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概要と使いどころ
Filter degenerate, uninformative inputs before statistical tests: single-sequence alignments, empty files, constant features, zero-variance inputs, all-NaN columns. See nan-safe-correlation for NaN-aware correlation; statistical-analysis for test guidance.
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Methodology for exploratory data analysis on scientific files. Decision frameworks by data type (tabular, sequence, image, spectral, structural, omics), quality assessment, report generation, format detection across 200+ formats. Use when given a data file for initial exploration or to pick an analysis before a pipeline.
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Predict RNA secondary structure, MFE folding, base-pair probabilities, RNA-RNA interactions via ViennaRNA Python bindings. Pipeline: sequence → MFE → partition function and pair-probability matrix → dot-bracket → duplex. Use for siRNA/sgRNA targeting, ribozyme design, RNA accessibility. Use RNAfold CLI for batch use without Python.
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Benchling R&D Python SDK: CRUD on registry entities (DNA, RNA, proteins, custom), inventory, ELN, workflow automation. Needs Benchling account and API key. Use biopython for local sequence analysis; pubchem for chemical DBs.
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Auto-annotate plasmids with features (promoters, terminators, resistance, origins, tags, fluorescent proteins) via BLAST against curated DBs (Addgene, fpbase, SnapGene). FASTA or raw sequence in; annotated GenBank, interactive HTML maps, CSV tables out. Handles circular topology. Use to verify synthetic constructs, prep Addgene submissions, share maps, or batch-annotate cloning libraries.
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Three-tiered sgRNA design guide using validated Addgene sequences, CRISPick pre-computed datasets, or de novo design rules for CRISPR experiments
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API + Python SDK for ordering cell-free protein expression and binding assays. Submit sequences for expression (10–100 µg), measure binding affinity (KD) against targets, track status, and retrieve results programmatically — no wet-lab setup. Built for ML-guided directed evolution and antibody/nanobody optimization. Requires Adaptyv account and API key.
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Python library for biology: sequence manipulation (DNA/RNA/protein), pairwise/multiple alignment, phylogenetic trees (NJ, UPGMA), diversity (Shannon, Faith PD, Bray-Curtis, UniFrac), ordination (PCoA, CCA, RDA), stats (PERMANOVA, ANOSIM, Mantel), file I/O (FASTA, FASTQ, Newick, BIOM). Use for microbiome, community ecology, or phylogenetics.
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Query InterPro REST API for protein domain architecture, family classification, and member-DB integration. Search entries, retrieve a protein's domains, list family members, get taxonomic distribution, link to PDB. Unifies Pfam, PANTHER, PIRSF, PRINTS, PROSITE, SMART, CDD, NCBIfam. Use uniprot-protein-database for sequences; pdb-database for 3D structures.
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Search the PRIDE Archive v3 REST API for proteomics datasets: discover projects by keyword + faceted filters (organism, instrument, disease, software), fetch project metadata, list and download RAW/PEAK/RESULT/FASTA files (with FTP/Aspera URLs), look up which projects mention a UniProt accession, and find similar projects. PRIDE v3 no longer exposes peptide/PSM-level identification endpoints — for spectrum-level data download the project's RESULT files. Use uniprot-protein-database for protein sequences; interpro-database for domain architecture.
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Molecular biology toolkit: sequence manipulation, FASTA/GenBank/PDB I/O, NCBI Entrez, BLAST automation, pairwise/MSA alignment, Bio.PDB, phylogenetic trees. Use for batch processing, custom pipelines, format conversion, PubMed/GenBank queries. For quick gene lookups use gget; for multi-service REST APIs use bioservices.
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Bringing up a complete ROS2 system on a robot's onboard computer: systemd services, launch file composition, ordered startup, and production monitoring. Use this skill when configuring a robot to start ROS2 nodes on boot, writing systemd unit files for ROS2 launch, composing layered launch files for full robot stacks, setting up watchdog monitoring, configuring udev rules for deterministic device naming, or debugging boot-time race conditions. Trigger whenever the user mentions robot bringup, robot startup, systemd for ROS2, ROS2 on boot, launch file composition, robot boot sequence, udev rules for cameras or serial ports, automatic restart for ROS2 nodes, network configuration for multi-machine ROS2, log rotation for robots, graceful shutdown of robot stacks, or SSH-based remote debugging. Also trigger for sourcing workspaces in systemd, ordered startup with health checks, or running ROS2 systems as long-running production services. Covers systemd on Ubuntu 22.04/24.04 with ROS2 Humble, Iron, and Jazzy.
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Creates professional logical flow diagrams and logical system architecture diagrams using draw.io XML format (.drawio files). Use when creating: (1) logical flow diagrams showing data/process flow between system components, (2) logical architecture diagrams representing system structure without cloud provider specifics, (3) BPMN process diagrams, (4) UML diagrams (class, sequence, activity), (5) data flow diagrams (DFD), (6) decision flowcharts, or (7) system interaction diagrams. This skill focuses on generic/abstract representations, not AWS/Azure-specific architectures (use aws-drawio-architecture-diagrams for cloud diagrams).
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When the user needs to design, write, or optimize email sequences -- including welcome series, nurture campaigns, re-engagement flows, onboarding emails, or newsletter strategy.
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When the user needs to organize product initiatives into a prioritized, time-sequenced plan with outcomes and dependencies.
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When the user needs to plan or execute a product launch — including pre-launch content sequences, launch funnels, JV/affiliate launches, cart open/close strategy, or evergreen launch funnels.
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Create 4D construction simulations by linking BIM elements to project schedules. Generate time-based visualizations, sequence analysis, and construction phasing with Gantt integration.
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Link BIM elements to schedule activities for 4D simulation. Visualize construction sequence over time.
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4D scheduling and 5D cost modelling in OpenConstructionERP: build task schedules, link tasks to BIM elements and BOQ lines, roll up the cost model over time, and export Gantt/sequence views. Use for schedule-cost integration workflows.
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メールシーケンス、ステップメール、ドリップキャンペーンの設計・最適化を行うスキル。 「メール設計」「ステップメール作成」「ウェルカムメール」等のリクエストで発動。 For in-app onboarding, see onboarding-cro.
Generates a Mermaid sequence diagram showing how data moves between components. Use when tracing request flows or documenting data transformation pipelines.
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Transform webinar recordings into multiple content assets including blog post series, social media snippets, infographic ideas, email sequences, and sales one-pagers. Extracts key moments, quotes, and insights for maximum content ROI. Use when users need to repurpose webinars, video content, or live presentations into multi-channel marketing materials.
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Argues the strongest honest case against a decision, plan, belief, hire, pricing move, strategy, or piece of work the user is leaning toward. Steelmans the other side, ranks at most three objections by consequence, runs a short pre-mortem, credits what the user got right, and ends with what would have to be true for their choice to work. Calibrated and collegial, never combative; says plainly when the position is strong. Use whenever the user says "play devil's advocate", "argue the other side", "poke holes in this", "what am I missing", "am I making a mistake", "talk me out of it", "stress-test this idea", "tell me why this is a bad idea", or asks for pushback on something they have mostly decided. Supports gentle, standard, and hard intensity. Not for interrogating requirements before a build (grill-the-brief) or staging a multi-persona debate (debate-simulator).
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API reference: Swift Concurrency. async/await, Task, TaskGroup, actors, AsyncSequence, AsyncStream, continuations.
日本語の概要は準備中です。原文の説明を表示しています。