「methodology」の検索結果

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

日本語の概要は準備中です。原文の説明を表示しています。

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

日本語の概要は準備中です。原文の説明を表示しています。

Reflection-first problem solving methodology for Convex development. Use before implementing any solution to ensure proper root cause analysis, 98% code confidence, and minimal change scope.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user requests to review, analyze, critique, or summarize academic papers, research articles, preprints, or scientific publications. Supports comprehensive structured reviews covering methodology assessment, contribution evaluation, literature positioning, and constructive feedback generation. Trigger on queries involving paper URLs, uploaded PDFs, arXiv links, or requests like "review this paper", "analyze this research", "summarize this study", or "write a peer review".

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill instead of WebSearch for ANY question requiring web research. Trigger on queries like "what is X", "explain X", "compare X and Y", "research X", or before content generation tasks. Provides systematic multi-angle research methodology instead of single superficial searches. Use this proactively when the user's question needs online information.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

日本語の概要は準備中です。原文の説明を表示しています。

Designs Bayesian clinical trials including Phase I dose-finding (BOIN, CRM, EWOC, mTPI-2), meta-analytic-predictive (MAP) priors with robust mixtures for external data borrowing, EXNEX for basket trials, hierarchical models for safety AE (Berry-Berry), Bayesian platform trials (I-SPY 2, GBM AGILE, REMAP-CAP), and posterior probability stopping rules. Covers FDA Bayesian Devices Guidance (2010), FDA Bayesian Methodology in Drugs Draft (January 2026), BOIN Fit-for-Purpose qualification (December 2021), and Project Optimus dose-optimisation. Use when designing dose-finding studies, platform trials, or sensitivity analyses with informative priors.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks how to design or improve a fleet safety scorecard — what KPIs to track, how to weight them, telematics signals vs document compliance vs roadside outcomes, monthly cadence, driver-facing vs admin-facing dashboards, gamification considerations, peer-comparison metrics, and how a scorecard ties to insurance premiums + retention. Reference SMS Methodology v3.20 for industry-standard weights.

日本語の概要は準備中です。原文の説明を表示しています。

Reflection-first problem solving methodology for Convex development. Use before implementing any solution to ensure proper root cause analysis, 98% code confidence, and minimal change scope.

日本語の概要は準備中です。原文の説明を表示しています。

Transparent, rigorous research with full methodology — not a black-box API wrapper. Conducts exhaustive investigation through mandated 2-cycle research per theme, APA 7th citations, evidence hierarchy, and 3 user checkpoints. Self-contained using native OpenClaw tools (web_search, web_fetch, sessions_spawn). Use for literature reviews, competitive intelligence, or any research requiring academic rigor and reproducibility.

日本語の概要は準備中です。原文の説明を表示しています。

[31] ANALYZE. Universal deep thinking methodology for any situation requiring quality reasoning. Use when solving problems, debugging, making decisions, analyzing code, planning, reviewing, or anytime you need thorough thinking instead of surface-level responses. Triggers on "think deeply", "analyze thoroughly", "reason carefully", "deep thinking", "understand completely", or any task requiring careful thought.

日本語の概要は準備中です。原文の説明を表示しています。

Analyze and fix production errors from Sentry crash reports. Use when investigating AppHang, ANR, crashes, or production errors. Includes complete workflow from JSON analysis to bug fix implementation with evidence-based methodology. Triggers on sentry, crash, AppHang, ANR, error analysis, production error, bug analysis, crash report, freeze, hang, not responding, stacktrace, breadcrumbs, exception.

日本語の概要は準備中です。原文の説明を表示しています。

Perform 12-Factor App compliance analysis on any codebase. Use when evaluating application architecture, auditing SaaS applications, or reviewing cloud-native applications against the original 12-Factor methodology.

日本語の概要は準備中です。原文の説明を表示しています。

Codified expertise for quality control, non-conformance investigation, root cause analysis, corrective action, and supplier quality management in regulated manufacturing. Informed by quality engineers with 15+ years experience across FDA, IATF 16949, and AS9100 environments. Includes NCR lifecycle management, CAPA systems, SPC interpretation, and audit methodology. Use when investigating non-conformances, performing root cause analysis, managing CAPAs, interpreting SPC data, or handling supplier quality issues.

日本語の概要は準備中です。原文の説明を表示しています。

Python testing strategies using pytest, TDD methodology, fixtures, mocking, parametrization, and coverage requirements.

日本語の概要は準備中です。原文の説明を表示しています。

Perl testing patterns using Test2::V0, Test::More, prove runner, mocking, coverage with Devel::Cover, and TDD methodology.

日本語の概要は準備中です。原文の説明を表示しています。

Kotlin testing patterns with Kotest, MockK, coroutine testing, property-based testing, and Kover coverage. Follows TDD methodology with idiomatic Kotlin practices.

日本語の概要は準備中です。原文の説明を表示しています。

Django testing strategies with pytest-django, TDD methodology, factory_boy, mocking, coverage, and testing Django REST Framework APIs.

日本語の概要は準備中です。原文の説明を表示しています。

Go testing patterns including table-driven tests, subtests, benchmarks, fuzzing, and test coverage. Follows TDD methodology with idiomatic Go practices.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user requests to review, analyze, critique, or summarize academic papers, research articles, preprints, or scientific publications. Supports comprehensive structured reviews covering methodology assessment, contribution evaluation, literature positioning, and constructive feedback generation. Trigger on queries involving paper URLs, uploaded PDFs, arXiv links, or requests like "review this paper", "analyze this research", "summarize this study", or "write a peer review".

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill instead of WebSearch for ANY question requiring web research. Trigger on queries like "what is X", "explain X", "compare X and Y", "research X", or before content generation tasks. Provides systematic multi-angle research methodology instead of single superficial searches. Use this proactively when the user's question needs online information.

日本語の概要は準備中です。原文の説明を表示しています。

Systematic performance profiling and optimization methodology. Covers CPU profiling, memory profiling, heap analysis, goroutine/thread analysis, FlameGraph generation, latency profiling, database query profiling, network I/O profiling, and continuous performance regression detection. USE WHEN: investigating performance issues, optimizing slow code, reducing memory usage, diagnosing GC/CPU bottlenecks, finding N+1 queries, analyzing pprof/flamegraph output, or establishing a performance baseline. Triggers on "profiling", "performance analysis", "slow code", "flame graph", "pprof", "heap dump", "memory leak", "CPU spike", "bottleneck".

日本語の概要は準備中です。原文の説明を表示しています。

Systematic debugging methodology covering root cause analysis, log-based debugging, production debugging, memory leak diagnosis, deadlock detection, performance anomaly investigation, and reproducible bug reproduction. Distilled from real experience at Google, DeepMind, ByteDance, and Huawei. USE WHEN: investigating production incidents, debugging hard-to-reproduce bugs, analyzing crash dumps, finding race conditions, diagnosing memory leaks, debugging performance regressions, or any situation requiring systematic root cause analysis. Triggers on "debugging", "root cause", "bug", "crash", "segfault", "deadlock", "race condition", "memory leak".

日本語の概要は準備中です。原文の説明を表示しています。

Conduct exhaustive multi-source investigation with methodology tracking, source evaluation, and iterative depth.

日本語の概要は準備中です。原文の説明を表示しています。