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概要と使いどころ
Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.
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End-to-end binder design using BindCraft hallucination. Use this skill when: (1) Designing protein binders with built-in AF2 validation, (2) Running production-quality binder campaigns, (3) Using different design protocols (fast, default, slow), (4) Need joint backbone and sequence optimization, (5) Want high experimental success rate. For backbone-only generation, use rfdiffusion. For QC thresholds, use protein-qc. For tool selection guidance, use binder-design.
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Expert guide for Backend.AI distributed computing platform. Automatically activates when users ask about: - Backend.AI architecture, components (Manager, Agent, Storage Proxy, Webserver, App Proxy) - Features (session scheduling, Sokovan orchestrator, multi-tenancy, resource allocation) - APIs (REST, GraphQL), authentication, RBAC authorization - Container runtime (kernels, jail sandbox, hook library, virtual folders) - Accelerator support (CUDA, ROCm, TPU, NPU, Graphcore IPU) - Client SDKs (Python, Java, JavaScript, PHP) - Setup, requirements (Python 3.13+, Docker, PostgreSQL, Redis, etcd) - How WebUI connects to/interacts with Backend.AI backend - Plugin interfaces, development setup, infrastructure Use when user mentions "Backend.AI", "backend.ai", "Sokovan", component names, or asks about the backend platform this WebUI connects to. allowed-tools: WebFetch, Read
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Align protein structures using Foldseek 3Di, TM-align, US-align, DALI, or Foldmason for structural MSA. Predict, score, and superpose backbone coordinates when sequence identity is below the twilight zone or remote-homology detection is required. Use when sequence MSA fails (<25% identity), when the dark proteome is the target, when AlphaFoldDB / ESM Atlas search is needed, or when structural superposition is the goal.
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Map nucleosome center positions, occupancy, and fuzziness from ATAC-seq fragment-size patterns using NucleoATAC, ATACseqQC, DANPOS3, or scprinter. Use when characterizing nucleosome organization at promoters and enhancers, calling +1/-1 nucleosomes flanking NFRs, generating V-plots for chromatin structure visualization, or comparing nucleosome positioning between conditions.
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This skill should be used when the user asks to "create an agent", "add an agent", "write a subagent", "agent frontmatter", "when to use description", "agent examples", "agent tools", "agent colors", "autonomous agent", or needs guidance on agent structure, system prompts, triggering conditions, or agent development best practices for Claude Code plugins.
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Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.
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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
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Process and generate multimedia content using Google Gemini API. Capabilities include analyze audio files (transcription with timestamps, summarization, speech understanding, music/sound analysis up to 9.5 hours), understand images (captioning, object detection, OCR, visual Q&A, segmentation), process videos (scene detection, Q&A, temporal analysis, YouTube URLs, up to 6 hours), extract from documents (PDF tables, forms, charts, diagrams, multi-page), generate images (text-to-image, editing, composition, refinement). Use when working with audio/video files, analyzing images or screenshots, processing PDF documents, extracting structured data from media, creating images from text prompts, or implementing multimodal AI features. Supports multiple models (Gemini 2.5/2.0) with context windows up to 2M tokens.
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Write articles, guides, blog posts, tutorials, newsletter issues, and other long-form content in a distinctive voice derived from supplied examples or brand guidance. Use when the user wants polished written content longer than a paragraph, especially when voice consistency, structure, and credibility matter.
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Automated cell behavior analysis from microscopy or XR lab recordings. Classifies cell motion phenotypes (migration, proliferation, apoptosis, division, quiescence), computes population-level quantitative metrics (growth rate, migration velocity, directionality index), and emits structured JSON for downstream reporting, plotting, or ELN integration.
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Systematically interpret a Medtronic CareLink or MiniMed 780G Daily Review download in a structured 6-step clinical workflow — covering Time in Range, insulin delivery, day/night patterns, hypo and hyperglycemia root causes, and a prioritised action plan. Trigger when a clinician uploads or shares a CareLink report, MiniMed download, 780G Daily Review, pump download, or asks to review a patient's CGM or insulin pump data.
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This skill provides structured education to patients and families about Cushing's syndrome pathophysiology, treatment options, and post-remission expectations. It is triggered when a clinician encounters a new Cushing's syndrome patient or family needing disease information, such as at initial diagnosis or before treatment initiation.
