「generating」の検索結果

Provider-independent production workflow for AI agents creating educational animated lessons, classroom explainers, STEM visualizations, history/social-science animations, training modules, microlearning clips, whiteboard-style explainers, diagram-driven videos, and generated or assembled instructional animation assets. Use when planning, scripting, storyboarding, generating, reviewing, localizing, or QAing animation whose primary purpose is learning.

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Provider-independent production workflow for AI agents creating brand launch films, product reveal videos, manifesto films, campaign hero films, website hero videos, investor/customer launch assets, and social cutdowns. Use when planning, scripting, generating, editing, reviewing, or delivering launch films that must align strategy, claims, brand voice, visual direction, product proof, accessibility, compliance, and multi-platform delivery.

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Prepare personalized email outreach by researching prospects, verifying email addresses, building company context, and generating relevant talking points. End-to-end outreach preparation from prospect identification to send-ready intelligence.

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Work with FASTQ quality scores using Biopython. Use when analyzing read quality, filtering by quality, trimming low-quality bases, or generating quality reports.

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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.

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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.

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Compute evolutionary distances and build phylogenetic trees using Biopython Bio.Phylo.TreeConstruction. Use when creating distance matrices from alignments, building NJ/UPGMA trees, generating bootstrap consensus, or needing quick exploratory phylogenies before running full ML analysis.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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Build a differential-ready consensus peakset from per-replicate ATAC-seq peaks using iterative overlap removal, fixed-width re-centering, and majority-rule overlap. Use when generating a stable peak coordinate system for downstream differential accessibility, ML feature engineering, cross-sample comparison, or fixed-width peak counts; covers Corces 2018 iterative overlap (501 bp), DiffBind summit re-centering, and ENCODE consistency rules.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Dimensionality reduction and clustering for single-cell RNA-seq using Seurat (R) and Scanpy (Python). Use for running PCA, computing neighbors, clustering with Leiden/Louvain algorithms, generating UMAP/tSNE embeddings, and visualizing clusters. Use when performing dimensionality reduction and clustering on single-cell data.

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Annotate CLIP-seq peaks or crosslink sites to RNA features (5'UTR, CDS, 3'UTR, intron, splice junction, snoRNA, tRNA, ncRNA, repeat elements) with ChIPseeker, RCAS, RBP-Maps (Yeo splicing regulatory maps), and bedtools, applying feature-priority hierarchies, transcript-context resolution, and metagene aggregation. Use when characterizing where in transcripts an RBP binds, comparing peak distribution across regions, generating splicing-regulatory maps relative to alternative-splicing events, or distinguishing exonic vs intronic vs UTR binding.

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Identifies essential genes from CRISPR-Cas9 fitness screens using BAGEL2 (Kim & Hart 2021 Genome Med), a Bayesian classifier scoring per-gene Bayes Factors via log-likelihood ratios over per-sgRNA fold changes, calibrated against CEGv2 core-essentials (Hart 2017 G3, ~684 genes) and NEGv1 non-essentials (Hart 2014, ~927 genes). Covers the fc + bf + pr workflow, the linear-extrapolation improvement over BAGEL1 truncation, multi-target off-target correction, tumor-suppressor sensitivity (BAGEL2 detects enrichment), and BF-to-FDR calibration (BF >6 ≈ FDR 0.05 from Hart 2017). Use when classifying essential vs non-essential genes, calibrating BAGEL2 thresholds against PR curves, identifying tumor suppressors alongside essentials, comparing BAGEL2 hits to MAGeCK / drugZ, or generating publication-quality essentiality calls.

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Generate alignment statistics using samtools flagstat, stats, depth, coverage, and mosdepth. Use when assessing alignment quality, calculating coverage, or generating QC reports.

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Proteina-Complexa flow-based protein backbone generation with fold-conditioned sampling guidance. Use this skill when: (1) Generating de novo protein backbones with hierarchical fold conditioning, (2) Exploring long-chain backbone generation beyond standard diffusion baselines, (3) Using NVIDIA Proteina-style flow matching workflows for controllable backbone design, (4) Comparing flow-based backbone generation against RFdiffusion or BoltzGen, (5) Prototyping fold-guided backbone campaigns before sequence design. This skill is based on the public NVIDIA Digital Bio Proteina project and uses "Proteina-Complexa" as the BioClaw-facing skill label. For sequence design after backbone generation, use proteinmpnn or solublempnn. For QC thresholds, use protein-design-qc.

