「driven」の検索結果

Test-driven development for behaviour a unit test cannot reach, by writing the expectation against the running app before writing the code. Declare the consequence first, watch it fail, implement, watch it pass. Use when building a user-facing feature, when the user asks for TDD on UI or full-stack work, when a unit test cannot express the outcome that matters, or when you want a red-green loop that runs against the real app instead of mocks.

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Check that a form actually rejects bad input: the error message renders, the submit button stays disabled, and no request goes out. Use when validation logic was written but never driven, when a "required" or pattern check looks right on screen but was never proven, or when a bug report says the form submitted invalid data anyway.

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Build reactive/event-driven C# with R3 (Cysharp's modern reimplementation of Reactive Extensions). Covers the Observable<T>/Observer<T> model, the OnErrorResume error contract, async dispatch with AwaitOperation, Task/IAsyncEnumerable integration, TimeProvider/FrameProvider scheduling, the concurrency contract, and how R3 differs from System.Reactive (Rx.NET).

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Quality control for IMC/MIBI data across pixel, channel, image, slide, and batch levels, covering Poisson-count SNR (cell-level Gaussian-mixture and empty-channel comparison), spillover-matrix QC (the three physical sources), drift and the missing EQ-bead analog, acquisition artifacts, and sample-of-origin batch effects. Use when deciding whether to keep or drop a channel, ROI, or slide, distinguishing a dim antibody from a failed one, reading a spillover matrix, or diagnosing batch-driven clustering before analysis.

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Calls significant loops from protein-directed and targeted 3C assays (HiChIP, PLAC-seq, Capture Hi-C/PCHi-C, ChIA-PET) where the contact background is peak-anchored and coverage-biased, so generic Hi-C loop callers (cooltools dots, Juicer HiCCUPS) use the wrong null. Covers FitHiChIP (config-driven coverage+distance-decay spline regression, peak-to-peak vs peak-to-all foreground, loose vs stringent background, coverage vs ICE bias), MAPS (positive Poisson regression on bias factors for PLAC-seq/HiChIP), hichipper (restriction-site-distance bias model + library QC), CHiCAGO (Delaporte two-component Brownian+technical background for asymmetric bait x other-end Capture Hi-C), the with/without separate-ChIP anchor decision, and differential loops via diffloop. Use when calling loops from HiChIP/PLAC-seq/Capture Hi-C, choosing FitHiChIP/MAPS/CHiCAGO, picking peak-to-all vs peak-to-peak, setting the loop FDR, supplying ChIP peaks as anchors, QCing a HiChIP library, or comparing loops between conditions.

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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.

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Infer transcription factor regulons from single-cell RNA-seq with pySCENIC by combining GRNBoost2 co-expression, cisTarget motif-enrichment pruning, and AUCell per-cell activity scoring. Covers the motif-pruning-as-directionality principle, regulon specificity scoring, run-to-run stability, and database/species matching. Use when identifying TF regulons, scoring TF activity per cell, finding master regulators of cell identity, or comparing regulon activity across conditions. For enhancer-driven multiomic GRNs see multiomics-grn; for bulk inference and VIPER protein-activity see grn-inference.

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Build genome-browser-style multi-track figures with pyGenomeTracks (config-driven), Gviz (R), and IGV batch screenshotting. Covers BigWig coverage tracks, BED/peak overlays, gene-model rendering, Hi-C matrix tracks, BedPE link arcs, spike-in-aware normalization, and the bamCoverage --normalizeUsing trap. Use when producing publication figures of genomic loci with stacked aligned tracks (coverage, peaks, genes, interactions) for ChIP-seq, ATAC-seq, RNA-seq, Hi-C, or generic locus visualization.

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Download genome assemblies, gene records, and ortholog data from NCBI using the modern Datasets v2 CLI (replaces assembly_summary.txt scraping and many EFetch workflows). Use when bulk-pulling genome assemblies, gene metadata across species, ortholog sets, or BLAST databases; when E-utilities are too slow for genome-scale work; or when automatic checksum verification, parallel download, and clean accession-driven retrieval are required. Encodes the JSON-lines output format, dataformat conversion, --dehydrated for cloud workflows, and when Datasets is/isn't the right tool.

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Prioritizes rare-disease variants from trio/quad WES/WGS with de novo (DeNovoGear, Triodenovo), compound-heterozygous phasing (WhatsHap), mosaic VAF tiering, phenotype-driven ranking (Exomiser, Phen2Gene, AMELIE), ClinGen gene-disease validity gating, and ACMG SF v3.2 secondary findings reporting. Use when running diagnostic exome / genome pipelines, identifying candidate Mendelian disease genes, screening for incidental findings, or auditing VUS reclassification cycles. The ACMG/AMP classification framework (PVS1 decision tree, Pejaver PP3/BP4 calibration, Tavtigian point system) is in clinical-databases/acmg-classification.

