1,152 件 ・ 関連度順
概要と使いどころ
Generate consensus FASTA sequences by applying VCF variants to a reference using bcftools consensus. Use when creating sample-specific reference sequences or reconstructing haplotypes.
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Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.
日本語の概要は準備中です。原文の説明を表示しています。
Detect somatic and germline copy number variants from targeted, exome, and whole-genome sequencing with CNVkit, a read-depth caller that combines on-target and off-target (antitarget) coverage. Covers panel-of-normals construction, flat-reference tumor-only calling, hybrid/amplicon/WGS modes, CBS vs HMM segmentation selection, purity-aware integer calling, and reconciliation against GATK and allele-specific callers. Use when calling CNVs from hybrid-capture panels or exomes, deciding whether CNVkit (depth-only) is the right tool versus an allele-specific caller, building a panel of normals, diagnosing flat-reference false positives, or interpreting log2 ratios into copy-number states.
日本語の概要は準備中です。原文の説明を表示しています。
Call protein-RNA binding sites from CLIP-seq BAM with CLIPper, PureCLIP, Skipper, Piranha, omniCLIP, CTK, CLAM, or Paraclu. Use when choosing between coverage-based, HMM-based, beta-binomial window-based, and crosslink-site-based peak callers; applying ENCODE eCLIP thresholds (log2 IP/SMInput >= 3, -log10 p >= 3); deciding when SMInput is mandatory; or reconciling peak-set discordance between callers for the same RBP.
日本語の概要は準備中です。原文の説明を表示しています。
Infer orthologous genes and gene families across species using OrthoFinder3 (HOG-based phylogenetic orthology), SonicParanoid2, Broccoli, ProteinOrtho, OMA / FastOMA hierarchical orthologous groups, eggNOG-mapper, JustOrthologs, and TOGA whole-genome-alignment orthology. Use when building single-copy ortholog sets for phylogenomics, classifying co-orthologs and in/out-paralogs after gene duplication, propagating functional annotation via orthology with awareness of the ortholog conjecture, distinguishing speciation from duplication via gene-tree species-tree reconciliation, computing Quest-for-Orthologs benchmark performance, or running synteny-aware ortholog detection in WGD-affected lineages.
日本語の概要は準備中です。原文の説明を表示しています。
Discover RBP binding motifs from CLIP-seq peaks or single-nucleotide crosslink sites using HOMER, MEME/STREME, kpLogo, mCross (CL-position-registered motifs), PEKA (positional k-mer enrichment), RBPamp (affinity), and RNA Bind-n-Seq (RBNS) cross-validation. Use when characterizing RBP sequence specificity, registering motifs to crosslink positions, validating in vivo CLIP motifs against in vitro RBNS Kd, reconciling motif disagreements across tools, or correcting for the uracil crosslinking bias that contaminates raw CLIP motif logos.
日本語の概要は準備中です。原文の説明を表示しています。
Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.
日本語の概要は準備中です。原文の説明を表示しています。
Workflow for orthology, synteny, ancestral reconstruction, and evolutionary comparison across genomes.
日本語の概要は準備中です。原文の説明を表示しています。
Audit Apple Ads measurement, AdServices and AdAttributionKit, campaign and keyword structure, Search Match, App Store placements, custom product pages, bidding, budgets, MMP reconciliation, and policy. Use for Apple Ads, Apple Search Ads, App Store ads, Search Match, custom product pages, AdServices, or Apple app-install campaigns.
日本語の概要は準備中です。原文の説明を表示しています。
Import Figma content into a HyperFrames composition — rendered assets, brand tokens, components, storyboard sections → reconstructed motion (frames read as states, not slides) (REST/CLI), Figma Motion animations (MCP), and shaders (MCP source / native export). Use when the user pastes a figma.com link or asks to bring a Figma design, frame, logo, brand, or animation into a video/composition.
日本語の概要は準備中です。原文の説明を表示しています。
Reconcile this identity with the relay — republish keys, replenish one-time keys, rotate the fallback, and resend unacknowledged mail. Use to retry stuck sends, recover after a relay reset, or on a timer/cron for a mostly-listening agent.
