837 件 ・ 関連度順
概要と使いどころ
Drafts jurisdiction-compliant U.S. Articles of Incorporation for corporate entity formation. Analyzes formation documents, term sheets, and cap tables to produce a filing-ready charter with name, purpose, capital structure, registered agent, and governance provisions. Use when forming a new corporation, drafting a charter document, or structuring equity for venture-backed or closely held companies.
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Generate structured release notes from git history and closed issues within Claude Code session
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Use ruLake as the agent's working memory. Auto-invoke /rulake-memory:memory-recall when the agent needs to look up something it might already know; auto-invoke /rulake-memory:memory-remember after the agent learns or decides something worth pinning. Closes the self-learning loop without requiring the agent author to wire it explicitly.
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Run a feature end to end — scout the code, plan it, build it, and keep a session file so a closed terminal doesn't lose the thread.
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Close out a session — summarise what changed, capture what was learned, and prepare the commit.
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Resolve a verified cluster of Rembric issues from causal root to evidence-gated closure. Use after systemic triage identifies a shared root, or when the user asks to attack issues at the root, create a mechanism map, plan a deletion-first fix, or close a fixed/stale issue cluster. Use `diagnose` for a single defect whose reproduction is not yet established.
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Controls error rates across thousands of simultaneous tests in genomics discovery using false-discovery-rate methods (Benjamini-Hochberg 1995; Benjamini-Yekutieli 2001 for arbitrary dependence; Storey q-value with pi0 estimation; local FDR; independent filtering Bourgon 2010; covariate-weighted FDR via IHW Ignatiadis 2016), plus family-wise error control (Bonferroni, Holm) and the GWAS genome-wide threshold. Covers the FDR-versus-FWER choice as the discovery-versus-confirmatory distinction, the dependence assumptions behind BH (PRDS) versus BY, pi0 estimation, the independent-filtering and false-coverage-rate traps, and reproducibility ranking via IDR (Li 2011). Use when correcting p-values from genome-wide tests, choosing between BH/BY/q-value/Bonferroni, setting an FDR threshold, applying IHW or independent filtering, or interpreting q-values. For confirmatory trials with few pre-specified endpoints (closed testing, graphical/gatekeeping), see clinical-biostatistics/multiplicity-graphical.
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Calculates statistical power for high-dimensional genomics experiments (bulk RNA-seq, scRNA-seq, ATAC-seq, ChIP-seq, methylation, proteomics) under negative-binomial count models using RNASeqPower, PROPER, and simulation via powsimR, distinguishing per-gene from marginal (transcriptome-wide) power, the role of mean expression and dispersion, and the sequencing-depth-versus-replicate tradeoff. Covers simulation as the honest default for overdispersed counts, FDR-aware average power versus single-test power, observed/post-hoc power as an anti-pattern, and the winner's-curse / Type-S / Type-M consequences of underpowering. Use when planning replicate number for a sequencing experiment, deciding whether to add depth or samples, choosing closed-form versus simulation power, estimating power from pilot dispersions, or justifying replication in a grant. For clinical-trial power see clinical-biostatistics/power-and-sample-size; for the inverse sample-size question see experimental-design/sample-size.
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Build and analyze pangenomes for prokaryotes (Panaroo, PPanGGOLiN, PEPPAN, GET_HOMOLOGUES, anvi'o pangenomics) and eukaryotes (Minigraph-Cactus, PGGB, vg pangenome graphs). Implement Tettelin core/accessory/cloud genome decomposition (Tettelin 2005), Heap's law open/closed pangenome modeling, gene presence/absence GWAS (Scoary, pyseer), pangenome graph variant calling (vg, PanGenie), and structural-variation graph indexing. Use when assembling species- or genus-level pan-gene catalogs, separating core from accessory/shell/cloud genes, testing gene-content associations with phenotypes, building pangenome graphs from haplotype-resolved assemblies, calling SVs from pangenome graphs, or selecting between bacterial-pangenome and eukaryotic-pangenome workflows.
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Build whole-genome alignments using Progressive Cactus (Armstrong 2020 reference-free clade-level WGA), Minigraph-Cactus (Hickey 2024 pangenome-aware), LASTZ chain/net (UCSC pipeline), MUMmer4 (Marçais 2018 pairwise), minimap2 -x asm5/10/20 (Li 2018 fast pairwise), AnchorWave (Song 2022 WGD-aware), and Mauve / progressiveMauve (bacterial). Operates the HAL toolkit (Hickey 2013) for downstream extraction including halSynteny, halLiftover, halBranchMutations, and hal2maf. Use when constructing multi-species alignments for comparative-annotation projection (TOGA), synteny detection, conservation analyses (phyloP / PhastCons), or pangenome graph construction; selecting between reference-free (Cactus) and reference-anchored (LASTZ chains/nets) approaches; tuning sensitivity for closely vs distantly related genomes; or producing HAL files for genome-wide downstream tools.
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Implements multiplicity control for confirmatory clinical trials using graphical procedures (Bretz-Maurer-Hommel), gatekeeping (parallel, serial, mixed), Hochberg/Hommel/Holm with PRDS, and the closed-testing principle (Marcus-Peritz-Gabriel; Goeman 2021 admissibility). Covers FDA Multiple Endpoints Final Guidance (October 2022), graphical procedures via R gMCP, primary + key-secondary + subgroup hierarchies, and FWER vs FDR distinction. Use when designing the multiplicity strategy for confirmatory trials with multiple primary or key secondary endpoints.
