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概要と使いどころ
Keep a running brag document of your accomplishments so reviews and promo cases write themselves. Use when asked to start or update a brag doc, log a win, track accomplishments, or prep evidence for a review/promotion. Produces a structured, dated accomplishment log — impact-first entries with metrics, scope, and the evidence link — grouped so it drops straight into a self-review or promo packet.
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Check whether you're burning out as a caregiver — and get a realistic plan to protect yourself before you can't keep going. Use when asked I'm exhausted from caregiving, am I burning out caring for my parent, caregiver stress help, or I have nothing left to give. Produces an honest read on your burnout signs and how depleted you are, permission and reasons to accept help (which caregivers resist), specific ways to get support and respite, the guilt and identity traps to address, and a realistic self-care plan that fits a caregiver's actual life — because a caregiver who collapses can't care for anyone. Not medical or mental-health treatment.
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Run a real brainstorm — divergent generation without judgment, then convergent selection with explicit criteria — instead of listing ten obvious ideas and calling it creativity. Use when asked to brainstorm, generate ideas or options, explore a solution space, or name something. Produces a genuinely wide option set (including the weird tail), then a shortlist selected against named criteria with the rejects preserved.
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Audit whether the organisation's AI spend actually paid — measured against baselines, not vendor math or vibes. Use when a CFO asks what the AI tools returned, when renewing AI contracts, when consolidating overlapping AI subscriptions, or to build the measurement plan before the next spend. Produces an ROI audit with per-tool verdicts (keep/consolidate/cut), the honest-measurement method behind each number, and a baseline plan for whatever can't be scored yet. To forecast ROI before an investment use roi-estimator; this skill measures what already happened.
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Use this skill when planning, redesigning, or reviewing Xiaohongshu carousel visuals, covers, 3:4 image posts, page-by-page visual direction, image-generation prompts, style selection, layout critique, or XHS captions. It acts as a senior visual director for 小红书图文, not a generic copywriting assistant.
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Measure your own writing corpus for the words and sentence shapes you over-use, so an agent writing in your voice stops amplifying your tics into a style. Produces a counted baseline file and checks any new draft against it. Use when an agent's drafts start sounding like a caricature of you, before publishing anything written in your voice, or every ten new pieces to re-measure.
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Use when situating an Accounting, Organizations and Society (AOS) manuscript in the literature — entering one of the journal's own long-running conversations, engaging the interdisciplinary sources (organization theory, sociology, psychology) those conversations draw on, and marking precisely what the paper adds. Positions the argument; it does not build the theory itself (aos-theory-development).
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Use when positioning an ACL submission against the NLP literature, covering ACL Anthology citation practice, arXiv-versus-published version citation, concurrent LLM-era preprints, prior-cycle ARR resubmission overlap, anonymity-preserving self-citation, and the fast-moving baseline problem in computational linguistics.
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Use when scoping or sanity-checking a research question for an Academy of Management Journal (AMJ) manuscript — fit, theory-drivenness, and feasibility. Decides whether the idea can earn a theoretical contribution; it does not build the theory itself (use amj-theory-development) or position the literature (amj-literature-positioning).
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Use when strengthening AAMAS reproducibility evidence for interaction claims, including proofs and game definitions, opponent and population sets, self-play protocols, random seeds, compute, uncertainty on strategic outcomes, baselines, and consistency between what the paper claims about agents and what the artifact can actually show.
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Use when designing or auditing AAMAS experiments - self-play and population-based training, opponent selection, equilibrium and regret metrics, game-theoretic simulations, ablations, seeds, hyperparameters, compute, and claim-to-evidence fit - with emphasis on experiments that probe the interaction rather than chase a single-agent leaderboard.
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Monitor existing customer accounts for upsell and cross-sell signals: team growth on LinkedIn, new job postings, product usage patterns, funding announcements, and public company news. Produces a weekly expansion opportunity list with context and talk tracks. Chains web search, LinkedIn profile monitoring, and job posting detection.
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Create LinkedIn carousel posts as high-quality PNG images. Design informational multi-slide posts like "5 AI GTM workflows" with consistent styling, then automatically screenshot each slide at LinkedIn's optimal 1080x1080px format.
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Creates beautiful, branded HTML content assets — industry reports, landing pages, comparison sheets, one-pagers — from structured data. Uses Gamma API (preferred), v0.dev Platform API, or a self-hosted HTML template system with Tailwind CSS. Outputs self-contained HTML files that can be hosted as web pages or converted to PDF.