日本語の概要は準備中です。原文の説明を表示しています。
Author and maintain MANUAL and hybrid test cases and suites in TestRail, Xray (Jira), Zephyr Scale, and Qase. Covers test-case anatomy (title, preconditions, steps, expected results, test data), suite/section organization, bulk authoring from user stories and acceptance criteria, ambiguous-step linting, CSV/API import-export payloads per tool, requirement traceability and coverage gaps, review hygiene, and when a manual case should graduate to automation. Use when: "write a test case," "manual test case," "TestRail case," "Xray test," "Zephyr Scale case," "Qase case," "import CSV into TestRail," "lint these steps," "traceability report," "should this be automated." Not for: Generating automated TEST CODE — that is ai-test-generation. Sprint-level WHAT-to-test selection — that is test-planning. Related: ai-test-generation, test-planning, exploratory-testing, qa-project-context.
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Orchestrate go-to-market strategy by running positioning, offer construction, and channel allocation as a sequenced workflow during PRD v0.9 Go-to-Market. Triggers on requests to plan launch, define GTM strategy, or when user asks "how do we launch?", "go-to-market", "launch plan", "marketing strategy", "GTM", "launch this product". Chains three framework-grounded sub-skills (Dunford → Hormozi → ORB) and reconciles their outputs.
日本語の概要は準備中です。原文の説明を表示しています。
Use when working on the Bolt repository and you need to configure or compile code correctly and efficiently. This skill defines the canonical Bolt build workflow, including when and how to run `make`, `cmake --build ...`, and when build reconfiguration is necessary due to added files and test or build target changes.
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Adversarially review the current implementation plan with three independent critic subagents, reconcile their findings into a consensus, and apply the agreed feedback to the plan. Use after drafting a plan (in plan mode or a plan/design doc) and before starting implementation, or whenever the user asks to pressure-test, critique, or harden a plan.
日本語の概要は準備中です。原文の説明を表示しています。
Run the evidence loop of one long-horizon GPU kernel optimization episode. Use this skill to reconstruct the incumbent, profile and localize a bottleneck, research progressively, plan one coherent direction, implement and repair, validate development correctness and performance, and record every decisive experiment in the episode journal.
日本語の概要は準備中です。原文の説明を表示しています。
Hoyeon browser automation workflow for Codex. Use when the user invokes "$hoyeon-browser-work" or asks Codex to perform a browser task through recon-first chromux automation. This adapter loads the canonical browser-work skill and follows its Codex runtime surface.
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Recon-first browser automation. Orchestrator explores the site first via chromux, saves a guide file with insights, then delegates execution to browser-explorer agent. Use when: "/browser-work", "브라우저 작업", "사이트에서 해줘", "웹에서 해줘", "LinkedIn에서", "크롬으로", "browser task", "automate this site".
日本語の概要は準備中です。原文の説明を表示しています。
Censys search engine for internet-connected hosts, TLS certificates, and web properties. Use when: certificate transparency monitoring, finding hosts by certificate fingerprint, alternative to Shodan for TLS/SSL analysis, discovering hosts running specific services, or tracking infrastructure changes via cert issuance.
日本語の概要は準備中です。原文の説明を表示しています。
Run autonomous AI-driven penetration tests on web applications using tools like Shannon, PentAGI, and similar frameworks. Use when tasks involve setting up automated penetration testing pipelines, combining AI agents with security tools (nmap, subfinder, nuclei, sqlmap), building autonomous exploit chains, generating pentest reports with proof-of-concept exploits, or integrating AI pentesting into CI/CD pipelines. Covers the full pentest lifecycle from reconnaissance to reporting using AI orchestration.
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Keeps specification documents and code in agreement. Audit mode finds every divergence when an implementation is claimed complete; sync mode detects spec drift in staged changes and updates the spec after user approval, so each commit is a reconciled snapshot of spec, tests, and code. Use when an implementation is claimed complete against a spec, before committing changes that may drift from the spec, or after approving decisions that must flow back into it.
