「weight」の検索結果

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Improves typography by fixing font choices, hierarchy, sizing, weight, and readability so text feels intentional. Use when the user mentions fonts, type, readability, text hierarchy, sizing looks off, or wants more polished, intentional typography.

日本語の概要は準備中です。原文の説明を表示しています。

Core UI/UX engineering skill for building highly interactive, spatial, weightless, and glassmorphism-based web interfaces using GSAP and 3D CSS.

日本語の概要は準備中です。原文の説明を表示しています。

A radically minimal, blank-canvas interface built as a pure edge-to-edge surface, with almost no color and typography carrying the visual weight. Black serves as the only filled color, the only divider, and the sole surface tone cards.

日本語の概要は準備中です。原文の説明を表示しています。

Strong visual presence with heavyweight typography, high-contrast colors, and commanding layouts.

日本語の概要は準備中です。原文の説明を表示しています。

Code quality dashboard. Wraps existing project tools (type checker, linter, test runner, dead code detector, shell linter), computes a weighted composite 0-10 score, and tracks trends over time. Use when: "health check", "code quality", "how healthy is the codebase", "run all checks", "quality score". (gstack)

日本語の概要は準備中です。原文の説明を表示しています。

Add an iOS App Clip target to an Expo app. Use when the user mentions App Clip, AASA, apple-app-site-association, appclips, smart app banner, or wants to ship a lightweight iOS Clip invoked from a URL alongside their parent app.

日本語の概要は準備中です。原文の説明を表示しています。

Maintain weighted collections, datasets, groups, selectors, and random content tables.

日本語の概要は準備中です。原文の説明を表示しています。

Use authoritative, deterministic, weighted, and testable randomness without breaking prediction or reproducibility.

日本語の概要は準備中です。原文の説明を表示しています。

Pick an icon strategy and produce a coherent icon set that doesn't look mass-produced. Solves the "Lucide everywhere" problem — every AI-generated UI uses the same 24px stroke-1.5 outline icons, which is the second-biggest vibecoded tell after Inter-on-purple-gradient. Generates custom SVG sets, tunes existing icon libraries to match archetype + typography, defines stroke weight, optical sizing, and corner-radius rules. Load when the user asks to pick icons, design an icon set, customize Lucide / Phosphor / Heroicons, generate SVG icons, make icons feel custom, says "the icons look generic", "design a custom icon system", "icons for this product", or when frontend-design routes here during icon craft. Sub-skill of frontend-design.

日本語の概要は準備中です。原文の説明を表示しています。

Tactical fast path: turn a small problem, bug report, edit request, or narrow refactor into three deliverables — a brief change-spec (docs/specs/), a detailed implementation-ready plan (docs/plans/), and a TODO.md with agent-pickable tasks and milestones. Load when the user describes a tactical problem and wants quick planning artifacts, says "plan this change", "create a TODO", "write a plan for this", "problem to plan", "break this into tasks for agents", "I want to change X — plan it", or when process-decomposer routes here after determining the user needs lightweight planning deliverables. Also triggers on "create tasks from this problem", "make this actionable", or "turn this into a plan agents can execute". For feature-sized work that needs an executable spec + constitution + cross-check gate, route to `spec-driven-development` (or `feature-spec`) instead.

日本語の概要は準備中です。原文の説明を表示しています。

Core UI/UX engineering skill for building highly interactive, spatial, weightless, and glassmorphism-based web interfaces using GSAP and 3D CSS.

日本語の概要は準備中です。原文の説明を表示しています。

Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.

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Performs differential expression on bulk RNA-seq count data with edgeR's negative-binomial GLM and quasi-likelihood F-test framework. Covers DGEList construction, filterByExpr, TMM/TMMwsp normalization, robust dispersion estimation, glmQLFit/glmQLFTest, TREAT for magnitude-bounded hypotheses, contrasts via no-intercept designs, voom and voomWithQualityWeights for heterogeneous samples, and the edgeR v4 bias-corrected APL changes. Use when running bulk DE with edgeR, choosing edgeR over DESeq2 (small n, transcript DE via catchSalmon, large samples), needing TREAT for a fold-change-threshold hypothesis, troubleshooting v3-to-v4 reproducibility, building paired or interaction designs, or handling library-quality heterogeneity.

