「genesis」の検索結果

Post-interaction retrospective analysis — use after completing a significant task, conversation, or phase to extract lessons, identify process improvements, and update procedures

日本語の概要は準備中です。原文の説明を表示しています。

Download, transcribe, analyze, and clip video content — vertical shorts, captions, thumbnails

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Daily triage accuracy calibration — use during scheduled calibration runs to verify triage classification accuracy against few-shot examples and adjust confidence thresholds

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Use when the user asks how code works, wants to understand architecture, trace execution flows, or explore unfamiliar parts of the codebase. Examples: "How does X work?", "What calls this function?", "Show me the auth flow"

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Use when the user is debugging a bug, tracing an error, or asking why something fails. Examples: "Why is X failing?", "Where does this error come from?", "Trace this bug"

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Use when the user needs to run GitNexus CLI commands like analyze/index a repo, check status, clean the index, generate a wiki, or list indexed repos. Examples: "Index this repo", "Reanalyze the codebase", "Generate a wiki"

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Use when the user asks about GitNexus itself — available tools, how to query the knowledge graph, MCP resources, graph schema, or workflow reference. Examples: "What GitNexus tools are available?", "How do I use GitNexus?"

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This skill should be used when the user asks to "write a LinkedIn message", "draft a connection request", "help me reach out to someone on LinkedIn", "write an InMail", "message this person", or when the prospect-researcher skill identifies a high-value contact worth reaching out to. Also triggered by "how should I approach [person/company]" in a LinkedIn context.

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Superforecasting with calibrated reasoning, Brier score tracking, and prediction ledger management

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Use when the user wants to rename, extract, split, move, or restructure code safely. Examples: "Rename this function", "Extract this into a module", "Refactor this class", "Move this to a separate file"

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Use when the user wants to know what will break if they change something, or needs safety analysis before editing code. Examples: "Is it safe to change X?", "What depends on this?", "What will break?"

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Artificial Life atlas covering open-ended evolution, chemical reaction networks, morphogenesis, self-replication, and programmable chemistry. Use when picking a simulation framework, wiring ALife models into the skill graph, or onboarding contributors to the ALife cluster.

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Anna's Archive integration for academic paper and book retrieval. Search shadow libraries (Library Genesis, Z-Library, Sci-Hub) via unified API with GF(3) balanced caching.

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Fix a GitHub issue end to end -- read it, reproduce, patch, add a regression test, verify, and open a PR. Use when given an issue number or URL in this repo.

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Run the repo's lint, format-check and test suite, then fix anything that fails. Use before opening a PR or when asked to "polish" or "clean up" the repo.

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Create or update a Wardley Map of how any domain delivers value. Maps the needs it serves, the capabilities involved, how each is evolving (genesis to commodity), and strategic plays. Applies to any domain, not only software.

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Academic research skill for Biblical Hebrew, Semitic linguistics, cuneiform studies, and comparative Ancient Near Eastern research. Provides Sefaria API for Hebrew Bible, CDLI/ORACC for cuneiform databases, and web discovery via Omnisearch, Exa, Firecrawl, and Obscura for finding scholarly sources across JSTOR, Perseus, Persée, Google Scholar, and academia.edu. Triggers on Hebrew quotes, cuneiform, Sefaria, ANE research, Minoan, search for scholarship, find papers, literature review, scholarly search, academic search, Genesis/Tehom, Ugaritic, Talmudic sources, extract from PDF, OCR academic.

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Use when the user asks about infostealer families (LummaC2, RedLine, Vidar, Stealc, Raccoon, Rhadamanthys, etc.), log marketplaces (Russian Market, Genesis successors, BidenCash, Hudson Rock corpus), or stealer-driven incidents and credential exposure. Self-updating knowledge cell.

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Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2/PE3/PE3b/PEmax variants, MOSAIC in situ saturation mutagenesis, the PRIME pooled-screen methodology (Ren 2023; ~3,699 ClinVar variant screens), chromatin context as a major locus-level determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level microbiology covering bacterial and viral biology, microbial physiology, pathogenesis, antimicrobial resistance, microbiome science, and industrial microbiology.

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Metaplex development on Solana — NFTs, tokens, compressed NFTs, candy machines, token launches. Use when working with Token Metadata, Core, Bubblegum, Candy Machine, Genesis, or the mplx CLI.

日本語の概要は準備中です。原文の説明を表示しています。

Designs and analyzes pooled prime-editor (PE) screens for installing precise genetic variants without bystander confounding. Covers pegRNA design with PRIDICT and PRIDICT2 (Mathis 2023/2024) for predicting per-pegRNA editing efficiency, pegRNA architecture (spacer + scaffold + PBS + RTT), PE2 / PE3 / PE3b / PEmax / PEAR variants, MOSAIC in situ saturation mutagenesis (Hsu JY et al 2024 bioRxiv), the PRIME pooled-screen methodology (Erwood/Doman 2023 Nat Biotechnol 41:885; ~3,699 ClinVar variant screens), chromatin context as a primary determinant of PE efficiency, scaffold-incorporation and indel byproduct quantification with CRISPResso2, and the cross-modal validation strategy of PE + base-editor screens for variant function. Use when designing a pegRNA library for variant installation, choosing between BE and PE for a specific edit, predicting pegRNA efficiency before library synthesis, analyzing PE screen output, distinguishing intended-edit from scaffold-incorporation, or scaling PE screens to thousands of variants.

日本語の概要は準備中です。原文の説明を表示しています。

Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.

日本語の概要は準備中です。原文の説明を表示しています。