Match BIM quantities to CWICR work items. Map element categories to cost codes, validate quantities, and generate cost-linked QTOs.
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概要と使いどころ
Match BIM quantities to CWICR work items. Map element categories to cost codes, validate quantities, and generate cost-linked QTOs.
日本語の概要は準備中です。原文の説明を表示しています。
Use bitsandbytes for k-bit PyTorch quantization, Hugging Face quantized model loading, 8-bit and paged optimizers, direct quantized layers/functions, and backend installation diagnostics.
日本語の概要は準備中です。原文の説明を表示しています。
Guides privacy impact assessment for emerging technologies including IoT, blockchain, AR/VR, quantum computing, and digital twins. Covers risk identification methodology, proportionality assessment, and technology-specific privacy challenges. Activate when evaluating new technology adoption, innovation projects, or emerging tech procurement. Keywords: PIA, emerging technology, IoT, blockchain, AR/VR, quantum computing, digital twins, innovation privacy.
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
日本語の概要は準備中です。原文の説明を表示しています。
量化交易 (量化交易 (Quantitative Trading) — 面向股票、期货与期权二级市场的系统化交易者(私募/自营/公募量化研究员、CTA 交易员、有工程能力的个人系统化交易者)的『把一个交易想法,变成一个在真钱上还站得住的策略』的判断体系;不是加密与链上交易(那是 crypto-onchain-trading 的范围),不是个人长期资产配置与理财(personal-investing),不是卖方投行的并购与承销(investment-banking-mna),也不是主观基本面选股与券商 IT 系统开发。覆盖:(a) 第一性张力 —— 这行的核心世界观分歧:**经济学解释先行 ⇄ 数据里挖出来就行**(一派要求任何超额收益背后先有风险补偿或行为偏差的故事,否则视为噪音;另一派认为解释是事后编的,只信严格的样本外与实盘,机器学习派把这条推到极致,两派对同一个因子会给出完全相反的判断);**横截面选股 ⇄ 时序趋势跟踪**(选股要在同一时点比较一篮子标的的相对好坏、假设均值回复与相对定价,CTA 趋势在单一品种的时间序列上假设动量延续,两者的研究方法、回测口径、风险来源和亏损形态几乎不重叠,却常被外行混为一谈);**样本内的漂亮曲线 ⇄ 多重检验之后还剩什么**(因子动物园与可复制性危机是本行最重要的一次集体自省:显著性门槛该抬多高、发表后收益衰减多少、大量已发表因子在严格复制下失效,以及回测过拟合的概率如何度量);**回测至上 ⇄ 只信实盘**(回测是唯一能低成本证伪的工具,也是最容易骗自己的工具:前视偏差、幸存者偏差、时点数据缺失、参数寻优、重复使用同一份历史数据;于是有人把纸上交易与小仓位实盘当成唯一可信的检验);**alpha ⇄ 容量与成本**(一个策略的规模是它自己的敌人:冲击成本随规模上升、换手越高越吃成本、拥挤度让同类策略在回撤时同时踩踏;毛收益漂亮而净收益为负是新手最常见的死法);**风险预算 ⇄ 收益最大化**(波动率目标、凯利与部分凯利、风险平价、回撤止损、杠杆与尾部,这一层的分歧决定了同一个信号在不同人手里是稳健产品还是爆仓故事);**高频做市 ⇄ 中低频统计套利与基本面量化**(延迟、撮合机制、报单结构与硬件是一套技能树,因子构建、组合优化与风险模型是另一套,混谈两者是外行破绽之一);**学术公开 ⇄ 业界闭源**(真正在赚钱的策略通常不发表,公开材料存在系统性的幸存者偏差与选择性披露,这是本行诚实边界的核心);**中国市场的制度约束 ⇄ 教科书假设**(T+1、涨跌停、融券与做空成本、股指期货基差与贴水、行业与市值中性化的实际口径、指数增强与市场中性产品的收益来源,以及监管对程序化交易与高频交易的报告与差异化收费要求,让直接照搬美股论文的做法在 A 股经常失效);**模型信心 ⇄ 制度与市场结构变化**(策略衰减、结构性断点、极端行情下相关性同时上升、去杠杆踩踏,这些不是尾部意外而是本行的常态风险)。