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概要と使いどころ
Use when the research design and method are the bottleneck for an Academy of Management Journal (AMJ) manuscript — matching design (archival, survey, experiment, multi-method, field) and level of analysis to the theoretical question. Designs the study; it does not run the estimation or validity checks (amj-data-analysis).
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Cross-method decision tree for calling hits in pooled CRISPR screens. Catalogs statistical models (MAGeCK RRA, MAGeCK MLE, BAGEL2, drugZ, JACKS, Chronos, CERES), experimental designs each is built for, failure modes outside design domain, reconciliation when methods disagree, multiple-testing and effect-size thresholds, the order of operations (count -> QC -> CN-correct -> hit-call -> validate), the second-best-sgRNA conservative rule, and consensus-hit strategy. Use when choosing among MAGeCK / BAGEL2 / drugZ / JACKS / Chronos for a given design, reconciling disagreement across two or three methods on the same screen, deciding whether to require consensus, gating downstream validation by hit-confidence tier, or interpreting unstable hit lists across reruns.
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Detect horizontal gene transfer (HGT / LGT) using compositional methods (GC%, codon usage, tetranucleotide z-scores via SIGI-HMM, AlienHunter, IslandViewer 4, IslandPath-DIMOB), phylogenetic-incongruence methods (AvP, HGTphyloDetect, ALE / GeneRax / AleRax reconciliation, RANGER-DTL), and BLAST-distribution methods (HGTector v2, DarkHorse, Alien Index). Use when screening prokaryote genomes for genomic islands and HGT events, distinguishing HGT from incomplete lineage sorting / differential gene loss / hybridization, mapping donor lineages via phylogenetic placement, separating eukaryotic HGT from contamination, ruling out gBGC as a false signal, or quantifying DTL rates with ALE/GeneRax on bacterial trees.
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Price financial instruments in MATLAB using the Financial Instruments Toolbox. Route to the appropriate numerical method reference based on the user's request: Monte Carlo simulation (AssetMonteCarlo, IRMonteCarlo, RoughVolMonteCarlo), FFT / Numerical Integration (Vanilla European options), or Interest-Rate Trees (option-embedded bonds with IRTree). Use when the user asks to price financial instruments or compute Greeks using any of these methods. Use one of the following models depending on the pricing method and instrument: Black-Scholes, Bachelier, Heston, Bates, Merton, Hull-White, Black-Karasinski, Black-Derman-Toy, Cox-Ingersoll-Ross, Linear Gaussian 2 Factor (G2PP), Brace-Gatarek-Musiela (BGM), SABR-BGM, RoughBergomi, RoughHeston.
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Build the authoritative final method explanation for a submission-ready subquestion from the method card, human decision ledger, code plan, final results, and robustness evidence.
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Validate a third-party control repo across four automated layers plus one printed manual recipe. Layer 1 asserts native-source structure (Android getName() and iOS +moduleName to manifest nativeModule; @ReactMethod / RCT_EXPORT_METHOD to methods; no @ReactModule) plus load/init readiness (ReactPackage public no-arg constructor, iOS [cls new] no-arg init, requiresMainQueueSetup NO, non-throwing eager construction), so launch-time crashes surface before any build. Layer 2 validates the committed `./manifest.json` against the ppmplugin-format rules. Layer 3 asserts request/response/error-code agreement across native and PCF. Layer 4 compiles the PCF (auto-skipped if absent). Layer 5 prints a device end-to-end recipe. Native compile belongs to /build-android-binary and /build-ios-binary — this is the cheap structural pre-flight before those slow builds. Reports pass/fail per layer with a fix hint and updates .extension-state.md.
