「representation」の検索結果

The BloodGen3Module package provides functions for R user performing module repertoire analyses and generating fingerprint representations. Functions can perform group comparison or individual sample analysis and visualization by fingerprint grid plot or fingerprint heatmap. Module repertoire analyses typically involve determining the percentage of the constitutive genes for each module that are significantly increased or decreased. As we describe in details;https://www.biorxiv.org/content/10.11

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R generic interface to Hi-C contact matrices in `.(m)cool`, `.hic` or HiC-Pro derived formats, as well as other Hi-C processed file formats. Contact matrices can be partially parsed using a random access method, allowing a memory-efficient representation of Hi-C data in R. The `HiCExperiment` class stores the Hi-C contacts parsed from local contact matrix files. `HiCExperiment` instances can be further investigated in R using the `HiContacts` analysis package.

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GeoToolbox PlaceDescriptor patterns with MapKit integration for location representation, geocoding, and multi-service place identifiers. Use when working with place descriptors, geocoding, or cross-service location data.

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Generates a Python CLI tool for bidirectional conversion between 4-byte floating-point numbers and hexadecimal memory representations, featuring a continuous loop and robust input parsing.

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Generate images using Google Gemini's image generation capabilities. Use this skill when the user needs to create, generate, or produce images for any purpose including UI mockups, icons, illustrations, diagrams, concept art, placeholder images, or visual representations.

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Comprehensive toolkit for protein language models including ESM3 (generative multimodal protein design across sequence, structure, and function) and ESM C (efficient protein embeddings and representations). Use this skill when working with protein sequences, structures, or function prediction; designing novel proteins; generating protein embeddings; performing inverse folding; or conducting protein engineering tasks. Supports both local model usage and cloud-based Forge API for scalable inference.

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GSEA and over-representation analysis (ORA) for RNA-seq and proteomics. Wraps Enrichr for ORA against MSigDB, KEGG, GO, and 200+ databases; runs preranked GSEA on ranked DE gene lists. Outputs enrichment tables and running-score plots. Use after DESeq2 or edgeR for pathway-level interpretation.

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PyTorch-based ML platform for drug discovery: graph molecular representation learning, property prediction (ADMET, activity), retrosynthesis, drug-target interaction (DTI), and pretraining on large molecular datasets. Provides GNN layers (GraphConv, GAT, MPNN), pretrained models, and benchmark datasets.

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Creates professional logical flow diagrams and logical system architecture diagrams using draw.io XML format (.drawio files). Use when creating: (1) logical flow diagrams showing data/process flow between system components, (2) logical architecture diagrams representing system structure without cloud provider specifics, (3) BPMN process diagrams, (4) UML diagrams (class, sequence, activity), (5) data flow diagrams (DFD), (6) decision flowcharts, or (7) system interaction diagrams. This skill focuses on generic/abstract representations, not AWS/Azure-specific architectures (use aws-drawio-architecture-diagrams for cloud diagrams).

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Research why neural architectures and training methods work through forward computation, geometry, gradients, optimization dynamics, historical experiments, and competing explanations. Use for deep mechanism questions about neural networks, AI models, layers, representations, or training; explain the meaning in plain language with evidence and explicit limits.

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Use when adding hypermedia links to REST responses, building self-describing APIs, or implementing Spring HATEOAS. Use when you see EntityModel, CollectionModel, or RepresentationModel in the project.

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Create detailed user personas based on research and data. Develop realistic representations of target users to guide product decisions and ensure user-centered design.

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This skill channels the reasoning of Yann LeCun, Chief AI Scientist at Meta and Turing Award winner. Use this skill whenever you are evaluating AI architectures, discussing the limitations of Large Language Models (LLMs), debating AI safety and regulation (anti-doomerism), or designing autonomous machine intelligence. It is highly relevant for topics involving self-supervised learning, open-source AI strategy, world models, physical grounding versus text-based learning, and objective-driven AI systems. Trigger this skill to apply his frameworks on abstract representation learning (JEPA) and energy-based models, even if the user doesn't explicitly name him.

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Creates visual representations of system structure including architecture diagrams, data flow diagrams, deployment diagrams, and sequence diagrams. Use when Claude needs to visualize system components, infrastructure, data flows, or interactions. Supports Mermaid (recommended for Markdown/GitHub), PlantUML (for detailed UML), and Graphviz/DOT (for complex networks). Trigger when users request diagrams, visualizations, or ask to "show", "diagram", "visualize", or "map out" system architecture, infrastructure, data flows, or component interactions.

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Performs abstract interpretation to produce summarized execution traces and high-level program behavior representations. Highlights key control flow paths, variable relationships, loop invariants, function summaries, and potential runtime states using abstract domains (intervals, signs, nullness, etc.). Use when analyzing program behavior, understanding execution paths, computing loop invariants, tracking variable ranges, detecting potential runtime errors, or generating program summaries without concrete execution.