日本語の概要は準備中です。原文の説明を表示しています。
医疗美容 (医疗美容 / 注射美容 (Medical Aesthetics & Injectables) — 以「医疗本质 + 消费属性双高」为特征的中国医美认知操作系统：从「求美者咨询与面诊（需求/解剖/审美/预算/禁忌）→ 方案设计（注射 vs 手术、单项 vs 联合、分次 vs 一次）→ 产品与术式选型（玻尿酸/肉毒/再生类/光电/手术）→ 知情同意与风险告知 → 操作执行（无菌/层次/剂量/解剖避险）→ 术后管理与随访 → 并发症识别与处理/修复 → 机构合规运营与获客」的完整临床-审美-合规-经营决策链。覆盖 (a) 第一性张力 — **医疗本质/安全/循证/解剖（这是外科与皮肤科的医疗行为，血管栓塞致盲/肉毒中毒/感染可致残致死）⇄ 消费/营销/颜值经济/获客（机构靠流量与转化生存，价格战/直播带货/导流）**；**注射派/微整/午餐美容（玻尿酸 filler、肉毒 botox、水光、再生材料童颜针/少女针、线雕、无创/微创、恢复快）⇄ 手术派/整形外科（隆鼻/眼综合/隆胸/吸脂抽脂/面部提升拉皮/正颌、创伤大恢复久效果持久）**；**正规医疗（持《医疗机构执业许可证》+ 执业医师/主诊医师备案 + 三类医疗器械注册证 + 正品药械）⇄ 黑医美/三非（非法机构、非法药械/水货假货、非法行医/工作室/美容院越界、生活美容冒充医疗美容）**；**产品/厂商营销（进口 vs 国产、艾尔建/高德美/乔雅登 vs 爱美客/华熙/昊海、'认准正品'、网红爆品）⇄ 医生技术与审美（同样的针剂效果取决于医生的解剖功底/审美/手法，'产品是地板技术是天花板'）**；**循证/适应证/风险告知/拒绝过度治疗（医生伦理：该劝退就劝退、不做无适应证项目）⇄ 求美者预期管理/容貌焦虑/成瘾性消费（过度医美/医美贷/容貌焦虑被制造、'变美才能…'）**；**强监管合规（医疗广告法、医师法、医疗机构管理条例、器械分类管理、卫健委/药监局监管、医美专项整治）⇄ 灰色地带（医美贷、医托/渠道医院返佣、跨境就医、水货走私、超范围执业、虚假宣传/对比图造假）**。(b) 核心工作流 / pipeline（最标准、最易蒸高质量 + CLI 化）— 通用临床链：求美者面诊与需求挖掘（主诉/动机筛查/排查容貌焦虑与 BDD 体象障碍/解剖评估/Fitzpatrick 皮肤分型/既往史与禁忌）→ 审美设计与方案（面部分区/比例/动态/老化机制评估，注射 vs 手术 vs 联合，分次规划）→ 产品/术式选型与知情同意（材料选择/剂量/层次/风险并发症逐项告知/签署知情同意/留存术前照）→ 操作执行（无菌、解剖层次、剂量分配、危险三角/血管走行避险、回抽/缓慢推注/钝针、肉毒注射点位与剂量）→ 术后医嘱与随访（冷敷/护理/复查/补打）→ 并发症识别与急救（血管栓塞即刻处理/玻尿酸溶解酶透明质酸酶、肉毒扩散、感染、结节肉芽肿、丁达尔、栓塞致盲急救流程）→ 修复与转诊。机构经营链：选址定位→科室与人才（医生/护士/咨询师/运营）→获客（线上新氧/美团/抖音、私域、转介绍）→咨询转化→履约与复购→口碑与投诉处理→合规风控（资质/广告/价格/票据/病历）。(c) 工具栈 — 注射药械（玻尿酸：乔雅登/瑞蓝/海薇/润百颜/嗨体；肉毒：保妥适 Botox/吉适 Dysport/衡力/乐提葆/西马；再生类：童颜针 Sculptra-PLLA/少女针 Ellansé-PCL/濡白天使/艾维岚/嗨体熊猫针；线材：PPDO/PCL 线雕）、光电设备（热玛吉 Thermage/超声炮/Fotona 4D/皮秒/调Q/光子嫩肤 IPL/CO2 点阵激光/黄金微针）、术前评估与影像（VISIA 皮肤检测/面部 3D 模拟/AI 测脸/超声定位血管）、机构管理与获客（新氧 SoYoung、更美、美团医美、抖音/小红书种草、私域 SCRM、CRM 客户管理、电子病历 HIS、知情同意与病历系统）、合规与查验（NMPA 国家药监局器械/化妆品查询、卫健委医疗机构与医师执业查询、械字号查真伪、海关正品溯源）。