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概要と使いどころ
Python typing exclusion worker: remove assigned mypy exclusion modules in small scoped batches, fix typing issues, run validation, and produce a structured completion summary. Use when running parallel typing-debt workers or when asked to remove modules from pyproject mypy exclusion overrides.
日本語の概要は準備中です。原文の説明を表示しています。
Grilling session that mines the user for fragments — heterogeneous nuggets of writing (claims, vignettes, sharp sentences, half-thoughts) — and appends them to a single document as raw material for a future article. Use when the user wants to develop ideas before imposing structure, or mentions "fragments", "ideate", or "raw material" for writing.
日本語の概要は準備中です。原文の説明を表示しています。
Create exercise directory structures with sections, problems, solutions, and explainers that pass linting. Use when user wants to scaffold exercises, create exercise stubs, or set up a new course section.
日本語の概要は準備中です。原文の説明を表示しています。
Set up Terraform infrastructure-as-code for cloud resources, including provider configuration, modules, state management, and CI integration.
日本語の概要は準備中です。原文の説明を表示しています。
Audit technical SEO — meta tags, structured data, Open Graph, sitemaps, robots.txt, performance, and accessibility signals.
日本語の概要は準備中です。原文の説明を表示しています。
Add PostHog log capture to track application logs. Use after implementing features or reviewing PRs to ensure meaningful log events are captured with structured properties. Also handles initial OTLP exporter setup if not yet configured.
日本語の概要は準備中です。原文の説明を表示しています。
Write effective prompts for LLMs — structure, few-shot examples, chain-of-thought, system prompts, and output parsing.
日本語の概要は準備中です。原文の説明を表示しています。
Diagnose why a PostHog endpoint is slow or expensive and propose a concrete fix — bump the cache TTL, enable materialisation, restructure variables, or rewrite the query. Use when the user says "this endpoint is slow", "my endpoint times out", "we're hitting the cost cap on this one", or asks "should I materialise this?". Focuses on a single named endpoint, not a project-wide audit.
日本語の概要は準備中です。原文の説明を表示しています。
Create a clean, review-ready pull request with a good title, structured description, linked issues, and appropriate reviewers.
日本語の概要は準備中です。原文の説明を表示しています。
Write reusable ChatCrystal task memories after substantive work completes. Use when implementation or debugging produced a durable fix, pitfall, pattern, or decision worth preserving, and when the environment can either persist it through `write_task_memory` or emit a structured memory candidate for later save.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze a repository to generate recommended Claude Code settings.json permissions. Use when setting up a new project, auditing existing settings, or determining which read-only bash commands to allow. Detects tech stack, build tools, and monorepo structure.
日本語の概要は準備中です。原文の説明を表示しています。
Deep literature review — PubMed, EuropePMC, bioRxiv preprints, citation networks, evidence synthesis. Disambiguates queries, runs collision-aware searches, grades evidence T1-T4, and produces structured reports. Use for systematic literature review, meta-analysis evidence collection, and detailed answer-with-citations workflows.
日本語の概要は準備中です。原文の説明を表示しています。
Produce and interpret PCA, t-SNE, UMAP, and PHATE plots for high-dimensional omics data with rigor about which method preserves what (variance, local structure, manifold, transitions), hyperparameter sensitivity, and the well-documented limits of 2D embeddings. Covers PCA biplot/scree/loadings, t-SNE PCA initialization (Kobak-Berens 2019), UMAP n_neighbors/min_dist trade-offs, and the Chari-Pachter 2023 critique. Use when visualizing high-dimensional data — bulk PCA, single-cell embeddings, multi-omics integration projections.
日本語の概要は準備中です。原文の説明を表示しています。
Expert guidance for GRPO/RL fine-tuning with TRL for reasoning and task-specific model training
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end GWAS workflow from VCF to association results. Covers PLINK QC, population structure correction, and association testing for case-control or quantitative traits. Use when running genome-wide association studies.
日本語の概要は準備中です。原文の説明を表示しています。
Metabolomics research — metabolite identification, study analysis, and database searches across HMDB, MetaboLights, Metabolomics Workbench, KEGG. Use for annotating mass-spec features to known metabolites, finding metabolomics studies of a disease, and structured metabolomics research reports with metabolite-pathway mapping.
