「que」の検索結果

Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

日本語の概要は準備中です。原文の説明を表示しています。

ToolUniverse plugin router. STEP 1 BEFORE ANY ANALYSIS: if the data folder contains `*_executed.ipynb`, run `tu run read_executed_notebook '{"data_folder":"<path>","search":"<keyword>"}'` to extract its cell outputs and apply EVERY filter/sample-exclusion the notebook used — even when the question says 'Using DESeq2/Run X/Compute Y' (this describes the METHOD the notebook used, not a request to rerun). The notebook's cell outputs are the only published authoritative answers; reimplementing or reading stale pre-computed CSVs in the data folder produces different numbers because of outlier-sample removal, library version, and filter steps you don't see by skimming. STEP 2 routing — pick a sub-skill name from this exact list (never invent): tooluniverse-rnaseq-deseq2 (RNA/miRNA-seq DE, correlation, PCA, clustering, dispersion), tooluniverse-gene-enrichment (GO/KEGG/Reactome/GSEA/pathway enrichment), tooluniverse-statistical-modeling (regression, ANOVA, ordinal/logistic, chi-square, correlation, power), tooluniverse-image-analysis (microscopy, colony, fluorescence, dose-response, .tif — including ANOVA / Dunnett / power-analysis on image-derived measurements), tooluniverse-epigenomics (DNA methylation, CpG, m6A, MeRIP-seq, bisulfite, ChIP-seq, chromatin), tooluniverse-sequence-analysis (FASTQ, Trimmomatic, BWA, samtools, coverage), tooluniverse-variant-analysis (VCF, VAF, SNP, mutation), tooluniverse-phylogenetics (treeness, PhyKIT, parsimony), tooluniverse-single-cell (scRNA, h5ad, scanpy), tooluniverse-crispr-screen-analysis (MAGeCK, sgRNA), tooluniverse-proteomics-analysis (mass spec, TMT). Use for CSV/Excel/VCF/FASTA/h5ad and any biology/chemistry/medicine analysis question.

日本語の概要は準備中です。原文の説明を表示しています。

Upstash サーバーレスデータプラットフォームリファレンス。 @upstash/redis — REST API、pipelining、transactions、JSON、Search、グローバルレプリケーション。 @upstash/ratelimit — Fixed Window、Sliding Window、Token Bucket、limit、blockUntilReady。 QStash — publishJSON、schedules、queues、DLQ、URL Groups、callbacks、flow-control。 @upstash/vector — upsert、query、ANN、hybrid index、sparse index、embedding models、namespace。 Rust 製ローカル vector DB エンジン fandhe-db とは別（こちらはマネージド SaaS の JS SDK）。 @upstash/workflow — durable execution、serve、context.run/sleep/call/invoke、waitForEvent、parallel steps、agents。 Upstash Search — search、upsert、fetch、range、filtering、reranking、algorithm、@upstash/search。 Upstash Box — サンドボックス、agent、filesystem、git、browser（CDP/AI actions/recordings）、network policy、snapshots、schedules。

Fastify (Node.js 高速 HTTP サーバーフレームワーク, v5) の API リファレンス。 `fastify.register`, encapsulation, `fastify-plugin`, `decorateRequest` / `decorateReply`, `onRequest` / `preHandler` / `onSend` フック, JSON Schema + Ajv, Type Providers (TypeBox / Zod), `fastify.inject`, `FST_ERR_*`, find-my-way ルーティング, fastify-cli, v4→v5 移行。

nuqs (Type-safe URL search params state manager for React / Next.js) リファレンス。 useQueryState, useQueryStates, parsers (parseAsString / parseAsInteger / parseAsBoolean / parseAsArrayOf 等)、 Next.js App Router / Pages Router、SSR、シャロールーティング、history 制御。 createSerializer, createStandardSchemaV1, inferParserType ユーティリティ、URL 長さ制限 (limits)。