(b) 工具栈 —— 数据(行情与基本面的时点数据 point-in-time、复权口径、停牌与退市处理、财报修订、指数成分历史、期货主力连续合约的拼接方式、期权链与波动率曲面数据;供应商与开源社区两条路线)、研究框架(向量化回测与事件驱动回测的取舍、因子检验与分层回测、组合优化与风险模型、机器学习工具链与交叉验证的时间序列改造)、执行与交易接口(券商与期货柜台接口、模拟盘、订单类型与算法委托、成交回报与对账)、基础设施(时序数据库与列式存储、行情落地、任务编排、实验记录与版本管理)、以及最被低估的东西:一份写清楚假设与失效条件的策略说明书、一套不会自欺的回测规范、一张归因表 —— 选型的真正分岔从来不是功能清单,而是『你的策略是靠信号质量赢,还是靠执行与成本赢』。(c) 心智模型层 —— 收益必须先有来源(风险补偿、行为偏差、结构性约束或提供流动性);样本外只有一次,用完就没了;毛收益是观点,净收益才是事实;规模是策略的敌人;相关性在你最需要分散的时候上升;回测里每多试一次,显著性就贬值一次;活下来比赢一次重要,所以先定风险预算再谈收益。(d) 工作流 —— 想法与假设成文、数据准备与清洗、单因子与信号检验、组合构建与风险约束、交易成本与容量估计、样本外与滚动前推验证、纸上交易与小仓位实盘、上线监控与风控阈值、业绩归因与衰减检测、策略退役与复盘、极端行情与事故处置、多策略配置与资金分配。(e) 表达 DNA、质量基准(什么算一次可信的回测与一次合格的策略上线)、反模式(外行与新手最容易犯的错:只看年化与最大回撤、参数寻优后的曲线拟合、忽略成本与容量、用未来数据、拿主力连续合约当真实可交易序列、把杠杆当收益来源、爆仓后归因于黑天鹅)、智识谱系(学术因子与资产定价派、系统化 CTA 与趋势跟踪派、金融机器学习派、市场微观结构与执行派、期权与波动率交易派、风险管理与尾部批评派、中国私募的指数增强与市场中性实践派)。) Master OS — automated mastery of 量化交易 (Quantitative Trading) — 面向股票、期货与期权二级市场的系统化交易者(私募/自营/公募量化研究员、CTA 交易员、有工程能力的个人系统化交易者)的『把一个交易想法,变成一个在真钱上还站得住的策略』的判断体系;不是加密与链上交易(那是 crypto-onchain-trading 的范围),不是个人长期资产配置与理财(personal-investing),不是卖方投行的并购与承销(investment-banking-mna),也不是主观基本面选股与券商 IT 系统开发。覆盖:(a) 第一性张力 —— 这行的核心世界观分歧:**经济学解释先行 ⇄ 数据里挖出来就行**(一派要求任何超额收益背后先有风险补偿或行为偏差的故事,否则视为噪音;另一派认为解释是事后编的,只信严格的样本外与实盘,机器学习派把这条推到极致,两派对同一个因子会给出完全相反的判断);**横截面选股 ⇄ 时序趋势跟踪**(选股要在同一时点比较一篮子标的的相对好坏、假设均值回复与相对定价,CTA 趋势在单一品种的时间序列上假设动量延续,两者的研究方法、回测口径、风险来源和亏损形态几乎不重叠,却常被外行混为一谈);**样本内的漂亮曲线 ⇄ 多重检验之后还剩什么**(因子动物园与可复制性危机是本行最重要的一次集体自省:显著性门槛该抬多高、发表后收益衰减多少、大量已发表因子在严格复制下失效,以及回测过拟合的概率如何度量);**回测至上 ⇄ 只信实盘**(回测是唯一能低成本证伪的工具,也是最容易骗自己的工具:前视偏差、幸存者偏差、时点数据缺失、参数寻优、重复使用同一份历史数据;于是有人把纸上交易与小仓位实盘当成唯一可信的检验);**alpha ⇄ 容量与成本**(一个策略的规模是它自己的敌人:冲击成本随规模上升、换手越高越吃成本、拥挤度让同类策略在回撤时同时踩踏;毛收益漂亮而净收益为负是新手最常见的死法);**风险预算 ⇄ 收益最大化**(波动率目标、凯利与部分凯利、风险平价、回撤止损、杠杆与尾部,这一层的分歧决定了同一个信号在不同人手里是稳健产品还是爆仓故事);**高频做市 ⇄ 中低频统计套利与基本面量化**(延迟、撮合机制、报单结构与硬件是一套技能树,因子构建、组合优化与风险模型是另一套,混谈两者是外行破绽之一);**学术公开 ⇄ 业界闭源**(真正在赚钱的策略通常不发表,公开材料存在系统性的幸存者偏差与选择性披露,这是本行诚实边界的核心);**中国市场的制度约束 ⇄ 教科书假设**(T+1、涨跌停、融券与做空成本、股指期货基差与贴水、行业与市值中性化的实际口径、指数增强与市场中性产品的收益来源,以及监管对程序化交易与高频交易的报告与差异化收费要求,让直接照搬美股论文的做法在 A 股经常失效);**模型信心 ⇄ 制度与市场结构变化**(策略衰减、结构性断点、极端行情下相关性同时上升、去杠杆踩踏,这些不是尾部意外而是本行的常态风险)。(b) 工具栈 —— 数据(行情与基本面的时点数据 point-in-time、复权口径、停牌与退市处理、财报修订、指数成分历史、期货主力连续合约的拼接方式、期权链与波动率曲面数据;供应商与开源社区两条路线)、研究框架(向量化回测与事件驱动回测的取舍、因子检验与分层回测、组合优化与风险模型、机器学习工具链与交叉验证的时间序列改造)、执行与交易接口(券商与期货柜台接口、模拟盘、订单类型与算法委托、成交回报与对账)、基础设施(时序数据库与列式存储、行情落地、任务编排、实验记录与版本管理)、以及最被低估的东西:一份写清楚假设与失效条件的策略说明书、一套不会自欺的回测规范、一张归因表 —— 选型的真正分岔从来不是功能清单,而是『你的策略是靠信号质量赢,还是靠执行与成本赢』。