「eth」の検索結果

Run a pre-mortem — imagine the project has already failed one year from now and work backward to find the root causes before they happen. Load when the user asks for a pre-mortem, wants to imagine failure before committing, asks "what could go wrong before we start", "assume this fails — why", "risk analysis before launch", "what kills this project", "what could go wrong", or when deep-thinking diagnoses a pre-mortem frame. Based on Gary Klein's prospective hindsight method, which surfaces failure causes more effectively than forward risk analysis. Most useful right before a major commitment.

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Turn assumptions, funnel opportunities, and product questions into a prioritised, feasibility-checked experiment backlog. Filters by traffic reality, metric latency, and method feasibility — not just ICE/RICE scoring. Maintains a living portfolio with status (idea → designed → running → readout → archived). Load when the user says "what should we test next", "build an experiment backlog", "prioritise our tests", "where should we experiment", "what's worth testing", or when the experimentation orchestrator routes here.

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Write a rigorous, decision-grade experiment spec — falsifiable hypothesis, primary metric, guardrails, randomisation unit, exposure definition, method (A/B, holdout, switchback, quasi-experiment, MAB), MDE/duration plan, peek policy, validity threats, and pre-committed decision rule. Platform-agnostic. Load when the user has a candidate experiment and needs to spec it before launch, or says "spec this experiment", "write the test plan", "design this A/B test", "what's the hypothesis", "how big a sample do we need", "how long should we run this", "define the metrics for this test", or when the experimentation orchestrator routes here.

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Map symbol dependencies, callers, and blast radius before editing code. Load when the user asks what depends on a symbol, what breaks if they change something, blast radius of a change, reverse dependencies, or which tests cover a function. Also triggers on "who calls this", "impact of changing", "dependency map", "what uses this", "find callers", or before any non-trivial edit when safe-change is not yet active. Pairs with codebase-understanding for broad architecture; this skill is symbol-scoped and edit-gated.

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Quickly understand an unfamiliar codebase or project by mapping its architecture, identifying key components and data flows, and surfacing complexity hotspots. Load when the user asks to understand a repo, explain how something works, map the architecture, onboard to a codebase, or explore how components connect. Also triggers on "walk me through this codebase", "how does this project work", "explain the architecture", "what does this repo do", "show me the structure", "onboard me", or any request to build a mental model of a codebase before making changes.

日本語の概要は準備中です。原文の説明を表示しています。

Turn a rough idea into a fully approved design before any code is written. Load when the user wants to brainstorm, explore ideas, design a feature, think through approaches, plan a new capability, or figure out what to build. Also triggers on "let's think through", "help me design", "explore options", "what's the best approach for", "I have an idea for", "before we build", or any request to design something before implementation. Enforces a hard gate: no code, no implementation until user approves a design. For executable feature specs (FRs, NFRs, ACs as Given/When/Then), route to `feature-spec` instead — brainstorming owns approach and architecture, not machine-readable requirements.

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Review a built frontend against its chosen direction, catch drift back to generic AI defaults, enforce state coverage, ethical patterns, UX heuristics, and polish, and check contrast with APCA (not the legacy WCAG ratio). Produces specific, prioritized fixes — never vibes-based feedback. Works with pasted screenshots or Playwright MCP automated capture. Load when the user asks to review a UI, audit a design, check if a frontend looks generic or vibecoded, evaluate visual quality or polish, says "review this UI", "is this design good", "audit my frontend", "does this feel like [product]", "design QA", or when frontend-design routes here. Sub-skill of frontend-design.

日本語の概要は準備中です。原文の説明を表示しています。

Orchestrator for the experimentation skill suite — turn assumptions and product questions into rigorous, well-instrumented experiments and decision-grade readouts. Routes through backlog → spec → runbook → readout based on user need and existing artefacts. Platform-agnostic with PostHog as the primary binding. Load when the user asks to design an experiment, A/B test something, set up an experiment, run a holdout, test a hypothesis, decide what to test next, read out experiment results, analyse a test, or says "should we A/B test this", "experiment on the landing page", "is this lift real", "ship or kill this test", "what should we test next", "build an experiment backlog", "test the pricing page", "validate this with an experiment".

日本語の概要は準備中です。原文の説明を表示しています。

Surface every assumption embedded in a plan, strategy, or document, assess how critical and how validated each one is, and identify which ones to test first. Load when the user asks to map assumptions, surface hidden beliefs, find what must be true for this to work, run an assumption audit, or when deep-thinking diagnoses an assumption frame. Also triggers on "what are we assuming", "what must be true for this to work", or "find the untested beliefs". Based on David Bland and Alex Osterwalder's assumption mapping method from Testing Business Ideas.

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Prisma Client API reference covering model queries, filters, operators, and client methods. Use when writing database queries, using CRUD operations, filtering data, or configuring Prisma Client. Triggers on "prisma query", "findMany", "create", "update", "delete", "$transaction".

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Enter explore mode - a thinking partner for exploring ideas, investigating problems, and clarifying requirements. Use when the user wants to think through something before or during a change.

日本語の概要は準備中です。原文の説明を表示しています。

Braintree Automation: manage payment processing via Stripe-compatible tools for customers, subscriptions, payment methods, and transactions

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Create a delightful, unexpected "wow" experience for the user by dynamically discovering and creatively combining other enabled skills. Triggers when the user says "surprise me" or any request expressing a desire for an unexpected creative showcase. Also triggers when the user is bored, wants inspiration, or asks for "something interesting".

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill instead of WebSearch for ANY question requiring web research. Trigger on queries like "what is X", "explain X", "compare X and Y", "research X", or before content generation tasks. Provides systematic multi-angle research methodology instead of single superficial searches. Use this proactively when the user's question needs online information.

