「quant」の検索結果

Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

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Use to select models to run locally with llama.cpp and GGUF on CPU, Mac Metal, CUDA, or ROCm. Covers finding GGUFs, quant selection, running servers, exact GGUF file lookup, conversion, and OpenAI-compatible local serving.

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You are a technical debt expert specializing in identifying, quantifying, and prioritizing technical debt in software projects. Analyze the codebase to uncover debt, assess its impact, and create acti

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You are a technical debt expert specializing in identifying, quantifying, and prioritizing technical debt in software projects. Analyze the codebase to uncover debt, assess its impact, and create acti

日本語の概要は準備中です。原文の説明を表示しています。

Build financial models, backtest trading strategies, and analyze market data. Implements risk metrics, portfolio optimization, and statistical arbitrage.

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Deep research with structured reports and charts. ONLY use when the user explicitly requests research/analysis, or needs data visualization with charts, or quantitative/comparative analysis across multiple sources. Do NOT use for simple questions or quick lookups.

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Master local LLM inference, model selection, VRAM optimization, and local deployment using Ollama, llama.cpp, vLLM, and LM Studio. Expert in quantization formats (GGUF, EXL2) and local AI privacy.

日本語の概要は準備中です。原文の説明を表示しています。

Master local LLM inference, model selection, VRAM optimization, and local deployment using Ollama, llama.cpp, vLLM, and LM Studio. Expert in quantization formats (GGUF, EXL2) and local AI privacy.

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Integrate on-device AI using Foundation Models framework, Core ML, and open-source LLM runtimes on Apple Silicon. Covers Foundation Models (LanguageModelSession, @Generable, @Guide, SystemLanguageModel, structured output, tool calling), Core ML (coremltools, model conversion, quantization, palettization, pruning, Neural Engine, MLTensor), MLX Swift (transformer inference, unified memory), and llama.cpp (GGUF, cross-platform LLM). Use when building tool-calling AI features, working with guided generation schemas, converting models, or running on-device inference.

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Evaluate design from a UX perspective, assessing visual hierarchy, information architecture, emotional resonance, cognitive load, and overall quality with quantitative scoring, persona-based testing, and actionable feedback. Use when the user asks to review, critique, evaluate, or give feedback on a design or component.

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Quantum-resistant, self-learning version control for AI agents with ReasoningBank intelligence and multi-agent coordination

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Optimize AgentDB performance with quantization (4-32x memory reduction), HNSW indexing (150x faster search), caching, and batch operations. Use when optimizing memory usage, improving search speed, or scaling to millions of vectors.

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Reads Copilot conversation history and extracts executive-ready success stories. Use when the user asks to study prior Copilot sessions, summarize what was done before, mine evidence, or quantify time, cost, risk, and priority alignment from GitHub Copilot history in any workspace or repository.

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High-performance numerical and quantum compute skill for scientific workloads; use when working on numeric algorithms, simulation, or acceleration.

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Analyze session replay patterns across experiment variants to understand user behavior differences. Use when the user wants to see how users interact with different experiment variants, identify usability issues, compare behavior patterns between control and test groups, or get qualitative insights to complement quantitative experiment results.

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Simulate wave propagation — acoustic, electromagnetic, elastic, and quantum waves. FDTD, spectral methods, and absorbing boundary conditions for 1D/2D/3D wave equations with sources, scattering, and dispersion.

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Select colormaps and qualitative palettes for scientific figures using perceptual-uniformity, color-vision-deficiency safety, and luminance-monotonicity criteria. Covers Crameri scientific colormaps, viridis/cividis/magma, Okabe-Ito categorical, ColorBrewer, and the rainbow/jet critique. Use when choosing palettes for heatmaps, scatter, networks, or any encoding where color carries quantitative or categorical meaning.

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Meta-analysis / evidence synthesis — pool effect sizes across studies (odds ratios, risk ratios, hazard ratios, mean differences, correlations, GWAS betas) with fixed- or random-effects models, quantify heterogeneity (Q, I², τ²), and build a forest plot. Use when you have results from MULTIPLE studies and need a single pooled estimate, or to synthesize evidence from a systematic review / multiple GWAS / replicated experiments. Handles the error-prone effect-size + standard-error preparation (converting OR/HR/CI, two-group means±SD, proportions, and correlations into the (effect, SE) the pooling step needs).

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Discover conserved quantities and symmetries from trajectory data. Identifies energy, momentum, angular momentum, and custom invariants using neural networks and symbolic methods. Inspired by Noether's theorem.

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End-to-end RNA-seq workflow from FASTQ files to differential expression results. Covers QC, quantification (Salmon or STAR+featureCounts), and DESeq2 analysis with visualization. Use when running RNA-seq from FASTQ to DE results.

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End-to-end small RNA-seq analysis from FASTQ to differential miRNA expression and target prediction. Use when analyzing miRNA, isomiR, tRF, or piRNA sequencing data through preprocessing, quantification, discovery, DE, and targets.

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Optimizes LLM inference with NVIDIA TensorRT for maximum throughput and lowest latency. Use for production deployment on NVIDIA GPUs (A100/H100), when you need 10-100x faster inference than PyTorch, or for serving models with quantization (FP8/INT4), in-flight batching, and multi-GPU scaling.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end proteomics workflow from MaxQuant output to differential protein abundance. Orchestrates data import, normalization, imputation, and statistical testing with limma (default) or MSstats for complex feature-level designs. Use when processing mass spectrometry proteomics.

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End-to-end GWAS workflow from VCF to association results. Covers PLINK QC, population structure correction, and association testing for case-control or quantitative traits. Use when running genome-wide association studies.

日本語の概要は準備中です。原文の説明を表示しています。