日本語の概要は準備中です。原文の説明を表示しています。
Dereplicate a putative natural product and assign its chemical taxonomy. Use to answer "is [compound] a known natural product", "what microbe/organism produces [compound]", "what chemical class is [compound]", "dereplicate this metabolite (by formula/exact mass/InChIKey/SMILES)", or "classify this molecule into ChemOnt". Searches NPAtlas for known microbial natural products (producing organism + literature reference), assigns the ChemOnt kingdom→superclass→class→subclass hierarchy via ClassyFire, resolves systematic IUPAC names to structure via OPSIN, and cross-references identity in PubChem. NOT for general drug/compound identity or ADMET (use tooluniverse-chemical-compound-retrieval / tooluniverse-small-molecule-discovery) and NOT for metabolomics pathway/enrichment analysis (use tooluniverse-metabolomics skills).
日本語の概要は準備中です。原文の説明を表示しています。
Create new scientific tools for ToolUniverse framework with proper structure, validation, and testing. Use when users need to add tools to ToolUniverse, implement new API integrations, create tool wrappers for scientific databases/services, expand ToolUniverse capabilities, or follow ToolUniverse contribution guidelines. Supports creating tool classes, JSON configurations, validation, error handling, and test examples.
日本語の概要は準備中です。原文の説明を表示しています。
Small molecule identification, characterization, and procurement — PubChem, ChEMBL, BindingDB, ADMET-AI, SwissADME, eMolecules, Enamine. Covers compound name to structure to activity to ADMET properties to commercial sourcing. Use for chemical biology, lead identification, probe selection, and the full small-molecule discovery pipeline.
日本語の概要は準備中です。原文の説明を表示しています。
Perform comprehensive exploratory data analysis on scientific data files across 200+ file formats. This skill should be used when analyzing any scientific data file to understand its structure, content, quality, and characteristics. Automatically detects file type and generates detailed markdown reports with format-specific analysis, quality metrics, and downstream analysis recommendations. Covers chemistry, bioinformatics, microscopy, spectroscopy, proteomics, metabolomics, and general scientific data formats.
日本語の概要は準備中です。原文の説明を表示しています。
Pharmacokinetic (PK) analysis of concentration-time data — non-compartmental analysis (NCA) for Cmax, Tmax, AUC (0-t and 0-∞), terminal half-life, clearance (CL), volume of distribution (Vd), MRT, and absolute bioavailability (F). Also one-compartment fitting. Use when you have plasma/serum drug concentrations over time after a dose and need PK parameters, or to compute bioavailability from IV + oral AUCs. NOT for ADMET property prediction from structure (use tooluniverse-admet-prediction).
日本語の概要は準備中です。原文の説明を表示しています。
Performs structure-based virtual screening using AutoDock Vina, SMINA, GNINA (CNN scoring), and DiffDock-L hybrid workflows with explicit choice rules across rigid vs flexible docking, cross-docking vs self-docking, binding-site detection (P2Rank, fpocket), receptor preparation (PDB2PQR, PROPKA), ligand preparation (meeko, OpenBabel), and ultralarge-library screening (ZINC22, Enamine REAL). Use when screening chemical libraries against a protein target to find candidate binders, ranking docking poses, or selecting a docking workflow for a specific scenario.
日本語の概要は準備中です。原文の説明を表示しています。
Decision-grade statistical analysis for metabolomics intensity tables. Covers transformation and scaling (Pareto vs unit-variance as a hidden hypothesis), unsupervised structure (PCA/HCA for QC), permutation-validated PLS-DA/OPLS-DA (R2 vs Q2, double CV, VIP as heuristic), univariate testing (Welch/Mann-Whitney/ANOVA/LMM with covariate adjustment), and dependence-aware multiple testing. Use when testing which metabolites differ, building or validating a discriminant model, choosing a scaling, or correcting many correlated tests. For sample-wise normalization/drift correction see metabolomics/normalization-qc; for ML classifiers and selection-inside-CV leakage see machine-learning/biomarker-discovery and machine-learning/model-validation; for pathway interpretation see metabolomics/pathway-mapping; for design/power/multiplicity regime see experimental-design/multiple-testing.
日本語の概要は準備中です。原文の説明を表示しています。
Enumerates virtual chemical libraries via reaction SMARTS transformations using RDKit and Reaction templates, with explicit handling of atom mapping, template extraction (RDKit reaction mining), product validation, RECAP/BRICS fragmentation, R-group decomposition, matched molecular pair analysis (MMPA), and Free-Wilson analysis. Use when generating combinatorial libraries from building blocks, enumerating analog series, deriving structure-activity rules, or extracting transformations from reaction data.
日本語の概要は準備中です。原文の説明を表示しています。