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概要と使いどころ
Master entry point for all Stitch design workflows. Routes from user request → design spec → prompt assembly → screen generation → iteration (edit, variants, design systems) → design system extraction → framework conversion (Next.js, Svelte, HTML, React Native, or SwiftUI) → optional quality pass.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes a Stitch project's screens and synthesizes a natural-language DESIGN.md — visual atmosphere, color palette with hex values, typography rules, and Stitch-ready prompt snippets. Use this before stitch-loop or any multi-page build to establish design consistency.
日本語の概要は準備中です。原文の説明を表示しています。
Deep exploration and synthesis workflow with dynamic planning and hub-and-spoke coordination. Use for deep analysis, deep understanding, or codebase investigation.
日本語の概要は準備中です。原文の説明を表示しています。
Deep exploration and synthesis workflow with dynamic planning and hub-and-spoke coordination. Use for deep analysis, codebase understanding, or thorough investigation of a focus area.
日本語の概要は準備中です。原文の説明を表示しています。
Deep exploration and synthesis workflow using agent teams with dynamic planning and hub-and-spoke coordination. Use when asked for "deep analysis", "deep understanding", "analyze codebase", "explore and analyze", or "investigate codebase".
日本語の概要は準備中です。原文の説明を表示しています。
Solve competitive programming and LeetCode-style problems with educational explanations. Use when asked to "solve this problem", "help with this leetcode", "competitive programming solution", "solve this algorithm problem", "coding challenge solution", "how to solve this coding problem", or any algorithmic problem-solving request.
日本語の概要は準備中です。原文の説明を表示しています。
Generate Claude Code native Tasks from an existing spec. Use when user says "create tasks", "generate tasks from spec", "spec to tasks", "task generation", or wants to decompose a spec into implementation tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Deep exploration and synthesis workflow using Agent Teams with dynamic planning and hub-and-spoke coordination. Use when asked for "deep analysis", "deep understanding", "analyze codebase", "explore and analyze", or "investigate codebase".
日本語の概要は準備中です。原文の説明を表示しています。
Rewrite text so it reads like a real person wrote it, not an AI. Auto-detects Russian vs English and applies the matching rule set. Use when the user asks to humanize text, remove the "AI smell", de-AI, or make AI output sound natural - especially for Russian. Russian requests count too - очеловечь, перепиши как человек, оживи текст, убери запах ИИ, сделай живее, звучит как робот, убери канцелярит. Also use when asked whether a text was written by AI - нейросеть писала?, похоже на ChatGPT?, видно ли, что это ИИ, человек или бот писал, did AI write this? - then check and report findings without rewriting. While installed, also keep your own Russian and English writing free of the quick-list stock phrases, silently; never edit the user's text unless asked.
日本語の概要は準備中です。原文の説明を表示しています。
Plan, implement, or improve an internationalization and localization strategy for UI content, formatting, and regional adaptation. Use when the user asks to add i18n, localize, translate, support multiple languages, handle regional formats, manage locale switching, or build a multilingual product.
日本語の概要は準備中です。原文の説明を表示しています。
Retrieve protein sequences, annotation, and structures from UniProtKB, the RCSB PDB, and AlphaFold DB. Use this skill to resolve a gene or protein name to a UniProt accession, pull sequences and FASTA files, find binding sites and domains, search the PDB by UniProt accession, sequence, ligand, or text, download mmCIF/PDB coordinates and biological assemblies, fetch AlphaFold models with their pLDDT confidence, and check whether a structure is actually usable before docking or simulating it. Also trigger on UniProt accessions, PDB ids, rest.uniprot.org, search.rcsb.org, files.rcsb.org, alphafold.ebi.ac.uk, id mapping, SEQRES, or missing residues.
日本語の概要は準備中です。原文の説明を表示しています。
Query the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biological relationships across genes and proteins, drugs, diseases, phenotypes, pathways, biological processes, exposures and anatomy. Use this skill to search entities by name, pull direct neighbours and their evidence types, summarise the local network around a disease, and find direct or two-hop drug-disease connections for repurposing hypotheses. Also trigger on PrimeKG, kg.csv, Harvard Dataverse knowledge graph, disease_protein, drug_protein, indication and contraindication edges, or network pharmacology over a biomedical knowledge graph.
日本語の概要は準備中です。原文の説明を表示しています。
Assemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support, or target safety dossier.
日本語の概要は準備中です。原文の説明を表示しています。
Use Therapeutics Data Commons through the PyTDC Python package for registry discovery, approved dataset access, task-aware splits (scaffold, cold-start, temporal, combination), evaluator metrics, benchmark groups, and bounded molecular-oracle workflows. Use this skill to find which TDC datasets exist for a therapeutic task, load them with a split that does not leak, score predictions with the task's own official metric rather than a generic one, and run benchmark groups reproducibly. Also trigger on PyTDC, Therapeutics Data Commons, tdc.single_pred, tdc.multi_pred, ADMET Benchmark Group, scaffold split, get_split, or molecular oracles such as GSK3B, JNK3 and DRD2.
日本語の概要は準備中です。原文の説明を表示しています。
Rowan is a cloud-native molecular modeling and medicinal-chemistry workflow platform with a Python API. Use for pKa and macropKa prediction, conformer and tautomer ensembles, docking and analogue docking, protein-ligand cofolding, MSA generation, molecular dynamics, permeability, descriptor workflows, and related small-molecule or protein modeling tasks. Ideal for programmatic batch screening, multi-step chemistry pipelines, and workflows that would otherwise require maintaining local HPC/GPU infrastructure.