Drizzle ORM (TypeScript ORM, drizzle-orm / drizzle-kit) の API リファレンス。 pgTable / mysqlTable / sqliteTable, `drizzle()`, `$inferSelect` / `$inferInsert`, RQB (Relational Queries) / `db.query`, `defineRelations`, magic `sql` operator, `drizzle-kit generate` / `push`, `drizzle.config.ts`, drizzle-zod, drizzle-seed, Drizzle Studio。SQL Server の低レベルドライバーは別スキル mssql。

Swift Standard Library・Concurrency・プロトコル/ジェネリクス・Observation リファレンス。 async/await、actor、Sendable、Task、TaskGroup、AsyncSequence、AsyncStream、 Equatable、Hashable、Comparable、Codable、Identifiable、Optional、Result、 generics、some/any opaque types、Observable、@Observable、ObservationRegistrar。

Apple データ永続化・データフロー・ネットワーク・ユーティリティリファレンス。 SwiftData / Core Data / Foundation / Combine。 @Model、ModelContainer、ModelContext、@Query、Predicate、FetchDescriptor、 NSManagedObject、NSFetchRequest、NSPersistentContainer、NSFetchedResultsController、 URLSession、JSONEncoder、JSONDecoder、Publisher、@Published、AnyCancellable、sink。

BullMQ (Redis ベースの Node.js ジョブキュー) リファレンス。 Queue, Worker, Job, FlowProducer, QueueEvents、レート制限、cron、 delayed / repeatable / priority ジョブ、再試行、デッドレター、フロー、メトリクス。 Python / Elixir / PHP / Rust マルチ言語対応。

Assigns pathogen lineages (SARS-CoV-2 Pangolin via UShER mode; Nextclade clade + QC; pango-designation alias_key.json resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage fitness modelling (Wenseleers / Bedford-Figgins multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data version pinning (mandatory for reproducibility), Nextclade dataset versioning (lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme version churn (V3 / V4 / V4.1 / V5.3.2 / Midnight 1200) with documented dropout regions, recombinant X-prefix Pango designation lag, GISAID vs INSDC dual-deposition tensions, and the Karthikeyan 2022 wastewater early-detection signal with explicit reproducibility caveats. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater pooled samples into lineage frequencies with Freyja, tracking lineage frequencies and growth advantages over time, pinning pangolin-data / Nextclade dataset versions for reproducibility, handling ARTIC primer dropouts (V4.1 amplicons 64 / 76 / 88-90), or running variant surveillance for SARS-CoV-2 / influenza / Mpox / RSV / H5N1 / measles.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

日本語の概要は準備中です。原文の説明を表示しています。

Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Monitor Query SDK for Java. Execute Kusto queries against Log Analytics workspaces and query metrics from Azure resources.

日本語の概要は準備中です。原文の説明を表示しています。

Pesquisa de Voz do Cliente (VOC) antes de escrever qualquer copy — coleta a linguagem literal do público em avaliações, fóruns, redes sociais, tickets de suporte e transcrições de vendas. Use quando o usuário disser "pesquisa de público", "voz do cliente", "VOC", "o que os clientes falam", "pesquisar concorrente", "analisar reviews", "levantar objeções", "não sei o que escrever", ou quando pedir copy sem que exista seção 6 preenchida em .claude/pwdev-copy-context.md. Produz frases verbatim, não paráfrases.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user requests to review, analyze, critique, or summarize academic papers, research articles, preprints, or scientific publications. Supports comprehensive structured reviews covering methodology assessment, contribution evaluation, literature positioning, and constructive feedback generation. Trigger on queries involving paper URLs, uploaded PDFs, arXiv links, or requests like "review this paper", "analyze this research", "summarize this study", or "write a peer review".