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Generate protein backbones using RFdiffusion, a diffusion-based generative model for de novo protein structure generation. Use this skill when: (1) Designing binder scaffolds for a target protein, (2) Generating novel protein backbones from scratch, (3) Scaffolding functional motifs into new proteins, (4) Specifying hotspot residues for interface design, (5) Creating symmetric oligomers. For sequence design after backbone generation, use proteinmpnn. For structure validation, use alphafold or chai. For QC thresholds, use protein-qc.

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Create beautiful, accessible user interfaces with shadcn/ui components (built on Radix UI + Tailwind), Tailwind CSS utility-first styling, and canvas-based visual designs. Use when building user interfaces, implementing design systems, creating responsive layouts, adding accessible components (dialogs, dropdowns, forms, tables), customizing themes and colors, implementing dark mode, generating visual designs and posters, or establishing consistent styling patterns across applications.

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Scaffolds new agent skills for the dotnet/skills repository. Use when creating a new skill, generating SKILL.md files, or setting up skill directory structures. Handles frontmatter generation, section templates, and validation guidance.

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Use when preparing a Formax code handoff: selecting files, generating repomix bundles, and writing a high-quality prompt for WebGPT or another coding agent with clear constraints and validation scope.

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Guidance for using Generator.Equals — a C# source generator for auto-generating Equals, GetHashCode, operators, and Diff/Inequalities methods via attributes.

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Runtime per-test healing with evidence: multi-attribute selector healing, environment-aware diagnosis, flake classification, quarantine management, and confidence-scored auto-repair. Goes beyond simple locator fallbacks to cover action-level healing, data healing, and observable repair workflows. Use when: "flaky test," "test stability," "self-healing locator," "broken locator recovery," "unreliable test," "quarantine flaky test." Not for: bulk regenerating selectors after a planned UI refactor — use selector-drift-recovery (this skill heals ONE test at runtime; that one rewrites many tests offline). Not for: classifying/clustering CI failures into bug reports — use ai-bug-triage. Related: playwright-automation, selector-drift-recovery, ci-cd-integration, qa-metrics, ai-bug-triage.

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Review EXISTING test code for quality, smells, and testability issues. Detects test smells across six dimensions — readability, reliability, diagnostic value, design, AI-generated, and coverage — analyzes testability of application code, and backs the qualitative smells with mutation testing. Use when: "review my tests," "test quality audit," "test smells," "testability analysis," "are these tests any good." Not for: generating new tests — use `ai-test-generation`. Not for: testing AI features in your product — use `ai-system-testing`. Related: unit-testing, shift-left-testing, coverage-analysis, ai-test-generation.

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Write effective unit tests with Jest, Vitest, or pytest. Covers the test-doubles taxonomy (stub/spy/mock/fake), Arrange-Act-Assert, coverage threshold configuration and CI gating, snapshot testing, fake timers, and mutation testing with Stryker/mutmut. Use when: "unit test," "Jest," "Vitest," "pytest," "mock," "coverage threshold," "test doubles," "mutation testing," "fake timers," "snapshot test." Not for: interpreting coverage reports or finding coverage gaps — use coverage-analysis; AI generating the test code for you — use ai-test-generation; auditing existing tests for smells — use ai-qa-review; browser/component rendering assertions — use cypress-automation or visual-testing. Related: coverage-analysis, ci-cd-integration, ai-test-generation, shift-left-testing.

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Turn a vague bug report into a VERIFIED minimal reproduction and then a failing regression test, agent-driven end to end. Covers extracting the implicit repro from a thin report (env, build, steps, data), the reproduce-minimize-isolate-capture loop, git bisect to find the introducing commit, building a deterministic minimal repro (fixed seeds, frozen time, stubbed network), writing the failing regression test BEFORE the fix (red) and confirming the fix flips it green, and writing repro evidence back into the ticket. Distinguishes flaky-not-reproducible from environment-specific. Use when: "reproduce this bug," "minimal reproduction," "repro steps," "find the commit that broke it," "git bisect," "make the repro deterministic," "write a failing test for this bug," "regression test for a defect," "can't reproduce this bug." Not for: Classifying/deduplicating/severity-routing existing failures without reproducing them — that is ai-bug-triage. Generating tests from specs rather than from a defect — that is ai-test-generation. Related: ai-bug-triage, ai-test-generation, test-reliability, systematic-debugging, qa-project-context.

日本語の概要は準備中です。原文の説明を表示しています。