622 件 ・ 関連度順
概要と使いどころ
Manage Linux systems covering systemd services, process management, filesystems, networking, performance tuning, and troubleshooting. Use when deploying applications, optimizing server performance, diagnosing production issues, or managing users and security on Linux servers.
日本語の概要は準備中です。原文の説明を表示しています。
.river-review.{yaml,json} の context.budget / ranking / reviewMode 設定をモデル仕様とリポジトリ規模に合わせて調整するレビュー観点。
Designs pegRNAs and nicking guides for prime editing (PE) -- choosing the nick/strand, tuning the primer-binding site (PBS) and reverse-transcription template (RTT) as a per-locus panel, selecting the PE system (PE2/PE3/PE3b/PE4/PE5/PEmax/PE7), adding MMR-evading and PAM-disrupting silent edits, appending epegRNA 3' motifs (tevopreQ1/mpknot), and ranking with PRIDICT/DeepPrime. Covers twinPE/PASTE for large insertions and the prime-vs-base-editing decision. Use when designing a scarless point mutation, small insertion/deletion, or any of the 12 base conversions without a double-strand break, when efficiency is low and MMR inhibition or pegRNA stabilization is needed, or when routing a large insertion to an integrase method. Generic guide scoring and base editing are separate skills.
日本語の概要は準備中です。原文の説明を表示しています。
Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.
日本語の概要は準備中です。原文の説明を表示しています。
Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
日本語の概要は準備中です。原文の説明を表示しています。
Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
日本語の概要は準備中です。原文の説明を表示しています。
Optimize end-to-end application performance with profiling, observability, and backend/frontend tuning. Use when coordinating performance optimization across the stack.
日本語の概要は準備中です。原文の説明を表示しています。
Expert patterns for Algolia search implementation, indexing strategies, React InstantSearch, and relevance tuning
日本語の概要は準備中です。原文の説明を表示しています。
Estimate calcium-normalized Gapon selectivity coefficients from paired exchange and solution chemistry, or initialize depth-explicit EcoSIM Gapon inputs from the closest bundled ecosystem template when paired chemistry is unavailable. Use when deriving or checking EcoSIM GKC4, GKCH, GKCA, GKCM, GKCN, or GKCK values; matching a target ecosystem, climate, vegetation, and management regime to a starting profile; remapping template values to target soil layers; or documenting that template-based values require calibration or tuning.
日本語の概要は準備中です。原文の説明を表示しています。
Diagnóstico e tuning de PostgreSQL — EXPLAIN ANALYZE, índice, VACUUM, bloat, lock, replicação, WAL, PITR e particionamento. Use quando o usuário disser "postgres", "query lenta", "índice", "EXPLAIN", "vacuum", "lock", "deadlock", "replicação", "conexões", "banco lento".
日本語の概要は準備中です。原文の説明を表示しています。
Optimize performance of the Adobe Dispatcher Apache HTTP Server module and related HTTPD configuration for AEMaaCS cloud workflows only, with cloud-specific baseline and runtime verification.
日本語の概要は準備中です。原文の説明を表示しています。
Single entry point for all AEM as a Cloud Service Dispatcher skills. Covers config authoring, technical advisory, incident response, performance tuning, security hardening, and full lifecycle orchestration for the Adobe Dispatcher Apache HTTP Server module and its HTTPD/dispatcher configuration.
日本語の概要は準備中です。原文の説明を表示しています。
Optimize end-to-end application performance with profiling, observability, and backend/frontend tuning. Use when coordinating performance optimization across the stack.
日本語の概要は準備中です。原文の説明を表示しています。
Expert patterns for Algolia search implementation, indexing strategies, React InstantSearch, and relevance tuning Use when: adding search to, algolia, instantsearch, search api, search functionality.
日本語の概要は準備中です。原文の説明を表示しています。
Designs pegRNAs and nicking guides for prime editing (PE) -- choosing the nick/strand, tuning the primer-binding site (PBS) and reverse-transcription template (RTT) as a per-locus panel, selecting the PE system (PE2/PE3/PE3b/PE4/PE5/PEmax/PE7), adding MMR-evading and PAM-disrupting silent edits, appending epegRNA 3' motifs (tevopreQ1/mpknot), and ranking with PRIDICT/DeepPrime. Covers twinPE/PASTE for large insertions and the prime-vs-base-editing decision. Use when designing a scarless point mutation, small insertion/deletion, or any of the 12 base conversions without a double-strand break, when efficiency is low and MMR inhibition or pegRNA stabilization is needed, or when routing a large insertion to an integrase method. Generic guide scoring and base editing are separate skills.
日本語の概要は準備中です。原文の説明を表示しています。
Build local BLAST databases and run searches using NCBI BLAST+ command-line tools. Use when running >50 queries, building custom databases with -parse_seqids and -taxid, downloading prebuilt NCBI databases via update_blastdb.pl, choosing -task variants (megablast/dc-megablast/blastn/blastn-short), tuning soft/hard masking, scaling threads, or extracting hits with blastdbcmd. Encodes BLAST v5 vs v4 database format, taxonomy filtering, makeblastdb pitfalls.
日本語の概要は準備中です。原文の説明を表示しています。
Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
日本語の概要は準備中です。原文の説明を表示しています。
Normalize read-depth copy-ratio profiles and segment them into copy-number regions using circular binary segmentation (CBS, DNAcopy), hidden Markov models, HaarSeg, and fused-lasso methods. Covers GC-content, mappability, and replication-timing (wave-artifact) bias correction, panel-of-normals/PCA denoising, diploid-baseline centering, and algorithm selection by sequencing depth and event size. Use when choosing a segmentation algorithm, correcting depth bias, diagnosing oversegmentation or a mis-centered baseline, tuning CBS or HMM parameters, or understanding why a downstream CNV caller produced fragmented or shifted segments.
日本語の概要は準備中です。原文の説明を表示しています。
Optimize end-to-end application performance with profiling, observability, and backend/frontend tuning. Use when coordinating performance optimization across the stack.
日本語の概要は準備中です。原文の説明を表示しています。
Expert patterns for Algolia search implementation, indexing strategies, React InstantSearch, and relevance tuning
日本語の概要は準備中です。原文の説明を表示しています。
Expert guidance for fine-tuning LLMs with Axolotl - YAML configs, 100+ models, LoRA/QLoRA, DPO/KTO/ORPO/GRPO, multimodal support
日本語の概要は準備中です。原文の説明を表示しています。
Expert guidance for fast fine-tuning with Unsloth - 2-5x faster training, 50-80% less memory, LoRA/QLoRA optimization
日本語の概要は準備中です。原文の説明を表示しています。
Expert guidance for GRPO/RL fine-tuning with TRL for reasoning and task-specific model training
日本語の概要は準備中です。原文の説明を表示しています。
OpenAI's model connecting vision and language. Enables zero-shot image classification, image-text matching, and cross-modal retrieval. Trained on 400M image-text pairs. Use for image search, content moderation, or vision-language tasks without fine-tuning. Best for general-purpose image understanding.
日本語の概要は準備中です。原文の説明を表示しています。