「nat」の検索結果

Navigate make-on-demand catalogues — ZINC-22 through CartBlanche and Enamine REAL Space — to find compounds that can actually be ordered. Use this skill to look substances up by ZINC identifier or structure, understand tranche partitioning by heavy-atom count and logP, and choose between screening an enumerated subset and searching a combinatorial synthon space with a fragment-growing method such as V-SYNTHES. Also trigger on ZINC22, CartBlanche, Enamine REAL, make-on-demand, tangible library, synthon, tranche, giga-scale enumeration, or ultra-large virtual screening.

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Assemble the human genetic evidence for and against a target before a programme commits to it — the evidence class that most improves the odds of surviving clinical development. Use this skill to pull gnomAD constraint metrics (LOEUF, pLI, observed/expected) that show whether loss of function is tolerated in people, retrieve GWAS Catalog associations and fine-mapped credible sets for a gene, and read a natural human knockout as a safety readout. Also trigger on gnomAD, LOEUF, pLI, loss-of-function intolerance, mutational constraint, GWAS Catalog, credible set, human knockout, genetic support, or target safety dossier.

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Pythonic wrapper around RDKit with a simplified interface and sensible defaults. Preferred for standard drug discovery work — SMILES/SELFIES/InChI conversion, molecule standardization and sanitization, descriptors, ECFP and other fingerprints, Tanimoto distance matrices, Butina clustering and diverse subset picking, Bemis-Murcko scaffolds and scaffold splits, BRICS/RECAP fragmentation, 3D conformer generation, SDF/CSV/Excel and cloud I/O, and parallel processing via n_jobs. Returns native rdkit.Chem.Mol objects, so it composes with RDKit throughout. Also trigger on datamol, `import datamol as dm`, dm.to_mol, dm.standardize_mol, dm.cluster_mols, or dm.pick_diverse. For advanced control or custom parameters, use the rdkit skill directly.

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Search the ClinicalTrials.gov registry through its version 2 REST API for interventional and observational studies, their phases, enrolment, endpoints, sponsors, and posted results. Use this skill to survey who is developing what against an indication, date a competitor's programme, read primary and secondary outcome measures, find eligibility criteria, and distinguish a study that completed from one that was terminated or withdrawn. Also trigger on ClinicalTrials.gov, NCT number, trial registry, study phase, enrolment, primary outcome measure, recruiting status, trial sponsor, or competitive landscape.

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Rowan is a cloud-native molecular modeling and medicinal-chemistry workflow platform with a Python API. Use for pKa and macropKa prediction, conformer and tautomer ensembles, docking and analogue docking, protein-ligand cofolding, MSA generation, molecular dynamics, permeability, descriptor workflows, and related small-molecule or protein modeling tasks. Ideal for programmatic batch screening, multi-step chemistry pipelines, and workflows that would otherwise require maintaining local HPC/GPU infrastructure.

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Use Therapeutics Data Commons through the PyTDC Python package for registry discovery, approved dataset access, task-aware splits (scaffold, cold-start, temporal, combination), evaluator metrics, benchmark groups, and bounded molecular-oracle workflows. Use this skill to find which TDC datasets exist for a therapeutic task, load them with a split that does not leak, score predictions with the task's own official metric rather than a generic one, and run benchmark groups reproducibly. Also trigger on PyTDC, Therapeutics Data Commons, tdc.single_pred, tdc.multi_pred, ADMET Benchmark Group, scaffold split, get_split, or molecular oracles such as GSK3B, JNK3 and DRD2.

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Query the Precision Medicine Knowledge Graph (PrimeKG) for multiscale biological relationships across genes and proteins, drugs, diseases, phenotypes, pathways, biological processes, exposures and anatomy. Use this skill to search entities by name, pull direct neighbours and their evidence types, summarise the local network around a disease, and find direct or two-hop drug-disease connections for repurposing hypotheses. Also trigger on PrimeKG, kg.csv, Harvard Dataverse knowledge graph, disease_protein, drug_protein, indication and contraindication edges, or network pharmacology over a biomedical knowledge graph.

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Ask Kimi a read-only free-form question about the current repository. Use for prose explanations, flow tracing, module comparisons, or conceptual reasoning where Codex should delegate the answer to local kimi-code rather than perform implementation.

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Transform Markdown or text specifications into human-readable HTML documents with summaries, reordered structure, visual explanations, diagrams, charts, and traceability to the source. Use when asked to convert a spec, requirements document, API spec, product spec, design doc, or technical document into readable HTML, especially when the user wants summarization, restructuring, diagrams, graphs, images, or visual aids rather than a literal Markdown-to-HTML conversion.

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Git-native issue tracking (beads), coding guidelines, knowledge injection, and spec-driven planning for AI agents. Drop-in replacement for bd/Beads with simpler architecture. Use for: tracking issues/beads with dependencies, creating bugs/features/tasks, planning specs, implementing features from specs, code reviews, committing code, creating PRs, loading coding guidelines (TypeScript, Python, TDD, golden testing, Convex, monorepo patterns), code cleanup, research briefs, architecture docs, agent handoffs, and checking out third-party library source code. Invoke when user mentions: tbd, beads, bd, shortcuts, issues, bugs, tasks, features, epics, todo, tracking, specs, planning, implementation, validation, guidelines, templates, commit, PR, pull request, code review, testing, TDD, test-driven, golden testing, snapshot testing, TypeScript, Python, Convex, monorepo, cleanup, dead code, refactor, handoff, research, architecture, labels, search, checkout library, source code review, or any workflow shortcut.

