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概要と使いどころ
Query RegulomeDB v2 GET REST API to score variants for regulatory function and retrieve overlapping evidence (TF binding, histone marks, DNase peaks, footprints, motifs, eQTLs, chromatin state). Scores range 1a (strongest) to 7 (none). Use for GWAS hit prioritization, regulatory variant annotation, cis-regulatory discovery. Use clinvar-database for pathogenicity; gwas-database for trait associations.
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ENCODE Portal REST API for regulatory genomics: TF ChIP-seq, ATAC-seq/DNase-seq peaks, histone marks, and RNA-seq across 1000+ cell types. Search experiments by assay/biosample/target; download BED/bigWig; retrieve SCREEN cCREs by region or gene. Use to annotate variants with regulatory tracks, find open chromatin in a cell type, or fetch peak files for ChIP/ATAC analysis. For regulatory variant scoring use regulomedb-database; for GWAS associations use gwas-database.
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Monarch Initiative knowledge graph REST API for disease-gene-phenotype associations and cross-species orthology. MONDO disease-to-gene/phenotype, HP phenotype profiles, cross-species comparisons. Use for rare disease gene prioritization and phenotype-based candidate ranking. For GWAS use gwas-database; for clinical pathogenicity use clinvar-database.
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Query NCBI ClinVar via E-utilities for variant clinical significance, pathogenicity, disease associations. Search by gene/rsID/condition/review status; returns ClinSig, submitter data, conditions, HGVS. For GWAS use gwas-database; for variant consequence prediction use Ensembl VEP.
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Query the ClinPGx (formerly PharmGKB) REST API plus the CPIC PostgREST companion API for pharmacogenomic clinical annotations, CPIC/DPWG dosing guidelines, gene-drug pairs, variant-drug associations, FDA/EMA drug labels, and PGx pathways. Two-host architecture: api.clinpgx.org for annotation records, api.cpicpgx.org for genotype→recommendation lookups. No auth. For germline pathogenicity use clinvar-database; for somatic cancer PGx use cosmic-database or opentargets-database; for drug bioactivity use chembl-database-bioactivity.
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Query Open Targets GraphQL API for target-disease associations, evidence, drug links, safety. Search targets by gene, diseases by EFO ID; scores from 20+ sources, drug mechanisms, tractability. For ChEMBL use chembl-database-bioactivity; for trials use clinicaltrials-database-search.
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Fast short-read DNA aligner for WGS/WES/ChIP-seq. 2× faster BWA-MEM successor; outputs SAM/BAM with read group headers for GATK. Primary plus supplementary records for chimeric reads. Use STAR for RNA-seq splice-aware alignment; Bowtie2 is a comparable alternative.
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Geospatial vector analysis extending pandas. Read/write spatial formats (Shapefile, GeoJSON, GeoPackage, Parquet, PostGIS), CRS handling, geometric ops (buffer, simplify, centroid, affine), spatial analysis (joins, overlays, dissolve, clipping, distance), visualization (choropleth, interactive maps, basemaps). Use for spatial joins, overlays, CRS transforms, area/distance, maps.
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scikit-learn compatible Python toolkit for time series ML: classify, cluster, regress, segment, transform with 30+ algorithms (ROCKET, InceptionTime, KNN-DTW, HIVE-COTE, WEASEL). Handles panel, multivariate, and unequal-length series. Maintained successor to sktime. Alternatives: sktime (larger ecosystem), tslearn (fewer algorithms), catch22 (features only).
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Python Materials Genomics library for structure analysis, thermodynamics, and electronic properties. Parse/create crystal structures (CIF, POSCAR), query Materials Project for DFT-computed properties, analyze phase and Pourbaix diagrams, compute XRD patterns, generate DFT inputs for VASP, Quantum ESPRESSO, CP2K. Alternatives: ASE (MD/geometry), AFLOW (high-throughput), OVITO (visualization).
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Python statistical modeling: regression (OLS, WLS, GLM), discrete (Logit, Poisson, NegBin), time series (ARIMA, SARIMAX, VAR), with rigorous inference, diagnostics, and hypothesis tests. Use scikit-learn for ML; statistical-analysis for test choice.
