「survival」の検索結果

Use when selecting predictive genes or other molecular features from bulk expression matrices for binary case-vs-control classification with elastic net logistic regression, including coefficient path and cross-validation plots. Trigger keywords: elastic net, glmnet, feature selection, binary classification, lambda.min, lambda.1se. NOT for: survival/Cox modeling, multiclass outcomes, single-cell data, or non-expression tables.

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Writes complete, publication-grade figure legends that can stand on their own. Use when writing or revising figure legends for any scientific figure — bar charts, line graphs, scatter plots, box plots, heatmaps, survival curves, flow cytometry plots, western blots, microscopy images, or schematic diagrams. Also triggers on "write a figure legend for", "help me describe this figure", "my figure needs a legend", "write Figure 1 legend", or "what should a figure legend include".

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Use when validating an existing prognostic risk signature on an external bulk expression cohort with survival outcomes, producing risk scores, Kaplan-Meier curves, risk distribution plots, heatmap, and time-dependent ROC curves. NOT for: model training, feature selection, nomogram construction, calibration analysis, or single-cell data.

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Use when longevity of a non-perishable option matters. Treat survival duration as a remaining-life prior, then check domain drift before favoring the proven.

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Routes any game-development request to the right specialized skill(s): it detects the engine (Godot, Unity, Unreal, Bevy, Phaser, PixiJS, three.js, LÖVE, pygame, Roblox) and the task, then reads the chosen skill before acting. Use to make a game or to decide which skill applies — for players, levels, enemies, shaders, art direction, sprites, tiles, textures, 3D assets, UI/UX, cameras, game feel, physics, input, audio, saving, multiplayer, AI, dialogue, procedural generation, or performance, for genres (platformer, roguelike, RPG, FPS, tower-defense, card game, visual novel, survival-crafting, puzzle), and for shipping (game jam, Steam, itch). Start here when unsure which gamedev skill to use.

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Help users identify the drivers of long-term retention and implement behavioral mechanics that keep customers coming back. This guide focuses on measuring the survival curve of users and optimizing the product environment for high frequency usage.

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Use when designing or auditing AAAI experiments for the broad-AI program committee, including baselines, ablations, statistical significance, robustness, human evaluation, AI-for-Social-Impact and alignment/safety evidence, compute and cost reporting, and reproducibility-checklist alignment for Phase-1 survival.

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Computes sample size and power for clinical trials including continuous, binary, and time-to-event endpoints; superiority, non-inferiority, and equivalence designs; FDA 2016 non-inferiority margin selection with M1/M2 framework; Schoenfeld 1981 and Lakatos 1988 for survival; Schuirmann TOST and 80-125% bioequivalence; minimum clinically important difference (MCID) vs δ distinction. Use when justifying trial size in protocol or SAP per CONSORT 2025 item 16a.

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Use this skill when fitting accelerated life models, computing mean time to failure (MTTF), B10 life and similar quantities, fitting life distributions like Weibull for reliability analysis, comparing distribution fits, computing confidence intervals on reliability quantities with bootstrapping, performing lifetime prediction, computing failure rates, plotting Kaplan-Meier curves, computing survival functions, or doing reliability analysis.

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Expert blueprint for Battle Royale games including shrinking zone/storm mechanics (phase-based, damage scaling), large-scale networking (relevancy, tick rate optimization), deployment systems (plane, freefall, parachute), loot spawning (weighted tables, rarity), and performance optimization (LOD, occlusion culling, object pooling). Use for multiplayer survival games or last-one-standing formats. Trigger keywords: battle_royale, zone_shrink, storm_damage, deployment_system, loot_spawn, networking_optimization, relevancy_system, snapshot_interpolation.

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Expert blueprint for horror games: sawtooth tension pacing, Director macro-AI, sensory predator AI, sanity/stress FX, and scarcity loops. Use when building psychological/survival horror, dual-brain stalker AI (cheating Director + honest LoS/sound), flashlight/fog atmosphere, or safe-room saves. Keywords: horror_game, tension_pacing, director_system, sensory_perception, sanity_system, volumetric_fog, AI_reaction_time.

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Expert blueprint for inventory systems (Diablo, Resident Evil, Minecraft) covering slot-based containers, stacking logic, weight limits, equipment systems, and drag-drop UI. Use when building RPG inventories, survival item management, or loot systems. Keywords inventory, slot, stack, equipment, crafting, item, Resource, drag-drop.