日本語の概要は準備中です。原文の説明を表示しています。

Build weighted gene co-expression networks to identify modules of co-regulated genes, relate them to phenotypes, and find hub genes using WGCNA, hdWGCNA, MEGENA, CEMiTool, and Gaussian graphical models. Covers signed-network choice, soft-threshold selection, module preservation, and the marginal-vs-partial-correlation distinction. Use when finding co-expression modules, identifying hub genes, relating gene networks to clinical or experimental traits, or building single-cell co-expression networks. For directed TF-target inference see scenic-regulons and grn-inference; for condition rewiring see differential-networks.

日本語の概要は準備中です。原文の説明を表示しています。

Creates DE-specific diagnostic and result visualizations using DESeq2/edgeR built-in functions and lightweight ggplot2 wrappers. Covers MA plot (with the shrunken-LFC compression effect), volcano (with the apeglm caveat that p-values are unchanged), PCA on VST/rlog (never raw counts), sample distance heatmaps, top-DE-gene heatmaps with the row-scaling trap, dispersion / BCV plot interpretation, p-value histogram diagnostics, plotCounts for individual genes, blind=TRUE vs FALSE rationale, and the n=3 visualization stake. Use when generating DE diagnostic plots, choosing VST vs rlog for visualization, troubleshooting suspicious plot patterns (shifted MA cloud, batch-dominated PCA, anti-conservative p-value histogram), or building a standard QC figure panel.

日本語の概要は準備中です。原文の説明を表示しています。

Performs time-to-event analysis for clinical trials including Cox proportional hazards regression with PH diagnostics, restricted mean survival time (RMST) under non-PH, competing risks via Fine-Gray vs cause-specific Cox, weighted log-rank and MaxCombo for non-proportional hazards, recurrent events (Andersen-Gill, PWP, WLW), and interval-censored data. Use when analyzing time-to-event endpoints (OS, PFS, DOR, TTR, TTNT) in oncology or other clinical trials.

日本語の概要は準備中です。原文の説明を表示しています。

Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

日本語の概要は準備中です。原文の説明を表示しています。

Estimate causal effects of an exposure on an outcome from GWAS summary statistics using genetic instruments. Implements IVW (fixed/random), MR-Egger, weighted median/mode, MR-RAPS, CAUSE, GSMR-HEIDI, MR-PRESSO, MVMR, MR-Clust, LCV, and LHC-MR via TwoSampleMR, MendelianRandomization, MR-PRESSO, cause, and lhcMR. Use when testing causal direction between traits, evaluating drug-target effects via cis-pQTL/cis-eQTL, performing multivariable mediation MR, distinguishing causation from correlated horizontal pleiotropy, or producing STROBE-MR-compliant sensitivity batteries.

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Use when a carrier or driver asks about winter trucking, snow chain requirements, hot-weather precautions, summer tire failures, fuel additive use (anti-gel), idle management in extreme temperatures, weight restrictions in spring thaw, or how seasonal demand patterns affect freight rates and capacity.

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Use when a carrier asks about trailer types — dry van, reefer, flatbed, step-deck, conestoga, tanker, dump, lowboy, intermodal chassis, auto-hauler. Covers length / weight rules, common specs, reefer unit options (Carrier vs Thermo King), liftgate options, kingpin setting, and trailer-to-tractor matching.

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Use this skill when the user asks about Household Goods (HHG) movers — 49 CFR 375 + 376 consumer protection rules, FMCSA HHG-specific authority, mover certification, binding vs non-binding estimates, dispute resolution, weight ticket requirements, valuation coverage, and how HHG operations differ from general freight. Cite 49 CFR 375.

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Use this skill when the user asks about logging / log hauling operations — short-haul exemption specifics for logging, log truck securement, axle weights, state-by-state logging permits (especially OR, WA, ID, BC), bunk + stake configurations, and how logging fits into FMCSA + state rules. Reference 49 CFR 393 for cargo securement of logs.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when the user asks anything that touches US Department of Transportation (DOT) or Federal Motor Carrier Safety Administration (FMCSA) regulation for commercial motor vehicles (CMVs) — including who's regulated, MC vs DOT number differences, operating authority, BOC-3 process agents, MCS-150 biennial updates, intrastate vs interstate distinctions, exemptions, or pointing to the right CFR section. Cite the actual regulation when answering. Don't guess; if you're not sure which Part applies, ask the user to clarify the operation type (for-hire vs private, passenger vs property, intra vs interstate, hazmat, gross weight rating).

日本語の概要は準備中です。原文の説明を表示しています。