(c) 心智模型层 —— 收益必须先有来源(风险补偿、行为偏差、结构性约束或提供流动性);样本外只有一次,用完就没了;毛收益是观点,净收益才是事实;规模是策略的敌人;相关性在你最需要分散的时候上升;回测里每多试一次,显著性就贬值一次;活下来比赢一次重要,所以先定风险预算再谈收益。(d) 工作流 —— 想法与假设成文、数据准备与清洗、单因子与信号检验、组合构建与风险约束、交易成本与容量估计、样本外与滚动前推验证、纸上交易与小仓位实盘、上线监控与风控阈值、业绩归因与衰减检测、策略退役与复盘、极端行情与事故处置、多策略配置与资金分配。(e) 表达 DNA、质量基准(什么算一次可信的回测与一次合格的策略上线)、反模式(外行与新手最容易犯的错:只看年化与最大回撤、参数寻优
日本語の概要は準備中です。原文の説明を表示しています。
音乐制作 / 混音 (音乐制作 / 混音 (Music Production & Mixing) — 录音棚与卧室工作室里把一首歌从编曲/录音/编程做到混音/母带成品的工程+艺术认知操作系统,面向制作人(producer)、混音师(mixing engineer)、母带工程师(mastering engineer)、beatmaker、唱作人/bedroom producer,以及想入行/服务这行(录音棚、plugin 厂商、sample 公司)的视角。覆盖: (a) 第一性张力 — **服务歌曲/情绪 (serve the song / emotion-first: 技术只为打动人,'if it sounds good it is good',用耳朵不用眼睛) ⇄ 技术正确/工程纪律 (technical correctness: gain staging 增益结构、headroom 余量、相位 phase、监听校准、LUFS 响度规范)**; **黄金耳朵/直觉混音 (mix by ears, reference-driven, 不看分析仪) ⇄ 看表/分析仪/规则 (mix by metrics: EQ 曲线、频谱仪 spectrum analyzer、相关计 correlation meter)**; **少即是多/减法混音 (subtractive, 'less is more', 录好源头 = 混音成功一半) ⇄ 重度处理/'we'll fix it in the mix' (heavy processing, 后期补救)**; **In-the-box 全数字 (ITB: DAW + 插件,召回方便,bedroom 可达专业) ⇄ 模拟硬件/outboard (analog console + 硬件,'mojo'/谐波染色 vs 召回噩梦)**; **人性化/groove/不完美 (humanize, push/pull, 'the feel') ⇄ 量化/网格/修音 (quantize to grid, pitch-correct, 'in the pocket' 靠编辑)**; (b) 核心工作流 / pipeline (最标准、最易蒸高质量+CLI 化) — 编曲制作 arrangement/production → 录音/编程 tracking/programming → 编辑 editing (comping 选段/quantize/pitch-correct/time-align) → 混音 mixing (gain staging → balance 平衡 → EQ → compression → 空间 reverb/delay → 自动化 automation → 总线/母线处理 bus/mix-bus) → 母带 mastering (响度/EQ/限制 limiting/dither/排序+间隔) → 交付 delivery (DDP/streaming spec/stems); (c) 工具栈 — DAW (Pro Tools 录音棚标准/Ableton Live 电子+现场/Logic Pro Mac 性价比/FL Studio beatmaker/Cubase/Studio One/Reaper); 插件 (EQ: FabFilter Pro-Q/SSL/API; 压缩: 1176/LA-2A/SSL bus comp 及其复刻 Waves/UAD/Plugin Alliance; 混响: Valhalla/Lexicon/Bricasti; 调音: Auto-Tune/Melodyne; 限制器 limiter: Pro-L 2/Ozone); 硬件 (监听音箱 monitors: Yamaha NS-10/Genelec; 声学处理 acoustic treatment; 转换器 converters: Apollo/RME; 话筒 mics: U47/SM7B/57); 采样/音色 (Splice/sample packs/Kontakt/Serum 合成器); (d) 知识正典 — Mixing Secrets for the Small Studio (Mike Senior)、The Mixing