「dr」の検索結果

Estimate how likely a protein therapeutic is to provoke an anti-drug antibody response, and locate the sequence regions responsible. Use this skill to tile a sequence into peptides, predict class II MHC presentation across a population-representative allele panel, aggregate predicted binders into a per-region and whole-molecule risk score, compare a candidate against its closest human germline, and decide which liabilities are worth deimmunising. Also trigger on immunogenicity, anti-drug antibody, ADA, T-cell epitope, MHC class II, HLA-DRB1, NetMHCIIpan, NetMHCpan, deimmunisation, tregitope, or population coverage.

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Decide whether a protein has a pocket worth targeting, and where it is, before committing to a docking or design campaign. Use this skill to run fpocket cavity detection, rank cavities by druggability and volume, compare apo and holo conformations to spot induced fit, identify allosteric and cryptic cavities that only open in simulation, and convert a chosen cavity into the search box coordinates a docking run needs. Also trigger on fpocket, cavity detection, druggability score, alpha sphere, cryptic pocket, allosteric site, pocket volume, hotspot mapping, or undruggable target assessment.

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Build and deploy full-stack web and mobile apps with AWS Amplify Gen2 (TypeScript code-first). Covers auth (Cognito), data (AppSync/DynamoDB including schema modeling, enum types, relationships, authorization rules), storage (S3), functions, APIs, and AI (Amplify AI Kit with Bedrock). Supports React, Next.js, Vue, Angular, React Native, Flutter, Swift, and Android. Always use this skill for Amplify Gen2 topics — even for questions you think you know — it contains validated, version-specific patterns that prevent common mistakes. TRIGGER when: user mentions Amplify Gen2; project has amplify/ directory or amplify_outputs; code imports @aws-amplify packages; user asks about defineBackend, defineAuth, defineData, defineStorage, or npx ampx. SKIP: Amplify Gen1 (amplify CLI v6), standalone SAM/CDK without Amplify (use aws-serverless), direct Bedrock without Amplify AI Kit (use bedrock).

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Apply the Minimum Sufficient Language (MSL) principle through the MSL Kernel to write anything a reader must act on. Bind the reader and what they already know, partition facts from the machinery that produced them, emit each admitted fact as an action, a verification, a judgment, or a state, and stop when every claim is checkable and the reader can act. Use for status updates, work-in-progress reports to your own user, closeout and convergence comments, tickets, pull request and review write-ups, incident and postmortem notes, emails, memos, and any draft for readers outside the work. Also use when the user says MSL, Minimum Sufficient Language, write this for stakeholders, drop the jargon, make this readable, or asks for a paste-ready draft.

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Use whenever the user mentions Betaflight, FPV drone firmware, flight-controller config, PID/filter/rates tuning, or blackbox log analysis — or shares a Betaflight artifact: a CLI diff/dump (lines like 'diff all', 'set ', 'feature ', 'resource ') or a .bbl/.bfl blackbox log, even when not named as such — or runs a chirp tuning session via Sweep Studio / FPVLogForge (a chirp log ID to analyse, 'analyse log', 'résultat chirp', iterative Bode/step/Ms tuning). Covers flight symptoms (oscillations, wobble, propwash, jello, hot motors, drift), motor/ESC and RX/ELRS/CRSF setup, builds from 3" to 10" (cinewhoop, tinywhoop, longrange, X-class), version migrations (4.4 → 4.5 → 4.6), and configuring a new drone from scratch (setup wizard). Trigger even when phrased casually ("mon drone wobble", "PID help", "config FC") — under-triggering is worse than over-triggering.

