「can」の検索結果

TOP PRIORITY skill — find and immediately fix or remove every piece of wrong, outdated, or redundant information in ToolUniverse docs. Wrong code, broken links, incorrect counts, and overlapping instructions must be fixed or removed — never left in place. Runs five phases: (D) static method scan, (C) live code execution, (A) automated validation, (B) ToolUniverse audit, (E) less-is-more simplification. Core philosophy: each concept appears exactly once; remove don't add; no emojis; single setup entry point. Use when reviewing docs, before releases, after API changes, or when asked to audit, fix, or simplify documentation.

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Comprehensive ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiling for drug candidates. Integrates ADMET-AI predictions, SwissADME drug-likeness, PubChemTox experimental toxicity, ChEMBL clinical data, Lipinski rule-of-five, and CYP interaction data. Use for drug-likeness assessment, BBB penetration, bioavailability, hepatotoxicity prediction, ADME/PK profiling, or screening compound libraries before lab testing.

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Assess drug-drug interactions — CYP metabolic interactions (substrate/inhibitor/inducer), transporter (P-gp, BCRP, OATP) effects, pharmacodynamic synergy/antagonism, clinical significance scoring, and management recommendations. Use for polypharmacy review, prescribing decision support, and safety analysis when adding or switching drugs.

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Transform GWAS signals into drug targets and repurposing opportunities. Connects GWAS-significant loci to causal genes via fine-mapping/eQTL, then to druggable proteins via DGIdb/OpenTargets, then to existing drugs via ChEMBL. Use for GWAS-to-target hypothesis generation, druggable-fraction analysis of disease loci, and human-genetics-validated drug-repurposing prioritization.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.

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ADMET property prediction for drug candidates. Full pharmacokinetic panel (Caco-2, PPB, clearance, CYP), toxicity (hERG, AMES, DILI), drug-likeness (Lipinski, QED), using RDKit descriptors and TDC models.

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Assigns honest lipid annotation levels, designs class-based internal-standard quantification, and runs lipid-aware differential and enrichment analysis with lipidr, guarding against in-source-fragment phantoms, sn-position over-claims, and invalid cross-class quantification. Use when naming or canonicalizing lipid species (shorthand separators, Goslin), deciding shotgun vs RP vs HILIC LC-MS, picking internal standards (SPLASH/EquiSPLASH), interpreting MS-DIAL/LipidSearch output, or comparing lipid classes. For general feature detection see metabolomics/xcms-preprocessing and metabolomics/msdial-preprocessing; for non-lipid annotation confidence see metabolomics/metabolite-annotation; for normalization/QC see metabolomics/normalization-qc; for multivariate stats see metabolomics/statistical-analysis.

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Designs QC, corrects signal drift, removes batch effects, filters features, normalizes samples, and imputes missing values for untargeted LC-MS/GC-MS metabolomics, framing each step as a measurement model that can create or erase biological signal. Use when processing a peak/feature table before statistical analysis, choosing a drift-correction or sample-normalization method, deciding QC RSD vs D-ratio filtering, or handling left-censored missing values. The feature table is produced by metabolomics/xcms-preprocessing or metabolomics/msdial-preprocessing; transformation/scaling for modeling defers to metabolomics/statistical-analysis; cross-study design issues link to experimental-design/batch-design.

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Meta-skill — browse and discover all installed stellar.new skills. Use when a user says "what skills do I have", "show me available skills", "what can I do", "find a skill for X", "which skill should I use", "help me navigate", "what does stellar.new do", or "where do I start". Lists skills by journey phase, surfaces the SKILL_ROUTER trigger phrases, and recommends the next skill given current context.

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Structured bug diagnosis and fixing workflow — reproduce, diagnose root cause, apply minimal fix, write regression test, and scan for similar patterns

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Extract applicant details from rental application PDFs and generate a side-by-side XLSX for comparing income, employment, and move-in dates.

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Extract candidate information from a resume PDF, then generate a formatted employee profile document for HR onboarding.

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Extract applicant details, employment history, income, and references from a rental application form into structured JSON for tenant screening.

