「dpo」の検索結果

Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

日本語の概要は準備中です。原文の説明を表示しています。

Implements missing-data sensitivity analyses for confirmatory clinical trials including MMRM under MAR (with Kenward-Roger correction), reference-based multiple imputation (J2R, CR, CIR, LMCF per Carpenter-Roger 2013), Permutt delta-adjustment / tipping-point analysis, pattern-mixture identifying restrictions (CCMV, NCMV, ACMV), and the Cro vs Bartlett variance debate. Use when handling missing primary or secondary endpoint data in regulatory submissions following NRC 2010 and ICH E9(R1).

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Assesses RNA-seq data quality specifically for alternative splicing analysis. QC layers include experimental design audit (library prep, read length, depth, replicates), STAR 2-pass cohort-style alignment, junction saturation curves and discovery plateau detection, novel-vs-known junction ratio diagnostics, junction-overhang distribution, splice-site strength scoring (MaxEntScan intrinsic + SpliceAI context-aware), strandedness verification, GENCODE basic vs comprehensive choice, and rRNA contamination screening. Splicing analysis is more demanding than DGE on read length, depth, library prep, alignment strategy, and annotation choice — failures silently bias PSI estimates and inflate novel-junction false positives. Use when evaluating data suitability for splicing analysis, troubleshooting low event detection, or designing sequencing experiments where AS is a primary endpoint.

日本語の概要は準備中です。原文の説明を表示しています。

Verify device legitimacy and app integrity using DeviceCheck (DCDevice per-device bits) and App Attest (DCAppAttestService key generation, attestation, and assertion flows). Use when implementing fraud prevention, detecting compromised devices, validating app authenticity with Apple's servers, protecting sensitive API endpoints with attested requests, or adding device verification to a backend architecture.

日本語の概要は準備中です。原文の説明を表示しています。

Guide for upgrading Stripe API versions, webhook endpoints, server-side SDKs, Stripe.js, and mobile SDKs

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This skill should be used when user asks to "upload my model to Ultralytics Platform", "push this run to the platform", "upload a dataset to platform", "download a dataset from platform", "search platform datasets", "start cloud training", "train on platform GPUs", "export a model on platform", "deploy a model endpoint", "run Moondream on Platform", "auto-annotate a Platform dataset", "run hosted AI inference", "why is my run not showing on platform", or mentions platform.ultralytics.com, ul:// URIs, ultralytics-platform, or ULTRALYTICS_API_KEY.

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Optimize MongoDB client connection configuration (pools, timeouts, patterns) for any supported driver language. Use this skill when working/updating/reviewing on functions that instantiate or configure a MongoDB client (eg, when calling `connect()`), configuring connection pools, troubleshooting connection errors (ECONNREFUSED, timeouts, pool exhaustion), optimizing performance issues related to connections. This includes scenarios like building serverless functions with MongoDB, creating API endpoints that use MongoDB, optimizing high-traffic MongoDB applications, creating long-running tasks and concurrency, or debugging connection-related failures.

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Reverse-engineer a website's internal API by recording browser traffic into a HAR file, then generate a standalone client or CLI that calls the endpoints directly, with no browser needed after the first recording. Use when asked to "derive a client", "build a CLI for <site>", "reverse engineer this site's API", "record network requests", "turn this site into an API", or when the same site will be automated repeatedly and direct HTTP calls would beat driving the browser every time.

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Discover OPC UA servers, connect MATLAB clients, and browse/navigate server nodes using opcuaserverinfo, the Local Discovery Service (LDS), opcua, connect, setSecurityModel, certificate-trust functions, findNodeById, opcuanode, and Namespace/Children traversal. Use when finding OPC UA servers on the network, querying endpoints and security policies, connecting to a server, authenticating with username/password or certificates, configuring security modes, handling certificate-trust or hostname-mismatch errors, troubleshooting failed connections or empty discovery, inspecting an OPC UA certificate (.der/.pem), browsing an address space, finding nodes by name or NodeId, navigating node hierarchies, invoking method nodes, or batch-processing large namespaces. Trigger on: opcuaserverinfo, LDS, opcua, opc.ua.Client, setSecurityModel, opc.ua.trustServerCertificate, OPC UA certificate, findNodeById, opcuanode, browse OPC UA, find node, OPC UA namespace, OPC UA method node, Industrial Communication Toolbox.