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Generate abstract Control Flow Graph (CFG) representations of programs showing loops, branches, and function calls for static analysis or verification. Use when users need to: (1) Visualize program control flow structure, (2) Generate CFGs for static analysis tools, (3) Create control flow abstractions for formal verification, (4) Analyze program paths and reachability, (5) Document program structure. Supports both function-level (intraprocedural) and program-level (interprocedural) analysis with multiple output formats (textual, DOT/Graphviz, JSON).

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Define production-ready visual intent for Blender scenes and standalone assets, including focal hierarchy, depth layers, visual flow, scale and repetition rhythm, camera mobility, representation fidelity, and performance budgets. Use for original or reference-guided Blender work before construction choices are executed, especially environments, architecture, products, hero assets, or scenes whose modeling quality depends on coordinated spatial design rather than isolated objects.

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Think and work like an expert Functional Genomics Scientist. Use when a task calls for Functional Genomics Scientist judgment. Reasons from perturbation as causal probe, genotype-to-phenotype linkage, library representation, and effect-size-plus-FDR statistics through MAGeCK/BAGEL/CERES-Chronos, CRISPRcleanR, CRISPResso2, MPRAnalyze, and Perturb-seq pipelines while treating MOI/bottleneck artifacts, copy-number and p53/DSB toxicity, RNAi seed effects, and guide-assignment or gating errors as first-class failure modes.

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Use this skill for provider-independent reality capture that turns photographed or video-derived real places, objects, aerial sites, interiors, or people into photogrammetric meshes, NeRFs, or 3D Gaussian splats. It guides representation choice, capture planning, calibration and scale, reconstruction or training, cleanup, compression and LOD, coordinate and interchange handoff, visual/geometric QA, archival records, and property, location, people, and cultural rights checks. Do not use it for text-to-3D generation, synthetic asset invention, guaranteed metrology, or broad downstream finishing after handoff.

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Provider-independent production workflow for AI-assisted fashion campaigns, lookbooks, editorial fashion films, ecommerce/editorial hybrids, social cutdowns, virtual try-on assets, generated model/lifestyle ads, and retouched fashion visuals; use when an agent must plan, prompt, produce, review, localize, or deliver fashion imagery or video while preserving garment truthfulness, model consent, fit representation, claims substantiation, platform compliance, accessibility, and fashion QA.

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Provider-independent production workflow for recutting long talking-head, podcast, interview, webinar, panel, lecture, livestream, founder call, or customer-call footage into short clips, highlight reels, trailers, audiograms, captioned vertical videos, and social cutdowns. Use when an agent must ingest source recordings, transcribe and diarize speakers, select quotes without misrepresentation, preserve context, handle consent/rights/disclosures, clean jump cuts and audio, add captions, graphics, lower thirds, b-roll, platform variants, synthetic-media boundaries, review packets, delivery specs, and recut QA.

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Resolves rsIDs, navigates RsMergeArch/SNPHistory merge chains, and converts between rsID, SPDI, HGVS, and VCF representations using the dbSNP Build 156 JSON architecture. Use when normalizing variant identifiers, joining variant databases by cluster ID, or tracking deprecated rsIDs through historical merges.

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Build and maintain digital twins - virtual representations of physical systems that synchronize with real-world counterparts for monitoring, prediction, and optimization. Use when "digital twin, virtual model, real-time synchronization, physical-virtual coupling, predictive maintenance, asset modeling, system replica, live simulation, " mentioned.

