「aria」の検索結果

Estimates bivariate genetic correlation (rg) between traits from GWAS summary statistics or individual-level genotypes using cross-trait LDSC, HDL, LAVA, rho-HESS, GREML-bivariate, Popcorn, and HDL-L. Use when quantifying shared genetic architecture between two traits, screening MR validity before causal inference, distinguishing global from locus-level rg, estimating trans-ancestry rg, separating partial from full causation via LCV gcp, or producing a STROBE-MR-compliant cross-trait sensitivity battery. Cross-trait LDSC intercept absorbs sample overlap and is NOT a bias; HDL is biased under sample overlap above ~5%. High rg between exposure and outcome motivates CHP-aware MR sensitivity (CAUSE, LHC-MR).

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Detect allele-specific chromatin accessibility from ATAC-seq using WASP, GATK ASEReadCounter, or RASQUAL. Use when mapping cis-regulatory genetic variants from heterozygous SNPs, separating cis from trans regulation, building chromatin QTL (caQTL) maps, validating GWAS variant function with allelic imbalance, or detecting reference allele mapping bias before downstream analysis.

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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or Enformer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.

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This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

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Recommends continuous subcutaneous insulin infusion (CSII) over multiple daily injections (MDI) for adults with type 1 diabetes who have achieved their A1C goal but experience severe hypoglycemia or high glucose variability, provided the patient and caregivers are willing and able to use the device. Consider CSII when clinicians hear 'A1C is at goal but patient has severe lows or glucose swings' or think 'pump for hypoglycemia-prone controlled T1DM'.

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Screen a child aged 13+ with obesity for eligibility for bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) using the CMAJ 2025 guideline. Trigger when a clinician asks whether a child qualifies for weight loss surgery, bariatric surgery in adolescents, sleeve gastrectomy in a teenager, or when to refer for surgical management of pediatric obesity.

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Build anomaly detection applications with Azure AI Anomaly Detector SDK for Java. Use when implementing univariate/multivariate anomaly detection, time-series analysis, or AI-powered monitoring.

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Adversarial code review that breaks the self-review monoculture. Use when you want a genuinely critical review of recent changes, before merging a PR, or when you suspect Claude is being too agreeable about code quality. Forces perspective shifts through hostile reviewer personas that catch blind spots the author's mental model shares with the reviewer.

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When the user wants to plan, design, or implement an A/B test or experiment. Also use when the user mentions "A/B test," "split test," "experiment," "test this change," "variant copy," "multivariate test," "hypothesis," "conversion experiment," "statistical significance," or "test this." For tracking implementation, see analytics-tracking.

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Splits scarce time, budget or traffic across competing products, channels, campaigns or variants by treating them as a multi-armed bandit - Thompson sampling over beta posteriors, with optimism for anything not yet tried enough to judge. Use when deciding what to work on next, how to divide a marketing budget, which product to prioritise, whether to kill something that is underperforming, or when picking a winner among test variants.

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Use when reviewing PRs/diffs/branches/documents for .NET quality, correctness, performance, security, data access, messaging, and observability. Includes adversarial critical-thinking mode for skeptical/cynical review requests. Keywords: code review, review PR, review diff, critical review, cynical review, adversarial review, production readiness, low GC, AOT, security review.

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Edit an existing image — inpaint, background swap, variation — via providers that support it. Use when editing/modifying/inpainting an image or making variations.

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Produce 3+ distinct hi-fi design variations — basic to bold, one file with tweak controls — when the user asks for options, alternatives, "show me a few takes". Extends fe-design.

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Adversarial critique — devil's advocate, stress-test, honest teardown ('poke holes', 'be brutal', 'was hältst du davon'); explicit request only. Routine code or design review → code-review.

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Quando o usuário quer planejar, avaliar ou construir uma ferramenta gratuita para fins de marketing — geração de leads, valor em SEO ou conscientização de marca. Use também quando o usuário menciona "engenharia como marketing", "ferramenta gratuita", "ferramenta de marketing", "calculadora", "gerador", "ferramenta interativa", "ferramenta de geração de leads", "construir uma ferramenta para leads" ou "recurso gratuito". Esta competência conecta engenharia e marketing — útil para fundadores e profissionais de marketing técnico.

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Quando o usuário quer planejar, projetar ou implementar um teste A/B ou experimento. Também use quando o usuário menciona "teste A/B", "split test", "experimento", "testar essa mudança", "copy variante", "teste multivariado" ou "hipótese". Para implementação de rastreamento, veja analytics-tracking.

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Load this skill whenever the project contains SVG graphics — inline SVGs, external SVG files, SVG icons, SVG illustrations, or SVG-based data visualizations. Under no circumstances use SVG without proper accessible titles, descriptions, and ARIA roles where required. Absolutely always add <title> and <desc> to meaningful SVGs and set role="img" with aria-labelledby pointing to those elements. Also apply this skill whenever the project accepts untrusted or user-uploaded SVG content, which requires sanitization before rendering.

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Load this skill whenever the project contains dynamic content updates, status messages, alerts, notifications, loading indicators, or any use of aria-live, role="status", role="alert", or role="log". Under no circumstances add or modify live-region markup without applying these rules. Prioritize correct politeness levels and avoid redundant announcements. Never use a fixed-delay clear-and-reinsert workaround — no standard guarantees it works.

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Apply semantic HTML/JSX and WAI-ARIA correctly and minimally. Apply when implementing any UI, especially forms, interactive components, or when accessibility is mentioned.

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Multi-agent adversarial verification with convergence loop. Two independent review agents must both pass before output ships. Use when output must clear two independent adversarial reviewers before it ships.

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Validate and implement Sinclair ZX Spectrum 48K ROM-visible behavior in the EMULATORS repository, including reset and restart vectors, IM1/NMI handling, keyboard scanning and repeat, beeper and tape routines, screen/printer output, channels and streams, BASIC tokenization and execution, expression evaluation, memory movement, system variables, calculator stack, floating-point formats, ROM traps, localized ROM selection, and firmware/hardware timing contracts. Use when Codex reviews or edits ZX Spectrum ROM loading, KERNAL-style traps, keyboard, tape, screen, printer, BASIC files, tokens, system variables, startup, interrupts, or compatibility tests.

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Mathematical foundations, logical structures, and formal verification guidance. Trigger when: - Designing protocol contracts, formal specifications, verifying state spaces, or using proof assistants. - Tasks involve: TLA+, Alloy, Lean, Coq, model checkers, invariants, temporal logic. - Prompt contains keywords: formal verification, alloy, tla+, lean, coq, invariant, state machine, model checker, liveness, safety.

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SOP for normative specification and behavioral contracts. Trigger when: - Defining invariants, permitted transitions, and forbidden states. - Navigating steps: Identify, Formalize, Verify, Record, Connect. - Prompt contains: /spec, spec workflow, normative constraint, invariant, BCP 14.

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