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概要と使いどころ
CraftedWell brand guidelines for presentations and documents. Use this skill whenever creating or styling documents (docx, pdf) or presentations (pptx) for CraftedWell. Apply warm, artisanal aesthetic with chocolate/caramel color palette, Georgia headings, and Arial body text.
日本語の概要は準備中です。原文の説明を表示しています。
Generate pytest tests for Typer CLI commands. Includes fixtures (temp_storage, sample_data), CliRunner patterns, confirmation handling (y/n/--force), and edge case coverage. Use when user asks to "write tests for", "test my CLI", "add test coverage", or any CLI + test request.
日本語の概要は準備中です。原文の説明を表示しています。
Provides checklist for reviewing Typer CLI command implementations. Covers structure, Annotated syntax, error handling, exit codes, display module usage, destructive action patterns, and help text conventions. Use when user asks to review/check/verify a CLI command, wants feedback on implementation, or asks if a command follows best practices.
日本語の概要は準備中です。原文の説明を表示しています。
Help users build a strategic professional network and public audience by transitioning from passive learning to active, value-driven contribution.
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Help users build and scale a high-velocity growth experimentation engine that prioritizes impact and fosters a culture of rapid learning.
日本語の概要は準備中です。原文の説明を表示しています。
Observability dashboard. Session stats, agent tracking, hook performance, learning health. Triggers: metrics, stats, dashboard, observability.
日本語の概要は準備中です。原文の説明を表示しています。
Audit whether prior learnings actually fired, then install mechanisms for this run's recurrences. No finding without an install path and a firing test. Triggers: retrospective, reflect, what did we learn, patterns, post-mortem, why does this keep happening.
日本語の概要は準備中です。原文の説明を表示しています。
中文学习教练技能。用于学习编程、英语、设计、产品、AI、数学或任何技能时，先诊断水平，再用讲解、练习、反馈、复习的循环推进。触发语包括"进入学习模式""我想学""带我练""帮我制定学习计划""像教练一样教我"。
日本語の概要は準備中です。原文の説明を表示しています。
基于 instinct 的持续学习系统，通过 hooks 观察会话，创建带置信度评分的 atomic instincts， 并将高置信度 instinct 演进为 skills/commands/agents。v2.1 增加项目级 instincts 防止跨项目污染。
日本語の概要は準備中です。原文の説明を表示しています。
Capture durable session learnings, stage for human promotion to 05-knowledge/lizard, and propose skill/CLAUDE.md patches. Triggered by /harvest, SessionEnd hook staging, or nightly enhance. Never writes durable knowledge without your approval.
日本語の概要は準備中です。原文の説明を表示しています。
Use when positioning an AISTATS submission against AI, machine-learning, statistics, and uncertainty literature, including arXiv preprints, workshop versions, concurrent submissions, prior conference versions, PMLR archival status, and the two-community citation coverage that AISTATS reviewers expect.
日本語の概要は準備中です。原文の説明を表示しています。
Use when preparing an accepted AAMAS paper for the IFAAMAS open-access camera-ready, covering author de-anonymization, proceedings metadata, two-column reflow of game figures and learning curves, resolving rebuttal-stage promises, registration, in-person presentation, and the public code and environment release for a multiagent paper.
日本語の概要は準備中です。原文の説明を表示しています。
Use when positioning an AAMAS submission against multiagent, game-theory, and reinforcement-learning literature spread across AAMAS, AAAI, IJCAI, NeurIPS, ICML, EC, and JAAMAS, including arXiv and workshop versions, concurrent submissions, prior conference versions, and the cross-community citation coverage AAMAS reviewers expect.
日本語の概要は準備中です。原文の説明を表示しています。
Diagnose Meta Ads campaign performance and account gaps using Meta's actual system mechanics — including customer-journey coverage, Breakdown Effect, Learning Phase, Auction Overlap, Pacing, and Creative Fatigue. Use for performance diagnosis, account audits, full-funnel or TOF/MOF/BOF gap analysis, deciding what to test or create next, and producing novice-friendly recommendations without forcing every campaign or ad into a funnel stage.