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Recommends use of hybrid closed-loop pump rather than insulin pump with CGM (without algorithm) or multiple daily injections with CGM for pregnant individuals with type 1 diabetes. Triggered when deciding on insulin delivery methods for pregnant patients with type 1 diabetes.
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Read-only view of the execution roadmap. Lists every epic with its per-status tallies, nests the still-open rows beneath their epic, collapses wholly-finished epics into one rollup line, and closes by naming the next planned task in file order. Four verbs — `list` (the reader's view), `tasks` and `epics` (filterable row and epic queries), `next` (the first planned task). Invoke any time to see what is left to build. Not a workflow phase; never writes; never starts or commits work.
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Expert-level topology knowledge. Use when working with topological spaces, continuity, compactness, connectedness, metric spaces, homeomorphisms, fundamental groups, homology, manifolds, or algebraic topology. Also use when the user mentions 'open set', 'closed set', 'compactness', 'connectedness', 'homeomorphism', 'homotopy', 'fundamental group', 'covering space', 'manifold', 'homology', 'Euler characteristic', or 'topological invariant'.
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Delete local branches that have been merged or whose PRs are closed/stale
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Review a written plan or design doc through a designer's lens before implementation - seven passes over information architecture, interaction states, emotional arc, AI-slop risk, design-system alignment, responsive and accessibility coverage, and unresolved decisions. Each dimension is rated 0-10 with an explicit statement of what would make it a 10, then the plan is edited to get there. Use when a plan has a UI surface and you want the design gaps closed before code is written. Not for auditing a live site.
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Babysit a GitHub pull request after creation by continuously polling review comments, CI checks/workflow runs, and mergeability state until the PR is merged/closed or user help is required. Diagnose failures, retry likely flaky failures up to 3 times, auto-fix/push branch-related issues when appropriate, and keep watching open PRs so fresh review feedback is surfaced promptly. Use when the user asks Codex to monitor a PR, watch CI, handle review comments, or keep an eye on failures and feedback on an open PR.
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Pursue an agreed goal to a working outcome without waiting: decompose it, re-prioritise as evidence arrives, branch, gate, get an independent review (a different model or a fresh reviewer subagent — the writer never approves), merge, prune, and bank the operator's decisions in STATUS.md instead of blocking on them. Trigger on "get it done", "don't wait for me", "proceed autonomously", or when an epic or roadmap objective is handed over. Not a close-out: this work set is expected to grow.
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Refine a Jira/Linear ticket before planning — 'refine ticket', 'tighten AC on PROJ-123', 'ist das Ticket klar?'; rewritten ticket, risks, persona voices, close-prompt.
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Estimate a Jira/Linear ticket — 'estimate PROJ-123', 'wie groß ist das?', 'should we split this?' — size + risk + split + uncertainty, sibling of /refine-ticket, close-prompt.
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Create, edit, review, preview, and export polished Marp Markdown slide decks in Canvas Notebook. Use when the user wants Markdown-native presentations, `.marp.md` or `.slides.md` files, version-controlled decks, Marp PDF/image/PPTX/HTML export, speaker notes, dashboard-style slides, data cards, or better looking decks that should remain close to plain text.
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[Utilities] Use when the user invokes, lists, saves, updates, or deletes a PROJECT-SPECIFIC saved prompt — a named, reusable procedure stored with the project rather than in the portable framework. `/custom-prompt list` prints every defined prompt with its description; `/custom-prompt <free-text request>` matches the request to the closest saved prompt and executes it only after a confirmation gate; `/custom-prompt save|update|delete ...` maintains the registry — save never stores raw wording, it drafts the best version of the prompt and confirms the name, description, inferred goal, and steps with the user first. Triggers: custom prompt, custom prompts, list custom prompts, save this prompt, save this prompt task, update this prompt, my saved prompt, project prompt, playbook, recipe, runbook.
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At the end of a long working session, produce a counterfactual trace note — a backward walk through the session that identifies the small number of load-bearing moments (observations, failures, accidents, decisions) without which the final outcome would not exist. Use this whenever the user asks to "close the session", "run the butterfly", "trace back", "what actually mattered here", asks for a session retrospective, or asks how the session arrived at its result. Also use it when a session ends with a significant outcome (a fix, a design decision, a shipped artifact) and the user wants a note capturing why it happened, not just what happened. Do NOT use for simple summaries of short sessions — this skill is for causal tracing, and it only earns its cost when the session was long enough to contain real forks.
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Use when building, refactoring, or debugging a macOS menu bar app with SwiftUI, or when a MenuBarExtra misbehaves — the icon renders wrong or vanishes, the Settings window opens behind other apps, the popover cannot be closed, controls inside a .menu style do not render, the Dock icon comes back, or the app quits when the item is dragged off the menu bar. Triggers include menu bar app, status bar app, tray app, MenuBarExtra, NSStatusItem, LSUIElement, hide Dock icon.
日本語の概要は準備中です。原文の説明を表示しています。