「lora」の検索結果

Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Explore goals, constraints, and alternative approaches before choosing a design. Use when the user requests ideation or design exploration.

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Simulate transcription factor perturbation effects on cell state in silico with CellOracle and Dynamo, and predict transcriptional responses to genetic perturbations with GEARS, scGen, and CPA. Covers the direction-not-magnitude principle, local-linear validity, the GRN/velocity error it inherits, baseline discipline (mean and additive baselines), and the validation gap. Use when predicting TF knockout or overexpression effects, ranking driver TFs for fate transitions, or planning perturbation experiments. For GRN construction see multiomics-grn; for experimental Perturb-seq see single-cell/perturb-seq.

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Build enhancer-driven gene regulatory networks (eGRNs) by integrating single-cell RNA-seq and ATAC-seq using SCENIC+, CellOracle base GRNs, Pando, FigR, DIRECT-NET, TRIPOD, and scMEGA. Covers the accessibility-defines-enhancers principle, peak-to-gene linking and its cell-composition confound, the paired-vs-unpaired decision, and TF-region-gene eRegulon triplets. Use when analyzing 10x multiome or paired/unpaired scRNA+scATAC to infer cis-regulatory GRNs. For RNA-only regulons see scenic-regulons; for in silico TF perturbation see perturbation-simulation.

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Visualize biological networks (PPI, gene-regulatory, co-expression, pathway) with layout algorithm choice (ForceAtlas2, Fruchterman-Reingold, Kamada-Kawai, hive plots), edge bundling, community-based coloring, and reproducible seeds using NetworkX, PyVis, igraph, and Cytoscape automation. Use when rendering biological networks for static publication, interactive HTML exploration, or Cytoscape-format export.

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Designs novel molecules using REINVENT 4 (de novo, scaffold decoration, linker design, R-group, molecular optimization), MolMIM, Diffusion-based generators (DiGress, DiffSMol), and JT-VAE with explicit handling of multi-parameter optimization (MPO), goal-directed scoring functions, transfer/reinforcement/curriculum learning, synthetic accessibility scoring, and chemical space exploration vs exploitation. Use when designing new chemical matter against a target, decorating a scaffold, linking fragments, or optimizing a hit for multiple ADMET / activity properties simultaneously.

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Performs logistic regression for clinical trial outcomes (binary, ordinal, multinomial) with marginal-vs-conditional estimand reporting per FDA 2023 covariate adjustment guidance, g-computation/standardisation for marginal effects, modified Poisson for RR, Brant test for proportional odds, Firth penalty for separation, and Hauck-Donner detection. Use when modeling binary or ordinal endpoints in confirmatory or exploratory clinical trials.

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Tests associations between categorical variables in clinical data using chi-square, Fisher's exact, Boschloo, Cochran-Mantel-Haenszel, and modern McNemar variants with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen). Use when analyzing categorical outcomes, paired binary endpoints, or testing treatment-outcome independence in confirmatory or exploratory clinical trials.

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Hand-drawn paper-wireframe template — white paper background, monochromatic ink palette, SVG turbulence "wobble" filters for pen-quiver authenticity, handwritten fonts (Caveat / Kalam / Ma Shan Zheng / Long Cang), wavy dividers, sketch-rect overlays, marginalia annotations. For PRD illustrations, IA flow docs, low-fidelity layout exploration, "draft / not final" stakeholder communication. Three skeletons (single-page editorial / app multi-screen flow / IA sitemap) — pick one up front based on the artifact, do NOT inherit only the brush strokes.

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Produce a deterministic, read-only evidence map of the repository for SDD Composy (languages, manifests, commands, modules, boundaries, staleness) and publish the context bundle only on request. Use before a PRD or TechSpec, or when the map is stale — 'mapear o repositório', 'atualizar o contexto do código', 'what does this codebase look like for SDD'. Do NOT use for architecture decisions, code review, or repository exploration without an SDD workspace.

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Design isolated repeatable automation, distinguish interactive browser exploration, and handle flaky results through evidence and reproduction.

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Execute an explicitly authorized exploratory charter and record notes, findings, evidence, and follow-up without claiming false coverage.

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Design shotgun: generate multiple AI design variants, open a comparison board, collect structured feedback, and iterate. Standalone design exploration you can run anytime. Use when: "explore designs", "show me options", "design variants", "visual brainstorm", or "I don't like how this looks". Proactively suggest when the user describes a UI feature but hasn't seen what it could look like. (gstack)

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Read-only file search and codebase exploration specialist. Use when you need to find files by pattern, search code with regex, navigate unfamiliar codebases, or understand code architecture without making changes.

