「sequence」の検索結果

MHC (major histocompatibility complex) molecules are cell surface complexes that present antigens to T cells. The repertoire of antigens presented in a given genetic background largely depends on the sequence of the encoded MHC molecules, and thus, in humans, on the highly variable HLA (human leukocyte antigen) genes of the hyperpolymorphic HLA locus. More than 28,000 different HLA alleles have been reported, with significant differences in allele frequencies between human populations worldwide

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doubletrouble aims to identify duplicated genes from whole-genome protein sequences and classify them based on their modes of duplication. The duplication modes are i. segmental duplication (SD); ii. tandem duplication (TD); iii. proximal duplication (PD); iv. transposed duplication (TRD) and; v. dispersed duplication (DD). Transposon-derived duplicates (TRD) can be further subdivided into rTRD (retrotransposon-derived duplication) and dTRD (DNA transposon-derived duplication). If users want a s

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Single "start here" orchestrator for new cold email operators. Asks infrastructure-status questions first, then runs /icp-onboarding → /lead-magnet-brainstorm → /campaign-strategy in sequence, producing a consolidated campaign-plan.md. Ends with an interactive menu of next skills branched on whether the user already has domains/inboxes. Use as the very first invocation on any new repo checkout or when onboarding someone to cold email from zero.

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Run the fixed 6-step session-opening sequence — pwd, read progress, git log, count remaining features, init.sh, smoke-test last feature — before touching any new work. The orientation ritual that lets fresh-context sessions reconstruct project state in under a minute.

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Frameworks from Kim & Mauborgne for creating uncontested market space and making competition irrelevant. Use when reframing competitive strategy, escaping commoditization, designing a new category, or applying Strategy Canvas, ERRC, Six Paths, Three Tiers of Noncustomers, Buyer Utility Map, or Strategic Sequence. Includes selection-bias caveats and inline decline notes for iconic cases that later collapsed.

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Applies Geoffrey Moore's chasm-crossing strategy for B2B tech products moving from visionary early adopters to pragmatist mainstream. Use when a product has early traction but stalls before mainstream adoption, when planning a beachhead/niche strategy, when designing whole-product offerings, when positioning against established competitors, or when scaling from innovator usage to industry standard. Triggers include 'stuck between early adopters and mainstream', 'we need a beachhead', 'pragmatist customers won't buy', 'how do we go from 10 to 1000 customers'. NOT for PLG/freemium SaaS (Slack, Notion, Cursor), pure consumer apps, two-sided marketplaces, or AI-native products with bottoms-up viral adoption - their dynamics break the visionary-to-pragmatist sequence.

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Designs a deliberate sequence of offers (attraction, upsell, downsell, continuity) so a new customer generates enough cash within ~30 days to fund acquiring the next one - Alex Hormozi's client-financed acquisition. Use when customers buy once and never again, when CAC eats all the profit, when you can't afford to advertise profitably, when the business grows but cash shrinks, when you sell one product at one price, when deciding what to sell first or next, or when structuring upsells, downsells, payment plans, trials, and continuity. Covers the 30-day payback rule, attraction/upsell/downsell/continuity offer types, and cash-flow sequencing for validated markets.

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Build a WhatsApp marketing strategy — WhatsApp Business setup, broadcast campaigns, automated flows, customer service, drip sequences, and conversational marketing. Use when the user says "WhatsApp marketing", "WhatsApp Business", "WhatsApp campaigns", "WhatsApp broadcasts", "WhatsApp automation", "WhatsApp drip", "market on WhatsApp", "WhatsApp for business", "WhatsApp chatbot", "WhatsApp customer service", "WhatsApp API", "messaging marketing India", or wants to use WhatsApp as a marketing and customer communication channel. Especially relevant for brands in India, the Middle East, Southeast Asia, Brazil, and Africa.

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Use when the user asks about Vibe Motion, motion graphics, kinetic typography, animated text, brand animations, logo animations, infographic animation, presentation animation, data-driven video, or prompt-to-motion-graphic workflows. Vibe Motion is fundamentally different from video generation — it creates deterministic code-based motion graphics, not AI-predicted pixel sequences. Use this when the text/logo must stay perfectly crisp and editable (code). For a cinematic/kinetic AI-generated video ad built from a storyboard (pixel render, native audio), use higgsfield-motion-design instead.

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Plan and execute product launches with week-by-week timelines and channel-specific playbooks. Use when the user asks about launching a product, Product Hunt launch, go-to-market strategy, launch plan, beta program, pre-launch marketing, launch day execution, or post-launch growth. Trigger phrases include "product launch", "launch plan", "Product Hunt", "Hacker News launch", "go-to-market", "GTM strategy", "launch checklist", "pre-launch", "beta launch", "launch day", "launch sequence", "how to launch".

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Improve user onboarding flows to increase activation and retention. Use when asked to design welcome screens, setup wizards, product tours, onboarding checklists, or activation sequences. Trigger phrases: "onboarding flow", "user activation", "welcome screen", "product tour", "onboarding checklist", "first-run experience", "setup wizard", "aha moment", "time to value", "user onboarding", "activation rate".

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Advanced distributed patterns - event sourcing, CQRS, saga, stream processing, append-only log, exactly-once delivery, sequencer, double-entry ledger, erasure coding, order book, watermarks

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JTBD workflow classification and routing - ODI two-phase framework, five job types with workflow sequences, baseline type selection, workflow anti-patterns, and common recipes

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Use when responsive HTML email has to render correctly in every client — table-based structure, inline CSS, 600px max width, dark mode handling, quirks for Gmail, Apple Mail, Outlook and Yahoo, bulletproof buttons, and a pre-send test checklist, shipping a self-contained .html file to paste into Klaviyo, Mailchimp, HubSpot, or Brevo. Trigger on 'HTML email', 'code an email template', 'responsive email', 'why does my email break in Outlook', 'email dark mode is broken', 'the newsletter looks wrong on mobile'. Not for — sequence strategy and subject lines, see `14-email-marketing-global`; a web page, see `12-landing-page-brief-global`; brand colors and fonts, see `46-brand-guideline-global`.