日本語の概要は準備中です。原文の説明を表示しています。

BullMQ expert for Redis-backed job queues, background processing, and reliable async execution in Node.js/TypeScript applications. Use when: bullmq, bull queue, redis queue, background job, job queue.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Monitor Query SDK for Java. Execute Kusto queries against Log Analytics workspaces and query metrics from Azure resources.

日本語の概要は準備中です。原文の説明を表示しています。

Assigns pathogen lineages (SARS-CoV-2 Pangolin via UShER mode; Nextclade clade + QC; pango-designation alias_key.json resolution) and tracks variant frequencies over time using Nextstrain (Augur + Auspice), wastewater deconvolution (Freyja, COJAC, alcov, lineagespot), lineage fitness modelling (Wenseleers / Bedford-Figgins multinomial logistic), and recombinant detection (3SEQ, RDP4, Bolotie). Covers Pangolin pangolin-data version pinning (mandatory for reproducibility), Nextclade dataset versioning (lineage-defining mutations change with dataset), Freyja barcode forward-only date constraint, ARTIC primer scheme version churn (V3 / V4 / V4.1 / V5.3.2 / Midnight 1200) with documented dropout regions, recombinant X-prefix Pango designation lag, GISAID vs INSDC dual-deposition tensions, and the Karthikeyan 2022 wastewater early-detection signal with explicit reproducibility caveats. Use when assigning Pango lineages and Nextclade clades to viral consensus sequences, building Nextstrain Augur surveillance pipelines, deconvolving wastewater pooled samples into lineage frequencies with Freyja, tracking lineage frequencies and growth advantages over time, pinning pangolin-data / Nextclade dataset versions for reproducibility, handling ARTIC primer dropouts (V4.1 amplicons 64 / 76 / 88-90), or running variant surveillance for SARS-CoV-2 / influenza / Mpox / RSV / H5N1 / measles.

日本語の概要は準備中です。原文の説明を表示しています。

Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.

日本語の概要は準備中です。原文の説明を表示しています。

Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

日本語の概要は準備中です。原文の説明を表示しています。

Use when running analytical SQL over Parquet/CSV/JSON without a warehouse, replacing pandas for data wrangling, joining S3 data in-place, building local data marts, or embedding OLAP into an app. Triggers: read_parquet/read_csv setup, partitioned dataset queries, hive partitioning, glob patterns for S3, COPY TO export, attach Postgres/MySQL, UDFs in Python/R, MotherDuck cloud sync, columnar performance vs row stores. NOT for OLTP workloads (concurrent writes), distributed analytics at petabyte scale (use Spark/Trino), or vector search (use pgvector/Lance).

日本語の概要は準備中です。原文の説明を表示しています。

Interviews a request until no essential choice is left to guess, then hands the settled decisions on. Trigger on 'grill me', 'interview me before you build', 'stress-test this idea', 'ask me questions until it's clear', 'what am I missing before we start', or a vague plan, feature, prompt or skill where a wrong build costs more than questions. Or say grillwright (grill, record, resume, questionnaire — for someone else to answer, docs — check against glossary and ADRs). Builds nothing — prompts are promptwright's, skills skillwright's, agents agentwright's, game code slicesmith's, what a running agent may do gatewarden's, even asked as a grill.

日本語の概要は準備中です。原文の説明を表示しています。

Patterns for scaling read-heavy Convex apps to millions of users. Use when optimizing bandwidth, reducing query costs, fixing slow queries, creating digest tables, replacing reactive subscriptions with one-shot fetches, adding compound indexes, debouncing writes, rate-controlling backfills, or running npx convex insights. Trigger when users mention "scale", "bandwidth", "performance", "optimize", "slow queries", "expensive queries", "digest table", "denormalize", or "thundering herd" in the context of Convex.

日本語の概要は準備中です。原文の説明を表示しています。

Azure Monitor Query SDK for Java. Execute Kusto queries against Log Analytics workspaces and query metrics from Azure resources.

日本語の概要は準備中です。原文の説明を表示しています。