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Calculates molecular descriptors and fingerprints using RDKit. Computes Morgan fingerprints (ECFP), MACCS keys, Lipinski properties, QED drug-likeness, TPSA, and 3D conformer descriptors. Use when featurizing molecules for machine learning or filtering by drug-likeness criteria.

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Amplicon sequence variant (ASV) inference from 16S rRNA or ITS amplicon sequencing using DADA2. Covers quality filtering, error learning, denoising, and chimera removal. Use when processing demultiplexed amplicon FASTQ files to generate an ASV table for downstream analysis.

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Cell segmentation from multiplexed tissue images. Covers deep learning (Cellpose, Mesmer) and classical approaches for nuclear and whole-cell segmentation. Use when extracting single-cell data from IMC or MIBI images after preprocessing.

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Deep learning-based variant calling from long reads using Clair3 for SNPs and small indels. Use when calling germline variants from ONT or PacBio alignments, particularly when high accuracy is needed for clinical or research applications.

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Predict TCR-epitope specificity using ERGO-II and deep learning models for T-cell receptor antigen recognition. Match TCRs to their cognate epitopes or predict TCR targets. Use when analyzing TCR repertoire specificity or identifying antigen-reactive T-cells.

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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

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Build a Stockbee-style setup model book from momentum-burst screener candidates, then update 3-day and 5-day forward outcomes with MFE/MAE, stop-hit status, outcome tags, and cohort statistics. Use when the user wants to study Stockbee Momentum Burst examples, track failed candidates, build setup fluency, review A/B setup quality, or convert screener outputs into a learning loop rather than immediate trade signals.

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Use when the user asks to "run a launch retro / post-mortem", "compare launch results vs targets by channel", or "decide what to keep or kill for the next launch"; produces a structured D1/W1/M1 retrospective — a per-channel actual-vs-target table (UTM-attributed own analytics as the truth column, platform self-reported numbers as reference, every figure labeled Measured / User-provided / Estimated), a 5-Whys chain on the single largest miss, keep / kill / change decisions per channel, 3-5 actionable learnings for the next launch, and an outcome snapshot submitted to the launch registry. Not for return math (CPA / ROI) — use roi-calculator; not for the stakeholder-facing report writeup — use report-generator; not for a metric deep-dive — use performance-analyzer. 发布复盘/渠道归因/5-Whys/keep-kill

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Use when the user asks to "analyze influencer campaign performance", "compare influencers", or "find what content worked"; produces metric scorecards vs target and benchmark, platform/influencer/content rankings, engagement-quality and sentiment reads, conversion-attribution breakdowns, and ranked learnings. Not for dollar-level return math — use roi-calculator. 达人营销效果分析/投放复盘

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Use when the user asks to "check pacing", "am I over/under-spending", "is this campaign on track to hit budget", or "why did spend spike/stall mid-flight"; returns a spend-vs-target-curve read, learning-phase status, an over/under-delivery call, and a reallocation trigger. Not for initial budget allocation — use budget-optimizer; not for choosing the bid strategy — use bid-strategy-planner; not for the RQS gate — use ad-account-auditor. 付费广告预算节奏监控/跑量过快过慢/在途配速

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Use when the user asks to "create a campaign report", "build an executive summary", or "deliver client results"; produces audience-tailored influencer marketing reports (executive, client, internal team) with data tables, narrative, key learnings, and recommendations. Not for raw metric computation — use performance-analyzer. 达人营销报告/结案汇报

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End-of-session ritual that audits changes, runs quality checks, captures learnings, and produces a session summary. Use when saying "wrap up", "done for the day", "finish coding", or ending a coding session.

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Provider-agnostic multi-LLM deliberation. Three phases — independent responses, cross-model anonymized ranking, chairman synthesis. Credentials come from explicit plugin configuration or pro-workflow-specific CLI variables. Persists transcript to a wiki page when --wiki <slug> is passed. Use when the user wants multiple AI perspectives, consensus-building, or the "LLM Council" approach for high-stakes reviews, plan critique, or contested learning rules.

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Complete AI coding workflow system. Orchestration patterns, 18 hook events, 8 agents, cross-agent support, reference guides, and searchable learnings. Works with Claude Code, Cursor, and 32+ agents.

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Capture a correction or lesson as a persistent learning rule with category, mistake, and correction. Stores, categorises, and retrieves rules for future sessions. Use after mistakes or when the user says "remember this", "don't forget", "note this", or "learn from this".

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Show session analytics, learning patterns, correction trends, heatmaps, and productivity metrics. Computes stats from project memory and session history. Use when asking for stats, statistics, progress, how am I doing, coding history, or dashboard.

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A minimal skill example - use when learning the skill format

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Builds, runs, debugs, and operates applications on AWS Lambda MicroVMs — Firecracker-isolated, snapshot-resumable serverless compute environments running inside a container with up to 8 hr lifetimes. Applicable when workloads need strong isolation between tenants, isolated serverless compute, sandbox compute, or secure multi-tenant execution. Also suited for AI/agent code-execution sandboxes, interactive code playgrounds and notebooks (Jupyter, REPLs, dev environments running user-supplied code), reinforcement-learning environments, multi-tenant CI executors and build runners, sessionful game or simulation servers, or isolated security scanners. Also applicable when the workload needs long-lived sessions, a real port-listening server (gRPC, WebSocket, custom TCP protocols), state preserved across periods of inactivity (suspend/resume), container-level access (FUSE, eBPF, custom syscalls), or session-affine routing.

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Performs a full AWS Well-Architected Framework review evaluating every framework question across all pillars discovered from the live AWS documentation by analyzing code, IaC, and configurations to produce evidence-backed findings with Eisenhower-prioritized remediation. Supports full reviews (every framework best practice with BP ID citations), quick reviews (question-level), pillar-scoped reviews, score-mode reviews (a maturity scorecard with per-pillar scores and filtered findings), and lens-specific reviews using lenses discovered from the live AWS documentation. Triggers on mentions of Well-Architected review, WA review, WAR, pillar assessment, architecture review across pillars, workload assessment, cloud readiness evaluation, or a Well-Architected score, grade, or scorecard request. Does not apply to single-pillar deep-dives, learning WA concepts, ADRs, or migration readiness assessments.

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Create, read, and list Apple Notes using JXA and AppleScript. Use when learning Notes automation, creating your first automated note, or testing read/write access to Apple Notes from scripts. Trigger: "apple notes hello world", "create apple note", "read apple notes", "apple notes example", "osascript notes".

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Run your first Apify Actor and retrieve results via apify-client. Use when starting a new Apify integration, testing connectivity, or learning the Actor call/dataset retrieval pattern. Trigger with "apify hello world", "apify example", "run an apify actor", "apify quick start", "first apify scrape".

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Create a minimal working Anthropic Claude Messages API example. Use when starting a new Claude integration, testing your setup, or learning basic Messages API patterns for text, vision, and streaming. Trigger with phrases like "anthropic hello world", "claude api example", "anthropic quick start", "simple claude code", "first messages api call".

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Create a minimal working Apollo.io example. Use when starting a new Apollo integration, testing your setup, or learning basic Apollo API patterns. Trigger with phrases like "apollo hello world", "apollo example", "apollo quick start", "simple apollo code", "test apollo api".

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Generate reviewable React or HTML code from a Figma design using the Anima SDK. Use when testing design-to-code conversion, learning Anima's code output format, or building your first automated design-to-code pipeline. Trigger with: "anima hello world", "anima example", "figma to react", "figma to code", "anima generate code".

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