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概要と使いどころ
Use when planning an ACM CCS project timeline across the two HotCRP review cycles, from venue fit through abstract registration, full-paper upload, rebuttal, notification, revision, artifact evaluation, ACM camera-ready, and in-person presentation, with backward-planning offsets and the security big-four deadline-hopping calendar.
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Use when strengthening the reproducibility of an ACM MM (ACM Multimedia) paper or preparing for the ACM MM Reproducibility track and ACM artifact badging — capturing environments, media/data access, seeds, and multimodal pipelines so an independent reviewer can rebuild results and reach Artifacts Evaluated or Results Reproduced badges.
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Manages Fabric Dataflow Gen2 items, including creation, M editing, connections, output destinations, getDefinition and updateDefinition inspection, executeQuery, refresh history, and Gen1-to-Gen2 save-as upgrades via saveAsNativeArtifact. Use for Dataflow items or Power Query M definitions. For pipeline JSON use pipeline-migration; for Spark or Warehouse transformations use their own skills.
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Assign cell types from marker expression in IMC/MIBI data using clustering (PhenoGraph/FlowSOM/Leiden/Pixie), marker-based probabilistic classifiers (Astir), or image-context CNNs (CellSighter), covering the double-positive segmentation artifact, lineage-vs-state markers, the two spillover types, and why a "cell type" in imaging is conditioned on a segmentation guess. Use when phenotyping segmented IMC cells, choosing clustering vs classification, diagnosing implausible double-positive populations, separating lineage from functional markers, or transferring labels across a cohort.
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Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
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Analyzes base-editing screens for variant function. Covers library design (Hanna 2021 ClinVar-scale CBE screen benchmarked on BRCA1/2, Cuella-Martin 2021 DDR saturation), CBE vs ABE chemistry choice (BE3/BE4 vs ABE7.10/ABE8.20/ABE8e), editing-window math (positions 4-8 from PAM-distal end; 4-7 for ABE7.10), bystander-edit quantification and the variant-call ambiguity it creates, sgRNA-efficiency filtering before hit calling, indel byproduct interpretation, the substitution-vs-indel diagnostic, variant annotation against ClinVar / COSMIC, and the Broad be-validation-pipeline. Use when designing a BE variant screen, choosing CBE vs ABE for a specific edit, interpreting bystander-confounded hits, distinguishing functional signal from indel artifact, integrating CRISPResso2 output with screen scoring, or deciding BE vs PE for SNV installation.
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Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the gene-independent DNA-damage / G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.
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Detect introgression and admixture between species or populations using Dsuite (Malinsky 2021 fast D-statistics), Patterson's D / ABBA-BABA test (Green 2010; Durand 2011), f4-ratio and f-branch statistic (Malinsky 2018), TreeMix (Pickrell & Pritchard 2012), HyDe (Blischak 2018), QuIBL (Edelman 2019), sprime (Browning 2018), Twisst (Martin 2017), PhyloNet (Than 2008) for explicit phylogenetic networks, and qpAdm / qpGraph (Patterson 2012). Distinguish introgression from incomplete lineage sorting (ILS), ancestral structure, ghost-lineage admixture, and rate variation. Use when testing inter-species gene flow, dating admixture events, identifying introgressed segments, building phylogenetic networks for reticulate evolution, or applying the ABBAclustering (Koppetsch-Malinsky-Matschiner 2024) framework for divergent-species gene flow.
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Model gene-family birth-death dynamics across a species tree using CAFE5 (Mendes et al 2020 Bioinformatics 36:5516 gamma-distributed rate categories), CAFE5-error (annotation-error-aware), Count (Csurös 2010 ancestral state reconstruction), BadiRate (Librado 2012 likelihood + parsimony), DupliPHY-Family, and ALE/AleRax (for per-family DTL; see [[gene-tree-species-tree-reconciliation]]). Test lineage-specific gene-family expansions and contractions, distinguish biological dynamics from annotation artifacts, account for assembly fragmentation, identify functional enrichment in expanded / contracted families. Use when correlating gene-family changes with phenotype evolution, ranking lineages by adaptive gene-family-rate shifts, post-WGD dosage-balance analysis, or building Birth-death models from OrthoFinder presence/absence matrices.
