「spike」の検索結果

Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract) with SES scaling, k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user asks to "monitor brand mentions", "set up social listening", "did anything spike about us this week", or "watch these accounts for buying triggers"; runs always-on keyless listening — a versioned listening-query architecture (brand variants incl. misspellings and 中文 names, exclusion terms, per-source syntax for HN Algolia / Bluesky / GDELT / Tavily), a mention sweep with six-class triage (crisis / bug / lead / praise / question / spam) each routed with an SLA, a 7-day rolling baseline with spike flags (the crisis trigger input), a B2B trigger watchlist (funding / hiring / launch signals), and an explicit coverage disclosure where X/IG/TikTok/LinkedIn/小红书 numbers are proxy-labeled, never Measured. Not for launch-window telemetry (T-0→T+30 rank and review polling) — use launch-monitor. 舆情监听/品牌提及监测/基线突刺/触发信号

日本語の概要は準備中です。原文の説明を表示しています。

Use when the user asks to "monitor my launch", "track our Product Hunt / Hacker News ranking", or "watch the launch window"; runs the T-0 to T+30 window watch — pre-launch instrumentation verification (UTM/event checks, the upstream of RAMP P1), HN rank/points/comments polling with a comments-over-points flamewar early-warning (Estimated heuristic), PH votes/featured status, store charts and reviews, news echo, D0/W1/M1 KPI snapshots vs targets, spike-vs-sustain and owned-capture reads, and alert thresholds against the launch-tier KPI targets. Not for launch-day go/rollback calls — use launch-day-conductor; not for metric deep-dives — use performance-analyzer; not for SEO rank tracking — use rank-tracker. 发布监控/排名轮询/火焰战比/spike-sustain

日本語の概要は準備中です。原文の説明を表示しています。

Implement API threat protection using Google Apigee policies including JSON/XML threat protection, OAuth 2.0, SpikeArrest, and Advanced API Security for OWASP Top 10 defense.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

日本語の概要は準備中です。原文の説明を表示しています。

Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

Visualizes ChIP-seq data using deepTools (computeMatrix, plotHeatmap, plotProfile, bamCoverage, bamCompare), pyGenomeTracks (modern INI-driven track plots), Gviz (R browser-style), EnrichedHeatmap (ComplexHeatmap-based), ChIPseeker tag heatmaps, and IGV batch screenshots. Handles bigWig normalization choices (CPM, BPM, RPGC, spike-in scaled), bamCompare operations (log2 ratio, subtract, SES), k-means clustering of heatmaps for biological subgrouping, and spike-in-scaled tracks for global-shift experiments. Use when generating publication-quality ChIP-seq signal heatmaps, profile plots, genome-browser tracks, or comparing samples visually.

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes CUT&RUN (Skene Henikoff 2017) and CUT&Tag (Kaya-Okur 2019) chromatin profiling data. Handles SEACR vs MACS2 peak calling (with the btaf375 2025 benchmark guidance), pA-MNase vs pA-Tn5 vs pAG-Tn5 chimera differences, E. coli spike-in carryover normalization, IgG-only control logic (no input), characteristic fragment-size signatures (25-75 bp for CUT&Tag), and lower depth requirements (5M reads typical vs 25M for ChIP). Use when calling peaks from CUT&RUN/CUT&Tag, scaling by E. coli spike-in carryover, choosing SEACR norm mode, or comparing CUT&RUN/Tag results to traditional ChIP.

日本語の概要は準備中です。原文の説明を表示しています。

Identifies differentially bound ChIP-seq regions between conditions using DiffBind, csaw (sliding windows), DESeq2/edgeR/PyDESeq2 on count matrices, NormR (control-aware), or MAnorm2. Distinguishes three distinct normalization problems (composition bias, trended bias, global shifts) and matches each to its appropriate fix including spike-in scaling. Use when comparing ChIP-seq binding between experimental conditions, choosing normalization for global vs local changes, integrating spike-in data, or reconciling DiffBind/DESeq2 disagreement.

日本語の概要は準備中です。原文の説明を表示しています。

Create time-boxed technical spike documents for researching and resolving critical development decisions before implementation.

日本語の概要は準備中です。原文の説明を表示しています。

Throwaway experiments to validate an idea before build.

日本語の概要は準備中です。原文の説明を表示しています。

OpenClawのテスト中に起きるメモリ増加や不足を調べます。測定結果やメモリ内の記録を比較し、実際の解放漏れとテスト実行側の保持を見分け、修正を検証します。

• Vitestのメモリ不足を調べたいとき
• 同一プロセスのメモリ記録を比較したいとき
• 解放漏れとモジュール保持を見分けたいとき

ECC ToolsのGitHub Appで起きるPRの過剰作成や利用上限の抜け、高額モデルの意図しない使用をコードから追い、費用増加の原因と修正を検証するスキル。

• PRの過剰作成の原因調査
• 利用上限を超える同時処理の点検
• 無料枠での高額モデル利用の確認

Throwaway experiments to validate an idea before build.