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Poisson-model peak caller for ChIP-seq/ATAC-seq BAMs. MACS3 callpeak finds enriched regions (TF sites or histone marks) vs input/IgG; outputs BED narrowPeak/broadPeak for motif analysis, annotation, and differential binding. Use narrow peaks for TF ChIP-seq and ATAC-seq; broad for H3K27me3, H3K9me3, and other broad marks.
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Download, resize, and remove backgrounds from product images at scale. Use when the user asks to "process product images", batch-download images from the schedule, strip backgrounds, or standardize product photos.
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Provides Better Auth integration patterns for NestJS backend and Next.js frontend with Drizzle ORM and PostgreSQL. Use when setting up Better Auth with NestJS backend, integrating Next.js App Router frontend, configuring Drizzle ORM schema, implementing social login (GitHub, Google), adding plugins (2FA, Organization, SSO, Magic Link, Passkey), implementing email/password authentication with session management, or creating protected routes and middleware.
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Posts review findings from a JSON file as inline comments on a GitHub Pull Request, attaching each comment to its file and line. Use when you have a list/JSON of review findings (each with a file path, line number, and a message such as summary/failure_scenario) and want them published on a PR as inline review comments. Triggers include "post these review comments on the PR", "associate comments to files in the PR", "publish review findings to PR
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Process construction payment applications. Validate schedule of values, calculate retainage, track billing status, and generate G702/G703 forms.
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Process and manage construction change orders. Track costs, approvals, and impact on schedule and budget.
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大きなPDFファイルを圧縮するスキル。ファイルサイズを最大98%削減。 「PDFを圧縮して」「PDFを軽くして」「ファイルサイズを小さくして」等のリクエストで発動。
ai-agent-campのレッスンをCodexで開始・進行するスキル。 「レッスン開始」「次のレッスン」「start-0-1を始めたい」「Codexでレッスン」「スラッシュコマンドのレッスン」等のリクエストで発動。
PDF/PPTX/Excelファイルの読み取り・編集・分析を行うサブエージェント。 大きなドキュメントの処理をメインコンテキストから分離し、コンテキスト消費を最適化する。 「PDFを分析」「PPTXの内容を読んで」「Excelを解析」「スライドを編集」等のリクエストで発動。
Drive the agentkit CLI (aliases agentkit / ak) to scaffold, build, deploy, and manage agents on Volcengine AgentKit from the terminal — runtimes, knowledge bases, memory collections, tools, harnesses, invocation, SSO auth, sandboxes, and evaluation datasets. Use when a user wants to create/deploy an agent project, call or inspect a deployed runtime, manage AgentKit resources, or resolve a CLI/auth/deploy error. Does NOT handle non-AgentKit deployment, general Docker/k8s operations, Volcengine IAM management, or writing agent application code (use veadk-agent-development for that).
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Cleans up CRM data from HubSpot, Salesforce, Pipedrive, Zoho, Close, Attio, or any CRM CSV export. Finds duplicate contacts and companies with fuzzy matching (not just exact email), normalizes emails, phones to E.164, names, domains, states, and countries, flags stale, invalid, role, and test records, finds broken contact-company associations, and produces a reviewable merge plan plus import-ready files without touching the live CRM. Use this skill whenever the user wants to dedupe, find or merge duplicate contacts, merge companies or accounts, clean up a CRM, prep a CRM migration or re-import, or says the CRM export is a mess. Also use it when they mention only one symptom, like "the same person is in here three times", "half our leads are junk", or "our company records don't match".
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Removes the egregore watchdog daemon and its associated files. Use when stopping automated session relaunching or cleaning up egregore infrastructure.
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Use when comparing an exposure-outcome association across countries with parallel national surveys (KNHANES, NHANES, CHNS). Harmonizes variables, runs parallel weighted analyses and builds comparison tables for 2-country (KR+US) or 3-country (KR+US+CN) designs.
日本語の概要は準備中です。原文の説明を表示しています。