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Spot-check citations in library files for obvious hallucinations. Resolves DOIs against the DOI registry, validates arXiv IDs, checks the format of journal references. Soft-fails on transient lookup failures rather than blocking. Recommended after kb-ingest and as part of periodic library hygiene.

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Use when a product idea needs pressure-testing against alternatives, category, urgency, and distribution.

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Use this skill when working with Twilio communication APIs for SMS/MMS messaging, voice calls, phone number management, TwiML, webhook integration, two-way SMS conversations, bulk sending, or production deployment of telephony features. Includes official Twilio patterns, production code examples from Twilio-Aldea (provider-agnostic webhooks, signature validation, TwiML responses), and comprehensive TypeScript examples.

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Desktop GUI automation via OpenInterpreter — mouse, keyboard, screenshot, and OCR control for native macOS/Linux applications. Three modes: Library (Claude reasons, OI executes), OS subprocess (full autonomous computer use), and Local agent (Ollama, offline). This skill should be used when interacting with desktop apps that have no CLI or API, automating GUI workflows, reading screen content via OCR, or controlling mouse/keyboard.

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Use this skill when working with Telnyx communication APIs for SMS/MMS messaging, voice calls, phone number management, messaging profiles, webhook integration, two-way SMS conversations, bulk sending, message scheduling, or production deployment of telephony features. v2.0 includes official Telnyx documentation, production patterns from Twilio-Aldea (Ed25519 signature validation, provider-agnostic webhooks, idempotency), and TypeScript code examples.

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Scrape pages locally with anti-bot bypass, TLS impersonation, and adaptive element tracking — no API keys, no cloud. Handles Cloudflare protection, CSS/XPath element extraction, and survives site redesigns. Complements firecrawl (cloud) with 100% local execution. Triggers on Cloudflare bypass, anti-bot scraping, stealth fetch, local scraping, Scrapling.

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Inverted orchestration—Codex CLI acts as CTO (planning and reviewing), Claude Code executes with native tools. Use when a task benefits from external architectural oversight before and after implementation.

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This skill should be used to search, inspect, list, and recover local Codex sessions through Codex's native App Server APIs. Trigger for requests such as find a prior Codex conversation, search Codex transcript text, list recent Codex work, locate matches inside a session, or produce a safe Codex resume command. Do not use for Claude Code sessions, project source-code search, or web search.

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Create text effects impossible with CSS alone — kinetic typography, flowing text around animated obstacles, calligrams, shrinkwrap chat bubbles, typographic ASCII art, glyph path animation, variable font waves, glyph morphing, illuminated manuscripts. Single-file HTML output, zero build step. Powered by @chenglou/pretext + opentype.js. Triggers on text effects, kinetic typography, text animation, calligram, glyph art, typography art.

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Search and download images from 15 APIs in parallel (Openverse, Pexels, Pixabay, Met Museum, Cleveland Museum, Art Institute of Chicago, Getty Museum, NASA, Rijksmuseum, Wikimedia Commons, Unsplash, Smithsonian, Europeana, Iconify, Pollinations AI). Supports license filtering, presets (military, museum, stock), cached results, and bulk download with metadata sidecars. Triggers on find images, stock photos, public domain artwork, museum images, CC-licensed, NASA photos, icons.

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Polish screen recordings with Recordly (open-source Screen Studio alternative) — auto-zooms, cursor animations, webcam overlays, styled backgrounds, timeline editing. Also includes Slant: browser-based 3D perspective renderer with 12 animation presets and MP4/GIF export. Triggers on screen recording, demo video, Recordly, screen capture polish, product walkthrough, 3D perspective, Slant.

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Generate and edit high-quality images using Google's Nano Banana Pro (Gemini 3 Pro Image) AI model. Use this skill when working with AI image generation or editing tasks including (1) Creating images from text prompts with professional quality, (2) Editing existing images with natural language instructions, (3) Multi-turn iterative image refinement, (4) Product photography and marketing visuals, (5) Creating infographics and diagrams with text, (6) Photorealistic and artistic image generation, (7) Batch image generation workflows, (8) Testing and troubleshooting Gemini image generation API. Supports up to 4K resolution, multiple aspect ratios, reference images, and advanced prompting techniques for cinema-quality results.

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Strip AI writing patterns from prose across five registers — casual, professional, academic, technical, and narrative. Applies 200+ pattern rules to eliminate predictable LLM tells. Triggers on clean up writing, remove AI slop, edit prose, make this sound less AI.

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Research UI component patterns across the component.gallery corpus — 60 canonical component types, ~95 production design systems, 2,600+ examples — plus an AI-era overlay (prompt inputs, tool-call cards, streaming status, citations) and composite patterns (command palette, app shell, agent console). Compare implementations, find alternative component names, ground frontend decisions in real-world precedent. Pairs with minoan-frontend-design for research-then-build workflows. Triggers on component patterns, how do others implement X, design system research, component comparison, AI chat components, agent UI patterns.

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