(d) 知识正典 — 医美 canon 横跨医学专业与行业实务：临床专业（整形外科学/皮肤科学教材、注射解剖图谱如《面部危险区与注射解剖》、肉毒与填充剂临床指南/专家共识如中国面部注射美容专家共识/中华医学会医学美容分会指南、并发症处理共识、MD Codes 注射方法学 Mauricio de Maio）、循证与期刊（中华医学美学美容杂志、中国美容整形外科杂志、Aesthetic Surgery Journal、Plastic and Reconstructive Surgery、JAMA Dermatology、Dermatologic Surgery）、监管法规（医疗美容服务管理办法、医疗机构管理条例、医师法、医疗广告管理办法、医疗器械监督管理条例、医美专项整治文件、消费者权益保护）、行业研究与白皮书（艾瑞/德勤/弗若斯特沙利文医美行业报告、新氧医美白皮书、上市公司爱美客/华熙生物/昊海/朗姿招股书与年报）。(e) figures/流派 — 临床专家与学术（整形外科与皮肤科主任医师、注射美容专家共识执笔人、医学美容分会与整形美容协会专家、知名公立三甲整形科/八大处/上海九院/华西/中国医学科学院整形外科医院专家、注射解剖与并发症权威）、产业与企业（爱美客/华熙生物/昊海/朗姿/华韩等上市公司创始人与高管、新氧/更美创始人、连锁医美机构创始人）、医生 KOL 与科普（做科普打假的皮肤科/整形科医生、揭黑医美与营销套路的从业者）、海外术式 originator（MD Codes 的 Mauricio de Maio、各注射技法/线雕/光电术式发明人）。流派分歧：注射派 vs 手术派、医疗循证派 vs 消费营销派、'产品论'（认准大牌正品）vs '医生论'（技术审美决定效果）、保守自然派 vs 网红改造派（过度医美/科技脸/欧式大平行）、公立学院派 vs 民营连锁派、'劝退伦理'派 vs '满足需求'派。(f) 行业话术/黑话 — 面诊 / 主诉 / 求美者 / 适应证 / 禁忌证 / 知情同意 / 注射层次（皮内/真皮/皮下/骨膜上/SMAS）/ 剂量 / 单位（U）/ 支（玻尿酸 1ml）/ 回抽 / 钝针 vs 锐针 / 危险三角 / 血管栓塞 / 栓塞致盲 / 溶解酶（透明质酸酶）/ 丁达尔现象 / 结节 / 肉芽肿 / 移位 / 肉毒 / 除皱 / 瘦脸针 / 瘦肩针 / 玻尿酸 / 填充 / 水光 / 童颜针 / 少女针 / 再生材料 / 胶原再生 / 线雕 / 提升 / 热玛吉 / 超声炮 / 光子嫩肤 / 皮秒 / 抗衰 / 微整 / 轻医美 / 重医美 / 联合治疗 / 全脸设计 / MD Codes / 三庭五眼 / 黄金比例 / 苹果肌 / 卧蚕 / 泪沟 / 法令纹 / 木偶纹 / 颞部 / 面部老化 / 容积缺失 / 三非 / 黑医美 / 水货 / 假货 / 械字号 / 妆字号 / 国械注准 / 正品溯源 / 渠道医院 / 医托 / 导流 / 医美贷 / 面诊转化 / 升单 / 复购 / 拓客 / 体验价 / 钓鱼 / 莆田系 / 修复 / 翻车 / 容貌焦虑 / BDD（体象障碍）/ 过度医美 / 科技脸 / 自然派 / 五分钟变美 / 午餐美容。(g) 争议/批判 — 「医疗本质 vs 消费营销」（医美被当快消品营销、价格战与品质安全冲突）、「黑医美与三非泛滥」（非法机构/水货假货/非法行医致毁容致死案例、生活美容越界打针）、「容貌焦虑与过度医美」（贩卖容貌焦虑、医美成瘾、未成年医美、医美贷套路贷、整容低龄化）、「虚假宣传与对比图造假」（夸大效果、伪科普、网红医生带货、'一针逆龄'）、「产品论 vs 医生论」（认正品 vs 重技术，水货与正品之争、同质化价格战）、「渠道返佣与医托」（渠道医院高返佣推高价格、医托拉客）、「并发症与维权难」（栓塞致盲/感染/毁容、举证难维权难、修复市场乱）、「监管与灰色地带」（超范围执业、医师资质挂靠、跨境医美、医美贷金融风险）。