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概要と使いどころ
Test email sending locally using Mailpit with .NET Aspire. Captures all outgoing emails without sending them. View rendered HTML, inspect headers, and verify delivery in integration tests.
日本語の概要は準備中です。原文の説明を表示しています。
Call protein-RNA binding sites from CLIP-seq BAM with CLIPper, PureCLIP, Skipper, Piranha, omniCLIP, CTK, CLAM, or Paraclu. Use when choosing between coverage-based, HMM-based, beta-binomial window-based, and crosslink-site-based peak callers; applying ENCODE eCLIP thresholds (log2 IP/SMInput >= 3, -log10 p >= 3); deciding when SMInput is mandatory; or reconciling peak-set discordance between callers for the same RBP.
日本語の概要は準備中です。原文の説明を表示しています。
Batch effect correction for CRISPR screens covering ComBat empirical-Bayes, RUV, SVA, control-sgRNA normalization, and the model-based alternative of including batch as a covariate in MAGeCK MLE or Chronos. Covers screen-specific batch sources (passage cohort, library lot, infection day, sequencing run, Cas9 lot, FBS lot), PCA + variance-decomposition diagnostic to decide if correction is needed, when correction harms biology by over-correcting condition into batch, limma removeBatchEffect for visualization-only correction, and relationship to multi-condition design matrices. Use when combining screens for joint analysis, when passage cohort confounds biology, when DepMap-style panels need Chronos with batch covariates, when picking ComBat vs RUV, or when correction harms biology and should be replaced with explicit covariate modeling.
日本語の概要は準備中です。原文の説明を表示しています。
Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.
日本語の概要は準備中です。原文の説明を表示しています。
Prepares statistical reports for clinical trials following CONSORT 2025, SPIRIT 2025, ICH E9(R1) estimands, and FDA 2023 covariate adjustment guidance. Covers Table 1 generation, analysis populations (ITT/FAS/PP/Safety), the 5 ICH E9(R1) intercurrent-event strategies, MMRM under MAR (mmrm), reference-based MI (rbmi J2R/CR/CIR), Permutt tipping-point sensitivity, and Rubin's-rules vs frequentist variance debate. Use when preparing regulatory submissions, defining estimands, or implementing missing-data sensitivity analyses.
日本語の概要は準備中です。原文の説明を表示しています。
Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.
日本語の概要は準備中です。原文の説明を表示しています。
Detects differential alternative splicing between conditions using rMATS-turbo (binomial LRT on junction counts), leafcutter (Dirichlet-multinomial GLM on intron clusters), MAJIQ V3 deltapsi/HET (Bayesian posterior on LSVs), SUPPA2 (empirical-null on TPM-derived PSI), or Shiba (junction-imbalance-corrected, 2025 SOTA at low coverage). Reports FDR-corrected significance and delta PSI effect sizes. Tools differ in statistical model, annotation dependence, calibration regime, and replicate-count requirements. Use when comparing splicing patterns between treatment groups, tissues, or disease states.
日本語の概要は準備中です。原文の説明を表示しています。
Force the states a happy-path run never reaches (a failing API, an empty list, a slow request, a timeout, an expired session, a toast that auto-dismisses) and check the UI actually handles them. Use when error handling was written but never run, when a loading or empty state needs verifying, when a bug only happens on a slow connection, or when a timer, poll, debounce or retry needs testing without sleeping.
日本語の概要は準備中です。原文の説明を表示しています。
Prove sign-in lands the user where they should be, sign-out really ends the session so a protected page sends them back to sign in, and an expired session asks to sign in again instead of breaking. Use when auth, a login form, a logout button, route guards or token refresh were added or changed, or when a user reports being logged out, or not logged out, unexpectedly.
日本語の概要は準備中です。原文の説明を表示しています。
Schedule and execute background work on iOS using BGTaskScheduler. Use when registering BGAppRefreshTask for short background fetches, BGProcessingTask for long-running maintenance, BGContinuedProcessingTask (iOS 26+) for foreground-started work that continues in background, background URLSession downloads, or background push notifications. Covers Info.plist configuration, expiration handling, task completion, and debugging with simulated launches.
日本語の概要は準備中です。原文の説明を表示しています。
This skill should be used when user asks to "set up overleaf", "configure overleaf cookie", "overleaf auth failed", "overleaf 401", "overleaf session expired", "overleaf unauthorized", or needs to install or refresh their Overleaf session cookie for the overleaf-skills plugin.
日本語の概要は準備中です。原文の説明を表示しています。
Apply systematic problem-solving techniques when stuck. Use for complexity spirals, innovation blocks, recurring patterns, assumption constraints, simplification cascades, scale uncertainty.
日本語の概要は準備中です。原文の説明を表示しています。
SPIRV-Tools optimizer pass development, IR manipulation, and PassTest registration.
日本語の概要は準備中です。原文の説明を表示しています。
glslang SPIR-V Builder API for types, instructions, control flow, and decorations.
日本語の概要は準備中です。原文の説明を表示しています。
When the user wants to plan growth using the AARRR framework, diagnose growth bottlenecks, or map actions across the customer lifecycle. Also use when the user mentions "growth funnel," "AARRR," "pirate metrics," "acquisition activation retention," "customer lifecycle metrics," or "growth framework." For retention tactics, use retention-strategy.
