Open science notebook for documenting experimental procedures
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Open science notebook for documenting experimental procedures
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Integration with protocols.io experimental protocol platform
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Designs production-grade ML pipeline infrastructure with experiment tracking, Kubeflow/Airflow DAGs, feature store schemas, model registries, and automated retraining workflows.
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Feature flag strategy, lifecycle, and operations. Use when designing a flag taxonomy, planning a gradual rollout, building kill switches, auditing flag debt, defining governance, running progressive delivery, or rolling back via flags.
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Data science across machine learning, statistical modeling, and experimentation. Use when selecting ML algorithms, engineering features, designing A/B tests, evaluating model performance, or building predictive pipelines.
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Chaos engineering: hypothesis-driven fault injection to surface weakness before users do. Use when designing a chaos experiment, planning a gameday, choosing what to inject, computing blast radius, or building a chaos maturity model.
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When the user wants to set up a recurring, self-running marketing workflow — a repeatable loop an AI agent runs on a cadence (weekly, daily, on a trigger) rather than a one-off task. Also use when the user mentions 'marketing loop,' 'recurring marketing workflow,' 'automate my marketing,' 'marketing on autopilot,' 'weekly marketing review,' 'ad fatigue check,' 'content refresh loop,' 'churn watch,' 'ranking drop alert,' 'always-on marketing,' 'marketing automation workflow,' or 'run this every week.' Use this to pick, adapt, and schedule an ongoing marketing loop that orchestrates the other marketing skills. For one-off marketing ideas, see marketing-ideas. For the experimentation loop specifically, see ab-testing.
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Triage improvement work and run or resume accepted measured loops in a local project. Architecture, documentation, UX, product study, open research, taste, and one-shot fixes stay direct unless the user explicitly requests repeated measurement with a complete experiment contract.
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EXPERIMENTAL — mutation testing with muter to measure whether tests actually assert anything: mutants that survive reveal assertion-free coverage. Advisory report only, never a merge gate. Use on engine/logic targets when coverage numbers look good but bugs still slip through.
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sechm provides a simple interface between SummarizedExperiment objects and the ComplexHeatmap package. It enables plotting annotated heatmaps from SE objects, with easy access to rowData and colData columns, and implements a number of features to make the generation of heatmaps easier and more flexible. These functionalities used to be part of the SEtools package.
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omicsViewer visualizes ExpressionSet (or SummarizedExperiment) in an interactive way. The omicsViewer has a separate back- and front-end. In the back-end, users need to prepare an ExpressionSet that contains all the necessary information for the downstream data interpretation. Some extra requirements on the headers of phenotype data or feature data are imposed so that the provided information can be clearly recognized by the front-end, at the same time, keep a minimum modification on the existin
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ProteoDisco is an R package to facilitate proteogenomics studies. It houses functions to create customized (variant) protein databases based on user-submitted genomic variants, splice-junctions, fusion genes and manual transcript sequences. The flexible workflow can be adopted to suit a myriad of research and experimental settings.
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Monocle performs differential expression and time-series analysis for single-cell expression experiments. It orders individual cells according to progress through a biological process, without knowing ahead of time which genes define progre
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We present a statistical simulator, scDesign3, to generate realistic single-cell and spatial omics data, including various cell states, experimental designs, and feature modalities, by learning interpretable parameters from real data. Using a unified probabilistic model for single-cell and spatial omics data, scDesign3 infers biologically meaningful parameters; assesses the goodness-of-fit of inferred cell clusters, trajectories, and spatial locations; and generates in silico negative and positi
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SpotClean is a computational method to adjust for spot swapping in spatial transcriptomics data. Recent spatial transcriptomics experiments utilize slides containing thousands of spots with spot-specific barcodes that bind mRNA. Ideally, unique molecular identifiers at a spot measure spot-specific expression, but this is often not the case due to bleed from nearby spots, an artifact we refer to as spot swapping. SpotClean is able to estimate the contamination rate in observed data and decontamin
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Spatially-aware quality control (QC) software for both spot-level and artifact-level QC in spot-based spatial transcripomics, such as 10x Visium. These methods calculate local (nearest-neighbors) mean and variance of standard QC metrics (library size, unique genes, and mitochondrial percentage) to identify outliers spot and large technical artifacts. Scales linearly with the number of spots and is designed to be used with 'SpatialExperiment' objects.
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standR is an user-friendly R package providing functions to assist conducting good-practice analysis of Nanostring's GeoMX DSP data. All functions in the package are built based on the SpatialExperiment object, allowing integration into various spatial transcriptomics-related packages from Bioconductor. standR allows data inspection, quality control, normalization, batch correction and evaluation with informative visualizations.
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The sva package contains functions for removing batch effects and other unwanted variation in high-throughput experiment. Specifically, the sva package contains functions for the identifying and building surrogate variables for high-dimensi
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SpatialFeatureExperiment (SFE) is a new S4 class for working with spatial single-cell genomics data. The voyager package implements basic exploratory spatial data analysis (ESDA) methods for SFE. Univariate methods include univariate global spatial ESDA methods such as Moran's I, permutation testing for Moran's I, and correlograms. Bivariate methods include Lee's L and cross variogram. Multivariate methods include MULTISPATI PCA and multivariate local Geary's C recently developed by Anselin. The
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Provides large-scale single-cell omics data manipulation using Genomic Data Structure (GDS) files. It combines dense and sparse matrices stored in GDS files and the Bioconductor infrastructure framework (SingleCellExperiment and DelayedArray) to provide out-of-memory data storage and large-scale manipulation using the R programming language.
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This package aims to integrate GWAS-derived SNPs and coexpression networks to mine candidate genes associated with a particular phenotype. For that, users must define a set of guide genes, which are known genes involved in the studied phenotype. Additionally, the mined candidates can be given a score that favor candidates that are hubs and/or transcription factors. The scores can then be used to rank and select the top n most promising genes for downstream experiments.
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Fit linear models to overdispersed count data. The package can estimate the overdispersion and fit repeated models for matrix input. It is designed to handle large input datasets as they typically occur in single cell RNA-seq experiments.
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Save MultiAssayExperiments to h5mu files supported by muon and mudata. Muon is a Python framework for multimodal omics data analysis. It uses an HDF5-based format for data storage.
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hoodscanR is an user-friendly R package providing functions to assist cellular neighborhood analysis of any spatial transcriptomics data with single-cell resolution. All functions in the package are built based on the SpatialExperiment object, allowing integration into various spatial transcriptomics-related packages from Bioconductor. The package can result in cell-level neighborhood annotation output, along with funtions to perform neighborhood colocalization analysis and neighborhood-based ce
日本語の概要は準備中です。原文の説明を表示しています。