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概要と使いどころ
Use when polishing the prose and structure of an Academy of Management Review (AMR) manuscript to AOM house style and an argument-driven voice. Late-stage polish; it does NOT build theory or check logic — do those first with amr-theory-development and amr-data-analysis.
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Use when scoping or sanity-checking a research question for an Academy of Management Journal (AMJ) manuscript — fit, theory-drivenness, and feasibility. Decides whether the idea can earn a theoretical contribution; it does not build the theory itself (use amj-theory-development) or position the literature (amj-literature-positioning).
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Takes an existing screen recording or demo video and adds professional zoom/pan effects synchronized to the narration. Uses transcript-driven zoom targeting and Remotion for rendering. Optionally replaces audio with a soundtrack.
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End-to-end composite that turns a single brief into voice-tuned X post variants, LinkedIn post variants, and a matching social graphic. Orchestrates create-x-content + create-linkedin-content + goose-graphics in one invocation. Asks about graphic format when not specified, with heuristic-driven recommendations.
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Build the deterministic PIL pill overlays for a 'perfect-score + proof-points' UGC video ad (white 10/10 score header with a medal + orange sub with a finger-down + 3-4 green-check proof pills) and composite them onto a base clip in a diagonal L->R->L->R cascade, then mux the music bed into master-final.mp4. Config-driven (config.json), 1080x1920 9:16, FREE and deterministic (no paid calls, text stays pixel-crisp). Use for the overlay-proof-points format; the base clip + music come from separate paid capabilities.
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Assemble a 3D-CGI app sizzle — nano-banana CGI plates (blank-glow floating phone + a CGI studio with rim-light + placeholder burst shapes; studio look and phone finish come from the recipe choices) plus PIL compositing of the REAL App Store screenshots onto the bezel + burst-out overlays, driven by Kling 3.0 i2v steady-float per beat with a per-beat Ken-Burns FFmpeg push-in fallback when Kling garbles the UI, then VO/music mix (sidechain duck, loudnorm) + 1.15x speed + anti-AI grain finalize. The on-screen UI, any faces in it, and the wordmark are ALWAYS real assets composited via PIL — never AI-rendered. The paid steps (plates, i2v clips, VO, music) are separate capabilities; this ships the config + PIPELINE + FREE assembly and the recipe orchestrates the spend. Use for the cgi-app-sizzle video format.
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Generate a voiceover (VO) clip via ElevenLabs text-to-speech, ROUTED THROUGH THE elevenlabs-proxy so it bills the Ads agent. Voice id + script text come from the template recipe. Use for the spoken narration of VO-driven video-ad formats (cgi-app-sizzle, flat-vector-explainer, hypermotion). Never call ElevenLabs directly — the proxy attribution is required.
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Assemble an editorial-motion podcast-clip ad from a config — a real clipped podcast MP3 carries the narrative while N flat limited-palette editorial-illustration keyframes (one look pack) are animated NOT by generative i2v but by DETERMINISTIC ffmpeg ken-burns (zoompan) + hard cuts (no crossfades, which expose geometric drift), each beat snapped to its spoken line, the real audio muxed, Whisper-driven captions burned only mid-sentence, and closed on a PIL brand end card — never AI-rendered text. This is the FREE deterministic assembly stage (ffmpeg ken-burns + hard concat + audio mux + captions + end card); the real audio is clipped from source and the keyframes come from create-image-fal. Use for the editorial-motion-podcast format.
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Extract and normalize pricing tiers from any SaaS, API, cloud, or LLM vendor's pricing page. Use this skill whenever the user says "pricing for X", "how much does X cost", "pricing tiers", "cost comparison", provides a URL ending in `/pricing` or `/plans`, or asks to monitor pricing over time. Pairs well with `exportSkill` to turn a run into a cron-friendly workflow. Scrape-driven; no interact needed for typical pricing pages.
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Build reactive/event-driven C# with R3 (Cysharp's modern reimplementation of Reactive Extensions). Covers the Observable<T>/Observer<T> model, the OnErrorResume error contract, async dispatch with AwaitOperation, Task/IAsyncEnumerable integration, TimeProvider/FrameProvider scheduling, the concurrency contract, and how R3 differs from System.Reactive (Rx.NET).
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Quality control for IMC/MIBI data across pixel, channel, image, slide, and batch levels, covering Poisson-count SNR (cell-level Gaussian-mixture and empty-channel comparison), spillover-matrix QC (the three physical sources), drift and the missing EQ-bead analog, acquisition artifacts, and sample-of-origin batch effects. Use when deciding whether to keep or drop a channel, ROI, or slide, distinguishing a dim antibody from a failed one, reading a spillover matrix, or diagnosing batch-driven clustering before analysis.
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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.
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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.
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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.
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Download genome assemblies, gene records, and ortholog data from NCBI using the modern Datasets v2 CLI (replaces assembly_summary.txt scraping and many EFetch workflows). Use when bulk-pulling genome assemblies, gene metadata across species, ortholog sets, or BLAST databases; when E-utilities are too slow for genome-scale work; or when automatic checksum verification, parallel download, and clean accession-driven retrieval are required. Encodes the JSON-lines output format, dataformat conversion, --dehydrated for cloud workflows, and when Datasets is/isn't the right tool.
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Build genome-browser-style multi-track figures with pyGenomeTracks (config-driven), Gviz (R), and IGV batch screenshotting. Covers BigWig coverage tracks, BED/peak overlays, gene-model rendering, Hi-C matrix tracks, BedPE link arcs, spike-in-aware normalization, and the bamCoverage --normalizeUsing trap. Use when producing publication figures of genomic loci with stacked aligned tracks (coverage, peaks, genes, interactions) for ChIP-seq, ATAC-seq, RNA-seq, Hi-C, or generic locus visualization.
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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.
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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.
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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.
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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.
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Test-driven development for behaviour a unit test cannot reach, by writing the expectation against the running app before writing the code. Declare the consequence first, watch it fail, implement, watch it pass. Use when building a user-facing feature, when the user asks for TDD on UI or full-stack work, when a unit test cannot express the outcome that matters, or when you want a red-green loop that runs against the real app instead of mocks.
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Check that a form actually rejects bad input: the error message renders, the submit button stays disabled, and no request goes out. Use when validation logic was written but never driven, when a "required" or pattern check looks right on screen but was never proven, or when a bug report says the form submitted invalid data anyway.
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Turn a user journey you just clicked through into a saved regression check that re-runs deterministically, with no model in the loop and no test code to write. Use when you have driven the same flow twice, when the user wants regression coverage without a Playwright suite, when a refactor needs proving against every existing journey, or when re-verifying by hand is costing a full drive every time.
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Build, review, or improve Core Data persistence in apps that have not adopted SwiftData. Use when working with NSManagedObject subclasses, NSFetchedResultsController for list-driven UI, NSBatchInsertRequest / NSBatchDeleteRequest / NSBatchUpdateRequest for bulk operations, NSPersistentHistoryChangeRequest for persistent history tracking and multi-target sync, NSStagedMigrationManager for staged schema migrations (iOS 17+), NSCompositeAttributeDescription for composite attributes (iOS 17+), or when integrating Core Data threading with Swift Concurrency. For Core Data + SwiftData coexistence or migration, see the swiftdata skill instead.
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