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Calls germline small variants (SNPs and indels) from Oxford Nanopore and PacBio HiFi long reads with Clair3, a two-stage (pileup + full-alignment) deep-learning caller, selecting the chemistry- and basecaller-version-matched model, enabling read-based phasing, and benchmarking against GIAB with stratification. Covers why the model string is the experiment (no auto-detection, silent degradation on mismatch), why ONT homopolymer/STR indels are the residual error whole-genome F1 hides, and the somatic/trio/RNA boundary to the ClairS/Clair3-Trio family. Use when calling germline SNVs/indels from ONT or HiFi BAMs, choosing a Clair3 model, phasing variants, or benchmarking long-read calls.
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Detects m6A modifications from Oxford Nanopore direct-RNA-seq (DRS) signal using m6Anet (multiple-instance-learning over DRACH 5-mer signal). Covers the upstream pipeline (Dorado/Guppy basecalling -> minimap2 map-ont -> nanopolish eventalign -> m6anet dataprep -> m6anet inference), per-site vs per-read probability including the mod_ratio stoichiometry column, the DRACH-only constraint, minimum-coverage thresholds (20-50 reads/site), multi-condition comparison via xPore/Nanocompore/ELIGOS, Dorado native modification calling (RNA004, 2024+), and the cDNA-vs-DRS distinction (cDNA Nanopore CANNOT detect modifications). Use when calling m6A from ONT DRS without immunoprecipitation, choosing m6Anet vs xPore vs Nanocompore vs ELIGOS vs Dorado native, interpreting probability_modified vs mod_ratio vs per-read probabilities, deciding between m6Anet (known DRACH sites) and Dorado/Remora (genome-wide screening), pinning RNA002 vs RNA004 chemistry and basecaller versions, or troubleshooting eventalign/dataprep failures.
日本語の概要は準備中です。原文の説明を表示しています。
Predicts protein-coding gene structures (exons, introns, UTRs) in eukaryotic genomes with BRAKER3 (RNA-seq + protein evidence), BRAKER1/BRAKER2, GALBA (protein-only), Funannotate (fungi), GeMoMa (homology projection), or Helixer/Tiberius (deep-learning ab initio). Covers the evidence-first tool decision, mandatory soft-masking, the training-set-quality-dominates principle, OrthoDB clade-partition selection, the one-isoform-per-locus and missing-UTR traps, merge/split errors, and reference bias against orphan genes. Use when annotating a newly assembled eukaryotic genome, choosing a gene-prediction pipeline based on available evidence, or diagnosing a poor annotation.
日本語の概要は準備中です。原文の説明を表示しています。
Map N6-methyladenosine (m6A) RNA modifications at single-nucleotide resolution using miCLIP (Linder 2015), miCLIP2 + m6Aboost machine learning (Kortel 2021), GLORI (Liu 2023, antibody-free chemical conversion), DART-seq (Meyer 2019, APOBEC1-YTH fusion), m6Anet (nanopore direct RNA), or MeRIP-seq with calibration. Use when distinguishing antibody-based from antibody-free m6A detection methods, applying the DRACH motif constraint, reconciling cross-method disagreements (DART 44% in DRACH vs GLORI), or detecting m6Am at the cap.
日本語の概要は準備中です。原文の説明を表示しています。
Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
日本語の概要は準備中です。原文の説明を表示しています。
Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.
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Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.
日本語の概要は準備中です。原文の説明を表示しています。
Integrate Core ML models in iOS apps for on-device machine learning inference. Covers model loading (.mlmodel, .mlpackage, .mlmodelc), predictions with auto-generated classes and MLFeatureProvider, compute unit configuration (CPU, GPU, Neural Engine), MLTensor, VNCoreMLRequest, MLComputePlan, multi-model pipelines, and deployment strategies. Use when loading Core ML models, making predictions, configuring compute units, or profiling model performance.
日本語の概要は準備中です。原文の説明を表示しています。
This skill should be used when user asks to "improve my mAP", "why is my model overfitting", "my training is diverging", "read my results.csv", "interpret my training curves", "my AP50 is good but AP50-95 is bad", "my recall is low", "how do I pick learning rate", "which augmentations should I use", "should I use a bigger model", "tune hyperparameters", or asks how to train YOLO26 for detection, instance or semantic segmentation, pose, OBB, classification, or depth.
日本語の概要は準備中です。原文の説明を表示しています。