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手書きの図(紙・ホワイトボードの写真、スキャン、タブレットのメモ)や、別形式の図版(PNG/JPGのスクショ、PDF/SVG/EPS、PowerPoint・Keynote・draw.io・Excalidrawの図、Mermaid/Graphviz、matplotlib・Excelのグラフ、論文の図)をTikZに起こし、自分のLaTeX文書へそのまま\inputで挿入できる形(.tikz + 必要パッケージ + figure環境)で納品する。座標グリッドで読み取り、元画像との重ね合わせで検証し、文書のプリアンブルへ不足分だけ追記する。「この図をTikZにして」「手書きをtikzで清書」「図をLaTeXで描き直して」「この画像をtikzに起こして論文に入れたい」「pgfplotsで再現」などで使う。

Export the current chat session as a structured Markdown work timeline or blog-draft seed. Use when the user asks for a session log, work log, timeline, 作業ログ, ブログネタ, blog draft, article seed, Zenn, Qiita, or はてな. Do not use for verbatim dialogue export or distilled reusable knowledge only.

Create polished, validated architecture, workflow, sequence, data-flow, and lifecycle/state diagrams as explorable standalone HTML with inline SVG, dark/light themes, optional trace motion, and PNG/JPEG/WebP/SVG/WebM export. Accept plain-language requirements or pasted Mermaid flowchart, sequenceDiagram, and stateDiagram input; inspect repository evidence when the diagram must reflect real code. Use when the user asks to visualize system architecture, infrastructure, cloud/security/network topology, technical workflows, API call sequences, request lifecycles, data pipelines, ETL/ELT, data lineage, state machines, or to convert/beautify Mermaid. Also use for Archify, interactive or animated HTML diagrams, インタラクティブ図, 動く構成図. When an editable .drawio file is required, use the draw.io workflow instead and treat Archify HTML only as a supplement.

Drag and drop with @dnd-kit - draggable, droppable, sortable, collision detection, sensors, accessibility

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Analyzes loader and dropper samples by identifying staging behavior — embedded or downloaded next-stage payloads, decode/decrypt routines, and the execution mechanism used to run the next stage. Activates for requests to analyze a loader or dropper, find a staged payload, or map multi-stage delivery behavior.

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Reverses Android malware: unpacking APKs, decompiling DEX bytecode to readable Java, auditing the manifest for abused permissions and components, and locating dynamically loaded or native payloads. Activates for requests to analyze an APK, decompile DEX, or investigate a suspicious Android app.

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Use when a task needs the judgment of a rotary drill operator (driller) — diagnosing a drilling break or kick warning sign, running well-control shut-in and kill-mud-weight calculations, setting trip margin and swab/surge limits before pulling out of hole, optimizing weight-on-bit and RPM against mechanical specific energy, or reviewing a rig-floor near-miss.

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Use when a task needs the judgment of a Drilling and Boring Machine Tool Setter, Operator, or Tender — deciding whether a hole's depth-to-diameter ratio requires peck drilling, establishing a straight hole start before wander compounds, reducing cutting parameters for a long-reach boring setup versus a short-reach one, or diagnosing whether a dimensional drift traces to tool wear rather than assuming the tool still looks sharp.

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Detect documentation drift, stale references, and cross-document inconsistencies in any project. Scans for code-doc drift (API/function changes not reflected in docs), cross-doc drift (conflicting information across documents), and stale references (broken links, deleted files, outdated versions). Use when checking "doc freshness", "stale docs", "documentation drift", "broken links", "outdated documentation", "doc accuracy", "docs out of date", "doc audit", "doc health", or "verify documentation".

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This skill should be used when the user asks to "create a diagram", "draw a flowchart", "make a swimlane diagram", "create WBS", "generate RACI matrix", "build network diagram", "create org chart", or mentions draw.io, diagrams.net, BPMN, UML, Gantt, PERT, or project management diagrams. Integrates with next-ai-draw-io MCP server for real-time diagram creation and editing.

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Create and edit draw.io/diagrams.net diagrams as editable `.drawio` files. Covers architecture, UML/ERD/sequence, BPMN, network, and swimlane views authored from a description or converted from code, IaC, SQL, and API schemas, plus sync, query, test, review, export, and publish of existing diagrams. Use when the user asks for draw.io/diagrams.net or an editable diagram; prefer Mermaid/PlantUML when diagrams-as-code is enough.