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Extract candidate name, contact details, work history, and skills from resumes.

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Extract employee, employer, earnings, deductions, tax, and net pay from Spanish or Latin American payroll slips.

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Convert a resume PDF to clean markdown for LLM parsing or candidate pipelines.

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Gets a custom map into CARLA on UE 5.8 — the four distinct routes and which one to pick — via Util/Tools/Import.py for FBX+OpenDRIVE assets into a source build, CARLA_MAPS_TO_COOK to ship a map inside a package, or client.generate_opendrive_world() for an OpenDRIVE-only map at runtime with no build at all. Covers where imported assets land, why an imported map cannot be loaded from a package by name, and the four capabilities the UE4 skill has that ue58 lacks — standalone asset packages, their installer, semantic-material tagging, and a pedestrian navmesh that is generated but silently skipped. Use when the user asks to "import a map", "add a custom map", "load my .xodr", "package my own town", or "create a standalone map package".

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Imports a pedestrian into CARLA on UE 5.8 as a spawnable, animating walker — imports the skinned FBX bound to CARLA's shared pedestrian skeleton, duplicates a donor walker blueprint and repoints it at the new mesh, and registers it in WalkerParameters.json as walker.pedestrian.<id>. Can also export a shipped walker to FBX, which is how you obtain a rig-conforming mesh to start from. Use when the user asks to "import a walker/pedestrian", "add a custom character", "clone a walker", or has a walker that spawns but stands still.

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Imports FBX meshes into CARLA on UE 5.8 as spawnable props — drives the editor headlessly to import the mesh, derives the prop size from its measured bounds, and registers it in PropParameters.json so it appears in the blueprint library as static.prop.<name>. Handles the FBX unit-scale problem, verifies the result against a running server, and can revert cleanly. Use when the user asks to "import a prop", "add a custom mesh/object to CARLA", "make my model spawnable", or a prop imports but never shows up in the blueprint library.

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Launches a CARLA RPC server a carla.Client can connect to, working out for itself what you pointed it at — a downloaded/extracted release, a package cooked inside a checkout, or a source checkout run through the UE4 editor — headless or windowed, and shuts it down cleanly. ROS2=1 starts it with the native ROS 2 interface active (--ros2, --rmw=fastdds/cyclonedds/zenoh, --ros-domain-id). Use when the user asks to "run/start the CARLA server", "boot CARLA headless", "launch CARLA with a window", "run the CARLA I downloaded", "start CARLA with ROS2 enabled", or "serve a packaged CARLA build".

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Starts a CARLA UE 5.8 server from a ue58-dev tree — the editor binary in -game mode (the working headless server), the packaged shipping build, or the full editor — with offscreen/nullrhi rendering, custom RPC and streaming ports, and native ROS 2 via the single-dash -ros2 flag. Probes a running server, and stops one cleanly despite the 15-character process-name truncation. Use when the user asks to "run/start CARLA UE5", "launch a ue58 server", "run headless", "publish ROS 2 topics from UE5", or a client cannot reach the simulator.

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Packages an agent for CARLA Leaderboard submission — builds the docker image with make_docker.sh (plain or ROS variant), checks the four required roots and the egg layout it assumes, sets the agent/track/routes environment inside the image, and verifies the image can import the stack and load the agent before submission. Use when the user asks to "build the leaderboard docker image", "submit to the leaderboard", "package my agent", or make_docker.sh fails.

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Listens to a CARLA sensor and either saves its data to files, shows it live in a window, prints a one-shot summary, or (ros-info) reports the native ROS 2 topics, QoS and enabled-for-ROS state so you can echo it from ROS instead. Cameras save as PNG (depth/semantic auto-colourised) and display in a pygame window; lidar saves as .ply and shows as a top-down scatter; IMU/GNSS/radar/collision stream to JSONL or the console. Use when the user asks to "show/view the camera", "display the lidar", "save the sensor data / capture a dataset", or "what is this sensor reading". Select the sensor by id, type, or the actor it's attached to.

日本語の概要は準備中です。原文の説明を表示しています。