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Activation requires either supplied .NET coverage reports/percentages/line, branch, or condition metrics, or an explicit request to collect .NET coverage for analysis. USE FOR: interpreting that evidence, including Cobertura data, partial conditions, plateaus, target arithmetic, project-wide coverage-backed CRAP, and coverage-backed refactoring safety. Analyze supplied reports directly without rerunning tests or installing tools. DO NOT USE FOR: requests with neither coverage evidence nor explicit coverage-collection intent, including hypothetical change-survival questions (use test-gap-analysis); CRAP or refactoring safety for one named target (use crap-score); or requests owned by test-tagging, find-untested-sources, test-anti-patterns, run-tests, or code-testing.

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Guidelines for clinical decision support (CDS) documents: biomarker-stratified cohort analyses and GRADE-graded treatment reports. Covers structure, executive summaries, evidence grading (1A–2C), stats (HR, CI, survival), and biomarker integration. Use for pharma research docs, clinical guidelines, regulatory submissions.

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Guided statistical analysis: test choice, assumption checks, effect sizes, power, APA reporting. Pick tests, verify assumptions, or format results for publication. Covers frequentist (t-test, ANOVA, chi-square, regression, correlation, survival, count, reliability) and Bayesian. Use statsmodels or pymc-bayesian-modeling to fit.

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Use when data needs statistical analysis. Runs reproducible Python/R code for Table 1, diagnostic accuracy, agreement, regression, survival, propensity score, survey-weighted and repeated-measures models, with publication tables. Sample size is /calc-sample-size; pooling studies is /meta-analysis.

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Think and work like an expert Gerontologist. Use when a task calls for Gerontologist judgment. Reasons from senescence hallmarks, frailty, multi-morbidity, and life-course exposures through validated instruments (Fried phenotype, Rockwood CFS, SPPB/gait speed), epigenetic clocks (Horvath, PhenoAge, GrimAge), competing-risk survival (Fine-Gray), and NIA cohorts (HRS, NHATS, ITP) while treating survivor bias, differential attrition, healthy-volunteer bias, and frail-subset toxicity as first-class failure modes.

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Think and work like an expert Dentist-Scientist. Use when a task calls for Dentist-Scientist judgment. Reasons from oral biofilm-host ecology, tissue healing capacity, and patient-level clinical endpoints (DMFS, PD/CAL, implant survival) through PICO/PROSPERO protocols, CAMBRA and 2017 AAP/EFP staging, ISO 4049/14801 bench tests with thermocycling, and GRADE-rated reviews while treating in-vitro-to-chairside leaps, plaque-index surrogates without caries reduction, and examiner calibration drift as first-class failure modes.

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Think and work like an expert Biostatistician. Use when a task calls for Biostatistician judgment. Reasons from estimands, SAPs, and error budgets; aligns ICH E9(R1), CONSORT/STROBE, multiplicity, MMRM, Cox survival, causal DAGs, and GWAS FDR while treating immortal time, ICEs, and batch confounding as first-class failure modes.

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End-to-end clinical trial analysis workflow from CDISC SDTM/ADaM loading through ICH E9(R1) estimand-driven primary analysis to CONSORT 2025 regulatory-compliant reporting. Covers data preparation, FDA 2023 marginal vs conditional logistic regression, categorical tests with Boschloo, modern HTE/subgroup methods, missing-data sensitivity (MMRM, reference-based MI, Permutt tipping point), graphical multiplicity (Bretz-Maurer), survival analysis (Cox/RMST/competing risks) when applicable, and Table 1. Use when performing a complete analysis of clinical trial data.

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Workflow for predictive modeling, biomarker discovery, survival modeling, and explainability over omics-derived features.

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Patterns for designing and analyzing clinical trials, including survival analysis, endpoint selection, sample size calculation, interim analyses, and regulatory considerations. Covers FDA/EMA guidelines and modern adaptive designs. Use when ", " mentioned.

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Don't die. Runway calculation, default alive vs. default dead, when to raise vs. cut, zero-based budgeting for startups. The math that keeps companies alive long enough to win. Burn rate is not just accounting - it's strategic leverage. Companies with runway have options. Companies without runway have desperation. Use when "burn rate, runway, default alive, default dead, how much money, when to raise, cutting costs, layoffs, cash management, should we hire, running out of money, bridge round, extend runway, ramen profitable, finance, runway, cash, burn, survival, fundraising, startup" mentioned.

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Drafts and revises U.S. environmental indemnity agreements for real estate lending and acquisition transactions, allocating contamination and environmental-law liability to protect lenders, secured parties, or buyers. Covers indemnity scope, reps/warranties, covenants, remediation rights, escrows, insurance, survival, and assignment aligned to loan or acquisition documents. Use when drafting an environmental indemnity agreement, environmental liability allocation, lender environmental rider, or Phase I/II ESA-driven risk terms.

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