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Multi-agent exploration and task delegation for complex areas of interest. Use when you need to deeply explore a codebase area, gather information from multiple perspectives, or delegate parallel research tasks for comprehensive analysis.

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DALL-E 3 image generation workflow for this repo MCP server. Use for dalle3, DALL-E 3, OpenAI image generation, concept art, UCUF reference exploration, UI icon, badge, card art, prompt drafting, and saving generated images to local files under artifacts/ui-source or other workspace paths.

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GPT Image 2 image generation workflow for this repo MCP server. Use for gpt-image-2, OpenAI image generation, concept art, UCUF reference exploration, UI icon, badge, card art, prompt drafting, transparent-background asset drafts, and saving generated images to local files under artifacts/ui-source or other workspace paths.

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Orchestrator for the pre-decision business-idea lifecycle — generate ideas, model them, evaluate them, validate them with customers, and only then hand off to product-soul / brainstorming. Routes through `idea-generation`, `business-modeling`, `idea-evaluation`, and `customer-discovery`. Load when the user asks to explore business ideas, find a startup idea, evaluate a venture, validate an idea, says "what business should I start", "should I build this", "is this a good business", "I have a startup idea", "evaluate this venture", "model this business", "validate this idea", "Mom Test this", "Lean Canvas this", "Business Model Canvas", "Value Proposition Canvas", "go/no-go on this idea". Pre-decision suite — once one idea is committed, hands off to `product-soul`. Does NOT design features (use `brainstorming`) or audit built products (use `reality-check`).

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Score an unbuilt business idea on desirability, viability, feasibility, distribution wedge, why-now, founder-market-fit, market size, alternatives, defensibility, capital intensity, and regulatory/ethical risk — and return a GO / ITERATE / KILL verdict with kill criteria and a next kill test. Load when the user asks to evaluate a business idea, score a startup idea, screen an idea, decide whether to pursue this venture, do an idea review, or says "is this a good business idea", "should I build this", "evaluate this startup", "screen this idea", "go/no-go on this idea", "kill or pursue". Sub-skill of `venture-exploration`. Calls `fermi` for sizing, `assumption-mapping` for hidden beliefs, optional `pre-mortem` / `adversarial-hat` for high-stakes ideas. Does NOT evaluate built products — for that use `reality-check`.

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Generate 5–10 business idea candidates from a blank page or a founder's domain context — using pain mining, jobs-to-be-done, trend × capability mapping, constraint relaxation, adjacency search, and founder-market-fit prompts. Each candidate is a structured idea card (segment, JTBD, current alternative, why-now, distribution wedge, monetisation, "feels like"). Load when the user asks to generate business ideas, brainstorm startup ideas, find ideas to work on, says "what business should I start", "give me startup ideas", "I don't know what to build", "ideate ventures", "blank-page idea generation", "find me a startup idea", "explore business opportunities". Sub-skill of `venture-exploration`. Hard-bans "Uber for X" / "AI for X" with no specific JTBD, "everyone" segments, and idea cards missing any of the 7 required fields. Does NOT design or evaluate ideas generated — for that use `idea-evaluation`.

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Pick the right business-model canvas (Lean Canvas, Business Model Canvas, or Value Proposition Canvas) for the stage and fill it with specifics — one segment, one primary canvas, top-3 assumptions, no fluff in the moat or channel boxes. Load when the user asks to fill a business model canvas, lean canvas, value proposition canvas, model this business, map the business model, says "fill the BMC", "make a Lean Canvas", "Value Proposition Canvas for this", "model this idea", "what's the business model", "design the business model". Sub-skill of `venture-exploration`. Hard-bans "everyone" segments, generic channels ("SEO/social/content/ads"), and "unfair advantage = AI/data/network effects" with no concrete asset. Does NOT score viability — for that use `idea-evaluation`.

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Run Mom Test–style customer-discovery interviews to validate or kill an unbuilt idea — generate a non-leading interview guide, conduct or coach the conversations, and synthesize signal vs compliments. Load when the user asks to do customer discovery, run problem interviews, validate an idea with users, run a Mom Test, design an interview guide, or says "talk to customers", "validate the problem", "interview users", "Mom Test this", "did real users want it", "synthesize my interviews", "I just talked to N people". Sub-skill of `venture-exploration`. Hard-bans "would you use this?", solution-pitching, friend/family-only ICP, and treating compliments as validation. Calls `secure-*` before synthesizing any pasted external transcripts.

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Create stunning, animation-rich HTML presentations from scratch or by converting PowerPoint files. Use when the user wants to build a presentation, convert a PPT/PPTX to web, or create slides for a talk/pitch. Helps non-designers discover their aesthetic through visual exploration rather than abstract choices.

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Systematic exploratory QA testing of web applications — find bugs, capture evidence, and generate structured reports

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