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Use when the WHAT being sold needs work, not the price and not the copy — core promise, value stack, bonuses, guarantee and risk reversal, honest scarcity and urgency, tier packaging, upsell and downsell paths, and high-ticket or productized service structures. Trigger on 'design an offer', 'irresistible offer', 'value stack', 'add a guarantee', 'my offer is not converting', 'people say it is too expensive'. Also use when traffic and copy are fine and nobody is buying anyway. Not for — the number on the price tag, see `17-pricing-strategy-global`; the ad text selling it, see `05-ad-copy-global`; the page it sits on, see `12-landing-page-brief-global`; the launch sequence, see `59-go-to-market-global`.

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Use when the user needs email or lifecycle automation — welcome series, nurture, abandoned cart, re-engagement, broadcast, and transactional flows with subject lines, segmentation, cadence, and deliverability, plus legal variants: CAN-SPAM for US, GDPR opt-in for EU, PDPA for SEA, LGPD for LATAM. Covers Klaviyo, Mailchimp, and ActiveCampaign. Trigger on 'email marketing', 'welcome sequence', 'drip campaign', 'newsletter', 'abandoned cart emails', 'nobody opens our emails'. Not for — coding HTML that renders correctly in Outlook, see `49-html-email-template-global`; cold outbound to B2B prospects, see `33-b2b-lead-gen-global`; refer-a-friend loops, see `18-referral-program-global`.

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Use when the user wants a marketing image GENERATED or an image prompt written — personal brand portraits, logos and monograms, campaign key visuals, day-to-day social graphics, editorial art, infographics, web hero mockups, and quote graphics. Reads brand identity from project context, composes an on-brand prompt, generates via gpt-image-2 when an API key exists, otherwise outputs paste-ready prompts for DALL-E 3, MidJourney, Leonardo, or Ideogram. Trigger on 'design an image', 'make me a logo', 'MidJourney prompt', 'key visual for the campaign', 'generate a graphic for this post', 'I need a visual and have no designer'. Not for — briefing a human designer on a static, see `42-image-brief-global`; a slide sequence, see `43-carousel-brief-global`; the brand rules themselves, see `46-brand-guideline-global`; scoring a finished design, see `47-design-review-global`.

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Use when a campaign needs its full design asset list before anyone opens a tool — asset type, dimensions, channel, quantity, priority, owner, deadline, and status, with deadlines counted backward from launch day on a T-14 to D+1 timeline plus a naming convention. Trigger on 'campaign asset list', 'what does the designer need', 'list the design files', 'creative asset plan', 'how many banners do we need', 'the designer keeps asking what to make'. Not for — the spec for one individual image, see `42-image-brief-global`; a slide sequence, see `43-carousel-brief-global`; an urgent mid-campaign swap, see `48-quick-visual-brief-global`; resizing an existing master, see `50-asset-resize-global`.

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Use when a designer needs hands-on production direction inside a tool — Canva, Figma, or Adobe Express: which template to start from, the operating order, element-by-element mapping, grid and spacing, brand kit colors and fonts, export checklist, and the dos and do-nots. Trigger on 'Canva brief', 'Figma brief', 'production direction', 'how do I build this in Canva', 'layout direction for the designer', 'the junior designer needs step by step'. Not for — the creative concept for a static, see `42-image-brief-global`; the concept for a slide sequence, see `43-carousel-brief-global`; the brand rules being applied, see `46-brand-guideline-global`; adapting one master into every size, see `50-asset-resize-global`.

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Use when a specific campaign needs a brief the whole team can execute from — context, objective, audience, core message, creative direction, channels, deliverables, week-by-week timeline, approval gates, and risks. Trigger on 'campaign brief', 'creative brief', 'launch brief', 'brief the team on this campaign', 'we are running a promo next month', 'what is the plan for this campaign'. Also use when the user describes a promotion out loud and asks for something the team can actually run. Not for — the whole period plan, see `00-marketing-plan-global`; the list of design files needed, see `41-campaign-asset-list-global`; assigning work to one person, see `64-team-brief-global`; a new product launch sequence, see `59-go-to-market-global`.

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Use when ONE static image needs a full brief for a designer or photographer — visual objective, concept and mood, composition, overlay copy, colors and fonts read from the brand guideline, per-channel dimensions, deliverables, and approval criteria. Trigger on 'image brief', 'banner brief', 'thumbnail brief', 'brief for the designer', 'how should this graphic look', 'the design came back wrong again'. Also use when the user has a post idea and needs to explain the visual. Not for — a multi-slide sequence, see `43-carousel-brief-global`; tool-level production steps in Canva or Figma, see `45-design-tool-brief-global`; generating the image with AI, see `30-design-master-global`; an urgent same-day swap, see `48-quick-visual-brief-global`.

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讀取CSV文件，僅使用csv庫且不使用SequenceMatcher，計算第一列目標基因型與後續每一列基因型的相似度。

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基于历史数据利用统计分析方法预测下一组数字，严格遵守前5位(1-35)和后2位(1-12)的范围限制，输出简洁的预测结果。

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Use when a planned but unstarted phase should come off the roadmap. Removes the phase, renumbers the phases after it into a clean sequence, and commits the change as the historical record.

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