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投行并购 (投行并购 / 交易撮合 (Investment Banking M&A / Dealmaking) — 面向并购顾问、企业融资、卖方/买方交易执行的职业认知操作系统，从业者(分析师 Analyst / 经理 Associate / 副总裁 VP / 董事 Director / 董事总经理 MD / 内部公司发展 Corp Dev / PE 投资人)、想入行者、以及服务这行(法律/会计/估值/咨询)的视角。覆盖: (a) 第一性张力 — 投行 M&A 的核心世界观分歧: **价格 vs 价值 (price 是市场愿意付的, value 是内在的, deal 在两者缝隙里成交) ⇄ 确定性 vs 最高价 (certainty of close 对卖方常胜过纸面最高报价) ⇄ 顾问/中介 vs 委托代理 (banker 是 agent, 客户利益 vs 成交费的激励冲突真实存在, 「banker 总想成交」是行业原罪批判)**; 更深层 — 「过程/竞价纪律 (controlled auction 制造竞争张力、信息不对称管理) ⇄ 关系/信任 (relationship banking、长期 coverage、reputational capital)」, 「叙事/包装 (the story, equity story, positioning) ⇄ 数字/尽调 (the numbers, diligence, quality of earnings)」, 「估值的科学外衣 (DCF/comps 的伪精确) ⇄ 谈判的真实定价 (价格由 leverage、竞争、时机决定)」; (b) 估值与分析正典 (最标准化、最易蒸出高质量+CLI 化) — DCF (折现现金流: FCF 预测/WACC 折现率/terminal value 终值/Gordon growth vs exit multiple), Comparable Companies (可比公司/trading comps: EV/EBITDA, EV/Revenue, P/E), Precedent Transactions (先例交易/deal comps: control premium 控制权溢价), LBO (杠杆收购模型: IRR/MOIC/debt schedule/sources & uses), Accretion/Dilution (增厚/摊薄分析: EPS 影响、pro forma), Sum-of-the-Parts (分部估值/SOTP), Football Field (估值区间图), Merger Model (合并模型: synergies 协同/purchase accounting/goodwill), Sensitivity/scenario; (c) 交易流程与产出物 — 卖方流程 (sell-side: teaser 简介 → NDA → CIM/IM 信息备忘录 → management presentation → IOI 意向函 → data room 数据室 → LOI/term sheet → confirmatory diligence → SPA 买卖协议 → signing → closing), 买方流程 (buy-side: thesis/sourcing → outreach → valuation → bid → exclusivity → diligence → financing → close), auction 类型 (broad/targeted/negotiated/preemptive bid); 产出物: pitchbook 推介材料、CIM、fairness opinion 公平意见、board presentation、fee letter、engagement letter; (d) 交易结构与条款 — consideration (cash/stock/mix/earnout 对赌)、deal protections (breakup fee 分手费/go-shop/no-shop/MAC 重大不利变化条款)、representations & warranties 陈述与保证、escrow 托管、working capital adjustment 营运资金调整、reverse termination fee、collar 价格区间、tender offer vs merger、hostile vs friendly、defensive tactics (poison pill 毒丸/white knight 白衣骑士/staggered board); (e) 行业结构与角色 — bulge bracket (高盛/摩根士丹利/JPM/BofA/花旗) vs elite boutique (Centerview/Evercore/Moelis/Lazard/PJT/Perella) vs middle market (Houlihan Lokey/William Blair/Harris Williams) vs regional/independent; analyst→associate→VP→director→MD 晋升金字塔; coverage (行业组) vs product (M&A/ECM/DCM/leveraged finance/restructuring); sponsors group (服务 PE); 买方包括 PE/strategic acquirer/corp dev; (f) 量化指标与节奏 — deal fee (success fee 业内通常约 1-2% 视规模递减/retainer/Lehman formula)、league table 排行榜、pitch→mandate 转化、deal velocity、hours culture (analyst 80-100h/week 文化批判)、bonus/comp 结构、deal sheet (简历上的成交清单); (g) 争议/批判 — fairness opinion 是否橡皮图章 (利益冲突: 出意见的 banker 也收成交费)、estimate 的伪精确 (DCF garbage in garbage out、假设驱动结论)、banker 永远建议成交 (deal 偏见、empire building 助推 CEO 自利并购)、协同效应系统性高估 (大量并购毁灭价值、winner's curse 赢家诅咒)、analyst 血汗工厂文化 (2021 高盛 13 人 deck 事件、过劳死争议)、advisory 价值 vs 中介寻租之争、bulge vs boutique 的利益独立性叙事 (boutique 标榜「无承销利益冲突」)、SPAC 泡沫与 de-SPAC 教训; (h) 流派/思想谱系 — 估值学派 (Aswath Damodaran 估值教父/纽大、Tim Koller McKinsey《Valuation》、McKinsey valuation 体系) vs 公司金融教科书派 (Rosenbaum & Pearl《Investment Banking》行业圣经、Brealey Myers Allen、CFI/WSP/BIWS 培训体系) vs 交易实战派 (Bruce Wasserstein《Big Deal》、Joseph Perella/Felix Rohatyn 老派 dealmaker、现代 boutique 创始人) vs 行为/批判派 (并购毁灭价值的学术证据、Damodaran 对协同/控制权溢价的批判、Matt Levine《Money Stuff》解构华尔街逻辑) vs PE/buy-side 视角 (LBO 数学、value creation 杠杆/运营/multiple expansion)。不含: 二级市场股票交易/卖方研究 (equity research)、零售财富管理/private banking、纯 ECM/IPO 承销执行 (虽相关但聚焦 M&A advisory)、纯 PE 投后运营、量化交易/对冲基金策略、纯公司财务报表会计。) Master OS — automated mastery of 投行并购 / 交易撮合 (Investment Banking M&A / Dealmaking) — 面向并购顾问、企业融资、卖方/买方交易执行的职业认知操作系统，从业者(分析师 Analyst / 经理 Associate / 副总裁 VP / 董事 Director / 董事总经理 MD / 内部公司发展 Corp Dev / PE 投资人)、想入行者、以及服务这行(法律/会计/估值/咨询)的视角。覆盖: (a) 第一性张力 — 投行 M&A 的核心世界观分歧: **价格 vs 价值 (price 是市场愿意付的, value 是内在的, deal 在两者缝隙里成交) ⇄ 确定性 vs 最高价 (certainty of close 对卖方常胜过纸面最高报价) ⇄ 顾问/中介 vs 委托代理 (banker 是 agent, 客户利益 vs 成交费的激励冲突真实存在, 「banker 总想成交」是行业原罪批判)**; 更深层 — 「过程/竞价纪律 (controlled auction 制造竞争张力、信息不对称管理) ⇄ 关系/信任 (rela

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