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Build a RoadRunner Scenario programmatically from an OpenSCENARIO 1.x (.xosc) file using the `roadrunner-scenario-authoring` skill. Use when the user wants to recreate a scenario from a .xosc file, interpret an OpenSCENARIO file and build it programmatically, reconstruct a .xosc as a RoadRunner scenario, generate a MATLAB script from a .xosc file, or convert an OpenSCENARIO file to MATLAB code. Do NOT use when the user says "import" a .xosc file — that means they want RoadRunner's built-in importScenario API, not programmatic reconstruction. Handles position translation (LanePosition and RoadPosition to world coordinates), construct mapping, relative references, trajectory/route handling, parameter expressions, catalog references, and phase logic topology.

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Deploy and manage vLLM for high-throughput LLM inference. Configure continuous batching, tensor parallelism, quantization, and OpenAI-compatible API endpoints for production LLM serving.

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Configure Azure VNets, NSGs, and Azure Firewall. Implement hub-spoke topology and private endpoints. Use when designing Azure network infrastructure.

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CloudBase MCP reference. Use when connecting local or remote MCP, calling tools from the shell with mcporter, reading tool schemas, choosing the domestic or international endpoint, setting site, region, cloud mode, or plugin flags, or contributing a fix to the open-source MCP server, skills, or CLI.

日本語の概要は準備中です。原文の説明を表示しています。

Generate API endpoint documentation from Express route files. Use when the user asks to generate, update, or review API docs for Express.js routes.

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Generate API documentation from code. Use when the user wants to document APIs, create API reference, generate endpoint documentation, or needs help with OpenAPI/Swagger specs.

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API design patterns and conventions for this project. Covers RESTful URL naming, response format standards, error handling, and authentication requirements. Use when writing or reviewing API endpoints, designing new APIs, or making decisions about request/response formats.

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Use when adding a new docs section or product area, editing llms.ts / the llms.txt or llms/[...slug] / llms-full.txt routes / get-llm-text / skill.md / .well-known endpoints, or working on the "agent score", "llms.txt", or anything "agent-ready" in the docs and site apps. Explains the invariants the Mintlify agent-readiness audit measures and how to hold them.

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Summarize Workflow-tool fleet runs from the Agent Monitor — these fleets emit no hooks and are ingested from on-disk run journals. List recent runs with status and agents-per-run, then drill into a single run's per-agent detail. Reconciles against the live run-state endpoints. Use when reviewing Workflow() fleets rather than hook-instrumented interactive sessions.

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Identify stale and empty Claude Code sessions in the Agent Monitor and explain the cleanup endpoint (POST /api/settings/cleanup), always showing the exact list of what WOULD be removed before anything is deleted. Cleanup permanently deletes data, so this skill previews first and requires explicit user confirmation. Use when tidying the monitoring database.

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Polls the Agent Monitor /api/stats endpoint several times over a short window and reports the live deltas in active_sessions, active_agents, events_today, and ws_connections so you can see activity moving in real time. Use when watching the dashboard for live changes rather than a one-time snapshot.

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Probes each major Agent Monitor API route — /api/stats, /api/analytics, /api/sessions, /api/pricing/cost, /api/workflows/runs, /api/cc-config/overview — and reports each one's HTTP status, latency, and response shape, flagging which are reachable. Use to verify a dashboard install is wired up correctly.

日本語の概要は準備中です。原文の説明を表示しています。

Generate project documentation from codebase analysis — ARCHITECTURE.md, API_ENDPOINTS.md, DATABASE_SCHEMA.md. Reads source code, schema files, routes, and config to produce accurate, structured docs. Use when starting a project, onboarding contributors, or when docs are missing or stale. Triggers: 'generate docs', 'document architecture', 'create api docs', 'document schema', 'project documentation', 'write architecture doc'.

日本語の概要は準備中です。原文の説明を表示しています。

Query the OpenAI developer documentation via the OpenAI Docs MCP server using CLI (curl/jq). Use whenever a task involves the OpenAI API (Responses, Chat Completions, Realtime, etc.), OpenAI SDKs, ChatGPT Apps SDK, Codex, MCP integrations, endpoint schemas, parameters, limits, or migrations and you need up-to-date official guidance.

日本語の概要は準備中です。原文の説明を表示しています。