「orr」の検索結果

Corrects the gene-independent copy-number artifact in CRISPR-Cas9 screens (Aguirre 2016 / Munoz 2016 Cancer Discov) where amplified loci appear essential from DNA-damage burden of simultaneous cuts. Covers the p53-dependent G2-arrest mechanism, CRISPRcleanR (Iorio 2018) unsupervised pre-hoc correction, CERES (Meyers 2017) joint CN + gene-effect model, Chronos (Dempster 2021) DepMap-standard population-dynamics + CN model with lowest residual bias, the decision tree by data availability, the Spearman LFC-vs-CN diagnostic, focal-amplification examples (ERBB2 in HER2+, MYC in colorectal, FGFR1 in head and neck), and CRISPRi/a alternatives that bypass the artifact. Use when screening cancer cell lines, diagnosing essentiality at amplified loci, choosing CRISPRcleanR / CERES / Chronos, deciding whether CN correction is needed before MAGeCK / BAGEL2 / drugZ, or switching from Cas9 to CRISPRi.

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Correlates security events in IBM QRadar SIEM using AQL (Ariel Query Language), custom rules, building blocks, and offense management to detect multi-stage attacks across network, endpoint, and application log sources. Use when SOC analysts need to investigate QRadar offenses, build correlation rules, or tune detection logic for reducing false positives.

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Correlation-regime detection and crisis attribution — edge-density regime states with hysteresis, causal (no look-ahead) smoothing, regime-aware exposure context, first-mover crisis attribution with honest NAME / MACRO / AMBIGUOUS / ABSTAIN verdicts, and a correlation-rewiring leaderboard that catches slow bleed-outs

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Optimizes LLM inference with NVIDIA TensorRT for maximum throughput and lowest latency. Use for production deployment on NVIDIA GPUs (A100/H100), when you need 10-100x faster inference than PyTorch, or for serving models with quantization (FP8/INT4), in-flight batching, and multi-GPU scaling.

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When the user corrects a factual error, root-cause it immediately. Don't just note the correction — trace the error to its source, fix the source, and prevent recurrence. Every factual error is either a data error (bad brain page, bad memory file, bad rendered SOUL/USER identity, bad facts row) or a hallucination (LLM confabulated from partial signals).

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Optimizes LLM inference with NVIDIA TensorRT for maximum throughput and lowest latency. Use for production deployment on NVIDIA GPUs (A100/H100), when you need 10-100x faster inference than PyTorch, or for serving models with quantization (FP8/INT4), in-flight batching, and multi-GPU scaling.

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Query Fintel (fintel.io) institutional market data through its REST API or official MCP server. Use this skill whenever the user mentions Fintel or asks about short interest, short interest ratio or days to cover, short squeeze data, borrow rate or cost to borrow, shares available to borrow, daily short volume, fails-to-deliver (FTD), 13F institutional owners ("who owns X"), insider buying or selling from SEC Form 3/4/5, analyst price targets, ratings and forecasts, dividend or earnings history and calendars, EOD or last prices, security lookup by ticker, CUSIP, ISIN, or FIGI, Fintel leaderboards, or their Fintel watchlists and alerts. Read-only: GET endpoints only.

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[omh] Native program crashes or corrupts memory: prepare hypothesis-driven debugging of native binaries and instruct the executor to drive a DAP debugger instead of printf. Use when the user says: native-debugging, native debugging, native binary, segfault, segmentation fault, core dump, stack corruption, memory corruption.

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Batch effect correction for CRISPR screens. Covers normalization across batches, technical replicate handling, and batch-aware analysis. Use when combining screens from multiple batches or correcting systematic technical variation.

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Use when performing correlation analysis between two variables including Pearson and Spearman correlation methods. Supports command-line parameter input, automatic data format detection, parameter validation, result directory creation, and CSV or TXT format result export.

