「express」の検索結果

Analyze codon usage and calculate CAI (Codon Adaptation Index), RSCU, and Nc with Biopython, and produce naive max-CAI codon-optimized sequences. Use when scoring a gene's codon bias against a host, optimizing a CDS for heterologous expression, or studying synonymous codon selection.

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Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

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Performs gene-level association from GWAS summary statistics via genetically predicted tissue expression using FUSION, PrediXcan, S-PrediXcan, S-MultiXcan, UTMOST, MOSTWAS, kTWAS, EpiXcan, TIGAR-V2, and probabilistic fine-mapping with FOCUS and MA-FOCUS. Use when running TWAS from GWAS sumstats, prioritising candidate causal genes from a GWAS lead locus, picking single-tissue vs cross-tissue models, identifying LD-induced TWAS false positives, choosing ancestry-matched prediction weights, fine-mapping co-regulated TWAS hits, or triangulating TWAS with cis-eQTL Mendelian randomization and colocalization to nominate a causal gene.

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Comprehensive backend development guide for Langfuse's Next.js 14/tRPC/Express/TypeScript monorepo. Use when creating tRPC routers, public API endpoints, BullMQ queue processors, services, or working with tRPC procedures, Next.js API routes, Prisma database access, ClickHouse analytics queries, Redis queues, OpenTelemetry instrumentation, Zod v4 validation, env.mjs configuration, tenant isolation patterns, or async patterns. Covers layered architecture (tRPC procedures → services, queue processors → services), dual database system (PostgreSQL + ClickHouse), projectId filtering for multi-tenant isolation, traceException error handling, observability patterns, and testing strategies (Jest for web, vitest for worker).

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Infer gene regulatory networks (GRNs) from gene expression data using scalable algorithms (GRNBoost2, GENIE3). Use when analyzing transcriptomics data (bulk RNA-seq, single-cell RNA-seq) to identify transcription factor-target gene relationships and regulatory interactions. Supports distributed computation for large-scale datasets.

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This skill determines whether an adolescent or adult patient meets DSM-5 criteria for gender dysphoria (gender incongruence) by evaluating the presence of at least two of six specified criteria over a minimum 6-month duration, accompanied by clinically significant distress or impairment. It is triggered when a clinician queries whether the patient's reported symptoms align with gender dysphoria, such as persistent incongruence between experienced/expressed gender and designated gender.

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This skill suggests medical therapy to block aberrant hormone receptors for bilateral macronodular adrenal hyperplasia (BMAH) when surgery is not preferred or feasible. Consider this approach in patients with confirmed BMAH and evidence of aberrant hormone receptor expression (e.g., GIP, LH/hCG, serotonin) driving cortisol excess.

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Algorithmic philosophies are computational aesthetic movements that are then expressed through code. Output .md files (philosophy), .html files (interactive viewer), and .js files (generative algorithms).

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Atonement is an expression of care that may arise in an intelligence when its actions contribute to harm.

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Expert-level biochemistry knowledge. Use when working with proteins, enzymes, metabolism, DNA, RNA, carbohydrates, lipids, cell signaling, or bioenergetics. Also use when the user mentions 'enzyme kinetics', 'metabolism', 'glycolysis', 'Krebs cycle', 'DNA replication', 'protein folding', 'amino acids', 'ATP', 'oxidative phosphorylation', 'gene expression', 'lipid bilayer', or 'signal transduction'.

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Expert-level molecular biology knowledge. Use when working with DNA replication, transcription, translation, gene regulation, cloning, PCR, sequencing, CRISPR, epigenetics, or molecular techniques. Also use when the user mentions 'DNA replication', 'transcription', 'translation', 'gene expression', 'PCR', 'cloning', 'restriction enzyme', 'gel electrophoresis', 'Western blot', 'CRISPR', 'epigenetics', 'promoter', 'enhancer', or 'RNA splicing'.

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Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. This skill should be used when the user is looking for functionality that might exist as an installable skill.

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Type design analysis — encapsulation, invariant expression, usefulness, and enforcement.

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Type design analysis — encapsulation, invariant expression, usefulness, and enforcement.

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Use when configuring Laravel task scheduling — cron expressions, frequency helpers, overlap prevention, maintenance mode, or output handling.

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Audit how a brand is currently expressed across touchpoints and flag drift from its defined tokens, voice, and strategy. Use to inventory and critique an existing brand before changing it.

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Padrões de arquitetura backend, design de API, otimização de banco de dados e melhores práticas server-side para Node.js, Express e rotas de API Next.js.

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Crie designs de websites premium com qualidade Awwwards como componentes React (.jsx) que pareçam ter sido construídos por uma agência de primeira linha cobrando R$250k+ por projeto. Use esta skill sempre que o usuário pedir um website, landing page, portfólio, ou componente web que deve parecer caro, premium, luxo, editorial, high-end, ou de qualidade agência. Também dispare quando o usuário mencionar Awwwards, FWA, design premiado, ou referenciar marcas como Apple, Aesop, Bottega Veneta, Stripe, ou qualquer marca luxury/fashion/design-forward. Dispare quando o usuário disser coisas como "faça parecer profissional", "faça parecer caro", "quero que fique realmente bom", "design de alta qualidade", "não genérico", ou expressar insatisfação com aesthetics típicos de websites gerados por IA. NÃO dispare para dashboards, admin panels, ferramentas internas, ou UI funcional onde aesthetics são secundárias à utilidade — a skill padrão frontend-design cuida disso.

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Use this skill when a user asks to polish, rewrite, humanize, de-AI, localize, or oralize Chinese writing, including short-video scripts, articles, social posts, speeches, newsletters, and personal-IP content. The skill diagnoses “AI味”, preserves the user's meaning, adapts to optional style samples, replaces translation-like phrasing with natural Chinese expression, and outputs a polished version plus concise revision notes.

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Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. This skill should be used when the user is looking for functionality that might exist as an installable skill.

日本語の概要は準備中です。原文の説明を表示しています。

Helps users discover and install agent skills when they ask questions like "how do I do X", "find a skill for X", "is there a skill that can...", or express interest in extending capabilities. Use it proactively when an existing skill could be a ready-made building block, while keeping installation scoped to the current project unless the user explicitly requests a global install.

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Compatibility adapter into ui-implementation-workflow visual direction. Invoke explicitly for expressive marketing, brand, portfolio, or editorial work; do not use as the primary product UI workflow.

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Validate and implement Sinclair ZX Spectrum 48K ROM-visible behavior in the EMULATORS repository, including reset and restart vectors, IM1/NMI handling, keyboard scanning and repeat, beeper and tape routines, screen/printer output, channels and streams, BASIC tokenization and execution, expression evaluation, memory movement, system variables, calculator stack, floating-point formats, ROM traps, localized ROM selection, and firmware/hardware timing contracts. Use when Codex reviews or edits ZX Spectrum ROM loading, KERNAL-style traps, keyboard, tape, screen, printer, BASIC files, tokens, system variables, startup, interrupts, or compatibility tests.

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Scans GitHub Actions workflows and CI/CD pipeline configurations for supply chain attack vectors including unpinned actions, script injection via expressions, dependency confusion, and secrets exposure. Uses PyGithub and YAML parsing for automated audit. Use when hardening CI/CD pipelines or investigating compromised build systems.

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