「standard」の検索結果

Generates complete single-compound network-toxicology research designs from one exposure, one disease or toxic phenotype, and a validation direction. Use when a study centers on one compound–one disease link and needs target collection, overlap construction, enrichment, PPI hub prioritization, docking, optional transcriptomic cross-check, and conservative mechanistic synthesis. Covers five study patterns and always outputs Lite / Standard / Advanced / Publication+ with a recommended primary plan, stepwise workflow, figure plan, validation hierarchy, minimal executable version, publication upgrade path, and strictly verified literature retrieval.

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Designs complete integrated research plans for bulk transcriptomics, proteomics, metabolomics, and related omics from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a bulk multi-omics or single-omics-plus-clinical study — including disease-focused, mechanism-focused, biomarker-focused, stratification-oriented, or translational projects. It should define the research question, choose the best-fit study pattern, recommend example datasets as reference candidates only, specify the core analysis modules and method choices, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, cohort availability, assay coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.

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Use when you need a standardized R CLI workflow to run two-class SVM-RFE feature ranking on an expression-like matrix, choose an informative feature count from cross-validated error, and generate reproducible ranking and error plots. NOT for regression, multi-class classification, missing-value imputation, or remote data fetching.

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Use when you need a standardized R CLI workflow to train a two-class random forest model from an expression-like feature matrix, rank variable importance, and generate reproducible error and importance plots. NOT for regression tasks, multi-class classification, missing-value imputation, preprocessing, or remote data fetching.

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Designs cell-based and animal-based validation plans that translate computational, omics, biomarker, genetic, or clinical findings into experimentally testable validation routes. Always use this skill whenever a user wants to move from an in silico, statistical, or clinical association finding toward wet-lab validation using cell systems, organoid-like systems, xenograft or genetically relevant animal models. It should define the exact claim to test, separate mechanism-testing from association-support and translational-support goals, choose the best-fit model family, specify perturbation strategy, readouts, controls, sequencing of experiments, and four workload configurations (Lite / Standard / Advanced / Publication+) with one recommended primary plan. Never fabricate model availability, reagent availability, species relevance, assay feasibility, phenotype penetrance, expected effect sizes, validation success, or literature references.

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Use when performing time-dependent ROC curve analysis for survival data with follow-up time, event status, and a numeric marker. Supports CSV/TXT/TSV/Excel input, `risk_score` as the default marker unless `--marker_col` is provided, parameter validation, standardized output directories, AUC table export, ROC point export, and PDF figure generation.

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Use when you need a standardized R CLI workflow to build a protein-protein interaction network from a local gene list and an offline STRING cache, export node and edge tables, and render a reproducible PDF network plot. NOT for online API fetching, arbitrary graph databases, multi-omics integration, or non-STRING interaction sources.

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Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...

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Use when normalizing bulk gene or protein expression matrices with log2 transform, z-score standardization, or min-max scaling before downstream visualization or exploratory analysis. NOT for count-model normalization such as TPM/DESeq2 size factors, batch correction, or single-cell preprocessing.

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SkillsBench task PR review — classifies the task track (standard / research / multimodal), runs static policy checks against the track-specific rubric, benchmarks the task across oracle plus Claude and Codex (with and without skills), audits trajectories for cheating and skill invocation, and produces a `pr-N-task-timestamp-run.txt` review report alongside a `prN.zip` bundle of trajectories. Use when reviewing a SkillsBench task PR (by number, branch, or local task path), when the user asks to review a task, run benchmarks on a PR, audit a submission, classify a task as research or multimodal track, or prepare a comment to post on a SkillsBench PR.

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Extract audio from video files to WAV format. Use when you need to analyze audio from video, prepare audio for energy calculation, or convert video audio to standard format for processing.

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Automated Planning utilities for loading PDDL domains and problems, generating plans using classical planners, validating plans, and saving plan outputs. Supports standard PDDL parsing, plan synthesis, and correctness verification.

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Guide for mapping common Python libraries and idioms to Scala equivalents. Use when converting Python code that uses standard library modules (json, datetime, os, re, logging) or needs equivalent Scala libraries for HTTP, testing, or async operations.

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Comprehensive clinical laboratory data harmonization for multi-source healthcare analytics. Convert between US conventional and SI units, standardize numeric formats, and clean data quality issues. This skill should be used when you need to harmonize lab values from different sources, convert units for clinical analysis, fix formatting inconsistencies (scientific notation, decimal separators, whitespace), or prepare lab panels for research.

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An overview of the core data API of ObsPy, a Python framework for processing seismological data. It is useful for parsing common seismological file formats, or manipulating custom data into standard objects for downstream use cases such as ObsPy's signal processing routines or SeisBench's modeling API.

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Standardize video sampling and frame indexing so interval instructions and mask frames stay aligned with a valid key/index scheme.

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Reference for the standard clauses found in commercial non-disclosure agreements (mutual and one-way) — what each clause does, the surface forms it appears in, and how to recognise it in unfamiliar drafting. Use when reviewing, comparing, or extracting provisions from any confidentiality / NDA / mutual NDA / standstill-and-confidentiality agreement.

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Cheminformatics toolkit for fine-grained molecular control. SMILES/SDF parsing, descriptors (MW, LogP, TPSA), fingerprints, substructure search, 2D/3D generation, similarity, reactions. For standard workflows with simpler interface, use datamol (wrapper around RDKit). Use rdkit for advanced control, custom sanitization, specialized algorithms.

日本語の概要は準備中です。原文の説明を表示しています。

Generate argparse-based Python CLI applications with subparsers, type converters, and standard library patterns. Creates lightweight Python CLIs without external dependencies.

日本語の概要は準備中です。原文の説明を表示しています。

Validate implementation quality through custom checklists, scoring against constitution standards, specification coverage, and producing remediation recommendations.

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Execute development tasks to build features, producing code, tests, and configuration artifacts that satisfy specification requirements and comply with constitution standards.

日本語の概要は準備中です。原文の説明を表示しています。

Establish project governing principles including dev guidelines, code quality standards, testing policies, UX requirements, performance benchmarks, and security constraints.

日本語の概要は準備中です。原文の説明を表示しています。

Layered technical-writing standard: Diátaxis structure, Google developer style sentences, STE instruction rules, Global English syntax. Use for /technical-writing or when writing or reviewing docs, RFCs, readmes, PR descriptions, or commit messages.

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Applies Anthropic's official brand colors and typography to any sort of artifact that may benefit from having Anthropic's look-and-feel. Use it when brand colors or style guidelines, visual formatting, or company design standards apply.

日本語の概要は準備中です。原文の説明を表示しています。