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Outbound SDR (Sales Development Representative) operating system that runs the full top-of-funnel motion across HubSpot (CRM, engagement, and source of truth) and Exa (web research + signals). Use this skill WHENEVER the user is doing outbound sales development, building target/prospect lists, defining or refining an ICP, enriching leads, researching accounts or people before outreach, writing cold emails or multi-touch sequences, qualifying or scoring leads, logging activity to CRM, handing meetings off to AEs, or reporting on pipeline. Trigger it even when the user only says things like "find me 50 leads", "research this account", "write a cold email to this person", "score these leads", "log this in HubSpot", or "build a sequence"; these are all SDR tasks this skill governs. Do not wait for the user to say "SDR" or "prospecting" explicitly.

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非争议解决公共标准·为NDR域非诉技能提供合同交易起草审查与合规公共标准·触发：被NDR域skill起草前引用；边界：不适用于DR争议文书与法官裁判文书

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Drafts filing-ready U.S. amicus curiae briefs with rule-anchored compliance, additive thesis selection, record-safe fact handling, and verified authority control. Trigger when asked to draft an amicus or friend-of-the-court brief, prepare FRAP 29/32 or Supreme Court Rule 37 amicus filings, draft consent/leave or disclosure language, or handle amicus procedural requirements at any stage.

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Drafts the "Interest of Amicus Curiae" section of an amicus brief. Establishes institutional credibility, tethers the amicus's interest to the specific legal question, articulates non-party impacts, and embeds disclosure guardrails under FRAP 29 and Supreme Court Rule 37. Trigger when drafting amicus briefs, friend-of-the-court filings, interest statements, amicus disclosures, or when the user asks why an organization belongs in a case.

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Use when working with *.excalidraw or *.excalidraw.json files, user mentions diagrams/flowcharts, or requests architecture visualization - delegates all Excalidraw operations to subagents to prevent context exhaustion from verbose JSON (single files: 4k-22k tokens, can exceed read limits)

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DRY (Don't Repeat Yourself) review rules for code reviews: find the same knowledge — a rule, a constant, a parser, a validation, a protocol detail — implemented in several places that must change together, and tell it apart from code that merely looks alike. Use when reviewing a diff, a pull request or recent changes for duplication, on "DRY review", "is this duplicated", "copy-paste check", or when a review checklist asks for DRY. Pair it with the solid skill for design and with owasp-asvs for security.

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Patterns for vibe coding that produce production-quality output instead of garbage. Covers prompt engineering for AI coding, verification without reading every line, accept/reject/refine decision framework, architectural guardrails, context management (CLAUDE.md, .cursor/rules), TDD-driven vibe coding, screenshot-driven development, diff review discipline, and the anti-patterns that destroy quality. Activate on: "vibe coding", "AI coding quality", "Claude Code workflow", "AI-assisted development", "how to use AI for coding", "coding with AI", "agentic engineering workflow", "AI code quality", "vibe code without garbage", "production quality AI code", "CLAUDE.md setup", "cursorrules setup", "pre-commit hooks for AI", "TDD with AI", "test-driven vibe coding". NOT for: multi-person collaborative coding sessions (use cooperative-vibe-coding), building AI/LLM applications (use ai-engineer), prompt engineering for non-coding LLM use cases (use prompt-engineer).

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Advanced CV for infrastructure inspection including forest fire detection, wildfire precondition assessment, roof inspection, hail damage analysis, thermal imaging, and 3D Gaussian Splatting reconstruction. Expert in multi-modal detection, insurance risk modeling, and reinsurance data pipelines. Activate on "fire detection", "wildfire risk", "roof inspection", "hail damage", "thermal analysis", "Gaussian Splatting", "3DGS", "insurance inspection", "defensible space", "property assessment", "catastrophe modeling", "NDVI", "fuel load". NOT for general drone flight control, SLAM, path planning, or sensor fusion (use drone-cv-expert), GPU shader development (use metal-shader-expert), or generic object detection without inspection context (use clip-aware-embeddings).

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