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Produce honest product reviews and buying guides without fabricated first-hand experience, using disclosed evidence tiers: verified specs, owner-experience synthesis at scale, expert triangulation, and hands-on only when true. Use this skill whenever the user wants to write product reviews or buying guides without hands-on access, set up a review methodology, add evidence disclosure to review content, align reviews with Google's reviews system or FTC affiliate disclosure expectations, or decide when Review and Product schema are honest to use. Triggers on product review, buying guide, best-of list, review methodology, evidence basis, hands-on testing, we tested, affiliate review site, review disclosure, methodology block, original research, reviews system. Also triggers when review content claims testing that did not happen, or when an affiliate site needs a trust mechanism that survives scrutiny.
日本語の概要は準備中です。原文の説明を表示しています。
SPARC (Specification, Pseudocode, Architecture, Refinement, Completion) comprehensive development methodology with multi-agent orchestration
日本語の概要は準備中です。原文の説明を表示しています。
Intuitive framework for identifying spatially variable genes (SVGs) via edgeR, a popular method for performing differential expression analyses. Based on pre-annotated spatial clusters as summarized spatial information, DESpace models gene expression using a negative binomial (NB), via edgeR, with spatial clusters as covariates. SVGs are then identified by testing the significance of spatial clusters. The method is flexible and robust, and is faster than the most SV methods. Furthermore, to the
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Methods to infer clonal tree configuration for a population of cells using single-cell RNA-seq data (scRNA-seq), and possibly other data modalities. Methods are also provided to assign cells to inferred clones and explore differences in gene expression between clones. These methods can flexibly integrate information from imperfect clonal trees inferred based on bulk exome-seq data, and sparse variant alleles expressed in scRNA-seq data. A flexible beta-binomial error model that accounts for stoc
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Provides R wrappers of several on-target and off-target scoring methods for CRISPR guide RNAs (gRNAs). The following nucleases are supported: SpCas9, AsCas12a, enAsCas12a, and RfxCas13d (CasRx). The available on-target cutting efficiency scoring methods are RuleSet1, Azimuth, DeepHF, DeepCpf1, enPAM+GB, and CRISPRscan. Both the CFD and MIT scoring methods are available for off-target specificity prediction. The package also provides a Lindel-derived score to predict the probability of a gRNA to
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Use when user asks about 南传, 上座部, 缅甸内观, Mahasi Method, 标记法, Noting Method, 腹部起伏, 毗婆舍那, vipassanā, 四念处, 七清净, 十六观智, 刹那定, 行舍智, 马哈希尊者, Mahasi Sayadaw, Mahasi Sasana Yeiktha, IMS, or wants teaching in 马哈希尊者 Mahāsi Sayādaw's voice. Triggers include "马哈希"、"Mahasi"、"Sayadaw"、"标记法"、"腹部起伏"、"缅甸内观"、"密集禅修"、"十六观智"、"刹那定"、"妄念太多" — invoke whenever user's question touches Burmese vipassanā / Mahasi noting method, even without explicit request.
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Use when you need to write fast unit tests for Quarkus applications — including pure tests with @ExtendWith(MockitoExtension.class), @QuarkusTest with @InjectMock for full CDI mock replacement, @InjectSpy for partial CDI bean mocking, REST Assured for resource-focused tests, @ParameterizedTest with @CsvSource / @MethodSource, QuarkusTestProfile for test-specific configuration overrides, and naming conventions (*Test → Surefire, *IT → Failsafe). For framework-agnostic Java use @131-java-testing-unit-testing. This should trigger for requests such as Add or improve unit tests in a Quarkus project; Reduce slow @QuarkusTest usage with Mockito-first tests; Add @InjectSpy partial mocking or QuarkusTestProfile configuration in Quarkus tests; Convert repeated test methods to @ParameterizedTest with @CsvSource or @MethodSource; Write fast pure unit tests for Quarkus services. Part of Plinth Toolkit
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Use when a large feature, story, plan, or spec idea needs to be split into small vertical slices with the Hamburger Method. This should trigger for requests such as Split this oversized story; Find the smallest useful slice; Break this feature into vertical slices; Apply the Hamburger Method; Turn this broad plan into tracked slices. Part of Plinth Toolkit
日本語の概要は準備中です。原文の説明を表示しています。
SPARC (Specification, Pseudocode, Architecture, Refinement, Completion) comprehensive development methodology with multi-agent orchestration
日本語の概要は準備中です。原文の説明を表示しています。
SPARC (Specification, Pseudocode, Architecture, Refinement, Completion) comprehensive development methodology with multi-agent orchestration
日本語の概要は準備中です。原文の説明を表示しています。
Provides patterns for testing utility classes, static methods, and helper functions. Validates pure functions, null handling, edge cases, and boundary conditions. Generates AssertJ assertions and @ParameterizedTest for string utils, math utils, validators, and collection helpers. Use when testing utils, test helpers, helper functions, static methods, or verifying utility code correctness.