日本語の概要は準備中です。原文の説明を表示しています。

Converts neuroscience acquisition data to Neurodata Without Borders files with NeuroConv and PyNWB, preserves metadata and timebases, checks evidence-based clock alignment, and produces schema validation, NWB Inspector findings and round-trip checks. Use for NWB conversion and synchronization of planar single-channel two-photon TIFF imaging plus timestamped behavioral position CSV; this skill does not perform spike sorting or claim tested support for arbitrary acquisition formats.

日本語の概要は準備中です。原文の説明を表示しています。

Two related workflows for a locally-cloned codebase, in one skill. Documentation mode produces a single, comprehensive, verifiable architecture document primarily by reading files on disk (local-first) — use it whenever the user wants to understand, map, document, research, or onboard onto a codebase ("research this repo", "write up the architecture", "do an architecture deep dive", "document how this codebase works", "map the system design", "create an onboarding doc"). Modernization mode generates a phased plan to modernize, migrate, upgrade, or rewrite a legacy system ("modernize this", "plan the migration", "how would we rewrite this", "how do we get off this legacy stack"); if no architecture document exists yet it first runs Documentation mode, then continues straight through to the plan. It assumes the legacy stack may be dead, runs a time-boxed feasibility spike, and picks the highest achievable rung on a safety ladder instead of demanding a fully-green legacy CI gate up front.

日本語の概要は準備中です。原文の説明を表示しています。

Detects ransomware encryption activity in real time using entropy analysis, file system I/O monitoring (Sysmon, watchdog, psutil), and behavioral scoring to identify mass file modification, abnormal entropy spikes in written data, and suspicious process behavior characteristic of encryption routines. Use when building real-time ransomware detection, tuning entropy thresholds, or investigating suspected active encryption on an endpoint.

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Detect abnormal access in AWS S3, GCS, and Azure Blob Storage by analyzing CloudTrail Data Events, GCS audit logs, and Azure Storage Analytics for after-hours bulk downloads, new-IP access, and API-call spikes (e.g. GetObject) via statistical baselines and time-series anomaly detection. Use when investigating suspected cloud data exfiltration or building related detection rules.

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Gets payroll ready to run without anyone getting shorted: pulls timesheets from Gusto, QuickBooks Payroll, or an uploaded spreadsheet, totals regular, overtime, and PTO hours by person, flags every anomaly it finds — missed punches, overtime spikes, rate changes, mid-period hires and terminations, hours off the schedule — and stages the run for the owner to approve line by line before a dollar moves. Anomalies are always raised, never quietly corrected. Once the owner runs it, the journal posts to the ledger or goes to the bookkeeper. Reach for this whenever payroll comes up at all — "run payroll," "payroll is due," "check the timecards," "did everyone clock out," "how many hours did the crew put in," "why is payroll so high this week," "I need to pay the guys Friday" — and use it after cash-flow-snapshot when the owner is worried about whether payroll clears.

日本語の概要は準備中です。原文の説明を表示しています。

Review and analyze product metrics with trend analysis and actionable insights. Use when running a weekly, monthly, or quarterly metrics review, investigating a sudden spike or drop, comparing performance against targets, or turning raw numbers into a scorecard with recommended actions.

日本語の概要は準備中です。原文の説明を表示しています。

Design experiments to test assumptions for an existing product — prototypes, A/B tests, spikes, and other low-effort validation methods. Use when validating assumptions, testing feature ideas cheaply, or planning product experiments.

日本語の概要は準備中です。原文の説明を表示しています。

Triage OpenSEO production errors in Cloudflare Workers Observability — verified query recipes, counting gotchas, and a known-noise filter list applied automatically. Use when asked to review Cloudflare logs/observability, count OOMs or worker errors, compare error rates between periods, or investigate a prod error spike.

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Mounts Cloud Storage buckets on Google Cloud as a POSIX file system using Cloud Storage FUSE (and the gcsfuse CLI tool). Use when interacting with the gcsfuse CLI or Cloud Storage FUSE mounts: decide whether FUSE, native gs:// reads, or Filestore/Managed Lustre fits a workload, deploy tuned mounts on GKE, Compute Engine, or Cloud Run, enable and size file, stat, and list caches, tune mount flags (--implicit-dirs) or config-file settings, apply workload profiles, keep ML checkpointing safe (rename atomicity, hierarchical namespace/HNS, close-time finalization, concurrent writers), or diagnose slow training, low throughput, or bill spikes with gcsfuse metrics. Covers mount semantics, gcsfuse CLI and config files, GKE gcsfuse CSI driver (Workload Identity principal:// bindings, profile StorageClasses, sidecar sizing), and Cloud Run volume mounts. Don't use for bucket administration or data management without a mount (google-cloud-storage-basics) or fully POSIX-compliant shared file systems (Filestore, Managed Lustre; use gke-storage).

日本語の概要は準備中です。原文の説明を表示しています。