatment groups, cell types, or developmental stages in ATAC-seq experiments.
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Predicts ADMET properties using ADMETlab 3.0 API or DeepChem models. Estimates bioavailability, CYP inhibition, hERG liability, and 119 toxicity endpoints with uncertainty quantification. Filters for PAINS and other structural alerts. Use when filtering compounds for drug-likeness or prioritizing leads by predicted safety.
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Quantifies crypto market regime health using free, keyless public data (CoinGecko + Binance funding). Generates a 0-100 composite score across 6 components (100 = risk-on) with a posture recommendation. No API key required. Use when user asks about crypto market conditions, whether it's alt season, BTC dominance, crypto risk-on vs risk-off, funding rates, or whether crypto exposure should be increased or reduced.
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Operate GJC SDK sessions from the CLI (`gjc sdk session list|inspect|send|status|tail|close|raw` plus the explicit raw control|query|global hatch). Advisory reference: broker-bound, credential-free output; mutating verbs run only when explicitly invoked.
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Use when the user asks to "figure out where our direct traffic really comes from", "measure dark social", "add a how-did-you-hear-about-us field", or "show social drives signups without click data"; produces a share-link/UTM hygiene spec for owned share surfaces, a self-reported attribution field design that replaces an existing form field (free-text first, coded later), a GA4 direct-traffic decomposition read (deep-URL directs, mobile-app skew, private-push correlation) with every derived number hard-labeled Estimated/proxy, and a branded-search-lift proxy from GSC plus Wikipedia pageviews — the declared dark-social method behind ECHO O2. Not for paid-channel attribution reconciliation (platform-claimed vs analytics conversions) — use attribution-reconciler. 暗社交归因/直接流量分解/自报来源字段/分享链路UTM
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Manages WhatsApp messaging through AWS End User Messaging Social. Covers managing templates (create, update, delete, library), sending messages (utility/marketing/auth templates and freeform), uploading and managing media, configuring event destinations for delivery tracking, and troubleshooting delivery failures. Applicable when a user needs to send WhatsApp messages, create or manage templates, upload media, configure delivery notifications, or diagnose messaging issues.
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Onboards RCS Business Messaging and Notify OTP via the pinpoint-sms-voice-v2 AWS CLI. Covers creating a branded RCS test agent (logo, banner, rich cards, suggested replies), adding verified testers, and sending/receiving the first RCS message; and configuring AWS End User Messaging Notify to send one-time-passcode (OTP) verification codes through AWS-managed phone numbers without buying a number or completing carrier registration. Also discovers which registration type a country requires from live API definitions and runs the universal registration lifecycle (create, derive fields, fill, submit, recover from denial, resubmit) shared by 10DLC, toll-free, short code, sender ID, RCS country launch, and Notify tier upgrade. Applicable to RCS agent setup, RCS message send/receive, Notify OTP configuration, verification-code delivery, registration requirements by country, and registration submission. Does not cover WhatsApp (see aws-social-messaging).
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Apple Notes cost optimization — it is free, focus on iCloud storage management. Trigger: "apple notes cost".
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Generates customized business agreements for 10 common relationship types with plain English annotations. Use when formalizing a business relationship, creating a partnership agreement, or drafting a service contract from scratch. Trigger with "/agreement-generator" or "create a freelancer agreement".
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TypeScript code shape inside a well-named module — taste, not lint. Prefer one class or namespace per file (the unit a test targets) over scattered free exports; consolidate related code, don't fragment. The unit of code should be the unit of spec. Use when authoring TS in `editor/grida-canvas*`, `editor/lib/`, or `packages/*`. Sibling to the `naming` skill; React-specific shape lives in `code-react`.
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