Engineer's Handbook / Recording Engineer's Handbook (Bobby Owsinski)、Zen and the Art of Mixing (Mixerman)、The Art of Mixing (David Gibson 可视化)、Modern Recording Techniques、Sound on Sound 杂志、Mix With The Masters 大师课、Pensado's Place; (e) figures/流派 — 混音大师 (Chris Lord-Alge CLA 摇滚/Andrew Scheps 'Stadium' 3-bus/Tony Maserati/Manny Marroquin/Serban Ghenea 流行隐形混音/Michael Brauer multing); 制作人 (Rick Rubin 减法/氛围、Quincy Jones、Dr. Dre 完美主义、Max Martin 流行结构、Jack Antonoff、Finneas bedroom→Grammy、Metro Boomin/trap、Timbaland、Pharrell); 母带 (Bob Katz K-system/响度战争批判、Bob Ludwig、Greg Calbi); 教育者 (Mike Senior、Pensado、Warren Huart Produce Like A Pro、Dan Worrall 技术深挖); (f) 行业话术/黑话 — gain staging/headroom/LUFS/true peak/comping/bouncing/printing/stems/DI/reamp/sidechain/parallel compression 并行压缩/mid-side/bus/aux/send-return/dry-wet/transient/sibilance/de-ess/pumping/mud 浑浊/harsh 刺耳/boxy/muddy/in the pocket/the pocket/quantize/swing/groove/vibe/mojo/reference track/A/B/recall/print/glue 胶水; (g) 争议/批判 — 响度战争 loudness war (Bob Katz/Loudness Penalty/streaming 归一化 LUFS 终结了吗)、修音/Auto-Tune 之争 (artistic vs cheating)、ITB vs 模拟玄学 (硬件 'warmth' 是否安慰剂、null test 盲测)、preset/AI 混音 (iZotope/LANDR/sample-based 是否毁了 craft)、bedroom producer 民主化 vs 录音棚消亡、'loudness'/over-compression、plugin 复刻 vs 真硬件、Spotify normalization 对母带的影响、过度依赖 reference/抄袭; (h) 创意 vs 技术张力是本行业 deep tacit 知识的核心 — 大量隐性 '听感' 知识难以言传,靠 reference/学徒/千小时积累。不含: 现场扩声 live sound/PA、音乐理论/作曲 composition (虽相关但聚焦录音棚后期制作)、配乐/film scoring (虽相关但聚焦歌曲制作)、纯硬件电子工程/合成器 DIY、音乐商业/版权/发行 (虽相关但聚焦制作技艺本身)。) Master OS — automated mastery of 音乐制作 / 混音 (Music Production & Mixing) — 录音棚与卧室工作室里把一首歌从编曲/录音/编程做到混音/母带成品的工程+艺术认知操作系统,面向制作人(producer)、混音师(mixing engineer)、母带工程师(mastering engineer)、beatmaker、唱作人/bedroom producer,以及想入行/服务这行(录音棚、plugin 厂商、sample 公司)的视角。覆盖: (a) 第一性张力 — **服务歌曲/情绪 (serve the song / emotion-first: 技术只为打动人,'if it sounds good it is good',用耳朵不用眼睛) ⇄ 技术正确/工程纪律 (technical correctness: gain staging 增益结构、headroom 余量、相位 phase、监听校准、LUFS 响度规范)**; **黄金耳朵/直觉混音 (mix by ears, reference-driven, 不看分析仪) ⇄ 看表/分析仪/规则 (mix by metrics: EQ 曲线、频谱仪 spectrum analyzer、相关计 correlation meter)**; **少即是多/减法混音 (subtractive, 'less is more', 录好源头 = 混音成功一半) ⇄ 重度处理/'we'll fix it i
日本語の概要は準備中です。原文の説明を表示しています。