(h) 大量隐性临床手艺 + 审美 + 沟通 + 经营软技能（注射的解剖空间感与层次手感、危险区避险与回抽习惯、剂量与审美的平衡、全脸动态设计、并发症的快速识别与急救决断、面诊的需求挖掘与预期管理与劝退、容貌焦虑/BDD 的筛查、知情同意的真实告知、机构的合规风控与口碑经营）是高 tacit、靠规范化培训 + 大量临床实操 + 并发症处理经验 + 审美修养积累的核心，且医疗安全红线不可让渡。水分极高（大量营销号/伪科普/带货软文/'某院某专家'刷屏/对比图造假/培训速成班割韭菜（'7天速成注射师'是非法行医温床）/黑医美洗白），须强 source 过滤：优先 临床专家共识/指南 + 监管法规原文（NMPA/卫健委）+ 厂商械字号官方信息 + 专业期刊 + 整形外科/皮肤科专家本人科普 + 上市公司披露 > 行业研究报告 > 二手转述 > 营销号/带货软文（严防当知识来源）。严防把'变美话术/带货推荐/速成培训'当医疗知识，严防软化并发症风险与黑医美批判。不含: 生活美容/美容院护理（皮肤管理/美甲美睫，非医疗）、口腔正畸种植牙（另立专科）、毛发移植植发（可少量提及不深覆盖）、减肥代谢类药物（司美格鲁肽等另属内分泌）、纯护肤品/化妆品配方（妆字号护肤是另一行）、心理整形咨询的纯心理治疗部分（借用 BDD 筛查但不深入精神科）。) Master OS — automated mastery of 医疗美容 / 注射美容 (Medical
日本語の概要は準備中です。原文の説明を表示しています。
Decide which model, effort level, and cascade shape each subagent gets, and how to keep improvement loops safe (evaluator-as-selector, stop on regression). Routes on measured cost-per-completed-task rather than per-token price, because a tier's token count varies more by task shape than price varies across tiers. Covers per-model effort semantics, the concision lever, cascade preconditions, context handoff, and watching a subagent fan-out live. Use when choosing a subagent's model or effort, when choosing how to escalate a failed attempt, or when asked which model or effort a task should get. Grounded in a 2026-07 calibration, a 2026-08 coding-cost study, a 2026-09 seeded-bug repair battery, a 2026-10 Haiku 5.5 ladder priced per spawn, and a 2026-10 retry-versus-escalation ladder on 295 SWE-bench Verified tasks; Managed Agents API specifics are operational, not calibrated.
日本語の概要は準備中です。原文の説明を表示しています。
Stop everything and surface a rule conflict — persona vs. docs vs. code. Present both sides and the conflict-hierarchy level; the user resolves. No silent reconciliation.
日本語の概要は準備中です。原文の説明を表示しています。