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Resolve the architecture of focal oncogene amplifications — extrachromosomal DNA (ecDNA), breakage-fusion-bridge (BFB) cycles, homogeneously staining regions (HSR), and linear amplification — from whole-genome sequencing with AmpliconArchitect, the AmpliconSuite pipeline, and AmpliconClassifier. Covers copy-number seed selection, breakpoint-graph reconstruction, balanced-flow optimization, ecDNA classification, and the limits of depth-only amplification calls. Use when a focal amplification needs structural characterization, when distinguishing ecDNA from chromosomal amplification, suspecting ecDNA-driven oncogene amplification or therapy resistance, or selecting copy-number seeds for amplicon reconstruction.

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Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

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Test whether two or more traits share a causal variant at a locus using Bayesian colocalization (coloc.abf, coloc.susie, HyPrColoc, moloc, eCAVIAR, SMR/HEIDI, PWCoCo, SharePro). Use when integrating GWAS with eQTL/sQTL/pQTL/mQTL, distinguishing shared causal variants from LD-driven coincidence, handling allelic heterogeneity, choosing between single-causal vs multi-causal methods, picking PP.H4 thresholds, running sensitivity over p12, or harmonising summary statistics for colocalization.

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Build, review, or improve Core Data persistence in apps that have not adopted SwiftData. Use when working with NSManagedObject subclasses, NSFetchedResultsController for list-driven UI, NSBatchInsertRequest / NSBatchDeleteRequest / NSBatchUpdateRequest for bulk operations, NSPersistentHistoryChangeRequest for persistent history tracking and multi-target sync, NSStagedMigrationManager for staged schema migrations (iOS 17+), NSCompositeAttributeDescription for composite attributes (iOS 17+), or when integrating Core Data threading with Swift Concurrency. For Core Data + SwiftData coexistence or migration, see the swiftdata skill instead.

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onboarding workflow for creating datasets and applications in Viking AI Search. Supports one-time import from local files (JSON, JSONL, CSV) and MySQL databases, plus scheduled incremental sync for append-only JSONL files and MySQL. All sources are first exported to a bootstrap JSONL file; backend-driven schema inference handles detection, and optional background sync keeps the dataset up to date as new data arrives.

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Use for new frontend applications, dashboards, games, creative websites, hero sections, and visually driven UI from scratch, or when the user explicitly asks for a redesign/restyle/modernization. Builds from clean, airy, high-taste, readable image-generated concept design with section-specific references, faithful implementation, and browser testing.

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AWS EventBridge serverless event bus for event-driven architectures. Use when creating rules, configuring event patterns, setting up scheduled events, integrating with SaaS, or building cross-account event routing.

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AWS Lambda serverless functions for event-driven compute. Use when creating functions, configuring triggers, debugging invocations, optimizing cold starts, setting up event source mappings, or managing layers.

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TikTok Shop analytics and performance tracking. Video metrics, live selling data, affiliate performance, advertising analytics, and business intelligence. Use when the user asks about TikTok Shop analytics, performance tracking, metrics analysis, or data-driven optimization.

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Backend API design, database architecture, microservices patterns, and test-driven development. Use for designing APIs, database schemas, or backend system architecture.

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Triage, repair, and close MCP attribution issues from the local report API with evidence-driven decisions and isolated Worktrunk worktrees. Use this skill when Codex needs to process `tool` attribution issues and skills-related attribution issues, inspect related runs, decide whether the issue is actionable in `mcp/src` or `config/source/skills`, update attribution fields as `owner=codex`, and then complete the fix loop through GitHub issue tracking, worktree-based code changes, PR submission, and follow-up iteration when the problem is repairable.

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Orchestrate iOS screenshot automation with xcodebuild/simctl for build-run, AXe for UI actions, JSON settings and plan files, Koubou-based framing (`asc screenshots frame`), and screenshot upload (`asc screenshots upload`). Use when users ask for automated screenshot capture, AXe-driven simulator flows, frame composition, or screenshot-to-upload pipelines.

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Suggest concrete optimizations for Claude Code usage based on historical session data. Covers cost reduction, speed improvement, error prevention, and workflow efficiency. Use for data-driven optimization planning.

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Build Google Apps Script automation for Sheets and Workspace. Custom menus, triggers (onEdit / time-driven / form submit), dialogs, sidebars, email batches, PDF export, external API. Use whenever the user wants to automate a Google Sheet, build a Sheets menu / sidebar / dialog, hit a Sheets row from email or a webhook, schedule a Sheets workflow, or asks 'how do I script this in Sheets'.

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