「eac」の検索結果

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes alternative splicing at single-cell resolution. The first decision is library chemistry — 10X 3' is fundamentally limited (RT primes from poly-A, R2 falls in 3' UTR, <0.1 junction read per cell per AS event). Plate-based full-length methods (Smart-seq3, FLASH-seq, VASA-seq, STORM-seq) and single-cell long-read (MAS-Iso-seq, scISOr-Seq2) are the chemistries that give per-cell isoform structure. Tools include MARVEL (R, Smart-seq integrated), BRIE2 (Bayesian PSI with regulatory features and ELBO_gain test), scQuint (junction-cluster, plate-based; not for 10X), SpliZ (annotation-free Z-score), Psix (graph-smoothness regulated AS), and Sierra (alternative polyadenylation, often confused with AS). Use when analyzing isoform usage in scRNA-seq, identifying cell-type-specific splicing, or determining whether scRNA-seq chemistry supports splicing analysis at all.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about weigh-station bypass services — Drivewyze, PrePass, BestPass, NORPASS, OOIDA toll savings — how they work, eligibility criteria, costs, and how they tie into CSA scores. Reference each provider's coverage area + pricing.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about CMV roadside inspection levels (Level I through Level VIII), what each level inspects, average inspection times, CVSA decal eligibility, what triggers a level upgrade, and how to coach drivers through a roadside inspection. Reference CVSA North American Standard Inspection Program.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about trucking insurance — types of coverage (commercial auto, cargo, occupational accident, workers comp, bobtail/non-trucking, MCS-90 endorsement), federal minimums (49 CFR 387), what each covers, owner-operator vs company-driver implications, and how to read a Certificate of Insurance (COI). Cite 49 CFR 387.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to understand the 6 levels of FMCSA roadside inspections and what each covers. Helps drivers know what to expect and helps carriers respond to inspection types.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill to differentiate IFTA (fuel tax) and IRP (apportioned registration). Covers what each is for, deadlines, and how they interact.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to pay CDL drivers — cents per mile (CPM), percentage of revenue, hourly, salary, sleeper-team rate, detention pay, driver-pay laws under FLSA (Fair Labor Standards Act), and how each model affects retention + recruitment. Cite FLSA + state wage laws.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about trucking terminology — bobtail vs deadhead vs loaded vs empty trailer — and the insurance, weight, and fuel-tax implications of each. Covers bobtail insurance (also called non-trucking liability), how to track bobtail miles for state taxes, and when "deadhead" affects driver pay.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks about CDL classes (A, B, C), endorsements (H, N, P, S, T, X), required for hazmat / passenger / school bus / tank / triple-trailer operations, what each class is permitted to operate, the TSA Security Threat Assessment for hazmat, and ELDT (Entry-Level Driver Training) requirements. Cite 49 CFR 383.

日本語の概要は準備中です。原文の説明を表示しています。

End-to-end Coval audio-quality testing workflow. Launches one run per audio-robustness scenario against the same voice agent + test set + metrics, polls for completion, and produces the multi-run report URL grouped by Persona. Use when a user wants to follow the Testing Across Audio Qualities cookbook (https://docs.coval.dev/guides/testing-across-audio-qualities) without doing each step by hand.

日本語の概要は準備中です。原文の説明を表示しています。

Search Experience Optimization: reads Google SERPs backwards to detect page-type mismatches, derives user stories from search intent signals, and scores pages from multiple persona perspectives. Identifies why well-optimized pages fail to rank by analyzing what Google rewards for each keyword. Use when user says "SXO", "search experience", "page type mismatch", "SERP analysis", "user story", "persona scoring", "why isn't my page ranking", "intent mismatch", or "wireframe".

日本語の概要は準備中です。原文の説明を表示しています。

Splits one big Claude task or automation into a set of focused AI Matrx agents that work on the person's own AI Matrx tables, then builds and test-runs each one. Use when the person says "split my task into agents", "turn my automation into AI Matrx agents", "make agents for my work", or after their data has moved into AI Matrx.

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the researcher helper; the coach updates its Lessons after each round. Use only when acting as researcher or coaching it. NOT for general research tasks.

日本語の概要は準備中です。原文の説明を表示しています。

Scheduled patrol that finds real persistence and error bugs and fixes them. Use when running the system-error repair patrol automation, or when stuck rows, SLA breaches, the system_errors queue, or app_log ERROR rows need a repair rather than a report.

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the reviewer helper; the coach updates its Lessons after each round. Use only when acting as reviewer or coaching it. NOT for writing a verifier brief (use subagent-dispatch).

日本語の概要は準備中です。原文の説明を表示しています。

The matrx-frontend side of the matrx-extend Chrome extension bridge. Use when adding or changing a FRONTEND_RPC action handler, a window-panels deep-link the extension opens, a headless API route it calls, or debugging a silent chrome.runtime.sendMessage or Broadcast round-trip. NOT for code in matrx-extend, matrx-local, or aidream (each has its own connect-* skill).

日本語の概要は準備中です。原文の説明を表示しています。

Platform agent skill and content blocks that teach agents a render block, building the block first if new. Use when asked to create the skill for a render block, skill-ify flashcards or quiz, add content blocks for a block, or add a new render block type. NOT for tool result displays (use create-tool-renderer).

日本語の概要は準備中です。原文の説明を表示しています。

next/dynamic code splitting and build-graph cost; first stop for build failures. Use before lazy-loading or deferring a heavy component, adding a dynamic import, React.lazy, or ssr: false; on 'window is not defined' or a hydration mismatch; shrinking the bundle; or on 'build failed', OOM, SIGKILL, a slower build, or 'Collecting page data'.

日本語の概要は準備中です。原文の説明を表示しています。

Working playbook preloaded into the browser-tester helper; the coach updates its Lessons after each round. Use only when acting as browser-tester or coaching it. NOT for general UI work (use matrx-frontend's browser-testing doc).

日本語の概要は準備中です。原文の説明を表示しています。

Find and identify the CCSPlayer_WeaponServices_EquipWeapon function and the CCSPlayer_WeaponServices_CanUse virtual function in CS2 binary using IDA Pro MCP. Use this skill when reverse engineering CS2 server.dll or libserver.so to locate the weapon-equip helper and the "is this weapon usable right now" vfunc by RTTI-walking the CCSPlayer_WeaponServices vtable and confirming each candidate's decompiled body against the known CCSPlayer_WeaponServices_PickupItem anchor's callee shapes. Trigger: CCSPlayer_WeaponServices_EquipWeapon, CCSPlayer_WeaponServices_CanUse

日本語の概要は準備中です。原文の説明を表示しています。

資金調達のためのコールドメール、ウォームイントロのブラーブ、フォローアップ、アップデートメール、投資家コミュニケーションのドラフト。エンジェル、VC、ストラテジック投資家、アクセラレーターへのアウトリーチで、簡潔でパーソナライズされた投資家向けメッセージが必要な場合に使用。

Designs and improves onboarding flows, empty states, and first-run experiences to help users reach value quickly. Use when the user mentions onboarding, first-time users, empty states, activation, getting started, or new user flows.

日本語の概要は準備中です。原文の説明を表示しています。

Teaches the AI to design like a high-end agency. Defines the exact fonts, spacing, shadows, card structures, and animations that make a website feel expensive. Blocks all the common defaults that make AI designs look cheap or generic.

日本語の概要は準備中です。原文の説明を表示しています。