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Diagnose monogenic and syndromic obesity in children and adolescents using a structured step-by-step algorithm. Use this skill whenever a clinician suspects a genetic cause of obesity, asks about leptin deficiency, MC4R mutation, POMC deficiency, PCSK1 deficiency, leptin receptor deficiency, Bardet-Biedl syndrome, Prader-Willi syndrome, Alström syndrome, or any case of early-onset severe obesity with hyperphagia. Also trigger for questions about targeted pharmacotherapy including setmelanotide or metreleptin, or when to order a genomic obesity panel. Cross-references the NHS Genomic Test Finder skill to surface the relevant R-code once a diagnosis is reached.
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Reconcile baseline-versioned files that the `create-baseline upgrade` CLI staged for LLM-assisted semantic merge. Use when the CLI prints "Open Claude Code and run /upgrade-project to reconcile". Reads the stage manifest at `.claude/state/upgrade/<ts>/manifest.json`, reasons through each pending file's three-way delta in main context, writes a reconciled LOCAL, then deletes the stage when every file lands. Supports `--dry-run` (preview the reconciled diff without writing) and a structured "needs-user-input" fallback when the conflict cannot be disambiguated automatically.
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Oracle-bound spec-review check that every structured Rollout prerequisite binds to an enforcement-type acceptance criterion. A prerequisite whose `enforced-by` is missing, dangling, or points at a non-enforcement AC is a BLOCKER (hard-blocks implementation entry via the checker fan-out verdict); a prerequisite left in free prose is ADVISORY. Read-only. Runs in the spec-review fan-out before implementation.
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Write executable failing tests from a recipe handed to you by the main context. Used by `/tdd` Step 2 and ad-hoc when a phase needs tests-first to drive implementation. Decisions about which scenarios to cover, which categories matter, and which fixtures to use are made by the caller — this skill executes that recipe with code-structure discipline.
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Workflow Phase 7 — Mechanical cleanup pass over the branch diff, followed by a `code-structure` review pass and a `verify` re-stamp. Shadows the global `simplify` skill at project scope; the cleanup pass is performed inline rather than via Skill self-call.
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MANDATORY skill for ALL code generation. Enforces top-down composition, consistent abstraction layers, and proper module hierarchy. Apply every time you write or modify code — in any language — no exceptions.
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Write the production code that makes a pre-decided set of failing tests pass, within an explicit write_set, following an explicit behavior contract. Used by `/tdd` Step 3 and by `/swarm-dispatch` workers. The caller has already decided architecture, naming, file layout, and abstraction boundaries — this skill executes that recipe with code-structure discipline and a 5-iteration RALPH loop. No scope expansion, no design decisions, no test edits.
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Draft a Business Requirements Document (BRD) for cross-functional or stakeholder-heavy work that needs more structure than an intake. Use after `/intake` when the request spans multiple systems/teams, carries regulatory weight, or needs formal sign-off. Output lives at `docs/brd/<slug>.md`.
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Orchestrates `impeccable` for every design task inside a workflow phase. Captures intent in natural language, classifies it (design / development / copy), translates design intents into a sequence of impeccable subcommand invocations, runs them in main context with state persistence at `.claude/state/design/<slug>.json`, and returns a structured report. ALWAYS invokes `impeccable` under the hood for the underlying design move; never picks aesthetic direction itself; never writes product code directly. Per CLAUDE.md Article X.2, all design tasks in workflow phases route through this skill.
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Use when a request needs external sources, current facts, listings, a supplied URL, papers, or library and API documentation. When using Firecrawl for the request, use firecrawl_search to find sources and firecrawl_scrape to read a supplied or discovered URL. Firecrawl also retrieves documents, collects structured data, and tracks website changes. Respect explicit source and tool preferences.
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An infographic skill for AI agents — works inside Claude Code, Codex, Hermes, OpenClaw, Cursor, and any agent host that loads skills. Create professional infographics as self-contained HTML files with PNG exports. Use when the user asks to create, design, generate, build, or make an infographic, data visualization, visual explainer, chart poster, cheatsheet, or pocket guide. Trigger phrases include "make this visual", "turn this into a graphic", "visualize this data", "infographic for X", "cheatsheet for X", or when the user provides structured data (tokenomics allocations, ecosystem/partner lists, timelines, comparisons, step-by-step processes) AND asks for a visual output. Covers tokenomics, ecosystem overviews, game overviews, cheatsheets, airdrop guides, comparisons, and process flows. Do NOT trigger for plain text answers, markdown tables, bulleted summaries, questions asking for advice or explanations about a topic (even when the topic is tokenomics, ecosystem, vesting, etc.), inline chat diagrams, or data processing with no visual output requested. The signal is "asks for a visual", not "mentions a keyword".
日本語の概要は準備中です。原文の説明を表示しています。