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Apply Swift API Design Guidelines to name, label, and document Swift APIs. Covers argument label rules (prepositional phrase rule, grammatical phrase rule, first-label omission), mutating/nonmutating pair naming (-ed/-ing participle pattern, form- prefix, sort/sorted, formUnion/union), side-effect naming (noun for pure, verb for mutating), documentation comment structure (summary by declaration kind, O(1) complexity rule), clarity at call site, role-based naming, protocol naming (-able/-ible/-ing), default arguments over method families, casing conventions, and terminology. Use when designing new Swift APIs, reviewing naming and argument labels, writing documentation comments, or refactoring for call site clarity.
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Implement, review, or improve WidgetKit widgets and controls. Use when building Home Screen, Lock Screen, StandBy, or CarPlay widgets with timeline providers; configurable widgets with AppIntentTimelineProvider; interactive widgets or Control Center controls with Button/Toggle wiring; WidgetKit push reloads, refresh budgets, deep links, Smart Stack relevance, Liquid Glass/accented rendering, widget extension setup, WidgetBundle, App Groups, and entitlements.
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E-commerce email marketing system builder. Creates complete email automation flows with full copywriting, subject lines, ESP setup instructions, segmentation rules, and annual campaign calendars. Generates copy-paste-ready email sequences for Klaviyo, Omnisend, Mailchimp, or any ESP. Covers welcome series, cart abandonment, browse abandonment, post-purchase, review requests, cross-sell, win-back, VIP/loyalty, replenishment, and sunset flows. Includes A/B test subject line variants, send timing, trigger conditions, branching logic, and seasonal campaign calendar. No API key required. Use when: (1) setting up email marketing for an e-commerce store, (2) writing email sequences and flows, (3) planning seasonal email campaigns.
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The Power BI report design canon covering design identity, visual hierarchy and the 3-30-300 rule, layout/spacing/alignment, color discipline, chart selection, KPI and card design, tables and matrices, accessibility, and the closing design gate. The shared reference home for report design judgment, routed to by the create-pbi-report, pbir-cli, review-report, modifying-theme-json, and custom-visual skills. Load when committing a design identity or making a design, layout, color, chart-selection, or accessibility decision for a report.
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Use when sculpting a stylized or cartoon character, bust, collectible or toy in ZBrush (Overwatch, Fortnite, Disney look), judging shape language (S and C curves, parallel lines, 70/30, silhouette read at a distance), exaggerating proportions on purpose, keeping stylized planes crisp through subdivision, sculpting stylized hair (chunky clumps, curve tube strands, ClayPolish), or designing a figure for toy production (articulation, wall thickness, scale).
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Use when grooming hair or fur in Maya with XGen (Interactive Groom splines or legacy descriptions): scalp hair, eyebrows, eyelashes, fur, guides, clumps, noise, parting, density maps, a fill layer, aiStandardHair shading, noisy or flickering hair renders, hair that must move (Linear Wire, nHair, Alembic caches), or a groom for Unreal (groom Alembic, cards). Also when XGen hair looks CG, clumps look uniform, the scalp shows through, or an XGen script fails.
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Use when modeling hard surface in ZBrush 2026 (sci-fi helmet, weapon, prop, armor plates, mechanical parts, kitbash, vents, panel lines, bolts, concept to game asset), when using ZModeler, Dynamic Subdivision and creasing, Live Boolean, Knife, Clip, Slice or Trim curves, IMM, ArrayMesh, NanoMesh or Panel Loops, or when edges look razor sharp, a Make Boolean Mesh fails or leaves holes, planes look wobbly, Mirror And Weld erased an edit, or ZRemesher ruins a hard-surface part.
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Evaluate code (especially LLM-generated) for structural simplicity using Rich Hickey's "Simple Made Easy" framework. Use this skill whenever reviewing a PR, diff, or code snippet for accidental complexity — particularly when the code was generated by an AI coding assistant and line-by-line review isn't feasible. Also use when the user asks about complecting, simplicity vs. easiness, structural coupling, or concept deduplication. Trigger on phrases like "is this simple", "does this complect", "review for complexity", "structural analysis", or any reference to Hickey, Simple Made Easy, or grey-box review.