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Configure Simulink models for Embedded Coder (ERT), Simulink Coder (GRT rapid-prototyping), or AUTOSAR code generation. Use when the user asks to generate embedded C or C++ code, run a full build of a model, produce a code generation report, configure a model for production/ECU deployment or rapid-prototyping code, target ARM or x86 hardware, apply MISRA C/C++ compliance (ERT/AUTOSAR only — Simulink Coder does not ship MISRA profiles), or set up GRT, ERT, AUTOSAR, or shared-library targets. Handles target selection, hardware mapping, model hierarchy propagation, and constraint introspection via the configure_for_codegen function. Do NOT use for GRT shared-library variants (grt_malloc.tlc), DDS, or ROS, or for iterative optimization workflows that measure baseline metrics, apply targeted changes, and re-measure to confirm improvement.
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Use the skill to control and verify the code interface configuration of your model — how Simulink® model elements are represented in the generated C or C++ code. This includes — (1) specifying names, types (storage classes), and placement of variables that represent model elements (for example, making a model parameter tunable as a global extern variable); (2) specifying names, types, and placement of functions that represent model algorithms; (3) selecting the deployment type (Component, Subcomponent, or Automatic); (4) selecting the interface configuration type (data or service interface); (5) linking a shared Embedded Coder dictionary to a model; (6) creating Embedded Coder dictionary entries and setting their properties; (7) for service interface configuration — specifying service interface definitions, including sender, receiver, client, and server services. Items 1 and 2 can be set per element or as a category-wide default. Item 1 applies to GRT and ERT models; the rest to ERT models only.
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Estimates tumor fraction (the genome-wide proportion of cfDNA molecules that are tumor-derived, the cfDNA analogue of bulk-tumor purity) from shallow whole-genome sequencing with ichorCNA, an HMM over 1 Mb bins that jointly EM-estimates tumor fraction, ploidy, and subclonal prevalence over a normal/ploidy grid. Encodes the load-bearing reframes: tumor fraction is the quantity that travels across assays and is NOT mutation VAF (clonal-het VAF approximately TF/2), CNA-based estimation has a hard ~3 percent limit-of-detection floor, and near-diploid or copy-neutral-LOH genomes return a falsely low value. Selects the estimator by data type (sWGS to ichorCNA, deep panel to max-VAF, methylation to deconvolution, sub-3 percent to fragmentomics or methylation). Use when quantifying tumor burden from a liquid biopsy, picking a tumor-fraction estimator for a given assay, or reconciling a TF estimate against a panel VAF.
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Turns Hi-C/Micro-C FASTQ into a deduplicated, filtered .pairs file with pairtools and decides whether the library worked. Covers the bwa mem -SP5M / bwa-mem2 / chromap --preset hic alignment idiom (mates mapped as independent single-end reads), pairtools parse vs parse2 and the walks-policy choice (5unique pairwise vs all for Pore-C/Micro-C concatemers), pair-type classification (keep UU and rescued UC), dedup (PCR vs optical/by-tile), select by pair_type/MAPQ/distance, restriction-fragment handling (restrict, Arima dual-enzyme, Micro-C/DNase fragment-free), and allele-specific phasing (pairtools phase to two coolers). The library-QC decision uses % long-range cis as the one-number quality metric, trans as the noise floor, orientation balance as fragment-map-free dangling-end/self-circle QC, and % duplicates as a complexity proxy. Use when processing Hi-C/Micro-C/Omni-C reads into pairs, judging library quality, handling multi-enzyme or restriction-agnostic protocols, or generating allele-specific contacts.
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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.
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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.
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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
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Calculates molecular fingerprints (ECFP/Morgan, FCFP, MACCS, RDKit, AtomPair, TopologicalTorsion, Avalon, MAP4, MHFP6) and physicochemical descriptors (Lipinski, QED, TPSA, Crippen LogP, 3D shape) with explicit choice tables, bit vs count semantics, and partial-charge model selection. Use when featurizing molecules for similarity, QSAR, virtual screening, or ML, or selecting the correct fingerprint for a chemotype-aware task.
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Standardizes molecular structures using the ChEMBL structure pipeline for normalization and parent selection plus RDKit rdMolStandardize for explicit custom steps such as tautomer canonicalization, salt/solvent stripping, charge handling, stereochemistry handling, mixture selection, and isotope normalization. Explicitly compares ChEMBL, canSARchem, RDKit, and PubChem standardization choices. Use when preparing libraries for QSAR training, joining datasets across sources, deduplicating compound collections, or building canonical compound registries.
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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.
日本語の概要は準備中です。原文の説明を表示しています。