Cyber Risk Quantification engineer for CyberRadar. Implements FAIR (Factor Analysis of Information Risk) methodology, Monte Carlo simulation for loss distribution modeling, financial impact quantification in multi-currency (SAR, USD, EUR, GBP), loss exceedance curves, risk treatment ROI calculation, insurance premium optimization, and board-ready financial risk reporting. Transforms qualitative risk assessments into monetary terms for executive decision-making. Triggers on: CRQ, FAIR, Monte Carlo, financial impact, loss modeling, risk quantification, cyber insurance, risk treatment ROI, financial risk.
日本語の概要は準備中です。原文の説明を表示しています。
Quantitative strategy frameworks: pairs trading/cointegration, volatility regime strategies, seasonality/calendar effects, multi-factor models (IC/IR), factor research and screening, correlation analysis, statistical methods (ADF/GARCH), strategy optimization, execution modeling, hedging, and ML-based prediction (sklearn). Also provides CLI access to run indicator scripts against K-line data. Triggers: "量化", "因子", "配对交易", "协整", "波动率策略", "季节性", "多因子", "IC", "机器学习", "对冲", "量化策略", "協整", "波動率策略", "季節性", "多因子", "對沖", "quant", "pairs trading", "cointegration", "volatility strategy", "seasonality", "multi-factor", "factor model", "IC IR", "machine learning", "hedging", "walk-forward", "配對交易", "機器學習", "因子選股"
日本語の概要は準備中です。原文の説明を表示しています。
End-to-end automated model quantization and accuracy tuning workflow. Use when user asks for automated model quantization and accuracy tuning, e.g. "自动量化", "量化调优", "一键量化", "精度调优", etc. 当用户给出多卡(≥2 卡)卡号时,量化阶段通过 EP 并行适配(msmodelslim-ep-parallel-adaptation)保证多卡 EP 并行,调优主流程仍在本 Skill。
日本語の概要は準備中です。原文の説明を表示しています。
执行模型量化。通过 msmodelslim quant 依据 Practice YAML 对模型进行量化。
日本語の概要は準備中です。原文の説明を表示しています。
在 W8A8 动态量化后,用 MindIE-SD 冒烟测试 DiT 量化权重是否可加载(可选 skill)。与 `quant-tuning-evaluate`(DiT 扩展节)的区别:本 skill 仅做"能跑通 + 权重可用"的轻量验证(4~16 条 prompt,几分钟出结果),不算分;后者产出视频集交 `quant-tuning-score-dit`(AISBench-VBench 16 维度)评分,是调优回路一环。不引入 vLLM-Ascend、不做精度指标评估(FID/CLIP-score 等)。
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
日本語の概要は準備中です。原文の説明を表示しています。
Quantiza LLMs para 8-bit ou 4-bit com redução de memória de 50-75% e perda mínima de acurácia. Use quando a memória GPU é limitada, precisa ajustar modelos maiores ou quer inferência mais rápida. Suporta formatos INT8, NF4, FP4, treinamento QLoRA e otimizadores 8-bit. Funciona com HuggingFace Transformers.