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Implements HIPAA de-identification methods under 45 CFR §164.514(a)-(b). Covers expert determination method and safe harbor method with 18 identifiers removal, re-identification risk assessment, limited dataset requirements, and data use agreements. Keywords: HIPAA de-identification, safe harbor, expert determination, 18 identifiers, limited dataset, PHI.
日本語の概要は準備中です。原文の説明を表示しています。
Fix misleading Flutter/Dart test failures where expected data is empty ([]) or default values instead of the mocked response, caused by stale Mockito generated mocks or missing stubs being silently swallowed by try/catch in provider/repository code. Use when: (1) Test expects non-empty data but gets [], (2) Mock stubs for a method are set up but the code under test returns fallback/empty results, (3) A PR added new methods to a service class and tests that previously passed now fail with misleading "expected X, actual: empty" assertions, (4) "Generated files are out of date" CI error alongside test failures. The root cause is MissingStubError thrown by unstubbed mock methods, caught by production try/catch blocks, causing silent fallback to empty state.
日本語の概要は準備中です。原文の説明を表示しています。
Turn vague or partially formed AI, computer-science, data-driven, and engineering-method research directions into evidence-grounded, falsifiable, paper-ready Research Idea Briefs through heuristic questioning, staged confirmation, literature positioning, novelty attack, and method-figure planning. Use when the user needs to clarify a research idea, formalize inputs/outputs/objectives/constraints, frame background and motivation, select 3-5 anchor papers, identify a defensible gap, derive 2-3 contributions, stress-test novelty, or design an input-to-output method framework and core-paper figure. Also trigger on requests such as 明确科研 idea、启发式梳理 idea、互动追问科研问题、梳理论文创新点、定义研究任务、找对标论文、把研究方向变成论文方案、画方法框架图. Do not use as the primary workflow for running experiments, exhaustive systematic reviews, drafting full manuscript sections, or polishing finished prose.
日本語の概要は準備中です。原文の説明を表示しています。
Think and work like an expert Formal Methods Researcher. Use when a task calls for Formal Methods Researcher judgment. Reasons from operational semantics and temporal logics through SPIN/TLA+/PRISM, Coq/Lean/Isabelle, Z3/CVC5, refinement and separation logic, vacuity and false-positive diagnosis, and Dafny/F* versus property-based testing boundaries.
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Systematic debugging methodology - scientific method, hypothesis testing, and root cause analysis that works across all technologiesUse when "bug, debugging, not working, broken, investigate, root cause, why is this happening, figure out, troubleshoot, doesn't work, unexpected behavior, debugging, root-cause, hypothesis, scientific-method, troubleshooting, bug-hunting, investigation, problem-solving" mentioned.
日本語の概要は準備中です。原文の説明を表示しています。
SPARC (Specification, Pseudocode, Architecture, Refinement, Completion) comprehensive development methodology with multi-agent orchestration
日本語の概要は準備中です。原文の説明を表示しています。
SPARC (Specification, Pseudocode, Architecture, Refinement, Completion) comprehensive development methodology with multi-agent orchestration
日本語の概要は準備中です。原文の説明を表示しています。