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Set up and run rank tracking using Ahrefs MCP: pick the right keywords to track, segment them by purpose, set baselines, and define alert thresholds. Use this skill when starting a new tracking project, baselining for a campaign, choosing what to monitor, or building a rank reporting cadence. Triggers on rank tracking, keyword tracking, monitor rankings, track positions, what should we track, ranking dashboard, baseline rankings, alert thresholds. Also triggers when a stakeholder wants weekly or monthly ranking visibility.
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Patterns for individual long-form content pieces. Case studies, whitepapers, research reports, definitive guides, manifestos, ebooks, long-form tutorials. The structural disciplines that distinguish publication-quality long-form from bloggy-long padding or academic bloat. Different from pillar-content-architecture (which covers hub structure); this skill covers individual deep-dive pieces. Triggers on long-form content, case study writing, whitepaper, research report, definitive guide, ebook, manifesto, long-form tutorial, deep-dive article, anchor piece, foundational article, structural archetypes. Also triggers when a piece is over 3,000 words and the team is unsure how to structure it, when a long-form draft feels padded or saggy, or when a flagship asset needs the depth to actually earn the length.
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Generate a phased delivery orchestration plan for creative-direction-driven work: which skills run when, what locks at which gate, how handoffs occur, and how the cadence implements in the team's tools (Jira, Linear, Notion, Figma, GitHub) with AI agents via MCP and CLI. A temporal map of phases, lock points, handoff specs, gate definitions, and QA verification gates. Distinct from `creative-brief` (static project brief) and `creative-direction` (aesthetic direction). Triggers on integration orchestrator, delivery cadence, project orchestration, when does the brief lock, how to phase creative direction, design-development handoff, QA gate, agent-driven QA, and when a creative-direction project is starting, mid-flight with broken cadence, or integrating AI agents into PM workflow. Does NOT fire for project scoping (use `creative-brief`), aesthetic direction (use `creative-direction`), or general project management without a creative-direction throughline.
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Build or audit a comprehensive brand style guide that documents the full brand system including story, logo system, color, typography, imagery, voice, applications, and dos/don'ts. Use this skill whenever the user wants to create brand guidelines, document an existing brand, build a brand book, audit an existing style guide for completeness, or produce the artifact that other teams will reference for years. Triggers on style guide, brand guidelines, brand book, brand standards, brand manual, style sheet, brand documentation, brand reference. Also triggers when the brand identity is finished and needs to be documented for handoff to designers, developers, vendors, or future team members.
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Systematic content refresh discipline. Quarterly audits, refresh prioritization (which pieces, when, how deep), refresh-vs-merge-vs-delete decisions, the lifecycle that distinguishes intentional refresh from set-and-forget decay. Builds on the refresh sections of pillar-content-architecture and editorial-qa with a program-level discipline. Triggers on content refresh, content decay, content audit, refresh prioritization, content lifecycle, refresh strategy, traffic decay, ranking drop, content freshness, evergreen content, content maintenance. Also triggers when traffic is eroding silently across an aging content library, when teams cannot decide which pieces to refresh, or when refresh work is happening but the impact is unclear.
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Write or edit website copy, blog content, and editorial pieces with attention to voice, structure, and goal. Use this skill whenever the user wants to write an article, draft website copy, edit existing content for clarity or voice, write a blog post, or produce general editorial content. Triggers on write a blog post, draft an article, write copy for, edit this, rewrite this, write content, write a guide, draft a how-to, write web copy. Also triggers when content has been outlined and now needs to be written, or when existing content needs voice or clarity edits.
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Playbook for designing SaaS and startup products that convert, retain, and monetize — landing pages & CRO, checkout & forms, onboarding/activation, churn reduction, pricing psychology, dashboards, behavioral-science tactics, feature discipline, positioning/ICP, go-to-market, and AI-era differentiation. Use when advising on product design, UX, conversion, landing pages, checkout, onboarding, trials, pricing, retention/churn, growth, or positioning for a startup or SaaS. Distilled from product designer Richard (@richardrx). Not for use on gambling, betting, or casino products.
日本語の概要は準備中です。原文の説明を表示しています。