日本語の概要は準備中です。原文の説明を表示しています。
Quantização de pesos consciente da ativação para compressão de LLM de 4-bit com aceleração 3x e perda mínima de acurácia. Use ao implantar modelos grandes (7B-70B) em memória GPU limitada, quando precisa de inferência mais rápida que GPTQ com melhor preservação de acurácia, ou para modelos com instruções ajustadas e multimodais. Vencedor do Prêmio Melhor Artigo MLSys 2024.
日本語の概要は準備中です。原文の説明を表示しています。
Quantização pós-treinamento em 4-bits para LLMs com perda mínima de precisão. Use para implantar modelos grandes (70B, 405B) em GPUs de consumo, quando você precisa de redução de memória 4× com <2% de degradação de perplexidade, ou para inferência mais rápida (aceleração de 3-4×) vs FP16. Integra com transformers e PEFT para fine-tuning QLoRA.
日本語の概要は準備中です。原文の説明を表示しています。
Post-training 4-bit quantization for LLMs with minimal accuracy loss. Use for deploying large models (70B, 405B) on consumer GPUs, when you need 4× memory reduction with <2% perplexity degradation, or for faster inference (3-4× speedup) vs FP16. Integrates with transformers and PEFT for QLoRA fine-tuning.
日本語の概要は準備中です。原文の説明を表示しています。
GGUF format and llama.cpp quantization for efficient CPU/GPU inference. Use when deploying models on consumer hardware, Apple Silicon, or when needing flexible quantization from 2-8 bit without GPU requirements.
日本語の概要は準備中です。原文の説明を表示しています。
Designs and validates quantitative targeted metabolomics assays (MRM/SRM on triple-quadrupole, PRM on high-resolution instruments) to report absolute concentrations. Covers the internal-standard strategy (external cal -> global IS -> standard addition -> stable-isotope-labeled IS), weighted calibration judged by back-calculated %RE not R-squared, ion-ratio quantifier/qualifier confirmation, matrix-effect/recovery characterization, and ICH M10 method validation. Use when quantifying a closed panel of known metabolites with units, building or validating an LC-MS/MS assay, choosing an IS or calibration weighting, or judging whether a reported concentration is trustworthy. For untargeted feature detection see metabolomics/xcms-preprocessing; for group statistics see metabolomics/statistical-analysis; for flux/MID/tracing see metabolomics/isotope-tracing.
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
日本語の概要は準備中です。原文の説明を表示しています。
GGUF format and llama.cpp quantization for efficient CPU/GPU inference. Use when deploying models on consumer hardware, Apple Silicon, or when needing flexible quantization from 2-8 bit without GPU requirements.
日本語の概要は準備中です。原文の説明を表示しています。
NVIDIA GPU上で大規模言語モデルの応答生成を高速化し、APIとして提供する設定を支援します。量子化や一括処理、複数GPUへの分散も扱います。
Simulate and audit closed and open quantum-system models with QuTiP 5, including deterministic, trajectory, steady-state, spectral, and phase-space workflows. Use for local quantum-dynamics work where physical assumptions, dimensions, and numerical convergence must be explicit.
日本語の概要は準備中です。原文の説明を表示しています。
Builds, simulates, transpiles, and executes quantum circuits with Qiskit and IBM Quantum Runtime. Use for Qiskit 2.x circuits and operators, V2 Sampler or Estimator primitives, target-aware transpilation, local or noisy simulation, IBM QPU execution, Runtime sessions or batches, error mitigation, and Qiskit ecosystem packages.
日本語の概要は準備中です。原文の説明を表示しています。