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Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only open in simulation, and convert a chosen cavity into the search box coordinates a docking run needs. Also trigger on fpocket, cavity detection, druggability score, alpha sphere, cryptic pocket, allosteric site, pocket volume, hotspot mapping, or undruggable target assessment.
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Navigate make-on-demand catalogues — ZINC-22 through CartBlanche and Enamine REAL Space — to find compounds that can actually be ordered. Use this skill to look substances up by ZINC identifier or structure, understand tranche partitioning by heavy-atom count and logP, and choose between screening an enumerated subset and searching a combinatorial synthon space with a fragment-growing method such as V-SYNTHES. Also trigger on ZINC22, CartBlanche, Enamine REAL, make-on-demand, tangible library, synthon, tranche, giga-scale enumeration, or ultra-large virtual screening.
日本語の概要は準備中です。原文の説明を表示しています。
Cofold protein-ligand, protein-protein, and nucleic-acid complexes with Boltz-2, and predict binding affinity with its trained affinity head. Use this skill to build Boltz input YAML, run structure prediction with MSAs, pocket constraints, templates, and modified residues, screen compound libraries by cofolding, and interpret confidence scores (pLDDT, pTM, ipTM, PDE) and affinity output (binder probability and log10 IC50). Also trigger on Boltz, Boltz-1, Boltz-2, cofolding, boltz predict, affinity_pred_value, affinity_probability_binary, ipTM, or open-weights AlphaFold3 alternatives.
日本語の概要は準備中です。原文の説明を表示しています。
Run and analyze molecular dynamics simulations with OpenMM and MDAnalysis. Set up protein and protein-ligand systems with PDBFixer, choose force fields and water models (AMBER14, CHARMM36m, ff19SB, GAFF2, TIP3P), solvate and add ions, run energy minimization, NVT/NPT equilibration and production MD on GPU, then analyze trajectories for RMSD, RMSF, radius of gyration, hydrogen bonds, native contacts, PCA and free energy surfaces. Use this skill for protein stability under mutation, ligand binding-mode and residence-time questions, conformational sampling, membrane proteins, and disordered ensembles. Also trigger on OpenMM, MDAnalysis, mdtraj, Simulation.step, LangevinMiddleIntegrator, PDBFixer, DCD or XTC trajectory, RMSD analysis, or production MD.
日本語の概要は準備中です。原文の説明を表示しています。
Search the ClinicalTrials.gov registry through its version 2 REST API for interventional and observational studies, their phases, enrolment, endpoints, sponsors, and posted results. Use this skill to survey who is developing what against an indication, date a competitor's programme, read primary and secondary outcome measures, find eligibility criteria, and distinguish a study that completed from one that was terminated or withdrawn. Also trigger on ClinicalTrials.gov, NCT number, trial registry, study phase, enrolment, primary outcome measure, recruiting status, trial sponsor, or competitive landscape.
日本語の概要は準備中です。原文の説明を表示しています。
Pythonic wrapper around RDKit with a simplified interface and sensible defaults. Preferred for standard drug discovery work — SMILES/SELFIES/InChI conversion, molecule standardization and sanitization, descriptors, ECFP and other fingerprints, Tanimoto distance matrices, Butina clustering and diverse subset picking, Bemis-Murcko scaffolds and scaffold splits, BRICS/RECAP fragmentation, 3D conformer generation, SDF/CSV/Excel and cloud I/O, and parallel processing via n_jobs. Returns native rdkit.Chem.Mol objects, so it composes with RDKit throughout. Also trigger on datamol, `import datamol as dm`, dm.to_mol, dm.standardize_mol, dm.cluster_mols, or dm.pick_diverse. For advanced control or custom parameters, use the rdkit skill directly.
日本語の概要は準備中です。原文の説明を表示しています。
Structure-based docking with AutoDock Vina, Vinardo, and AutoDock4 through the Meeko toolchain. Use this skill to define a docking box, prepare receptors and ligands as PDBQT, run single or batch docking, rescore, and interpret affinities, poses, and ligand efficiency. Covers box definition from a reference ligand or pocket residues, protonation and tautomer decisions, flexible side chains, exhaustiveness and seeds, redocking validation, and virtual screening over compound libraries. Also trigger on vina, smina, gnina, mk_prepare_ligand, mk_prepare_receptor, mk_export, scrub.py, PDBQT, autogrid4, docking box, or binding-pose prediction.
日本語の概要は準備中です。原文の説明を表示しています。
Compute relative and absolute binding free energies with the Open Free Energy toolkit — the rigorous alchemical alternative to docking scores when a congeneric series needs reliable potency ranking. Use this skill to plan a perturbation network over a ligand set, choose atom mappings, run hybrid-topology or separated-topology protocols, and analyse the result — per-edge ΔΔG with uncertainty, cycle-closure error, and mean unsigned error against measured affinities. Also trigger on OpenFE, alchemical transformation, thermodynamic cycle, RBFE, ABFE, SepTop, lambda window, MBAR, cycle closure, or perturbation map.
日本語の概要は準備中です。原文の説明を表示しています。
Orchestrate the full PaperOrchestra (Song et al., 2026, arXiv:2604.05018) five-agent pipeline to turn unstructured research materials (idea, experimental log, LaTeX template, conference guidelines, optional figures) into a submission-ready LaTeX manuscript and compiled PDF. TRIGGER when the user asks to "write a paper from my experiments", "turn this idea and these results into a paper", "generate a conference submission", "run paper-orchestra on X", or otherwise wants the end-to-end paper-writing pipeline. Coordinates the outline-agent, plotting-agent, literature-review-agent, section-writing-agent, and content-refinement-agent skills.
日本語の概要は準備中です。原文の説明を表示しています。