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Use this skill when the user requests to review, analyze, critique, or summarize academic papers, research articles, preprints, or scientific publications. Supports comprehensive structured reviews covering methodology assessment, contribution evaluation, literature positioning, and constructive feedback generation. Trigger on queries involving paper URLs, uploaded PDFs, arXiv links, or requests like "review this paper", "analyze this research", "summarize this study", or "write a peer review".

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Guide for creating high-quality MCP (Model Context Protocol) servers that enable LLMs to interact with external services through well-designed tools. Use when building MCP servers to integrate external APIs or services, whether in Python (FastMCP) or Node/TypeScript (MCP SDK).

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This skill enforces Sentry's blog writing standards across every post — whether you're helping an engineer write their first blog post or a marketer draft a product announcement.

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Profiles a genome from raw reads BEFORE assembly with a k-mer spectrum (KMC or Jellyfish histogram), then models it with GenomeScope2 to estimate genome size, heterozygosity, repeat content, and ploidy, and Smudgeplot to infer ploidy from heterozygous k-mer pairs (diploid AB vs triploid AAB vs tetraploid AABB). Covers choosing k via Merqury best_k.sh, the k-mer-coverage vs sequencing-coverage confusion, reading het/repeat/contamination/organelle peaks, why noisy ONT must not be used for counting, and how the estimate becomes the NG50 denominator, the Flye -g value, the hifiasm --hom-cov/purge setting, and the 1.5-2x-too-big haplotig sanity check. Use when starting any de novo assembly, deciding whether short reads can work, estimating genome size for an unknown organism, diagnosing ploidy, or sanity-checking an assembly's size against expectation.

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Evaluates genome assembly quality across the three orthogonal axes - contiguity (QUAST auN/NG50/NGx, not bare N50), completeness (BUSCO/compleasm gene-space plus Merqury k-mer completeness), and correctness (reference-free Merqury QV, Inspector/CRAQ structural errors, asmgene false-duplication/collapse). Covers why N50 is the most-gamed metric, why QV measured on the polishing reads is circular, distinguishing uncollapsed haplotigs from real WGD, and the EBP/VGP 6.C.Q40 standard. Use when judging whether an assembly is good enough to annotate or publish, comparing assemblers, diagnosing a fragmented or duplicated assembly, or assessing a phased diploid assembly.

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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.

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Turns Hi-C/Micro-C FASTQ into a deduplicated, filtered .pairs file with pairtools and decides whether the library worked. Covers the bwa mem -SP5M / bwa-mem2 / chromap --preset hic alignment idiom (mates mapped as independent single-end reads), pairtools parse vs parse2 and the walks-policy choice (5unique pairwise vs all for Pore-C/Micro-C concatemers), pair-type classification (keep UU and rescued UC), dedup (PCR vs optical/by-tile), select by pair_type/MAPQ/distance, restriction-fragment handling (restrict, Arima dual-enzyme, Micro-C/DNase fragment-free), and allele-specific phasing (pairtools phase to two coolers). The library-QC decision uses % long-range cis as the one-number quality metric, trans as the noise floor, orientation balance as fragment-map-free dangling-end/self-circle QC, and % duplicates as a complexity proxy. Use when processing Hi-C/Micro-C/Omni-C reads into pairs, judging library quality, handling multi-enzyme or restriction-agnostic protocols, or generating allele-specific contacts.

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Performs proximity operations on genomic intervals with bedtools (closest, window, flank, slop) and pybedtools - nearest-feature queries with signed/strand-aware distance, fixed-radius window searches, strand-aware promoter construction, and interval extension. Covers the closest -d/-D a/b/ref/-t/-k/-io/-iu/-id flags, the -D ref strand sign-flip, silent chromosome-end clipping in slop/flank, -t all tie double-counting, and the critical distinction between a geometry answer (nearest TSS) and a biology answer (which gene an element regulates). Use when assigning peaks or variants to genes, defining promoters from a gene model, building distance-to-TSS distributions, finding features within a window, or extending intervals - and when deciding whether nearest-gene is a fair prior (GWAS locus) or a trap (distal enhancer).

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Reads, queries, and writes bigWig indexed binary signal tracks (coverage, fold-change, conservation, methylation-rate) with pyBigWig (Python) and the UCSC Kent tools (bedGraphToBigWig, bigWigToBedGraph, bigWigInfo, bigWigSummary, bigWigAverageOverBed) and deepTools (multiBigwigSummary, computeMatrix, bigwigCompare). Covers the central trap that a wide query returns a precomputed zoom-level summary (by default the mean, which annihilates narrow peaks) not per-base data, when exact=True/values() is mandatory, the NaN-not-zero gap-handling fork, choosing mean vs max vs sum vs coverage by biological question, and the sorted-bedGraph plus chrom.sizes build requirement. Use when extracting signal at regions, computing mean signal per gene/peak, building a browser track from bedGraph, comparing tracks, or building TSS/gene-body metaprofiles.

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Assembles a genome de novo from Illumina short reads with SPAdes (isolate/careful/sc/meta/plasmid/rna modes), MEGAHIT (low-memory, huge datasets), Unicycler (bacterial finishing/hybrid), MaSuRCA (large hybrid), ABySS (Bloom-filter), and Platanus (heterozygous diploids), using multi-k de Bruijn graphs. Covers the repeat-resolution limit, why N50 plateaus at the genome not the depth, GenomeScope2 k-mer profiling first, the heterozygosity/haplotig trap, error-correction erasing rare alleles, GC dropout, and NG50/auN/BUSCO reporting. Use when assembling a bacterial isolate, fungal, small-eukaryotic, single-cell, or metagenome genome from Illumina reads, or when deciding whether short reads can even produce the assembly being asked for.

日本語の概要は準備中です。原文の説明を表示しています。