日本語の概要は準備中です。原文の説明を表示しています。
Use when building or debugging Unity gameplay systems: enemy AI that patrols, chases and attacks, NavMesh baking and agents (AI Navigation 2), feet sliding on agents, state machines or behavior trees, physics projectiles that tunnel, the physics spiral, layers and the collision matrix, CharacterController vs Rigidbody characters, object pooling, 'hundreds of enemies', DOTS, Burst or Jobs decisions, Netcode for GameObjects multiplayer, audio mixers, snapshots, volume sliders and 3D combat sounds.
日本語の概要は準備中です。原文の説明を表示しています。
Use when turning a dense sculpt, scan or AI-generated mesh into clean topology in Blender, for animation, subdivision or a game low poly with a triangle budget. Also when choosing between QuadriFlow or voxel remesh and manual retopo, placing loops around eyes, mouth and joints, deciding pole placement, setting up a Shrinkwrap cage, fixing volume loss after subdivision, preparing a low poly for baking, or auditing topology for spirals, 6-poles and triangles. Keywords: retopo, retopology, quad remesh, clean up an AI mesh, edge flow, low poly, bake prep.
日本語の概要は準備中です。原文の説明を表示しています。
OKR design as actually shipped, not as conference-talk theory. Outcome statements that drive decisions, key results that measure the right thing, scoring discipline, mid-quarter recalibration, and the difference between sandbagged OKRs (always 100%) and aspirational OKRs (always 30%) and stretch OKRs (genuine ambition with quarterly accountability). Triggers on OKR design, OKR setting, key result design, OKR scoring, mid-quarter recalibration, OKR cascading, outcomes vs outputs, quarterly planning, goal setting. Also triggers when a team's OKRs are always hit and producing no learning, when OKRs are demoralizing because they were set as fantasy, or when the team uses OKR vocabulary but the practice has decayed.
日本語の概要は準備中です。原文の説明を表示しています。
Design and write email automation sequences (welcome/onboarding, nurture, re-engagement, trial expiration, sales) for SaaS and B2B, with subject lines, copy, CTAs, and timing. Use when building drip campaigns or designing lifecycle email.
日本語の概要は準備中です。原文の説明を表示しています。
In-app paywall and upgrade screen optimization covering feature gate design, usage limit UX, trial expiration flows, upgrade trigger timing, save offer strategy, and ethical monetization patterns.
日本語の概要は準備中です。原文の説明を表示しています。
Implement Terraform provider ephemeral resources with the Plugin Framework: the Open/Renew/Close lifecycle, ephemeral schema design, registration via EphemeralResources, renewal for expiring credentials, and how ephemeral values flow into write-only attributes and provider configuration. Use when adding an ephemeral resource, exposing secrets/tokens/certificates that must never persist in state or plan, deciding between an ephemeral resource and a data source, or wiring short-lived credentials from one provider into another.
日本語の概要は準備中です。原文の説明を表示しています。
Turns a legal question, a set of draft questions, or source material such as a statute, jury instruction, rubric, contract checklist, or coding manual into a battery of narrow questions that TypeSafe's Jev, a fast classifier that returns probabilities rather than prose, can answer reliably across many documents. The skill breaks conclusions such as negligence, felony murder, or standing into element-level questions, writes the governing rule into each question, and delivers the questions alone, in Jev's request format or in plain English. Built for legal work that asks the same questions of many texts: coding statutes across jurisdictions, coding opinions or case files for empirical research, checking contracts against a review checklist, screening intake narratives, and grading student work against a rubric. Use when asked to write Jev questions, build a classifier for legal documents, or turn a legal test into yes-or-no questions. Running the questions requires Jev access; writing them does not.
日本語の概要は準備中です。原文の説明を表示しています。
When you want to draft, update, convert, or export a slide deck for a React/Next.js slide system (${SLIDE_DECK_REPO:-$HOME/code/your-slide-deck-site}/src/app/slides/). Writes TypeScript Slide[] arrays using your primitives (Eyebrow, Heading, Accent, Body, BulletList, Divider, TwoCol, GradientText), 12 cycling brand gradients, optional sections for "where am I" context, and speaker notes. Inspired by zarazhangrui/frontend-slides — "show, don't tell" for narrative (presents 3 angles, you pick) plus density modes (speaker-led vs reading-first). Four modes — new (draft from brief), update (modify existing, with overflow guards), ppt (convert legacy PPTX → React deck), export (Playwright snapshot existing React deck to standalone HTML, PDF, or Vercel URL — keeps brand). Triggers on "/slide-deck," "/slides new," "/slides export," "/slides update," "/slides ppt," "draft a deck," "deck for [topic]," "talk on [topic]," "keynote on [topic]," "internal deck for [audience]," "convert this pptx," "export this deck."
日本語の概要は準備中です。原文の説明を表示しています。
When you or another skill needs to fetch the content of a social media post by URL — tweet, X thread, LinkedIn post, Instagram post, TikTok video, Bluesky post, Reddit thread, Mastodon status, Threads post, Hacker News thread. Returns normalized structured data (author, posted_at, text, engagement counts, media URLs, replies if requested) regardless of platform. Tries strategies in order: direct API (Bluesky, Mastodon, HN, Reddit), agent-browser with modal dismissal (LinkedIn, X preview), Wayback Machine (older posts), paid APIs (ScrapeCreators / Apify — only if env keys present). Triggers on "/social-fetch <url>," "fetch this tweet," "fetch this post," "what does this LinkedIn say," "read this thread," "pull this post." Used by deep-research (citing specific posts), jab-hook (inspiration account analysis), business-brainstorm (competitor / operator commentary).
日本語の概要は準備中です。原文の説明を表示しています。