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Find the mistakes agents keep repeating in this repo and make each one impossible. Try architecture first, then types, then a lint whose error names the fix, then a test, and write docs last. Prove each check fails on a real past mistake. Repeat this each time the operator corrects you. Use for /correct.

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Find the mistakes agents keep repeating in this repo and make each one impossible. Try architecture first, then types, then a lint whose error names the fix, then a test, and write docs last. Prove each check fails on a real past mistake. Repeat this each time the operator corrects you. Use for /correct.

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Handles batch effects in bulk RNA-seq via design-matrix inclusion (the correct path for DE), ComBat/ComBat-seq for visualization, SVA for unknown latent factors, RUVSeq for negative-control-gene-anchored unwanted variation, and limma::removeBatchEffect for plotting only. Encodes the Nygaard 2016 cardinal sin against testing on a batch-corrected matrix, the choice between SVA/RUVg/RUVs/RUVr, the confounding non-identifiability problem, the single-cell boundary (Harmony/MNN are NOT for bulk), and the Goh 2017 harmonization critique. Use when designing a DE analysis with batch structure, troubleshooting batch-dominated PCA, choosing ComBat vs ComBat-seq, handling unknown batch via SVA, integrating across studies, or deciding when (rarely) to subtract batch.

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CAPA system management for medical device QMS, covering root cause analysis, corrective action planning, and effectiveness verification. Use for CAPA investigations, 5-Why and fishbone analysis, and corrective action tracking.

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Thin Bevy genre router for Horror. Keywords: Bevy, Horror, genre, ECS, router.

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Statistical and computational method to analyze the co-expression of gene pairs at single cell level. It provides the foundation for single-cell gene interactome analysis. The basic idea is studying the zero UMI counts' distribution instead of focusing on positive counts; this is done with a generalized contingency tables framework. COTAN can effectively assess the correlated or anti-correlated expression of gene pairs. It provides a numerical index related to the correlation and an approximate

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Append a learning entry to AGENTS_LEARNING.md when an AI agent makes a mistake. Auto-activates after a pre-write audit auto-fix, a retrospective correction loop, or a mid-session user correction. Use when: mistake, wrong, correction, my bad, agent error, learning log.

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Use when an app, service, or user-mode driver host heap fails or Application Verifier detects corruption; inspect history and bounds. Not for kernel pool corruption or ordinary OOM.

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Deep generative models for single-cell omics: probabilistic batch correction (scVI), semi-supervised annotation (scANVI), CITE-seq RNA+protein (totalVI), transfer learning (scARCHES), and DE with uncertainty. Unified setup→train→extract API on AnnData. Use harmony-batch-correction for fast linear correction without deep learning; muon for multi-modal MuData workflows.

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DepMap CRISPR gene effect (Chronos) analysis: sign convention for essentiality, per-gene NaN-safe Spearman correlation, data loading/alignment. For general NaN-safe correlation see nan-safe-correlation; for quality filtering see degenerate-input-filtering.

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Per-feature NaN-safe Spearman/Pearson correlation across many features (genes, proteins, variants) with missing values. Covers why bulk matrix shortcuts fail, correct pairwise deletion, degenerate input filtering, and large-dataset performance. Use statistical-analysis for test choice; shap-model-explainability for interpretability.

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Online (incremental) covariance, correlation, and precision estimation in Python — the streaming complement to sklearn.covariance. Use when code needs a covariance/correlation matrix updated per observation, recomputes np.cov/np.corrcoef in a rolling loop, must judge or compare covariance estimates, or proposes a new covariance methodology. Points to task-specific skills.

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Implements data subject rights mechanisms for AI systems including right to explanation of AI decisions, contestation procedures, human review, model output correction, and training data access. Covers GDPR Arts. 15-22 and AI Act Art. 86. Keywords: data subject rights, AI explanation, contestation, human review, training data access, model correction.

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PS1/PSX-era horror art direction combining low-poly affine textures, limited color depth, fog, and psychological horror staging for Blender assets.

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